AR024145A1 - Derivados de 5-fenil-pirimidina - Google Patents
Derivados de 5-fenil-pirimidinaInfo
- Publication number
- AR024145A1 AR024145A1 ARP000102642A ARP000102642A AR024145A1 AR 024145 A1 AR024145 A1 AR 024145A1 AR P000102642 A ARP000102642 A AR P000102642A AR P000102642 A ARP000102642 A AR P000102642A AR 024145 A1 AR024145 A1 AR 024145A1
- Authority
- AR
- Argentina
- Prior art keywords
- lower alkyl
- hydrogen
- halogen
- receptor
- compounds
- Prior art date
Links
- LVXOXXGCJHYEOS-UHFFFAOYSA-N 5-phenylpyrimidine Chemical class C1=CC=CC=C1C1=CN=CN=C1 LVXOXXGCJHYEOS-UHFFFAOYSA-N 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 6
- 229910052739 hydrogen Inorganic materials 0.000 abstract 5
- 239000001257 hydrogen Substances 0.000 abstract 5
- 229910052736 halogen Chemical group 0.000 abstract 3
- 150000002367 halogens Chemical group 0.000 abstract 3
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 3
- -1 lower alkoxyloxy Chemical group 0.000 abstract 3
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 102000002002 Neurokinin-1 Receptors Human genes 0.000 abstract 1
- 108010040718 Neurokinin-1 Receptors Proteins 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000004390 alkyl sulfonyl group Chemical group 0.000 abstract 1
- 125000004414 alkyl thio group Chemical group 0.000 abstract 1
- 125000000440 benzylamino group Chemical group [H]N(*)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 150000002431 hydrogen Chemical group 0.000 abstract 1
- 125000002768 hydroxyalkyl group Chemical group 0.000 abstract 1
- 125000005322 morpholin-1-yl group Chemical group 0.000 abstract 1
- 125000000587 piperidin-1-yl group Chemical group [H]C1([H])N(*)C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 abstract 1
- 102000005962 receptors Human genes 0.000 abstract 1
- 108020003175 receptors Proteins 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/34—One oxygen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/42—One nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/48—Two nitrogen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pulmonology (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Otolaryngology (AREA)
- Hospice & Palliative Care (AREA)
- Immunology (AREA)
- Rheumatology (AREA)
- Psychology (AREA)
- Cardiology (AREA)
- Addiction (AREA)
- Dermatology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyridine Compounds (AREA)
Abstract
Compuestos de formula general (1) en donde: R1 es hidrogeno o halogeno; R2 es hidrogeno, halogeno, alquilo inferior o alcoxilo inferior; R3 es halogeno,trifluorometilo, alcoxilo inferior o alquilo inferior; R4 y R4 son independientemente entre sí, hidrogeno o alquilo inferior; R5 es alquilo inferior, alcoxiloinferior, amino, hidroxilo, hidroxialquilo inferior, -(CH2)n-piperazinilo, -(CH2)n-morfolinilo opcionalmente substituido con alquilo inferior,-(CH2)n+1-imidazolilo, -O-(CH2)n+1-morfolinilo,-O-(CH2)n+1-piperidinilo, alquilo inferior-sulfanilo, alquilo inferior-sulfonilo, bencilamino,-NH-(CH2)n+1N(R4)2, -(CH2)n-NH-(CH2)n+1N(R4)2, -(CH2)n+1N(R4)2, o -O-(CH2)n+1N(R4)2, en donde R4 es hidrogeno o alquilo inferior; R6 es hidrogeno; R2y R6 oR1 y R6 pueden ser juntamente con los dos átomos de C del anillo, -CH=CH-CH=CH-, con la condicion de que n para R1 sea 1; n es independientemente 0-2; yX es -C(O)N(R4)- o N(R4)C(O)-; y las sales de adicion ácida farmacéuticamente aceptables de los mismos. Los compuestos de formula (1) tienen una elevadaafinidad para el receptor de la NK-1. Son por lo tanto, de utilidad para el tratamiento de enfermedades que están relacionadas con este receptor.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP99110482 | 1999-05-31 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR024145A1 true AR024145A1 (es) | 2002-09-04 |
