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MXPA03006224A - Inhibidores de cruzipaina y otras proteasas de cisteina. - Google Patents

Inhibidores de cruzipaina y otras proteasas de cisteina.

Info

Publication number
MXPA03006224A
MXPA03006224A MXPA03006224A MXPA03006224A MXPA03006224A MX PA03006224 A MXPA03006224 A MX PA03006224A MX PA03006224 A MXPA03006224 A MX PA03006224A MX PA03006224 A MXPA03006224 A MX PA03006224A MX PA03006224 A MXPA03006224 A MX PA03006224A
Authority
MX
Mexico
Prior art keywords
inhibitors
cruzipain
cysteine proteases
general formula
compounds
Prior art date
Application number
MXPA03006224A
Other languages
English (en)
Inventor
Quibell Martin
Original Assignee
Amura Therapeutics Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0101179A external-priority patent/GB0101179D0/en
Application filed by Amura Therapeutics Ltd filed Critical Amura Therapeutics Ltd
Publication of MXPA03006224A publication Critical patent/MXPA03006224A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Los compuestos de la formula general (I) o formula general (II), en donde R1, P1, P2, Q, Y, (X)o, (W)n, (V)m, Z y U son como se definen en la especificacion, son inhibidores de cruzipaina y otros inhibidores de proteasa de cisteina y son utiles como agentes terapeuticos, por ejemplo en enfermedad de Chagas, o para validar los compuestos objetivo terapeuticos.
MXPA03006224A 2001-01-17 2002-01-17 Inhibidores de cruzipaina y otras proteasas de cisteina. MXPA03006224A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB0101179A GB0101179D0 (en) 2001-01-17 2001-01-17 Biologically active compounds
US27535901P 2001-03-13 2001-03-13
PCT/GB2002/000184 WO2002057270A1 (en) 2001-01-17 2002-01-17 Inhibitors of cruzipain and other cysteine proteases

Publications (1)

Publication Number Publication Date
MXPA03006224A true MXPA03006224A (es) 2004-10-15

Family

ID=26245571

Family Applications (1)

Application Number Title Priority Date Filing Date
MXPA03006224A MXPA03006224A (es) 2001-01-17 2002-01-17 Inhibidores de cruzipaina y otras proteasas de cisteina.

Country Status (20)

Country Link
US (2) US7425562B2 (es)
EP (1) EP1362052B1 (es)
JP (1) JP4608183B2 (es)
KR (1) KR100860067B1 (es)
CN (1) CN1269822C (es)
AT (1) ATE356130T1 (es)
AU (1) AU2002219397B2 (es)
BR (1) BR0206501A (es)
CA (1) CA2436462C (es)
CY (1) CY1106640T1 (es)
DE (1) DE60218633T2 (es)
DK (1) DK1362052T3 (es)
ES (1) ES2281516T3 (es)
IL (2) IL156774A0 (es)
MX (1) MXPA03006224A (es)
NO (1) NO328208B1 (es)
NZ (1) NZ526913A (es)
PT (1) PT1362052E (es)
RU (1) RU2329266C2 (es)
WO (1) WO2002057270A1 (es)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MXPA03005601A (es) 2000-12-22 2004-12-02 Axys Pharm Inc Nuevos compuestos y composiciones como inhibidores de catepsina.
US7030116B2 (en) 2000-12-22 2006-04-18 Aventis Pharmaceuticals Inc. Compounds and compositions as cathepsin inhibitors
RS19504A (sr) 2001-09-14 2007-02-05 Aventis Pharmaceuticals Inc., Nova jedinjenja i kompozicije kao inhibitori katepsina
US6977256B2 (en) 2001-11-14 2005-12-20 Aventis Pharmaceuticals Inc. Compounds and compositions as cathepsin S inhibitors
WO2004007501A1 (en) * 2002-07-16 2004-01-22 Amura Therapeutics Limited Biologically active compounds
US7399765B2 (en) * 2003-09-19 2008-07-15 Abbott Laboratories Substituted diazabicycloalkane derivatives
EP1701960B1 (en) 2004-01-08 2010-03-17 Medivir Aktiebolag Cysteine protease inhibitors
SE0400022D0 (sv) * 2004-01-08 2004-01-08 Medivir Ab New compounds
JP2005350417A (ja) * 2004-06-11 2005-12-22 Dai Ichi Seiyaku Co Ltd 還元的エーテル化法を用いたピロリジン誘導体の製造法
KR101447897B1 (ko) * 2005-03-21 2014-10-07 비로베이, 인코포레이티드 시스테인 단백질분해효소 억제제로서의 알파 케토아미드화합물
GB0513839D0 (en) * 2005-07-07 2005-08-10 Medivir Ab Cysteine protease inhibitors
GB0513840D0 (en) * 2005-07-07 2005-08-10 Medivir Ab Cysteine protease inhibitors
GB0614053D0 (en) * 2006-07-14 2006-08-23 Amura Therapeutics Ltd Compounds
GB0614073D0 (en) 2006-07-14 2006-08-23 Amura Therapeutics Ltd Compounds
GB0614037D0 (en) * 2006-07-14 2006-08-23 Amura Therapeutics Ltd Compounds
GB0614046D0 (en) 2006-07-14 2006-08-23 Amura Therapeutics Ltd Compounds
GB0614044D0 (en) * 2006-07-14 2006-08-23 Amura Therapeutics Ltd Compounds
GB0614042D0 (en) 2006-07-14 2006-08-23 Amura Therapeutics Ltd Compounds
GB0614052D0 (en) * 2006-07-14 2006-08-23 Amura Therapeutics Ltd Compounds
WO2008114054A1 (en) * 2007-03-19 2008-09-25 Medivir Ab Protease inhibitors
US7893067B2 (en) * 2007-06-27 2011-02-22 Medivir Ab Cysteine protease inhibitors
WO2009087379A2 (en) * 2008-01-09 2009-07-16 Amura Therapeutics Limited Tetrahydrofuro (3, 2 -b) pyrrol- 3 -one derivatives as inhibitors of cysteine proteinases
GB0804701D0 (en) * 2008-03-13 2008-04-16 Amura Therapeutics Ltd Compounds
GB0804702D0 (en) 2008-03-13 2008-04-16 Amura Therapeutics Ltd Compounds
WO2012099785A2 (en) * 2011-01-20 2012-07-26 The Regents Of The University Of Colorado, A Body Corporate Modulators of tlr3/dsrna complex and uses thereof
EP2891492B1 (en) * 2012-08-30 2022-11-09 The University of Tokyo Endoparasite control agent
CN106279188A (zh) * 2016-07-21 2017-01-04 青岛科技大学 一种多取代呋喃并[2,3‑b]吡咯衍生物的制备方法

