[go: up one dir, main page]

AR028969A1 - Derivados de 3-azabiciclo[3.1.0] hexano utiles en terapia - Google Patents

Derivados de 3-azabiciclo[3.1.0] hexano utiles en terapia

Info

Publication number
AR028969A1
AR028969A1 ARP010102957A ARP010102957A AR028969A1 AR 028969 A1 AR028969 A1 AR 028969A1 AR P010102957 A ARP010102957 A AR P010102957A AR P010102957 A ARP010102957 A AR P010102957A AR 028969 A1 AR028969 A1 AR 028969A1
Authority
AR
Argentina
Prior art keywords
useful
derivatives
azabiciclo
hexane
therapy
Prior art date
Application number
ARP010102957A
Other languages
English (en)
Spanish (es)
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of AR028969A1 publication Critical patent/AR028969A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/04—Antipruritics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32—Alcohol-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/34—Tobacco-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36—Opioid-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/52—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Addiction (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Reproductive Health (AREA)
  • Dermatology (AREA)
  • Pain & Pain Management (AREA)
  • Endocrinology (AREA)
  • Otolaryngology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Gynecology & Obstetrics (AREA)
  • Hospice & Palliative Care (AREA)
  • Cardiology (AREA)
  • Nutrition Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
ARP010102957A 2000-06-23 2001-06-21 Derivados de 3-azabiciclo[3.1.0] hexano utiles en terapia AR028969A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB0015562.2A GB0015562D0 (en) 2000-06-23 2000-06-23 Heterocycles

Publications (1)

Publication Number Publication Date
AR028969A1 true AR028969A1 (es) 2003-05-28

Family

ID=9894368

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP010102957A AR028969A1 (es) 2000-06-23 2001-06-21 Derivados de 3-azabiciclo[3.1.0] hexano utiles en terapia

Country Status (34)

