AR034321A1 - Un cristal anhidro de compuesto de beta-lactama y un procedimiento para su preparacion - Google Patents
Un cristal anhidro de compuesto de beta-lactama y un procedimiento para su preparacionInfo
- Publication number
- AR034321A1 AR034321A1 ARP020101581A ARP020101581A AR034321A1 AR 034321 A1 AR034321 A1 AR 034321A1 AR P020101581 A ARP020101581 A AR P020101581A AR P020101581 A ARP020101581 A AR P020101581A AR 034321 A1 AR034321 A1 AR 034321A1
- Authority
- AR
- Argentina
- Prior art keywords
- beta
- anhydrous crystal
- tazobactam
- formula
- lactama
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 title 1
- 239000013078 crystal Substances 0.000 abstract 5
- -1 beta-lactam compound Chemical class 0.000 abstract 4
- LPQZKKCYTLCDGQ-WEDXCCLWSA-N tazobactam Chemical compound C([C@]1(C)S([C@H]2N(C(C2)=O)[C@H]1C(O)=O)(=O)=O)N1C=CN=N1 LPQZKKCYTLCDGQ-WEDXCCLWSA-N 0.000 abstract 4
- 229960003865 tazobactam Drugs 0.000 abstract 4
- 239000007864 aqueous solution Substances 0.000 abstract 2
- 102000006635 beta-lactamase Human genes 0.000 abstract 2
- 108020004256 Beta-lactamase Proteins 0.000 abstract 1
- 108090000204 Dipeptidase 1 Proteins 0.000 abstract 1
- 238000010438 heat treatment Methods 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 244000005700 microbiome Species 0.000 abstract 1
- 230000000144 pharmacologic effect Effects 0.000 abstract 1
- 230000002035 prolonged effect Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D499/87—Compounds being unsubstituted in position 3 or with substituents other than only two methyl radicals attached in position 3, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
Abstract
Un cristal anhidro de compuesto de beta-lactama representado por la fórmula (1). Un procedimiento para preparar el cristal anhidro de compuestos de beta-lactama representado por la fórmula (1), procedimiento que comprende los pasos de calentar una solución acuosa que contiene una sal de compuesto de beta-lactama representado por la fórmula (1) y ajustaNdo el pH de la solución acuosa a 3 o menos. El cristal anhidro de compuesto de beta-lactama(tazobactama)representado por la fórmula (1) muestra excelente estabilidad en almacenamiento y sustancialmente no se descompone incluso cuando se almacena a la temperatura común durante un tiempo prolongado. El cristal anhidro de tazobactama tiene una actividad farmacológica como la de la tazobactama conocida. Específicamente, el cristal anhidro de tazobactama presenta una actividad inhibitoria de beta- lactamasa cuando se une en forma irreversible a las beta-lactamasas producidas por microorganismos.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2001134187A JP3306473B1 (ja) | 2001-05-01 | 2001-05-01 | β−ラクタム化合物の無水結晶及びその製造法 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR034321A1 true AR034321A1 (es) | 2004-02-18 |
Family
ID=18981916
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP020101581A AR034321A1 (es) | 2001-05-01 | 2002-04-30 | Un cristal anhidro de compuesto de beta-lactama y un procedimiento para su preparacion |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US7674898B2 (es) |
| JP (1) | JP3306473B1 (es) |
| KR (1) | KR100739103B1 (es) |
| CN (1) | CN1247595C (es) |
| AR (1) | AR034321A1 (es) |
| WO (1) | WO2002090363A1 (es) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW200523264A (en) * | 2003-10-09 | 2005-07-16 | Otsuka Chemical Co Ltd | CMPB crystal and method for producing the same |
