AR029084A1 - Composiciones y metodos para el tratamiento del cancer - Google Patents
Composiciones y metodos para el tratamiento del cancerInfo
- Publication number
- AR029084A1 AR029084A1 ARP010102298A ARP010102298A AR029084A1 AR 029084 A1 AR029084 A1 AR 029084A1 AR P010102298 A ARP010102298 A AR P010102298A AR P010102298 A ARP010102298 A AR P010102298A AR 029084 A1 AR029084 A1 AR 029084A1
- Authority
- AR
- Argentina
- Prior art keywords
- prevention
- cancer
- thalidomide
- methods
- treatment
- Prior art date
Links
- 206010028980 Neoplasm Diseases 0.000 title abstract 3
- 201000011510 cancer Diseases 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 3
- 239000000203 mixture Substances 0.000 title abstract 3
- UEJJHQNACJXSKW-UHFFFAOYSA-N 2-(2,6-dioxopiperidin-3-yl)-1H-isoindole-1,3(2H)-dione Chemical compound O=C1C2=CC=CC=C2C(=O)N1C1CCC(=O)NC1=O UEJJHQNACJXSKW-UHFFFAOYSA-N 0.000 abstract 4
- 230000002265 prevention Effects 0.000 abstract 4
- 229960003433 thalidomide Drugs 0.000 abstract 4
- 239000002246 antineoplastic agent Substances 0.000 abstract 3
- 229940041181 antineoplastic drug Drugs 0.000 abstract 3
- 230000002411 adverse Effects 0.000 abstract 1
- 238000002512 chemotherapy Methods 0.000 abstract 1
- 239000003534 dna topoisomerase inhibitor Substances 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 229960004768 irinotecan Drugs 0.000 abstract 1
- UWKQSNNFCGGAFS-XIFFEERXSA-N irinotecan Chemical compound C1=C2C(CC)=C3CN(C(C4=C([C@@](C(=O)OC4)(O)CC)C=4)=O)C=4C3=NC2=CC=C1OC(=O)N(CC1)CCC1N1CCCCC1 UWKQSNNFCGGAFS-XIFFEERXSA-N 0.000 abstract 1
- 229940002612 prodrug Drugs 0.000 abstract 1
- 239000000651 prodrug Substances 0.000 abstract 1
- 238000001959 radiotherapy Methods 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
- 229940044693 topoisomerase inhibitor Drugs 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/7056—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing five-membered rings with nitrogen as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/716—Glucans
- A61K31/724—Cyclodextrins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Se refiere a las composiciones que comprenden talidomida y otras drogas anti û cáncer que se pueden utilizar en el tratamiento o prevencion del cáncer. Las drogas anti û cáncer preferidas son los inhibidores de topoisomerasa. Una composicion particular comprende talidomida, o una prodroga farmacéuticamente aceptable, sal, solvato, hidrato, o clatrato de los mismos, e irinotecan. También se refiere a los métodos de tratamiento o prevencion del cáncer que comprende la administracion de una talidomida y otra droga anti û cáncer al paciente que necesita el mencionado tratamiento o prevencion. También se refiere a los métodos para reducir o evitar los efectos secundarios adversos asociados con la administracion de la quimioterapia o de la terapia de radiacion que comprende la administracion de talidomida a un paciente que necesita de esa reduccion o prevencion.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US20414300P | 2000-05-15 | 2000-05-15 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR029084A1 true AR029084A1 (es) | 2003-06-04 |
Family
ID=22756804
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP010102298A AR029084A1 (es) | 2000-05-15 | 2001-05-15 | Composiciones y metodos para el tratamiento del cancer |
Country Status (18)
| Country | Link |
|---|---|
| US (2) | US7435726B2 (es) |
| EP (1) | EP1307197B1 (es) |
| JP (1) | JP5409981B2 (es) |
| KR (1) | KR100790589B1 (es) |
| AR (1) | AR029084A1 (es) |
| AT (1) | ATE322266T1 (es) |
| AU (2) | AU6147401A (es) |
| BR (1) | BR0110877A (es) |
| CA (1) | CA2408707C (es) |
| DE (1) | DE60118571T2 (es) |
| DK (1) | DK1307197T3 (es) |
| ES (1) | ES2258084T3 (es) |
| MX (1) | MXPA02011218A (es) |
| NZ (1) | NZ522767A (es) |
| PT (1) | PT1307197E (es) |
| TW (1) | TWI289449B (es) |
| WO (1) | WO2001087307A2 (es) |
| ZA (1) | ZA200209638B (es) |