Country Link
EP (1) EP1292574A1 (fr)
JP (1) JP2004512263A (fr)
KR (1) KR20040002386A (fr)
CN (1) CN1639121A (fr)
AP (1) AP2002002698A0 (fr)
AR (1) AR028969A1 (fr)
AU (1) AU781837B2 (fr)
BG (1) BG107329A (fr)
BR (1) BR0111867A (fr)
CA (1) CA2412188A1 (fr)
CZ (1) CZ20023967A3 (fr)
DO (1) DOP2001000187A (fr)
DZ (1) DZ3368A1 (fr)
EA (1) EA005117B1 (fr)
GB (1) GB0015562D0 (fr)
HR (1) HRP20020998A2 (fr)
HU (1) HUP0301228A3 (fr)
IL (1) IL153427A0 (fr)
IS (1) IS6637A (fr)
MA (1) MA26915A1 (fr)
MX (1) MXPA02012878A (fr)
NO (1) NO20026168L (fr)
NZ (1) NZ523141A (fr)
OA (1) OA12293A (fr)
PA (1) PA8519401A1 (fr)
PE (1) PE20020253A1 (fr)
PL (1) PL365956A1 (fr)
SK (1) SK17172002A3 (fr)
TN (1) TNSN01094A1 (fr)
UA (1) UA73176C2 (fr)
UY (1) UY26787A1 (fr)
WO (1) WO2001098267A1 (fr)
YU (1) YU91802A (fr)
ZA (1) ZA200210278B (fr)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
OA12711A (en) * 2001-10-22 2006-06-27 Pfizer Prod Inc 3-AzabicycloÄ3.1.0Ühexane derivatives as opoioid receptor antagonists.
JP2005531557A (ja) * 2002-05-17 2005-10-20 メルク　パテント　ゲゼルシャフト　ミット　ベシュレンクテル　ハフトング 選択的オピエート受容体モジュレーターとして効果的な化合物の使用
DE10259245A1 (de) 2002-12-17 2004-07-01 Merck Patent Gmbh Derivate des Asimadolins mit kovalent gebundenen Säuren
RU2434011C2 (ru) * 2004-02-23 2011-11-20 Глэксо Груп Лимитед Производные азабицикло [3.1.0]гексана, применимые в качестве модуляторов допаминовых рецепторов d3
GB0507680D0 (en) 2005-04-15 2005-05-25 Glaxo Group Ltd Compounds
US7807698B2 (en) 2005-06-14 2010-10-05 Glaxo Group Limited Azabicyclo[3.1.0]hexane derivatives as modulators of the dopamine D3 receptor
WO2007113258A1 (fr) * 2006-04-03 2007-10-11 Glaxo Group Limited Dérivés d'azabicyclo [3. 1. o] hexane utilisés comme modulateurs des récepteurs de la dopamine d3
RU2441655C2 (ru) 2007-03-30 2012-02-10 Тиога Фармасьютикалз Инк. Агонисты каппа-опиоидов для лечения синдрома раздраженного кишечника с преобладанием диареи и перемежающегося синдрома раздраженного кишечника
TWI423801B (zh) * 2007-08-27 2014-01-21 Theravance Inc 作為μ類鴉片受體拮抗劑之８－氮雜雙環〔３．２．１〕辛基－２－羥基苯甲醯胺化合物
WO2011154827A2 (fr) 2010-06-11 2011-12-15 Rhodes Technologies Procédés catalysés par métal de transition pour la préparation de composés de n-allyle et utilisation de ceux-ci
JP2013542929A (ja) 2010-09-28 2013-11-28 パナセア バイオテック リミテッド 新規ビシクロ環化合物
MX2016006482A (es) 2013-11-20 2016-12-09 Sanwa Kagaku Kenkyusho Co Derivado novedoso de 3-azabiciclo[3.1.0]hexano y uso del mismo para proposito medico.
CA2985327A1 (fr) 2015-05-20 2016-11-24 Sanwa Kagaku Kenkyusho Co., Ltd. Cristal de sel de nouveau derive de 3-azabicyclo[3.1.0]hexane et son utilisation pharmaceutique
CA3052479A1 (fr) 2017-02-17 2018-08-23 Trevena, Inc. Composes modulateurs du recepteur des opioides delta contenant des heterocycles aza a 7 chainons, et leurs procedes de preparation et d'utilisation
JP7316216B2 (ja) * 2017-02-17 2023-07-27 トレベナ・インコーポレイテッド ５員アザ複素環を含有するデルタ－オピオイド受容体調節化合物、その使用方法及び製造方法
CN110352055A (zh) 2017-03-02 2019-10-18 株式会社三和化学研究所 酒精使用障碍的治疗药物
CN108250088B (zh) * 2018-01-04 2020-10-30 四川之江高新材料股份有限公司 N，n，n′-三甲基-n′-羟乙基双氨基乙基醚的制备方法
CN115825305B (zh) * 2022-10-21 2024-09-20 昆明理工大学 一种分子印迹固相微萃取纤维及其制备方法与应用

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3065230A (en) * 1959-03-16 1962-11-20 Burroughs Wellcome Co Azabicyclohexanes and method of preparing them
PH24752A (en) * 1987-04-16 1990-10-01 Lilly Co Eli Piperidine opioid antagonists
US5159081A (en) * 1991-03-29 1992-10-27 Eli Lilly And Company Intermediates of peripherally selective n-carbonyl-3,4,4-trisubstituted piperidine opioid antagonists
DE4341403A1 (de) * 1993-12-04 1995-06-08 Basf Ag N-substituierte 3-Azabicycloalkan-Derivate, ihre Herstellung und Verwendung
PE20001420A1 (es) * 1998-12-23 2000-12-18 Pfizer Moduladores de ccr5
TWI244481B (en) * 1998-12-23 2005-12-01 Pfizer 3-azabicyclo[3.1.0]hexane derivatives useful in therapy

