BR0111867A - Derivados de 3-azabiciclo(3.1.0)hexano apresentando afinidade ao receptor da opióide - Google Patents
Derivados de 3-azabiciclo(3.1.0)hexano apresentando afinidade ao receptor da opióideInfo
- Publication number
- BR0111867A BR0111867A BR0111867-6A BR0111867A BR0111867A BR 0111867 A BR0111867 A BR 0111867A BR 0111867 A BR0111867 A BR 0111867A BR 0111867 A BR0111867 A BR 0111867A
- Authority
- BR
- Brazil
- Prior art keywords
- opioid receptor
- receptor affinity
- azabicyclo
- pharmaceutically
- hexane derivatives
- Prior art date
Links
- 102000003840 Opioid Receptors Human genes 0.000 title abstract 5
- 108090000137 Opioid Receptors Proteins 0.000 title abstract 5
- 150000005228 3‐azabicyclo[3.1.0]hexanes Chemical class 0.000 title 1
- 206010003645 Atopy Diseases 0.000 abstract 1
- 206010010774 Constipation Diseases 0.000 abstract 1
- 206010012335 Dependence Diseases 0.000 abstract 1
- 206010012434 Dermatitis allergic Diseases 0.000 abstract 1
- 208000030814 Eating disease Diseases 0.000 abstract 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 1
- 208000019454 Feeding and Eating disease Diseases 0.000 abstract 1
- 206010019196 Head injury Diseases 0.000 abstract 1
- 206010028813 Nausea Diseases 0.000 abstract 1
- 241000208125 Nicotiana Species 0.000 abstract 1
- 235000002637 Nicotiana tabacum Nutrition 0.000 abstract 1
- 208000012488 Opiate Overdose Diseases 0.000 abstract 1
- 201000001880 Sexual dysfunction Diseases 0.000 abstract 1
- 208000020339 Spinal injury Diseases 0.000 abstract 1
- 208000006011 Stroke Diseases 0.000 abstract 1
- 206010047700 Vomiting Diseases 0.000 abstract 1
- 201000008937 atopic dermatitis Diseases 0.000 abstract 1
- 208000010668 atopic eczema Diseases 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 235000014632 disordered eating Nutrition 0.000 abstract 1
- 208000002551 irritable bowel syndrome Diseases 0.000 abstract 1
- VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical class CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 abstract 1
- 230000008693 nausea Effects 0.000 abstract 1
- 229940002612 prodrug Drugs 0.000 abstract 1
- 239000000651 prodrug Substances 0.000 abstract 1
- 230000001823 pruritic effect Effects 0.000 abstract 1
- 231100000872 sexual dysfunction Toxicity 0.000 abstract 1
- 230000035939 shock Effects 0.000 abstract 1
- 208000017520 skin disease Diseases 0.000 abstract 1
- 230000008673 vomiting Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/34—Tobacco-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/52—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Addiction (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Pain & Pain Management (AREA)
- Dermatology (AREA)
- Otolaryngology (AREA)
- Cardiology (AREA)
- Hospice & Palliative Care (AREA)
- Heart & Thoracic Surgery (AREA)
- Gynecology & Obstetrics (AREA)
- Nutrition Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Indole Compounds (AREA)
Abstract
"DERIVADOS DE 3-AZABICICLO(3.1.0)HEXANO APRESENTANDO AFINIDADE AO RECEPTOR DA OPIóIDE". Compostos de fórmula I, onde os substituintes são como definidos aqui, e os derivados ou pró-drogas daqueles farmaceuticamente ou veterinariamente aceitáveis, e farmaceuticamente e veterinariamente úteis, em particular eles ligam-se aos receptores opiáceos (por exemplo, receptores opiáceos mu, kappa, delta). Eles são provavelmente úteis no tratamento de doenças ou estados modulados por receptores opiáceos, por exemplo, síndrome do cólon irritável; constipação; náusea; vómitos; dermatoses pruríticas, tais como dermatite alérgica e atopia; distúrbios alimentares, overdoses de opiáceos, depressão, adição ao tabaco e ao álcool, disfunção sexual, choque, derrame, lesão espinhal e traumatismo craniano.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0015562.2A GB0015562D0 (en) | 2000-06-23 | 2000-06-23 | Heterocycles |