Family
ID=8238270
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP000102642A AR024145A1 (es) | 1999-05-31 | 2000-05-29 | Derivados de 5-fenil-pirimidina |
Country Status (36)
| Country | Link |
|---|---|
| US (1) | US6756380B1 (es) |
| EP (1) | EP1187814B1 (es) |
| JP (1) | JP3590591B2 (es) |
| KR (1) | KR100478369B1 (es) |
| CN (1) | CN1187338C (es) |
| AR (1) | AR024145A1 (es) |
| AT (1) | ATE273962T1 (es) |
| AU (1) | AU769265B2 (es) |
| BR (1) | BR0011097A (es) |
| CA (1) | CA2375670C (es) |
| CO (1) | CO5170529A1 (es) |
| CZ (1) | CZ20014273A3 (es) |
| DE (1) | DE60013127T2 (es) |
| DK (1) | DK1187814T3 (es) |
| ES (1) | ES2225144T3 (es) |
| GC (1) | GC0000338A (es) |
| HK (1) | HK1046411B (es) |
| HR (1) | HRP20010867A2 (es) |
| HU (1) | HU225016B1 (es) |
| IL (2) | IL146519A0 (es) |
| JO (1) | JO2308B1 (es) |
| MA (1) | MA26794A1 (es) |
| MX (1) | MXPA01011704A (es) |
| MY (1) | MY136258A (es) |
| NO (1) | NO321334B1 (es) |
| NZ (1) | NZ515408A (es) |
| PE (1) | PE20010203A1 (es) |
| PL (1) | PL353492A1 (es) |
| PT (1) | PT1187814E (es) |
| RU (1) | RU2244710C2 (es) |
| SI (1) | SI1187814T1 (es) |
| TR (1) | TR200103460T2 (es) |
| TW (1) | TWI263638B (es) |
| WO (1) | WO2000073278A2 (es) |
| YU (1) | YU85001A (es) |
| ZA (1) | ZA200109496B (es) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AUPQ514600A0 (en) | 2000-01-18 | 2000-02-10 | James Cook University | Brain injury treatment |
| EA005927B1 (ru) | 2000-06-13 | 2005-08-25 | Басф Акциенгезельшафт | Фунгицидные 5-фенил-замещенные 2-(цианоамино)пиримидины |
| EP1406609B1 (en) | 2000-12-21 | 2006-09-06 | Nitromed, Inc. | Substituted aryl compounds as novel cyclooxygenase-2 selective inhibitors, compositions and methods of use |
| MXPA04012345A (es) | 2002-07-02 | 2005-02-25 | Hoffmann La Roche | Derivados de pirimidina 2,5-substituida como antagonistas ix del receptor ccr-3. |
| US7935698B2 (en) * | 2003-11-10 | 2011-05-03 | Synta Pharmaceuticals Corporation | Heteroaryl-hydrazone compounds |
| JP2007217282A (ja) * | 2004-03-04 | 2007-08-30 | Astellas Pharma Inc | 置換ピリミジン誘導体 |
| MXPA06012188A (es) * | 2004-04-22 | 2007-01-17 | Procter & Gamble | Ureas trisustituidas como inhibidores de citocina. |
| EP1819341A4 (en) * | 2004-11-10 | 2011-06-29 | Synta Pharmaceuticals Corp | IL-12 MODULATORY CONNECTIONS |
| KR20070094666A (ko) | 2005-02-25 | 2007-09-20 | 에프. 호프만-라 로슈 아게 | 약제 물질 분산성이 향상된 정제 |
| US9013997B2 (en) * | 2012-06-01 | 2015-04-21 | Broadcom Corporation | System for performing distributed data cut-through |
| SG11201507459YA (en) | 2013-03-15 | 2015-10-29 | Epigen Biosciences Inc | Heterocyclic compounds useful in the treatment of disease |
| GB201316600D0 (en) * | 2013-09-18 | 2013-10-30 | Redx Pharma Ltd | Agricultural chemicals |
| JP6609253B2 (ja) * | 2014-08-06 | 2019-11-20 | キッセイ薬品工業株式会社 | シアノチオフェン誘導体 |
| EP3250034B1 (en) * | 2015-01-30 | 2020-03-11 | Basf Se | Herbicidal phenylpyrimidines |
| CA3029873A1 (en) | 2016-07-20 | 2018-01-25 | Basf Se | Herbicidal compositions comprising phenylpyrimidines |
| US11180470B2 (en) | 2016-07-25 | 2021-11-23 | Basf Se | Herbicidal pyrimidine compounds |
| CN109561685A (zh) | 2016-07-25 | 2019-04-02 | 巴斯夫欧洲公司 | 除草的嘧啶化合物 |
| WO2018019555A1 (en) | 2016-07-26 | 2018-02-01 | Basf Se | Herbicidal pyrimidine compounds |
| WO2018019765A1 (en) | 2016-07-27 | 2018-02-01 | Basf Se | Herbicidal pyrimidine compounds |
| WO2018019574A1 (en) | 2016-07-28 | 2018-02-01 | Basf Se | Herbicidal pyrimidine compounds |
| WO2018229041A1 (en) | 2017-06-14 | 2018-12-20 | Basf Se | Herbicidal pyrimidine compounds |
| WO2019121408A1 (en) | 2017-12-20 | 2019-06-27 | Basf Se | Herbicidal pyrimidine compounds |