Also Published As

Publication number Publication date
EA005117B1 (ru) 2004-10-28
TNSN01094A1 (fr) 2005-11-10
ZA200210278B (en) 2003-12-19
EP1292574A1 (fr) 2003-03-19
NZ523141A (en) 2005-06-24
WO2001098267A8 (fr) 2003-02-27
JP2004512263A (ja) 2004-04-22
GB0015562D0 (en) 2000-08-16
NO20026168L (no) 2003-02-18
BG107329A (en) 2003-07-31
WO2001098267A1 (fr) 2001-12-27
MXPA02012878A (es) 2003-05-14
HRP20020998A2 (en) 2004-02-29
CZ20023967A3 (cs) 2004-02-18
EA200201269A1 (ru) 2003-06-26
PA8519401A1 (es) 2002-12-30
UA73176C2 (en) 2005-06-15
PL365956A1 (en) 2005-01-24
YU91802A (sh) 2006-05-25
HUP0301228A2 (hu) 2003-08-28
IL153427A0 (en) 2003-07-06
CA2412188A1 (fr) 2001-12-27
NO20026168D0 (no) 2002-12-20
SK17172002A3 (sk) 2004-09-08
AP2002002698A0 (en) 2002-12-31
PE20020253A1 (es) 2002-04-08
AU781837B2 (en) 2005-06-16
CN1639121A (zh) 2005-07-13
KR20040002386A (ko) 2004-01-07
BR0111867A (pt) 2003-07-01
MA26915A1 (fr) 2004-12-20
HUP0301228A3 (en) 2005-08-29
AU6259101A (en) 2002-01-02
IS6637A (is) 2002-11-28
UY26787A1 (es) 2002-01-31
OA12293A (en) 2004-03-18
DOP2001000187A (es) 2002-03-30
DZ3368A1 (fr) 2001-12-27

Similar Documents

Publication Publication Date Title
AR028969A1 (es) Derivados de 3-azabiciclo[3.1.0] hexano utiles en terapia
TW200503713A (en) Novel compounds
BR0316753A (pt) Método de tratamento para disfunção sexual
CA2422698A1 (fr) Derives d'indoline et leur utilisation en tant que ligands de recepteur 5-ht2
MY138478A (en) Benzazepine derivatives for the treatment of neurological disorders
MXPA04004370A (es) Derivados policiclicos de guanina inhibidores de fosfodiesterasa v.
GB0329214D0 (en) Novel compounds
WO2007025103A3 (fr) Composes organiques
IL188184A0 (en) Pyrazolo [3,4-d] azepine derivatives as histamine h3 antagonists
CR8094A (es) Derivados de imidazol antagonistas del receptor de glutamato
TW200611701A (en) Novel compounds
PT1736157E (pt) Derivados de morfinano como agentes anti-prurido
WO2006026204A3 (fr) Nouvelles gamma-lactames servant d'inhibiteurs de beta-secretase
MX2012006955A (es) Compuestos para el tratamiento de trastornos neurologicos.
MX2007006754A (es) Derivados de indenilo y uso de los mismos para el tratamiento de trastornos neurologicos.
WO2007128827A8 (fr) Dérivés de 17-oxymacbecin et leur utilisation dans le traitement du cancer et/ou des malignités touchant les lymphocytes b
WO2005097778A8 (fr) Tertrahydrobenzazepines en tant que ligands du recepteur h3 de l'histamine
GB0317491D0 (en) Organic compounds
WO2006029210A3 (fr) 1,3-diamines acycliques et leurs utilisations
WO2004063164A8 (fr) Procede de preparation de lactames polycycliques a fusion aryle
MXPA05001967A (es) Proceso para la produccion de derivado de indolopirrolocarbazol.
DE602005025395D1 (de) Schmerzlindernde assoziation mit einem dihydroimidazopyrazin-derivat
WO2006106432A8 (fr) Derives de 4-arylpiperidine et leur utilisation pour la preparation d'un medicament pour le traitement de troubles du systeme nerveux central
TW200621255A (en) Novel compounds
UA92330C2 (en) 2-acylaminothiazole derivatives

Legal Events

Date Code Title Description
FB Suspension of granting procedure