| PCT/IB2001/001035 WO2001098267A1 (en) | 2000-06-23 | 2001-06-07 | 3-azabicyclo (3.1.0) hexane derivatives having opioid receptor affinity |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR0111867A true BR0111867A (pt) | 2003-07-01 |
Family
ID=9894368
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR0111867-6A BR0111867A (pt) | 2000-06-23 | 2001-06-07 | Derivados de 3-azabiciclo(3.1.0)hexano apresentando afinidade ao receptor da opióide |
Country Status (34)
| Country | Link |
|---|---|
| EP (1) | EP1292574A1 (pt) |
| JP (1) | JP2004512263A (pt) |
| KR (1) | KR20040002386A (pt) |
| CN (1) | CN1639121A (pt) |
| AP (1) | AP2002002698A0 (pt) |
| AR (1) | AR028969A1 (pt) |
| AU (1) | AU781837B2 (pt) |
| BG (1) | BG107329A (pt) |
| BR (1) | BR0111867A (pt) |
| CA (1) | CA2412188A1 (pt) |
| CZ (1) | CZ20023967A3 (pt) |
| DO (1) | DOP2001000187A (pt) |
| DZ (1) | DZ3368A1 (pt) |
| EA (1) | EA005117B1 (pt) |
| GB (1) | GB0015562D0 (pt) |
| HR (1) | HRP20020998A2 (pt) |
| HU (1) | HUP0301228A3 (pt) |
| IL (1) | IL153427A0 (pt) |
| IS (1) | IS6637A (pt) |
| MA (1) | MA26915A1 (pt) |
| MX (1) | MXPA02012878A (pt) |
| NO (1) | NO20026168L (pt) |
| NZ (1) | NZ523141A (pt) |
| OA (1) | OA12293A (pt) |
| PA (1) | PA8519401A1 (pt) |
| PE (1) | PE20020253A1 (pt) |
| PL (1) | PL365956A1 (pt) |
| SK (1) | SK17172002A3 (pt) |
| TN (1) | TNSN01094A1 (pt) |
| UA (1) | UA73176C2 (pt) |
| UY (1) | UY26787A1 (pt) |
| WO (1) | WO2001098267A1 (pt) |
| YU (1) | YU91802A (pt) |
| ZA (1) | ZA200210278B (pt) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL161157A0 (en) * | 2001-10-22 | 2004-08-31 | Pfizer Prod Inc | 3-azabicyclo (3.1.0) hexane derivatives as opioid receptor antagonists |
| EP1505974B1 (en) * | 2002-05-17 | 2009-04-22 | Tioga Pharmaceuticals, Inc. | Use of compounds that are effective as selective opiate receptor modulators |
| DE10259245A1 (de) | 2002-12-17 | 2004-07-01 | Merck Patent Gmbh | Derivate des Asimadolins mit kovalent gebundenen Säuren |
| ATE451364T1 (de) * | 2004-02-23 | 2009-12-15 | Glaxo Group Ltd | Als modulatoren des dopamin-d3-rezeptors geeignete azabicycloä3.1.0ühexanderivate |
| GB0507680D0 (en) * | 2005-04-15 | 2005-05-25 | Glaxo Group Ltd | Compounds |
| WO2006133945A1 (en) * | 2005-06-14 | 2006-12-21 | Glaxo Group Limited | Novel compounds |
| EP2010518B1 (en) * | 2006-04-03 | 2011-02-16 | Glaxo Group Limited | Azabicyclo [3. 1. o] hexane derivatives as modulators of dopamine d3 receptors |
| KR101208326B1 (ko) | 2007-03-30 | 2012-12-05 | 티오가 파마슈티칼스, 인코포레이티드 | 설사-우세형 및 교대형 과민성 장 증후군의 치료를 위한 카파-아편제 작용제 |
| TWI423801B (zh) * | 2007-08-27 | 2014-01-21 | Theravance Inc | 作為μ類鴉片受體拮抗劑之８－氮雜雙環〔３．２．１〕辛基－２－羥基苯甲醯胺化合物 |
| JP5736040B2 (ja) | 2010-06-11 | 2015-06-17 | ローズ テクノロジーズ | Ｎ−アリル化合物の調製のための遷移金属触媒プロセスおよびその使用 |
| JP2013542929A (ja) | 2010-09-28 | 2013-11-28 | パナセア バイオテック リミテッド | 新規ビシクロ環化合物 |
| WO2015076310A1 (ja) * | 2013-11-20 | 2015-05-28 | 株式会社 三和化学研究所 | 新規３－アザビシクロ［３．１．０］ヘキサン誘導体及びその医薬用途 |
| WO2016186184A1 (ja) | 2015-05-20 | 2016-11-24 | 株式会社 三和化学研究所 | 新規３－アザビシクロ［３．１．０］ヘキサン誘導体の塩の結晶及びその医薬用途 |
| KR20190129867A (ko) | 2017-02-17 | 2019-11-20 | 트레베나, 인코포레이티드. | 5-원 아자-헤테로고리 함유 델타-오피오이드 수용체 조절 화합물, 및 그의 사용 및 제조 방법 |
