[go: up one dir, main page]

NO20020569L - Substituerte pyridaziner og kondenserte pyridaziner med angiogeneseinhiberende aktivitet - Google Patents

Substituerte pyridaziner og kondenserte pyridaziner med angiogeneseinhiberende aktivitet

Info

Publication number
NO20020569L
NO20020569L NO20020569A NO20020569A NO20020569L NO 20020569 L NO20020569 L NO 20020569L NO 20020569 A NO20020569 A NO 20020569A NO 20020569 A NO20020569 A NO 20020569A NO 20020569 L NO20020569 L NO 20020569L
Authority
NO
Norway
Prior art keywords
pyridazines
inhibitory activity
condensed
substituted
angiogenesis inhibitory
Prior art date
Application number
NO20020569A
Other languages
English (en)
Other versions
NO20020569D0 (no
Inventor
Jacques Dumas
Holia N Hatoum-Mokdad
Teddy Kite Joe
Harold C E Kluender
Wendy Lee
Dhanapalan Nagarathnam
Robert N Sibley
Ning Su
Stephen James Boyer
Original Assignee
Bayer Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Ag filed Critical Bayer Ag
Publication of NO20020569D0 publication Critical patent/NO20020569D0/no
Publication of NO20020569L publication Critical patent/NO20020569L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Ophthalmology & Optometry (AREA)
  • Dermatology (AREA)
  • Pain & Pain Management (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Rheumatology (AREA)
  • Vascular Medicine (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
NO20020569A 1999-08-10 2002-02-05 Substituerte pyridaziner og kondenserte pyridaziner med angiogeneseinhiberende aktivitet NO20020569L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US37132299A 1999-08-10 1999-08-10
PCT/US2000/021579 WO2001010859A1 (en) 1999-08-10 2000-08-08 Substituted pyridazines and fused pyridazines with angiogenesis inhibiting activity

Publications (2)

Publication Number Publication Date
NO20020569D0 NO20020569D0 (no) 2002-02-05
NO20020569L true NO20020569L (no) 2002-04-10

Family

ID=23463486

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20020569A NO20020569L (no) 1999-08-10 2002-02-05 Substituerte pyridaziner og kondenserte pyridaziner med angiogeneseinhiberende aktivitet

Country Status (19)

Country Link
EP (1) EP1208096B1 (no)
JP (1) JP2003506447A (no)
KR (1) KR20020019969A (no)
CN (1) CN1378543A (no)
AR (1) AR025068A1 (no)
AT (1) ATE265448T1 (no)
AU (1) AU775237B2 (no)
BR (1) BR0013113A (no)
CA (1) CA2381621A1 (no)
CO (1) CO5180637A1 (no)
DE (1) DE60010280T2 (no)
ES (1) ES2219382T3 (no)
IL (1) IL147885A0 (no)
MX (1) MXPA02001324A (no)
NO (1) NO20020569L (no)
NZ (1) NZ517087A (no)
PE (1) PE20010494A1 (no)
WO (1) WO2001010859A1 (no)
ZA (1) ZA200200691B (no)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DOP2000000070A (es) * 1999-09-28 2002-02-28 Bayer Healthcare Llc Piridinas y piridacinas sustituidas con actividad de inhibición de angiogénesis
US6689883B1 (en) 1999-09-28 2004-02-10 Bayer Pharmaceuticals Corporation Substituted pyridines and pyridazines with angiogenesis inhibiting activity
US7977333B2 (en) 2000-04-20 2011-07-12 Bayer Healthcare Llc Substituted pyridines and pyridazines with angiogenesis inhibiting activity
GB0111078D0 (en) 2001-05-04 2001-06-27 Novartis Ag Organic compounds
SI1427420T1 (sl) * 2001-09-12 2006-12-31 Novartis Ag Uporaba kombinacije, ki vsebuje 4-piridilmetilftalazine za zdravljenje raka
MXPA04005561A (es) * 2001-12-21 2004-12-06 Bayer Pharmaceuticals Corp Terapias de combinacion anti-angiogenesis que comprenden derivados de piridazina o piridina.
US7015227B2 (en) 2002-06-21 2006-03-21 Cgi Pharmaceuticals, Inc. Certain amino-substituted monocycles as kinase modulators
US20060128716A1 (en) * 2002-09-24 2006-06-15 Dugan Margaret H Use of 4-pyridylmethyl-phthalazine derivatives for the manufacture of a medicament for the treatment of myelodysplastic syndromes
JP2006507319A (ja) * 2002-11-12 2006-03-02 ノバルティス アクチエンゲゼルシャフト 中皮腫の処置
GB0612721D0 (en) 2006-06-27 2006-08-09 Novartis Ag Organic compounds
EP2137177B1 (en) 2007-04-05 2014-05-07 Amgen, Inc Aurora kinase modulators and method of use
US8962027B2 (en) 2007-06-19 2015-02-24 Rynel Inc. Materials comprising water-soluble polymer particles and methods of making and using them
EP2288611B1 (en) 2008-03-20 2013-05-15 Amgen Inc. Aurora kinase modulators and method of use
WO2010017240A2 (en) * 2008-08-04 2010-02-11 Amgen Inc. Aurora kinase modulators and methods of use
WO2010019473A1 (en) 2008-08-14 2010-02-18 Amgen Inc. Aurora kinase modulators and methods of use
AU2022212106A1 (en) * 2021-01-28 2023-08-17 University Of Florida Research Foundation, Incorporated Compounds and use thereof for treatment of neurodegenerative, degenerative and metabolic disorders