Families Citing this family (95)
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| WO2003090681A2 (en) * | 2002-04-24 | 2003-11-06 | Research Development Foundation | SYNERGISTIC EFFECTS OF NUCLEAR TRANSCRIPTION FACTOR NF-κB INHIBITORS AND ANTI-NEOPLASTIC AGENTS |
| US7968569B2 (en) | 2002-05-17 | 2011-06-28 | Celgene Corporation | Methods for treatment of multiple myeloma using 3-(4-amino-1-oxo-1,3-dihydro-isoindol-2-yl)-piperidine-2,6-dione |
| NZ536908A (en) * | 2002-05-17 | 2008-09-26 | Celgene Corp | Treating or preventing cancer comprising administering an effective amount of cytokine inhibitory drug plus a second active ingredient |
| US20100129363A1 (en) * | 2002-05-17 | 2010-05-27 | Zeldis Jerome B | Methods and compositions using pde4 inhibitors for the treatment and management of cancers |
| US7393862B2 (en) | 2002-05-17 | 2008-07-01 | Celgene Corporation | Method using 3-(4-amino-1-oxo-1,3-dihydro-isoindol-2-yl)-piperidine-2,6-dione for treatment of certain leukemias |
| US7323479B2 (en) | 2002-05-17 | 2008-01-29 | Celgene Corporation | Methods for treatment and management of brain cancer using 1-oxo-2-(2,6-dioxopiperidin-3-yl)-4-methylisoindoline |
| CN1981761B (zh) * | 2002-05-17 | 2011-10-12 | 细胞基因公司 | 使用免疫调节性化合物用于制备治疗和控制癌症和其它疾病药物中的应用及组合物 |
| USRE48890E1 (en) | 2002-05-17 | 2022-01-11 | Celgene Corporation | Methods for treating multiple myeloma with 3-(4-amino-1-oxo-1,3-dihydroisoindol-2-yl)-piperidine-2,6-dione after stem cell transplantation |
| US7196105B2 (en) * | 2002-06-24 | 2007-03-27 | Research Development Foundation | Treatment of human multiple myeloma by curcumin |
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| US7189740B2 (en) | 2002-10-15 | 2007-03-13 | Celgene Corporation | Methods of using 3-(4-amino-oxo-1,3-dihydro-isoindol-2-yl)-piperidine-2,6-dione for the treatment and management of myelodysplastic syndromes |
| US8404716B2 (en) | 2002-10-15 | 2013-03-26 | Celgene Corporation | Methods of treating myelodysplastic syndromes with a combination therapy using lenalidomide and azacitidine |
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| US8404717B2 (en) * | 2002-10-15 | 2013-03-26 | Celgene Corporation | Methods of treating myelodysplastic syndromes using lenalidomide |
| US11116782B2 (en) | 2002-10-15 | 2021-09-14 | Celgene Corporation | Methods of treating myelodysplastic syndromes with a combination therapy using lenalidomide and azacitidine |
| US7354948B2 (en) | 2002-11-06 | 2008-04-08 | Celgene Corporation | Methods for treatment of chronic uveitis using cyclopropyl-n-{2-[(1S)-1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl]-3-oxoisoindoline-4-yl}carboxamide |
| US7563810B2 (en) | 2002-11-06 | 2009-07-21 | Celgene Corporation | Methods of using 3-(4-amino-1-oxo-1,3-dihydroisoindol-2-yl)-piperidine-2,6-dione for the treatment and management of myeloproliferative diseases |
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| US20100009929A1 (en) | 2004-03-29 | 2010-01-14 | Cheng Jin Q | Compositions including triciribine and bortezomib and derivatives thereof and methods of use thereof |
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| ES2629682T3 (es) | 2004-03-29 | 2017-08-14 | University Of South Florida | Tratamiento efectivo de tumores y cáncer con fosfato de triciribina |
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| WO2016210262A1 (en) | 2015-06-26 | 2016-12-29 | Celgene Corporation | Methods for the treatment of kaposi's sarcoma or kshv-induced lymphoma using immunomodulatory compounds, and uses of biomarkers |
| EP3337495A4 (en) | 2015-08-18 | 2019-04-10 | Mateon Therapeutics, Inc. | USE OF VDA TO ENHANCE IMMUNOMODULATION THERAPIES AGAINST TUMORS |
| CN109195957A (zh) | 2016-02-25 | 2019-01-11 | 塔克西斯医药股份有限公司 | 合成方法和中间体 |
| KR101945492B1 (ko) * | 2016-04-29 | 2019-02-08 | (주)나디안바이오 | 나프토퀴논계 화합물을 유효성분으로 포함하는 항암제 치료 관련 부작용으로 나타나는 피로, 악액질, 통증, 인지능력 저하 및 조혈줄기세포 감소의 예방 또는 개선용 조성물 |
