AR021161A1 - Derivados del imidazol, analogos ciclicos de la somatostatina, composicion farmaceutica que los comprenden, uso de los mismos para la manufactura de unmedicamento - Google Patents
Derivados del imidazol, analogos ciclicos de la somatostatina, composicion farmaceutica que los comprenden, uso de los mismos para la manufactura de unmedicamentoInfo
- Publication number
- AR021161A1 AR021161A1 ARP990102857A ARP990102857A AR021161A1 AR 021161 A1 AR021161 A1 AR 021161A1 AR P990102857 A ARP990102857 A AR P990102857A AR P990102857 A ARP990102857 A AR P990102857A AR 021161 A1 AR021161 A1 AR 021161A1
- Authority
- AR
- Argentina
- Prior art keywords
- optionally substituted
- alkyl
- group
- independently
- substituents
- Prior art date
Links
- RAXXELZNTBOGNW-UHFFFAOYSA-N 1H-imidazole Chemical class C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- NHXLMOGPVYXJNR-ATOGVRKGSA-N somatostatin Chemical compound C([C@H]1C(=O)N[C@H](C(N[C@@H](CO)C(=O)N[C@@H](CSSC[C@@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CC=2C3=CC=CC=C3NC=2)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N1)[C@@H](C)O)NC(=O)CNC(=O)[C@H](C)N)C(O)=O)=O)[C@H](O)C)C1=CC=CC=C1 NHXLMOGPVYXJNR-ATOGVRKGSA-N 0.000 title 1
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 5
- 125000001424 substituent group Chemical group 0.000 abstract 4
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 3
- 125000004104 aryloxy group Chemical group 0.000 abstract 3
- 125000001475 halogen functional group Chemical group 0.000 abstract 3
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 125000003118 aryl group Chemical group 0.000 abstract 2
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 2
- -1 - CONR9R9 Chemical group 0.000 abstract 1
- 150000007649 L alpha amino acids Chemical class 0.000 abstract 1
- 125000002102 aryl alkyloxo group Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000004122 cyclic group Chemical group 0.000 abstract 1
- 125000004415 heterocyclylalkyl group Chemical group 0.000 abstract 1
- 150000002460 imidazoles Chemical class 0.000 abstract 1
- 229940079865 intestinal antiinfectives imidazole derivative Drugs 0.000 abstract 1
- 125000000896 monocarboxylic acid group Chemical group 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000003107 substituted aryl group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/655—Somatostatins
- C07K14/6555—Somatostatins at least 1 amino acid in D-form
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Immunology (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- Rheumatology (AREA)
- Obesity (AREA)
- Emergency Medicine (AREA)
- Zoology (AREA)
- Oncology (AREA)
- Ophthalmology & Optometry (AREA)
- Pain & Pain Management (AREA)
- Transplantation (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Toxicology (AREA)
- Communicable Diseases (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Urology & Nephrology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Abstract