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1293565A (en) * 1969-05-03 1972-10-18 Aspro Nicholas Ltd Aminophthalazines and pharmaceutical compositions thereof
JPH03106875A (ja) * 1989-09-20 1991-05-07 Morishita Pharmaceut Co Ltd １―（３―ピリジルメチル）フタラジン誘導体
JPH0673022A (ja) * 1992-08-27 1994-03-15 Kumiai Chem Ind Co Ltd ピリミジンまたはトリアジン誘導体及び除草剤
AU705229B2 (en) * 1994-08-09 1999-05-20 Eisai R&D Management Co., Ltd. Fused pyridazine compound
JP3919835B2 (ja) * 1994-08-09 2007-05-30 エーザイ・アール・アンド・ディー・マネジメント株式会社 縮合ピリダジン系化合物
CO4950519A1 (es) * 1997-02-13 2000-09-01 Novartis Ag Ftalazinas, preparaciones farmaceuticas que las comprenden y proceso para su preparacion
AU766081B2 (en) * 1999-03-30 2003-10-09 Novartis Ag Phthalazine derivatives for treating inflammatory diseases

Also Published As

Publication number Publication date
NZ517087A (en) 2004-05-28
BR0013113A (pt) 2002-04-30
DE60010280D1 (de) 2004-06-03
DE60010280T2 (de) 2009-10-15
ZA200200691B (en) 2003-10-29
ATE265448T1 (de) 2004-05-15
AU775237B2 (en) 2004-07-22
PE20010494A1 (es) 2001-06-27
IL147885A0 (en) 2002-08-14
MXPA02001324A (es) 2002-07-22
EP1208096B1 (en) 2004-04-28
WO2001010859A1 (en) 2001-02-15
KR20020019969A (ko) 2002-03-13
CO5180637A1 (es) 2002-07-30
CA2381621A1 (en) 2001-02-15
JP2003506447A (ja) 2003-02-18
EP1208096A1 (en) 2002-05-29
AR025068A1 (es) 2002-11-06
AU6895400A (en) 2001-03-05
CN1378543A (zh) 2002-11-06
ES2219382T3 (es) 2004-12-01
NO20020569D0 (no) 2002-02-05

Similar Documents

Publication Publication Date Title
NO20021520D0 (no) Substituerte pyridiner og pyridaziner med angiogeneseinhiberende aktivitet
DK0970070T3 (da) Phthalaziner med angiogenesis-hæmmende aktivitet
NO20020569L (no) Substituerte pyridaziner og kondenserte pyridaziner med angiogeneseinhiberende aktivitet
EP1240160A4 (en) SUBSTITUTED PYRIDAZINE WITH CYTOKIN INHIBITING ACTIVITY
NO20021449L (no) Substituerte 2-tio-3,5-dicyano-4-aryl-6-aminopyridiner og deres anvendelse
NO991951D0 (no) Tienopyrimidiner med fosfodiesterase V-inhiberende virkning
DE60005810D1 (de) Fussstütze und möbelstück
NO973143D0 (no) Heterocyklisk kondenserte pyridiner
NO20014560D0 (no) Quinasoliner og terapautisk anvendelse derav
DK1028125T3 (da) Dipeptidforbindelser med fungicidaktivitet og deres agronomiske anvendelse
NO20030625L (no) Kinolinderivater med VEGF-inhiberende aktivitet
DE60017338D1 (de) Führungsdraht
NO20024201D0 (no) Substituerte 3-fenyl-5-alkoksy-1,3,4-oksdiazol-2-on og anvendelse derav for hemning av hormonsensitiv lipase
DK1106607T3 (da) Uracilforbindelser og anvendelse deraf
FI20001593A7 (fi) Comt-entsyymiõ inhiboivaa aktiivisuutta omaavia kumariinijohdannaisia
NO20013409D0 (no) Anvendelse av pyrimidin-derivater for forhindring og behandling av cerebral ischemi
NO20021305L (no) DNA-konstruksjon og dens anvendelse
ES1036289Y (es) Muñequera deportiva perfeccionada.
PT1272456E (pt) Inibidores de angiogenese de hidrazida e alcoxiamida
EP1229795A4 (en) CHIMIOKINE BETA 13 HUMAN
ZA200500863B (en) Condensed pyridines and pyrimidines with Tie2 (tek) activity.
DE60005282D1 (de) Golfschlägerkopf, golfschläger und golfschlägerset
NO20023003D0 (no) Benzofenon-glykopyranosider, samt fremstilling og terapeutisk anvendelse
DK1177196T3 (da) Heteroaryldiazabicycloalkaner, deres fremstilling og anvendelse
ITMI990674V0 (it) Indumento per disabili e/o invalidi

Legal Events

Date Code Title Description
FC2A Withdrawal, rejection or dismissal of laid open patent application