| FI3490560T3 (fi) | 2016-07-29 | 2025-02-27 | Janssen Pharmaceutica Nv | Niraparibi käytettäväksi eturauhassyövän hoitomenetelmässä |
| KR101851470B1 (ko) | 2016-12-19 | 2018-06-11 | 한림대학교 산학협력단 | 퀘세틴이 함유된 유방암 예방 및 치료를 위한 약제학적 조성물 |
| US10774093B2 (en) | 2017-03-30 | 2020-09-15 | Taxis Pharmaceuticals, Inc. | Synthetic processes and synthetic intermediates |
| US10537585B2 (en) | 2017-12-18 | 2020-01-21 | Dexcel Pharma Technologies Ltd. | Compositions comprising dexamethasone |
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| JPS6019790A (ja) | 1983-07-14 | 1985-01-31 | Yakult Honsha Co Ltd | 新規なカンプトテシン誘導体 |
| US5422344A (en) * | 1990-05-08 | 1995-06-06 | The United States Of America As Represented By The Secretary Of The Department Of Health & Human Services | Method of treating retroviral infections in mammals |
| WO1992014455A1 (en) | 1991-02-14 | 1992-09-03 | The Rockefeller University | METHOD FOR CONTROLLING ABNORMAL CONCENTRATION TNF α IN HUMAN TISSUES |
| US5629327A (en) | 1993-03-01 | 1997-05-13 | Childrens Hospital Medical Center Corp. | Methods and compositions for inhibition of angiogenesis |
| US5643915A (en) | 1995-06-06 | 1997-07-01 | Andrulis Pharmaceuticals Corp. | Treatment of ischemia/reperfusion injury with thalidomide alone or in combination with other therapies |
| US5654312A (en) | 1995-06-07 | 1997-08-05 | Andrulis Pharmaceuticals | Treatment of inflammatory and/or autoimmune dermatoses with thalidomide alone or in combination with other agents |
| GB9523493D0 (en) * | 1995-11-16 | 1996-01-17 | British Biotech Pharm | Preparation of allyl succinate derivatives and starting materials therefore |
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2001
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- 2001-05-10 MX MXPA02011218A patent/MXPA02011218A/es active IP Right Grant
- 2001-05-10 CA CA2408707A patent/CA2408707C/en not_active Expired - Fee Related
- 2001-05-10 PT PT01935373T patent/PT1307197E/pt unknown
- 2001-05-10 BR BR0110877-8A patent/BR0110877A/pt active Search and Examination
- 2001-05-10 AU AU6147401A patent/AU6147401A/xx active Pending
- 2001-05-10 DK DK01935373T patent/DK1307197T3/da active
- 2001-05-10 EP EP01935373A patent/EP1307197B1/en not_active Expired - Lifetime
- 2001-05-10 JP JP2001583775A patent/JP5409981B2/ja not_active Expired - Fee Related
- 2001-05-10 DE DE60118571T patent/DE60118571T2/de not_active Expired - Lifetime
- 2001-05-10 AU AU2001261474A patent/AU2001261474B2/en not_active Ceased
- 2001-05-10 WO PCT/US2001/015327 patent/WO2001087307A2/en not_active Ceased
- 2001-05-10 NZ NZ522767A patent/NZ522767A/en not_active IP Right Cessation
- 2001-05-10 AT AT01935373T patent/ATE322266T1/de active
- 2001-05-10 ES ES01935373T patent/ES2258084T3/es not_active Expired - Lifetime
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- 2001-06-26 TW TW090111620A patent/TWI289449B/zh active
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2002
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| KR20030025922A (ko) | 2003-03-29 |
| ATE322266T1 (de) | 2006-04-15 |
| CA2408707A1 (en) | 2001-11-22 |
| CA2408707C (en) | 2010-04-13 |
| JP2003533484A (ja) | 2003-11-11 |
| AU6147401A (en) | 2001-11-26 |
| ZA200209638B (en) | 2003-11-27 |
| DE60118571T2 (de) | 2007-02-01 |
| ES2258084T3 (es) | 2006-08-16 |
| KR100790589B1 (ko) | 2008-01-02 |
| EP1307197A2 (en) | 2003-05-07 |
| NZ522767A (en) | 2004-07-30 |
| US7435726B2 (en) | 2008-10-14 |
| JP5409981B2 (ja) | 2014-02-05 |
| MXPA02011218A (es) | 2004-08-19 |
| WO2001087307A3 (en) | 2002-07-25 |
| US20020035090A1 (en) | 2002-03-21 |
| DK1307197T3 (da) | 2006-07-03 |
| BR0110877A (pt) | 2003-03-11 |
| AU2001261474B2 (en) | 2006-03-09 |
| TWI289449B (en) | 2007-11-11 |
| PT1307197E (pt) | 2006-08-31 |
| EP1307197B1 (en) | 2006-04-05 |
| US20050148524A1 (en) | 2005-07-07 |
| HK1054502A1 (en) | 2003-12-05 |
| DE60118571D1 (de) | 2006-05-18 |
| WO2001087307A2 (en) | 2001-11-22 |
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