| BR112019016775A2 (pt) | 2017-02-17 | 2020-03-31 | Trevena, Inc. | Compostos moduladores de receptor delta-opioide contendo aza-heterocíclico com 7 membros, métodos de uso e produção dos mesmos |
| WO2018159716A1 (ja) | 2017-03-02 | 2018-09-07 | 株式会社 三和化学研究所 | アルコール使用障害の治療薬 |
| CN108250088B (zh) * | 2018-01-04 | 2020-10-30 | 四川之江高新材料股份有限公司 | N，n，n′-三甲基-n′-羟乙基双氨基乙基醚的制备方法 |
| CN115825305B (zh) * | 2022-10-21 | 2024-09-20 | 昆明理工大学 | 一种分子印迹固相微萃取纤维及其制备方法与应用 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3065230A (en) * | 1959-03-16 | 1962-11-20 | Burroughs Wellcome Co | Azabicyclohexanes and method of preparing them |
| EP0287339B1 (en) * | 1987-04-16 | 1994-08-17 | Eli Lilly And Company | Piperidine opioid antagonists |
| US5159081A (en) * | 1991-03-29 | 1992-10-27 | Eli Lilly And Company | Intermediates of peripherally selective n-carbonyl-3,4,4-trisubstituted piperidine opioid antagonists |
| DE4341403A1 (de) * | 1993-12-04 | 1995-06-08 | Basf Ag | N-substituierte 3-Azabicycloalkan-Derivate, ihre Herstellung und Verwendung |
| TWI244481B (en) * | 1998-12-23 | 2005-12-01 | Pfizer | 3-azabicyclo[3.1.0]hexane derivatives useful in therapy |
| PE20001420A1 (es) * | 1998-12-23 | 2000-12-18 | Pfizer | Moduladores de ccr5 |
-
2000
- 2000-06-23 GB GBGB0015562.2A patent/GB0015562D0/en not_active Ceased
-
2001
- 2001-06-06 DO DO2001000187A patent/DOP2001000187A/es unknown
- 2001-06-07 AU AU62591/01A patent/AU781837B2/en not_active Ceased
- 2001-06-07 CN CNA018116086A patent/CN1639121A/zh active Pending
- 2001-06-07 HU HU0301228A patent/HUP0301228A3/hu unknown
- 2001-06-07 JP JP2002504223A patent/JP2004512263A/ja not_active Withdrawn
- 2001-06-07 HR HR20020998A patent/HRP20020998A2/hr not_active Application Discontinuation
- 2001-06-07 CA CA002412188A patent/CA2412188A1/en not_active Abandoned
- 2001-06-07 IL IL15342701A patent/IL153427A0/xx unknown
- 2001-06-07 EP EP01936728A patent/EP1292574A1/en not_active Withdrawn
- 2001-06-07 BR BR0111867-6A patent/BR0111867A/pt not_active IP Right Cessation
- 2001-06-07 CZ CZ20023967A patent/CZ20023967A3/cs unknown
- 2001-06-07 OA OA1200200386A patent/OA12293A/en unknown
- 2001-06-07 MX MXPA02012878A patent/MXPA02012878A/es unknown
- 2001-06-07 YU YU91802A patent/YU91802A/sh unknown
- 2001-06-07 DZ DZ013368A patent/DZ3368A1/xx active
- 2001-06-07 EA EA200201269A patent/EA005117B1/ru not_active IP Right Cessation
- 2001-06-07 NZ NZ523141A patent/NZ523141A/en unknown
- 2001-06-07 KR KR1020027017503A patent/KR20040002386A/ko not_active Ceased
- 2001-06-07 AP APAP/P/2002/002698A patent/AP2002002698A0/en unknown
- 2001-06-07 WO PCT/IB2001/001035 patent/WO2001098267A1/en not_active Ceased
- 2001-06-07 SK SK1717-2002A patent/SK17172002A3/sk unknown
- 2001-06-07 PL PL01365956A patent/PL365956A1/xx not_active Application Discontinuation
- 2001-06-12 PA PA20018519401A patent/PA8519401A1/es unknown
- 2001-06-21 PE PE2001000604A patent/PE20020253A1/es not_active Application Discontinuation
- 2001-06-21 AR ARP010102957A patent/AR028969A1/es unknown
- 2001-06-21 UY UY26787A patent/UY26787A1/es not_active Application Discontinuation
- 2001-06-22 TN TNTNSN01094A patent/TNSN01094A1/fr unknown
- 2001-07-06 UA UA20021210406A patent/UA73176C2/uk unknown
-
2002
- 2002-11-28 IS IS6637A patent/IS6637A/is unknown
- 2002-11-28 BG BG107329A patent/BG107329A/xx unknown
- 2002-12-16 MA MA26955A patent/MA26915A1/fr unknown
- 2002-12-19 ZA ZA200210278A patent/ZA200210278B/xx unknown
- 2002-12-20 NO NO20026168A patent/NO20026168L/no not_active Application Discontinuation
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