PE20010203A1 - Derivados de 5-fenil-pirimidina como antagonistas del receptor de la neuroquinina 1 - Google Patents
Derivados de 5-fenil-pirimidina como antagonistas del receptor de la neuroquinina 1Info
- Publication number
- PE20010203A1 PE20010203A1 PE2000000509A PE0005092000A PE20010203A1 PE 20010203 A1 PE20010203 A1 PE 20010203A1 PE 2000000509 A PE2000000509 A PE 2000000509A PE 0005092000 A PE0005092000 A PE 0005092000A PE 20010203 A1 PE20010203 A1 PE 20010203A1
- Authority
- PE
- Peru
- Prior art keywords
- phenyl
- alkyl
- alcoxyl
- trifluoromethyl
- halogen
- Prior art date
Links
- LVXOXXGCJHYEOS-UHFFFAOYSA-N 5-phenylpyrimidine Chemical class C1=CC=CC=C1C1=CN=CN=C1 LVXOXXGCJHYEOS-UHFFFAOYSA-N 0.000 title abstract 3
- 239000005557 antagonist Substances 0.000 title abstract 2
- -1 AMINO, HYDROXYL Chemical class 0.000 abstract 4
- 229910052736 halogen Inorganic materials 0.000 abstract 3
- 150000002367 halogens Chemical class 0.000 abstract 3
- ADTNSTHKMIPKIJ-UHFFFAOYSA-N 1-[3,5-bis(trifluoromethyl)phenyl]-n-methylmethanamine Chemical compound CNCC1=CC(C(F)(F)F)=CC(C(F)(F)F)=C1 ADTNSTHKMIPKIJ-UHFFFAOYSA-N 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- WZKSXHQDXQKIQJ-UHFFFAOYSA-N F[C](F)F Chemical group F[C](F)F WZKSXHQDXQKIQJ-UHFFFAOYSA-N 0.000 abstract 1
- 208000006673 asthma Diseases 0.000 abstract 1
- 208000027866 inflammatory disease Diseases 0.000 abstract 1
- 206010039073 rheumatoid arthritis Diseases 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/34—One oxygen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/42—One nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/48—Two nitrogen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pulmonology (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Otolaryngology (AREA)
- Hospice & Palliative Care (AREA)
- Immunology (AREA)
- Rheumatology (AREA)
- Psychology (AREA)
- Cardiology (AREA)
- Addiction (AREA)
- Dermatology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyridine Compounds (AREA)
Abstract
SE REFIERE A DERIVADOS DE 5-FENIL-PIRIMIDINA DE FORMULA I, DONDE: R1 ES H, HALOGENO; R2 ES H, HALOGENO, ALQUILO, ALCOXILO; R3 ES HALOGENO, TRIFLUOROMETILO, ALCOXILO, ALQUILO; R4 Y R4` SON H, ALQUILO; R5 ES ALQUILO, ALCOXILO, AMINO, HIDROXILO, HIDROXIALQUILO, -(CH2)n-PIPERAZINILO, -(CH2)n-MORFOLINILO, -(CH2)n+1-IMIDAZOLILO, -O-(CH2)n+1(NR4")2, ENTRE OTROS, R4" ES H, ALQUILO; R6 ES H; R2 Y R6 O R1 Y R6 PUEDEN SER JUNTO A DOS ATOMOS DE C DEL ANILLO -CH=CH-CH=CH-, CON LA CONDICION QUE n PARA R1 SEA 1; n ES 0-2; X ES -C(O)N(R4")-, -N(R4")C(O)-. SON COMPUESTOS PREFERIDOS (3,5-BIS-TRIFLUOROMETIL-BENCIL)-METIL-AMIDA DEL ACIDO 5-(2-CLORO-FENIL)-2-(4-METIL-PIPERAZIN-1-IL)-PIRIMIDIN-4-CARBOXILICO, (3,5-BIS-TRIFLUOROMETIL-BENCIL)-METIL-AMIDA DEL ACIDO 5-(2-CLORO-FENIL)-2-(2-MORFOLIN-4-IL-ETOXI)-PIRIMIDIN-4-CARBOXILICO, ENTRE OTROS. SE REFIERE TAMBIEN A UN PROCEDIMIENTO PARA LA PREPARACION Y A COMPUESTOS INTERMEDIOS. LOS DERIVADOS DE 5-FENIL-PIRIMIDINA DE FORMULA I SON ANTAGONISTAS DEL RECEPTOR DE LA NEUROQUININA 1 (NK-1), SUSTANCIA P) POR LO QUE PUEDEN SER UTILES EN ENFERMEDADES INFLAMATORIA, MIGRANA, ARTRITIS REUMATOIDEA, ASMA
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP99110482 | 1999-05-31 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20010203A1 true PE20010203A1 (es) | 2001-02-15 |
Family
ID=8238270
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2000000509A PE20010203A1 (es) | 1999-05-31 | 2000-05-26 | Derivados de 5-fenil-pirimidina como antagonistas del receptor de la neuroquinina 1 |
Country Status (36)
| Country | Link |
|---|---|
| US (1) | US6756380B1 (es) |