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3652574A (en) * 1970-04-01 1972-03-28 Abbott Lab Certain 1 2 3 4 - tetrahydro-5h-pyrido (4 3-b)indoles and the corresponding 1 2 3 4-tetrahydro-9h-pyrido(3 4-b)indoles and derivatives thereof
DE3601226A1 (de) * 1986-01-17 1987-07-23 Bayer Ag Dihydropyridinlactole, verfahren zur herstellung und ihre verwendung in arzneimitteln
RU2137768C1 (ru) * 1993-12-15 1999-09-20 Мерк энд Ко, Инк. Ингибиторы hiv протеазы
DZ2285A1 (fr) 1996-08-08 2002-12-25 Smithkline Beecham Corp Inhibiteurs de protéase de la cystéine.
WO1998008802A1 (en) 1996-08-28 1998-03-05 Smithkline Beecham Corporation Inhibitors of cysteine protease
DE69739236D1 (de) 1996-12-23 2009-03-12 Lilly Co Eli Cycloalkyl-, lactam-, lacton- und verwandte verbindungen als hemmer der beta-amyloidpeptidfreisetzung
AR013079A1 (es) * 1997-05-06 2000-12-13 Smithkline Beecham Corp Derivados sustituidos de tetrahidrofurano-3-onas, de tetrahidropirano-3- onas y tetrahidrotiofen-3-onas, un procedimiento para su preparacion unacomposicion farmaceutica de un medicamento util como inhibidores de proteasas e intermediarios
MA26618A1 (fr) 1998-04-09 2004-12-20 Smithkline Beecham Corp Composes et compositions pharmaceutiques pour le traitement du paludisme
CO5150165A1 (es) 1998-11-13 2002-04-29 Smithkline Beecham Plc Inhibidores de proteasa: tipo catepsina k
GB9911417D0 (en) * 1999-05-18 1999-07-14 Peptide Therapeutics Ltd Furanone derivatives as inhibitors of cathepsin s
EP1345931A2 (en) 2000-11-17 2003-09-24 Medivir UK Ltd Cysteine protease inhibitors
MXPA03005601A (es) 2000-12-22 2004-12-02 Axys Pharm Inc Nuevos compuestos y composiciones como inhibidores de catepsina.

Also Published As

Publication number Publication date
DE60218633T2 (de) 2008-02-21
US20040138250A1 (en) 2004-07-15
HK1060729A1 (en) 2004-08-20
PT1362052E (pt) 2007-04-30
DK1362052T3 (da) 2007-07-09
RU2003125270A (ru) 2005-02-20
NO20033220L (no) 2003-09-17
NO328208B1 (no) 2010-01-11
US7425562B2 (en) 2008-09-16
NO20033220D0 (no) 2003-07-16
AU2002219397B2 (en) 2008-02-14
KR100860067B1 (ko) 2008-09-24
KR20030075161A (ko) 2003-09-22
US20090247471A1 (en) 2009-10-01
DE60218633D1 (de) 2007-04-19
IL156774A (en) 2008-08-07
CA2436462A1 (en) 2002-07-25
ATE356130T1 (de) 2007-03-15
CN1486320A (zh) 2004-03-31
ES2281516T3 (es) 2007-10-01
CA2436462C (en) 2011-07-05
NZ526913A (en) 2004-12-24
IL156774A0 (en) 2004-02-08
CN1269822C (zh) 2006-08-16
JP2004518674A (ja) 2004-06-24
BR0206501A (pt) 2004-01-13
EP1362052B1 (en) 2007-03-07
WO2002057270A1 (en) 2002-07-25
JP4608183B2 (ja) 2011-01-05
RU2329266C2 (ru) 2008-07-20
EP1362052A1 (en) 2003-11-19
CY1106640T1 (el) 2012-01-25

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