| WO2019121373A1 (en) | 2017-12-20 | 2019-06-27 | Basf Se | Herbicidal pyrimidine compounds |
| WO2019121374A1 (en) | 2017-12-20 | 2019-06-27 | Basf Se | Herbicidal pyrimidine compounds |
| WO2019121352A1 (en) | 2017-12-20 | 2019-06-27 | Basf Se | Herbicidal pyrimidine compounds |
| BR112021005146A2 (pt) * | 2018-09-19 | 2021-06-15 | Bayer Aktiengesellschaft | hidrazidas de fenilpirimidina substituídas herbicidamente ativas |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3940394A (en) * | 1972-03-31 | 1976-02-24 | Santilli Arthur A | 2-pyrimidinylthio)alkanoic acids, esters, amides and hydrazides |
| AR208171A1 (es) | 1972-09-29 | 1976-12-09 | Ciba Geigy Ag | Procedimiento para la obtencion de nuevos derivados del acido cef-3-em-4-carboxilico |
| CN1067683C (zh) | 1993-12-29 | 2001-06-27 | 默克·夏普-道姆公司 | 取代的吗啉衍生物及其作为治疗剂的用途 |
| JPH11512399A (ja) | 1995-09-01 | 1999-10-26 | シグナル ファーマシューティカルズ，インコーポレイテッド | ピリミジンカルボキサミドおよび関連化合物ならびに炎症状態を処置するための方法 |
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2000
- 2000-01-02 JO JO200082A patent/JO2308B1/en active
- 2000-05-19 TW TW089109624A patent/TWI263638B/zh not_active IP Right Cessation
- 2000-05-22 US US09/575,789 patent/US6756380B1/en not_active Expired - Fee Related
- 2000-05-24 YU YU85001A patent/YU85001A/sh unknown
- 2000-05-24 ES ES00935104T patent/ES2225144T3/es not_active Expired - Lifetime
- 2000-05-24 IL IL14651900A patent/IL146519A0/xx not_active IP Right Cessation
- 2000-05-24 HK HK02108020.5A patent/HK1046411B/zh not_active IP Right Cessation
- 2000-05-24 MX MXPA01011704A patent/MXPA01011704A/es active IP Right Grant
- 2000-05-24 NZ NZ515408A patent/NZ515408A/xx unknown
- 2000-05-24 CZ CZ20014273A patent/CZ20014273A3/cs unknown
- 2000-05-24 DK DK00935104T patent/DK1187814T3/da active
- 2000-05-24 PL PL00353492A patent/PL353492A1/xx unknown
- 2000-05-24 EP EP00935104A patent/EP1187814B1/en not_active Expired - Lifetime
- 2000-05-24 CN CNB008082847A patent/CN1187338C/zh not_active Expired - Fee Related
- 2000-05-24 RU RU2001133456/04A patent/RU2244710C2/ru not_active IP Right Cessation
- 2000-05-24 HU HU0201527A patent/HU225016B1/hu not_active IP Right Cessation
- 2000-05-24 JP JP2000621344A patent/JP3590591B2/ja not_active Expired - Fee Related
- 2000-05-24 TR TR2001/03460T patent/TR200103460T2/xx unknown
- 2000-05-24 WO PCT/EP2000/004702 patent/WO2000073278A2/en not_active Ceased
- 2000-05-24 KR KR10-2001-7015319A patent/KR100478369B1/ko not_active Expired - Fee Related
- 2000-05-24 HR HR20010867A patent/HRP20010867A2/hr not_active Application Discontinuation
- 2000-05-24 PT PT00935104T patent/PT1187814E/pt unknown
- 2000-05-24 CA CA002375670A patent/CA2375670C/en not_active Expired - Fee Related
- 2000-05-24 AU AU50708/00A patent/AU769265B2/en not_active Ceased
- 2000-05-24 AT AT00935104T patent/ATE273962T1/de not_active IP Right Cessation
- 2000-05-24 BR BR0011097-3A patent/BR0011097A/pt not_active Application Discontinuation
- 2000-05-24 SI SI200030472T patent/SI1187814T1/xx unknown
- 2000-05-24 DE DE60013127T patent/DE60013127T2/de not_active Expired - Fee Related
- 2000-05-26 PE PE2000000509A patent/PE20010203A1/es not_active Application Discontinuation
- 2000-05-29 MY MYPI20002385A patent/MY136258A/en unknown
- 2000-05-29 CO CO00039601A patent/CO5170529A1/es not_active Application Discontinuation
- 2000-05-29 AR ARP000102642A patent/AR024145A1/es not_active Application Discontinuation
- 2000-05-30 GC GCP2000685 patent/GC0000338A/en active
-
2001
- 2001-11-15 IL IL146519A patent/IL146519A/en unknown
- 2001-11-16 ZA ZA200109496A patent/ZA200109496B/en unknown
- 2001-11-22 NO NO20015701A patent/NO321334B1/no not_active Application Discontinuation
- 2001-11-26 MA MA26425A patent/MA26794A1/fr unknown
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