| EP (1) | EP1187814B1 (es) |
| JP (1) | JP3590591B2 (es) |
| KR (1) | KR100478369B1 (es) |
| CN (1) | CN1187338C (es) |
| AR (1) | AR024145A1 (es) |
| AT (1) | ATE273962T1 (es) |
| AU (1) | AU769265B2 (es) |
| BR (1) | BR0011097A (es) |
| CA (1) | CA2375670C (es) |
| CO (1) | CO5170529A1 (es) |
| CZ (1) | CZ20014273A3 (es) |
| DE (1) | DE60013127T2 (es) |
| DK (1) | DK1187814T3 (es) |
| ES (1) | ES2225144T3 (es) |
| GC (1) | GC0000338A (es) |
| HK (1) | HK1046411B (es) |
| HR (1) | HRP20010867A2 (es) |
| HU (1) | HU225016B1 (es) |
| IL (2) | IL146519A0 (es) |
| JO (1) | JO2308B1 (es) |
| MA (1) | MA26794A1 (es) |
| MX (1) | MXPA01011704A (es) |
| MY (1) | MY136258A (es) |
| NO (1) | NO321334B1 (es) |
| NZ (1) | NZ515408A (es) |
| PE (1) | PE20010203A1 (es) |
| PL (1) | PL353492A1 (es) |
| PT (1) | PT1187814E (es) |
| RU (1) | RU2244710C2 (es) |
| SI (1) | SI1187814T1 (es) |
| TR (1) | TR200103460T2 (es) |
| TW (1) | TWI263638B (es) |
| WO (1) | WO2000073278A2 (es) |
| YU (1) | YU85001A (es) |
| ZA (1) | ZA200109496B (es) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AUPQ514600A0 (en) | 2000-01-18 | 2000-02-10 | James Cook University | Brain injury treatment |
| EA005927B1 (ru) | 2000-06-13 | 2005-08-25 | Басф Акциенгезельшафт | Фунгицидные 5-фенил-замещенные 2-(цианоамино)пиримидины |
| EP1406609B1 (en) | 2000-12-21 | 2006-09-06 | Nitromed, Inc. | Substituted aryl compounds as novel cyclooxygenase-2 selective inhibitors, compositions and methods of use |
| MXPA04012345A (es) | 2002-07-02 | 2005-02-25 | Hoffmann La Roche | Derivados de pirimidina 2,5-substituida como antagonistas ix del receptor ccr-3. |
| US7935698B2 (en) * | 2003-11-10 | 2011-05-03 | Synta Pharmaceuticals Corporation | Heteroaryl-hydrazone compounds |
| JP2007217282A (ja) * | 2004-03-04 | 2007-08-30 | Astellas Pharma Inc | 置換ピリミジン誘導体 |
| MXPA06012188A (es) * | 2004-04-22 | 2007-01-17 | Procter & Gamble | Ureas trisustituidas como inhibidores de citocina. |
| EP1819341A4 (en) * | 2004-11-10 | 2011-06-29 | Synta Pharmaceuticals Corp | IL-12 MODULATORY CONNECTIONS |
| KR20070094666A (ko) | 2005-02-25 | 2007-09-20 | 에프. 호프만-라 로슈 아게 | 약제 물질 분산성이 향상된 정제 |
| US9013997B2 (en) * | 2012-06-01 | 2015-04-21 | Broadcom Corporation | System for performing distributed data cut-through |
| SG11201507459YA (en) | 2013-03-15 | 2015-10-29 | Epigen Biosciences Inc | Heterocyclic compounds useful in the treatment of disease |
| GB201316600D0 (en) * | 2013-09-18 | 2013-10-30 | Redx Pharma Ltd | Agricultural chemicals |
| JP6609253B2 (ja) * | 2014-08-06 | 2019-11-20 | キッセイ薬品工業株式会社 | シアノチオフェン誘導体 |
| EP3250034B1 (en) * | 2015-01-30 | 2020-03-11 | Basf Se | Herbicidal phenylpyrimidines |
| CA3029873A1 (en) | 2016-07-20 | 2018-01-25 | Basf Se | Herbicidal compositions comprising phenylpyrimidines |
| US11180470B2 (en) | 2016-07-25 | 2021-11-23 | Basf Se | Herbicidal pyrimidine compounds |
| CN109561685A (zh) | 2016-07-25 | 2019-04-02 | 巴斯夫欧洲公司 | 除草的嘧啶化合物 |
| WO2018019555A1 (en) | 2016-07-26 | 2018-02-01 | Basf Se | Herbicidal pyrimidine compounds |
| WO2018019765A1 (en) | 2016-07-27 | 2018-02-01 | Basf Se | Herbicidal pyrimidine compounds |
| WO2018019574A1 (en) | 2016-07-28 | 2018-02-01 | Basf Se | Herbicidal pyrimidine compounds |
| WO2018229041A1 (en) | 2017-06-14 | 2018-12-20 | Basf Se | Herbicidal pyrimidine compounds |
| WO2019121408A1 (en) | 2017-12-20 | 2019-06-27 | Basf Se | Herbicidal pyrimidine compounds |
| WO2019121373A1 (en) | 2017-12-20 | 2019-06-27 | Basf Se | Herbicidal pyrimidine compounds |
| WO2019121374A1 (en) | 2017-12-20 | 2019-06-27 | Basf Se | Herbicidal pyrimidine compounds |
