AR021241A1 - Inhibidores de proteasas - Google Patents
Inhibidores de proteasasInfo
- Publication number
- AR021241A1 AR021241A1 ARP990105737A ARP990105737A AR021241A1 AR 021241 A1 AR021241 A1 AR 021241A1 AR P990105737 A ARP990105737 A AR P990105737A AR P990105737 A ARP990105737 A AR P990105737A AR 021241 A1 AR021241 A1 AR 021241A1
- Authority
- AR
- Argentina
- Prior art keywords
- protease inhibitors
- inhibitors
- decartilage
- inhibition
- diseases
- Prior art date
Links
- 229940042399 direct acting antivirals protease inhibitors Drugs 0.000 title 1
- 239000000137 peptide hydrolase inhibitor Substances 0.000 title 1
- 206010065687 Bone loss Diseases 0.000 abstract 1
- 102000004171 Cathepsin K Human genes 0.000 abstract 1
- 108090000625 Cathepsin K Proteins 0.000 abstract 1
- 102000005927 Cysteine Proteases Human genes 0.000 abstract 1
- 108010005843 Cysteine Proteases Proteins 0.000 abstract 1
- 230000015556 catabolic process Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 238000006731 degradation reaction Methods 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 230000005764 inhibitory process Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Este se refiere a compuestos de la formula (1), en la que: n es 1 o 2; o una de sus sales farmacéuticamente aceptables, que son inhibidores de cisteína-proteasas, particularmente catepsina K, y son utiles en el tratamiento de enfermedades en las quela inhibicion de la pérdida de huesos o de la degradacion decartílagos constituye un factor.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10841098P | 1998-11-13 | 1998-11-13 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR021241A1 true AR021241A1 (es) | 2002-07-03 |
Family
ID=22322023
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP990105737A AR021241A1 (es) | 1998-11-13 | 1999-11-11 | Inhibidores de proteasas |
Country Status (5)
| Country | Link |
|---|---|
| AR (1) | AR021241A1 (es) |
| AU (1) | AU1393900A (es) |
| CO (1) | CO5150165A1 (es) |
| PE (1) | PE20001237A1 (es) |
| WO (1) | WO2000029408A1 (es) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030144175A1 (en) | 1998-12-23 | 2003-07-31 | Smithkline Beecham Corporation | Protease inhibitors |
| US6534498B1 (en) | 1999-11-10 | 2003-03-18 | Smithkline Beecham Corporation | Protease inhibitors |
| AU1588901A (en) | 1999-11-10 | 2001-06-06 | Smithkline Beecham Corporation | Protease inhibitors |
| US6583137B1 (en) | 1999-11-10 | 2003-06-24 | Smithkline Beecham Corporation | Protease inhibitors |
| OA12323A (en) | 2000-03-21 | 2006-05-15 | Smithkline Beecham Corp | Protease inhibitors. |
| WO2002088106A2 (en) * | 2000-11-17 | 2002-11-07 | Medivir Ab | Cysteine protease inhibitors |
| CA2435117A1 (en) * | 2001-01-17 | 2002-07-25 | Amura Therapeutics Limited | Cyclic 2-carbonylaminoketones as inhibitors of cruzipain and other cysteine proteases |
| US6958358B2 (en) | 2001-01-17 | 2005-10-25 | Amura Therapeutics Limited | Inhibitors of cruzipain and other cysteine proteases |
| CN1269822C (zh) | 2001-01-17 | 2006-08-16 | 阿姆拉医疗有限公司 | 克鲁兹蛋白酶与其他半胱氨酸蛋白酶的抑制剂 |
| US7132449B2 (en) | 2001-01-17 | 2006-11-07 | Amura Therapeutics Limited | Inhibitors of cruzipain and other cysteine proteases |
| JP2005515254A (ja) | 2002-01-17 | 2005-05-26 | スミスクライン ビーチャム コーポレーション | カテプシンｋ阻害剤として有用なシクロアルキルケトアミド誘導体 |
| WO2009087379A2 (en) | 2008-01-09 | 2009-07-16 | Amura Therapeutics Limited | Tetrahydrofuro (3, 2 -b) pyrrol- 3 -one derivatives as inhibitors of cysteine proteinases |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5374623A (en) * | 1992-08-20 | 1994-12-20 | Prototek, Inc. | Cysteine protease inhibitors effective for in vivo use |
| CA2111930A1 (en) * | 1992-12-25 | 1994-06-26 | Ryoichi Ando | Aminoketone derivatives |
| MA26487A1 (fr) * | 1997-04-29 | 2004-12-20 | Smithkline Beecham Corp | Heterocyclecetohydrazides inhibiteurs de proteases, procede pour leur preparation et compositions pharmaceutiques les contenant . |
| AR013079A1 (es) * | 1997-05-06 | 2000-12-13 | Smithkline Beecham Corp | Derivados sustituidos de tetrahidrofurano-3-onas, de tetrahidropirano-3- onas y tetrahidrotiofen-3-onas, un procedimiento para su preparacion unacomposicion farmaceutica de un medicamento util como inhibidores de proteasas e intermediarios |
| PE73799A1 (es) * | 1997-05-08 | 1999-10-22 | Smithkline Beecham Corp | Inhibidores de proteasas |
| CN1255119A (zh) * | 1997-05-08 | 2000-05-31 | 史密丝克莱恩比彻姆公司 | 蛋白酶抑制剂 |
| MA26618A1 (fr) * | 1998-04-09 | 2004-12-20 | Smithkline Beecham Corp | Composes et compositions pharmaceutiques pour le traitement du paludisme |
| MA26631A1 (fr) * | 1998-05-21 | 2004-12-20 | Smithkline Beecham Corp | Composes a fonction bis-aminomethyl-carbonyle nouveaux, procede pour leur preparation et compositions pharmaceutiques les contenant |
-
1999
- 1999-11-10 CO CO99070943A patent/CO5150165A1/es unknown
- 1999-11-11 AR ARP990105737A patent/AR021241A1/es unknown
- 1999-11-12 PE PE1999001145A patent/PE20001237A1/es not_active Application Discontinuation
- 1999-11-12 WO PCT/GB1999/003777 patent/WO2000029408A1/en not_active Ceased
- 1999-11-12 AU AU13939/00A patent/AU1393900A/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| PE20001237A1 (es) | 2000-12-23 |
| CO5150165A1 (es) | 2002-04-29 |
| AU1393900A (en) | 2000-06-05 |
| WO2000029408A1 (en) | 2000-05-25 |
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