| TW200519119A (en) * | 2003-10-10 | 2005-06-16 | Otsuka Chemical Co Ltd | PENAM crystal and process for producing the same |
| US7417143B2 (en) * | 2004-04-07 | 2008-08-26 | Orchid Chemicals & Pharmaceuticals Limited | Process for the preparation of Tazobactam in pure form |
| US20150246931A1 (en) * | 2012-09-06 | 2015-09-03 | Hospira, Inc. | Process for the preparation of tazobactam |
| US8476425B1 (en) | 2012-09-27 | 2013-07-02 | Cubist Pharmaceuticals, Inc. | Tazobactam arginine compositions |
| CN105025901B (zh) * | 2012-09-27 | 2019-04-19 | 默沙东公司 | 他唑巴坦精氨酸抗生素组合物 |
| US9872906B2 (en) | 2013-03-15 | 2018-01-23 | Merck Sharp & Dohme Corp. | Ceftolozane antibiotic compositions |
| US20140274990A1 (en) | 2013-03-15 | 2014-09-18 | Cubist Pharmaceuticals, Inc. | Ceftolozane pharmaceutical compositions |
| DK2893929T3 (da) | 2013-03-15 | 2025-07-07 | Merck Sharp & Dohme Llc | Antibiotisk ceftolozansammensætninger |
| AU2014233637A1 (en) | 2013-09-09 | 2015-03-26 | Merck Sharp & Dohme Corp. | Treating infections with ceftolozane/tazobactam in subjects having impaired renal function |
| US8906898B1 (en) | 2013-09-27 | 2014-12-09 | Calixa Therapeutics, Inc. | Solid forms of ceftolozane |
| CN104958302B (zh) * | 2015-05-27 | 2016-11-16 | 济南康和医药科技有限公司 | 一种注射用头孢哌酮钠他唑巴坦钠药物组合物及其制备工艺 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4562073A (en) * | 1982-12-24 | 1985-12-31 | Taiho Pharmaceutical Company Limited | Penicillin derivatives |
| JPS60214792A (ja) * | 1984-04-06 | 1985-10-28 | Taiho Yakuhin Kogyo Kk | ペナム酸エステル誘導体 |
| JP2602685B2 (ja) | 1988-03-01 | 1997-04-23 | 大鵬薬品工業株式会社 | ２α−メチル−２β―（１，２，３−トリアゾール−１−イル）メチルペナム−３α−カルボン酸誘導体の製造法 |
| JP2648750B2 (ja) * | 1988-03-02 | 1997-09-03 | 大塚化学株式会社 | β−ラクタム誘導体の製造方法 |
| US4958020A (en) * | 1989-05-12 | 1990-09-18 | American Cyanamid Company | Process for producing β-lactamase inhibitor |
| JPH03206093A (ja) * | 1990-01-08 | 1991-09-09 | Yoshitomi Pharmaceut Ind Ltd | ペナムカルボン酸エステル |
| JPH03206038A (ja) * | 1990-01-08 | 1991-09-09 | Yoshitomi Pharmaceut Ind Ltd | 抗菌剤 |
| AU679800B2 (en) * | 1993-11-06 | 1997-07-10 | Taiho Pharmaceutical Co., Ltd. | Crystalline penicillin derivative, and its production and use |
| JP3445664B2 (ja) * | 1994-08-10 | 2003-09-08 | 大塚化学ホールディングス株式会社 | アミノメチルペナム誘導体及びトリアゾリルメチルペナム誘導体の製造法 |
-
2001
- 2001-05-01 JP JP2001134187A patent/JP3306473B1/ja not_active Expired - Lifetime
- 2001-07-23 WO PCT/JP2001/006321 patent/WO2002090363A1/ja not_active Ceased
- 2001-07-23 KR KR1020037014201A patent/KR100739103B1/ko not_active Expired - Fee Related
- 2001-07-23 US US10/476,221 patent/US7674898B2/en not_active Expired - Lifetime
- 2001-07-23 CN CNB018232000A patent/CN1247595C/zh not_active Ceased
-
2002
- 2002-04-30 AR ARP020101581A patent/AR034321A1/es not_active Application Discontinuation
-
2009
- 2009-06-19 US US12/457,746 patent/US20090264642A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| KR100739103B1 (ko) | 2007-07-13 |
| JP3306473B1 (ja) | 2002-07-24 |
| WO2002090363A8 (fr) | 2003-02-13 |
| WO2002090363A1 (fr) | 2002-11-14 |
| US20090264642A1 (en) | 2009-10-22 |
| US7674898B2 (en) | 2010-03-09 |
| CN1505633A (zh) | 2004-06-16 |
| KR20030092117A (ko) | 2003-12-03 |
| US20040162277A1 (en) | 2004-08-19 |
| CN1247595C (zh) | 2006-03-29 |
| JP2002326993A (ja) | 2002-11-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant, registration | ||
| FD | Application declared void or lapsed, e.g., due to non-payment of fee |