Derivados del imidazol, análogos cíclicos de somatostina, que comprenden un compuesto de la formula (1) o una sal farmacéuticamente aceptable del mismo,donde Y y Z, en cada caso, son independientemente un D- o L-alfa-aminoácido natural o no natural;n es, en cada caso, independientemente 0 a 50, siempre queambas n no sean 0 al mismo tiempo; m es 0 o un numero entero de 1 a 10; a es H o R1; b es OH, -OR1 o-NR9R9; o a se une con b para formar un enlace amídico; R1es independientemente H, alquilo (C1-4) o arilalquilo (C1-4); R2 es H o una porcion optativamente sustituida seleccionada entre el grupo que consiste enalquilo (C1-4), fenilo, fenilalquilo (C1-4) y heterociclil-alquilo (C1-4), donde la porcion optativamente sustituida está optativamente sustituida con uno omás sustituyentes, cada uno de los cuales es independientemente seleccionado entre el grupo que consiste en alquilo (C1-4), cicloalquilo (C3-8), -O-R6,S(O)q-R7, -N(R9R9), -NHCO-R6, NHSO2R9, -CO2-R9, -CONR9R9 y SO2NR9R9 donde qes 0, 1, 2 o 3; cada uno de R3 y R4 es independientemente H, halo o una porcionoptativamente sustituida seleccionada entre el grupo que consiste en alquilo (C1-4), cicloalquilo (C3-8), arilo y arilalquilo (C1-4); donde la porcionoptativamente sustituida está optativamente sustituida con uno o más sustituyentes seleccionados entre el grupo que consiste en OH, alquilo (C1-4), alcoxi(C1-4), ariloxi, arilalcoxi (C1-4).-NR9R9, COOH, -CONR9R9, y halo; o R3 y R4 junto con los carbonos a los cuales están unidos forman arilo optativamentesustituido, donde el arilo está optativamente sustituido con uno o más sustituyentes, cada uno de los cuales es independientemente seleccionado entre el grupoque consiste en OH, alquilo (C1-4), alcoxi (C1-4), ariloxi, arilalcoxi (C1-4), -NR9R9, -COOR5, -CONR9R9, y halo; R5 es, en cada caso, independientemente H, ouna porcion optativamente sustituida seleccionada entre el grupo que consiste en alquilo (C1-4) y arilalquilo (C1-4), donde la porcion optativamentesustituidaestá optativamente sustituida con uno o más sustituyentes, cada uno de los cuales es independientemente seleccionado entre el grupo que consiste en alquilo
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US8950398P | 1998-06-16 | 1998-06-16 | |
| US9818198A | 1998-06-16 | 1998-06-16 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR021161A1 true AR021161A1 (es) | 2002-07-03 |
Family
ID=26780645
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP990102857A AR021161A1 (es) | 1998-06-16 | 1999-06-15 | Derivados del imidazol, analogos ciclicos de la somatostatina, composicion farmaceutica que los comprenden, uso de los mismos para la manufactura de unmedicamento |
Country Status (12)
| Country | Link |
|---|---|
| EP (1) | EP1086131A1 (es) |
| JP (1) | JP2002518409A (es) |
| CN (1) | CN1200000C (es) |
| AR (1) | AR021161A1 (es) |
| AU (1) | AU745493B2 (es) |
| CA (1) | CA2335184A1 (es) |
| HU (1) | HUP0102902A3 (es) |
| NO (1) | NO20006320L (es) |
| PL (1) | PL345037A1 (es) |
| RU (1) | RU2242481C2 (es) |
| TW (3) | TW527361B (es) |
| WO (1) | WO1999065942A1 (es) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE279396T1 (de) | 1998-06-12 | 2004-10-15 | Sod Conseils Rech Applic | Imidazolderivate und ihre verwendung als somatostatin rezeptorliganden |
| FR2796945B1 (fr) * | 1999-07-30 | 2002-06-28 | Sod Conseils Rech Applic | Nouveaux derives d'hydantoines, de thiohydantoines, de pyrimidinediones et de thioxopyrimidinones, leurs procedes de preparation et leur application a titre de medicaments |
| JP2004518613A (ja) * | 2000-08-01 | 2004-06-24 | ソシエテ・ドゥ・コンセイユ・ドゥ・ルシェルシュ・エ・ダプリカーション・シャンティフィック・エス・ア・エス | イミダゾリル誘導体 |