| WO2019121352A1 (en) | 2017-12-20 | 2019-06-27 | Basf Se | Herbicidal pyrimidine compounds |
| BR112021005146A2 (pt) * | 2018-09-19 | 2021-06-15 | Bayer Aktiengesellschaft | hidrazidas de fenilpirimidina substituídas herbicidamente ativas |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3940394A (en) * | 1972-03-31 | 1976-02-24 | Santilli Arthur A | 2-pyrimidinylthio)alkanoic acids, esters, amides and hydrazides |
| AR208171A1 (es) | 1972-09-29 | 1976-12-09 | Ciba Geigy Ag | Procedimiento para la obtencion de nuevos derivados del acido cef-3-em-4-carboxilico |
| CN1067683C (zh) | 1993-12-29 | 2001-06-27 | 默克·夏普-道姆公司 | 取代的吗啉衍生物及其作为治疗剂的用途 |
| JPH11512399A (ja) | 1995-09-01 | 1999-10-26 | シグナル ファーマシューティカルズ，インコーポレイテッド | ピリミジンカルボキサミドおよび関連化合物ならびに炎症状態を処置するための方法 |
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2000
- 2000-01-02 JO JO200082A patent/JO2308B1/en active
- 2000-05-19 TW TW089109624A patent/TWI263638B/zh not_active IP Right Cessation
- 2000-05-22 US US09/575,789 patent/US6756380B1/en not_active Expired - Fee Related
- 2000-05-24 YU YU85001A patent/YU85001A/sh unknown
- 2000-05-24 ES ES00935104T patent/ES2225144T3/es not_active Expired - Lifetime
- 2000-05-24 IL IL14651900A patent/IL146519A0/xx not_active IP Right Cessation
- 2000-05-24 HK HK02108020.5A patent/HK1046411B/zh not_active IP Right Cessation
- 2000-05-24 MX MXPA01011704A patent/MXPA01011704A/es active IP Right Grant
- 2000-05-24 NZ NZ515408A patent/NZ515408A/xx unknown
- 2000-05-24 CZ CZ20014273A patent/CZ20014273A3/cs unknown
- 2000-05-24 DK DK00935104T patent/DK1187814T3/da active
- 2000-05-24 PL PL00353492A patent/PL353492A1/xx unknown
- 2000-05-24 EP EP00935104A patent/EP1187814B1/en not_active Expired - Lifetime
- 2000-05-24 CN CNB008082847A patent/CN1187338C/zh not_active Expired - Fee Related
- 2000-05-24 RU RU2001133456/04A patent/RU2244710C2/ru not_active IP Right Cessation
- 2000-05-24 HU HU0201527A patent/HU225016B1/hu not_active IP Right Cessation
- 2000-05-24 JP JP2000621344A patent/JP3590591B2/ja not_active Expired - Fee Related
- 2000-05-24 TR TR2001/03460T patent/TR200103460T2/xx unknown
- 2000-05-24 WO PCT/EP2000/004702 patent/WO2000073278A2/en not_active Ceased
- 2000-05-24 KR KR10-2001-7015319A patent/KR100478369B1/ko not_active Expired - Fee Related
- 2000-05-24 HR HR20010867A patent/HRP20010867A2/hr not_active Application Discontinuation
- 2000-05-24 PT PT00935104T patent/PT1187814E/pt unknown
- 2000-05-24 CA CA002375670A patent/CA2375670C/en not_active Expired - Fee Related
- 2000-05-24 AU AU50708/00A patent/AU769265B2/en not_active Ceased
- 2000-05-24 AT AT00935104T patent/ATE273962T1/de not_active IP Right Cessation
- 2000-05-24 BR BR0011097-3A patent/BR0011097A/pt not_active Application Discontinuation
- 2000-05-24 SI SI200030472T patent/SI1187814T1/xx unknown
- 2000-05-24 DE DE60013127T patent/DE60013127T2/de not_active Expired - Fee Related
- 2000-05-26 PE PE2000000509A patent/PE20010203A1/es not_active Application Discontinuation
- 2000-05-29 MY MYPI20002385A patent/MY136258A/en unknown
- 2000-05-29 CO CO00039601A patent/CO5170529A1/es not_active Application Discontinuation
- 2000-05-29 AR ARP000102642A patent/AR024145A1/es not_active Application Discontinuation
- 2000-05-30 GC GCP2000685 patent/GC0000338A/en active
-
2001
- 2001-11-15 IL IL146519A patent/IL146519A/en unknown
- 2001-11-16 ZA ZA200109496A patent/ZA200109496B/en unknown
- 2001-11-22 NO NO20015701A patent/NO321334B1/no not_active Application Discontinuation
- 2001-11-26 MA MA26425A patent/MA26794A1/fr unknown
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