| WO2004071448A2 (en) * | 2003-02-12 | 2004-08-26 | Transtech Pharma Inc. | Substituted azole derivatives as inhibitors of protein tyrosine phosphatases |
| US8017575B2 (en) | 2004-12-15 | 2011-09-13 | Wilfred Wayne Lautt | Treatment of insulin resistance by modulating somatostatin using somatostatin receptor antagonists |
| CN101341129B (zh) * | 2005-12-14 | 2011-12-14 | 布里斯托尔-迈尔斯斯奎布公司 | 作为因子xia抑制剂的芳基丙酰胺，芳基丙烯酰胺，芳基丙炔酰胺，或芳基甲基脲类似物 |
| JP5225098B2 (ja) * | 2005-12-14 | 2013-07-03 | ブリストル−マイヤーズ スクイブ カンパニー | 第ＸＩａ因子インヒビターとしてのアリールプロピオンアミド、アリールアクリルアミド、アリールプロピンアミド、またはアリールメチルウレアアナログ |
| MX357314B (es) | 2008-09-26 | 2018-07-04 | Ambrx Inc | Microorganismos y vacunas dependientes de replicacion de aminoacidos no naturales. |
| EP2168983A1 (fr) | 2008-09-30 | 2010-03-31 | Ipsen Pharma | Nouveaux composés octapeptidiques et leur utilisation thérapeutique |
| US8501804B2 (en) | 2008-10-27 | 2013-08-06 | Takeda Pharmaceutical Company Limited | Bicyclic compound |
| JP6989529B2 (ja) | 2016-02-09 | 2022-01-05 | シーディーアールディー ベンチャーズ インコーポレイテッド | ソマトスタチン受容体アンタゴニスト化合物及びその使用方法 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5770687A (en) * | 1995-06-07 | 1998-06-23 | Peptor Limited | Comformationally constrained backbone cyclized somatostatin analogs |
| GB9513224D0 (en) * | 1995-06-29 | 1995-09-06 | Sandoz Ltd | Organic compounds |
| US6673927B2 (en) * | 1996-02-16 | 2004-01-06 | Societe De Conseils De Recherches Et D'applications Scientifiques, S.A.S. | Farnesyl transferase inhibitors |
-
1999
- 1999-06-11 EP EP99931793A patent/EP1086131A1/en not_active Withdrawn
- 1999-06-11 CN CNB998075027A patent/CN1200000C/zh not_active Expired - Fee Related
- 1999-06-11 RU RU2001101530/04A patent/RU2242481C2/ru not_active IP Right Cessation
- 1999-06-11 AU AU48223/99A patent/AU745493B2/en not_active Ceased
- 1999-06-11 WO PCT/US1999/013304 patent/WO1999065942A1/en not_active Ceased
- 1999-06-11 HU HU0102902A patent/HUP0102902A3/hu unknown
- 1999-06-11 PL PL99345037A patent/PL345037A1/xx not_active Application Discontinuation
- 1999-06-11 JP JP2000554767A patent/JP2002518409A/ja active Pending
- 1999-06-11 CA CA002335184A patent/CA2335184A1/en not_active Abandoned
- 1999-06-15 TW TW088110016A patent/TW527361B/zh not_active IP Right Cessation
- 1999-06-15 AR ARP990102857A patent/AR021161A1/es unknown
- 1999-06-15 TW TW093100348A patent/TWI242442B/zh active
- 1999-06-15 TW TW091115003A patent/TWI242441B/zh active
-
2000
- 2000-12-12 NO NO20006320A patent/NO20006320L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| WO1999065942A8 (en) | 2000-02-17 |
| TWI242442B (en) | 2005-11-01 |
| TW527361B (en) | 2003-04-11 |
| AU4822399A (en) | 2000-01-05 |
| JP2002518409A (ja) | 2002-06-25 |
| PL345037A1 (en) | 2001-11-19 |
| NO20006320L (no) | 2001-02-12 |
| HUP0102902A2 (hu) | 2002-01-28 |
| EP1086131A1 (en) | 2001-03-28 |
| WO1999065942A1 (en) | 1999-12-23 |
| TWI242441B (en) | 2005-11-01 |
| CN1305496A (zh) | 2001-07-25 |
| RU2242481C2 (ru) | 2004-12-20 |
| HUP0102902A3 (en) | 2002-02-28 |
| CN1200000C (zh) | 2005-05-04 |
| NO20006320D0 (no) | 2000-12-12 |
| TW200410986A (en) | 2004-07-01 |
| CA2335184A1 (en) | 1999-12-23 |
| AU745493B2 (en) | 2002-03-21 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |