AR012426A1 - Un compuesto de indazol amida, un procedimiento para prepararlo, compuestos intermediarios, y una composicion farmaceutica que comprende dicho compuesto de indazol amida. - Google Patents
Un compuesto de indazol amida, un procedimiento para prepararlo, compuestos intermediarios, y una composicion farmaceutica que comprende dicho compuesto de indazol amida.Info
- Publication number
- AR012426A1 AR012426A1 ARP980101721A ARP980101721A AR012426A1 AR 012426 A1 AR012426 A1 AR 012426A1 AR P980101721 A ARP980101721 A AR P980101721A AR P980101721 A ARP980101721 A AR P980101721A AR 012426 A1 AR012426 A1 AR 012426A1
- Authority
- AR
- Argentina
- Prior art keywords
- compound
- amida
- indazol
- 3alkyl
- hydrogen
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 4
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- BAXOFTOLAUCFNW-UHFFFAOYSA-N 1H-indazole Chemical compound C1=CC=C2C=NNC2=C1 BAXOFTOLAUCFNW-UHFFFAOYSA-N 0.000 title 2
- 241000670727 Amida Species 0.000 title 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 239000001257 hydrogen Substances 0.000 abstract 3
- -1 indazole amide compound Chemical class 0.000 abstract 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
- 125000003118 aryl group Chemical group 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 125000006273 (C1-C3) alkyl group Chemical group 0.000 abstract 1
- 125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 abstract 1
- DITBWPUMEUDVLU-UHFFFAOYSA-N 1h-indazole-3-carboxamide Chemical class C1=CC=C2C(C(=O)N)=NNC2=C1 DITBWPUMEUDVLU-UHFFFAOYSA-N 0.000 abstract 1
- 108091005482 5-HT4 receptors Proteins 0.000 abstract 1
- PAYRUJLWNCNPSJ-UHFFFAOYSA-N Aniline Chemical compound NC1=CC=CC=C1 PAYRUJLWNCNPSJ-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 239000005557 antagonist Substances 0.000 abstract 1
- 125000005842 heteroatom Chemical group 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 abstract 1
- 150000007522 mineralic acids Chemical class 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 150000007524 organic acids Chemical class 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000004031 partial agonist Substances 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Urology & Nephrology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Paints Or Removers (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Compositions Of Macromolecular Compounds (AREA)
Abstract
Un compuesto de indazol amida, que tiene la formula general (I), en la cual R1 es hidrogeno; R2 es isopropilo; R3 y R3 son hidrogeno; R4 y R5 sonhidrogeno; R6 se selecciona del grupo que comprende alquilo C1-3, cicloalquilo C3-7, una cadenacerrada heterocíclica que tiene entre 5 y 6 miembros, dondede 1 a 4 miembros son heteroátomos, los mismos o diferentes entre sí, seleccionados del grupo que comprende N, O y S, dimetilamino-alquilo C1-3,metoxi-alquilo C1-3, N-fenilamida,aminosulf onilmetilo, dihidroxi-alquilo C2-3, arilo, arilo sustituido por un grupo como mínimo seleccionado entre halogenoe hidroxi y aril-alquilo C1-3; las sales de adicion ácidas del mismo con ácidos orgánicos e inorgánicos farmacéuticamenteaceptables y las sales cuaternariasfarmacéuticamente aceptables del mismo; un procedimiento para su preparacion; compuestos intermediarios; y una composicion farmacéutica que comprende dichocompuestos de indazol amida. El compuesto de indazolamidaposee afinidad c on los receptores 5HT4 y actua como antagonista o agonista parcial de laserotonina.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT97MI000867A IT1291569B1 (it) | 1997-04-15 | 1997-04-15 | Indazolammidi come agenti serotoninergici |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR012426A1 true AR012426A1 (es) | 2000-10-18 |
Family
ID=11376888
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP980101721A AR012426A1 (es) | 1997-04-15 | 1998-04-15 | Un compuesto de indazol amida, un procedimiento para prepararlo, compuestos intermediarios, y una composicion farmaceutica que comprende dicho compuesto de indazol amida. |
Country Status (26)
| Country | Link |
|---|---|
| US (1) | US6197769B1 (es) |
| EP (1) | EP0975623B1 (es) |
| JP (2) | JP4578581B2 (es) |
| KR (1) | KR100563867B1 (es) |
| CN (1) | CN1318416C (es) |
| AR (1) | AR012426A1 (es) |
| AT (1) | ATE219490T1 (es) |
| AU (1) | AU740360B2 (es) |
| BG (1) | BG64006B1 (es) |
| CA (1) | CA2286870C (es) |
| CZ (1) | CZ295190B6 (es) |
| DE (1) | DE69806141T2 (es) |
| DK (1) | DK0975623T3 (es) |
| EA (1) | EA002352B1 (es) |
| ES (1) | ES2178205T3 (es) |
| GE (1) | GEP20022654B (es) |
| HU (1) | HU227973B1 (es) |
| IL (1) | IL132127A (es) |
| IT (1) | IT1291569B1 (es) |
| PL (1) | PL193308B1 (es) |
| PT (1) | PT975623E (es) |
| SK (1) | SK284731B6 (es) |
| TR (1) | TR199902546T2 (es) |
| UA (1) | UA58550C2 (es) |
| WO (1) | WO1998046589A2 (es) |
| ZA (1) | ZA982926B (es) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1291569B1 (it) * | 1997-04-15 | 1999-01-11 | Angelini Ricerche Spa | Indazolammidi come agenti serotoninergici |
| EA005974B1 (ru) | 2001-02-23 | 2005-08-25 | Мерк Энд Ко., Инк. | N-замещенные неарильные гетероциклические антагонисты nmda/nr2b |
| US7259157B2 (en) | 2001-04-03 | 2007-08-21 | Merck & Co., Inc. | N-substituted nonaryl-heterocyclo amidyl NMDA/NR2B Antagonists |
| ITMI20030287A1 (it) | 2003-02-18 | 2004-08-19 | Acraf | Indazolammidi dotate di attivita' analgesica metodo, per |
| ITMI20030972A1 (it) * | 2003-05-15 | 2004-11-16 | Acraf | Indazolo dotato di attivita' analgesica, metodo per prepararlo e composizione farmaceutica che lo comprende. |
| ITMI20031468A1 (it) * | 2003-07-18 | 2005-01-19 | Acraf | Farmaco ativo nel dolore neuropatico |
| TW200533348A (en) * | 2004-02-18 | 2005-10-16 | Theravance Inc | Indazole-carboxamide compounds as 5-ht4 receptor agonists |
| TWI351282B (en) * | 2004-04-07 | 2011-11-01 | Theravance Inc | Quinolinone-carboxamide compounds as 5-ht4 recepto |
| US8309575B2 (en) | 2004-04-07 | 2012-11-13 | Theravance, Inc. | Quinolinone-carboxamide compounds as 5-HT4 receptor agonists |
| US7728006B2 (en) * | 2004-04-07 | 2010-06-01 | Theravance, Inc. | Quinolinone-carboxamide compounds as 5-HT4 receptor agonists |
| ATE441646T1 (de) * | 2004-11-05 | 2009-09-15 | Theravance Inc | 5-ht4-rezeptoragonistenverbindungen |
| JP5042028B2 (ja) * | 2004-11-05 | 2012-10-03 | セラヴァンス， インコーポレーテッド | キノリノン−カルボキサミド化合物 |
| CA2588037A1 (en) * | 2004-12-22 | 2006-06-29 | Theravance, Inc. | Indazole-carboxamide compounds |
| US20060183901A1 (en) * | 2005-02-17 | 2006-08-17 | Theravance, Inc. | Crystalline form of an indazole-carboxamide compound |
| US7446114B2 (en) * | 2005-03-02 | 2008-11-04 | Theravance, Inc. | Quinolinone compounds as 5-HT4 receptor agonists |
| ITMI20062230A1 (it) * | 2006-11-22 | 2008-05-23 | Acraf | Composto 2-alchil-indazolico procedimento per preparalo e composizione farmaceutica che lo comprende |
| UA99927C2 (uk) * | 2007-11-12 | 2012-10-25 | Ацьенде Кимике Риуните Анджелини Франческо А.Чи.Р.А.Ф. С.П.А. | Медикамент, який є активним при невропатичному болі |
| US8377968B2 (en) | 2008-06-02 | 2013-02-19 | Zalicus Pharmaceuticals, Ltd. | N-piperidinyl acetamide derivatives as calcium channel blockers |
| RU2013157374A (ru) * | 2011-06-07 | 2015-07-20 | Сумитомо Дайниппон Фарма Ко., Лтд. | Производное индазола и пирролопиридина и его фармацевтическое применение |
| HRP20160124T1 (hr) * | 2012-02-21 | 2016-03-11 | Aziende Chimiche Riunite Angelini Francesco A.C.R.A.F. - S.P.A. | Uporaba spojeva 1h-indazol-3-karboksamida kao inhibitora glikogen sinteze kinaze-3 beta |
| GEP20166489B (en) * | 2012-02-21 | 2016-06-10 | Acraf | 1h-indazole-3-carboxamide compounds as glycogen synthase kinase 3 beta inhibitors |
| US10208023B2 (en) | 2013-03-01 | 2019-02-19 | Mark G. DeGiacomo | Heterocyclic inhibitors of the sodium channel |
| MX2022000492A (es) | 2019-07-11 | 2022-07-04 | Praxis Prec Medicines Inc | Formulaciones de moduladores de canal de calcio tipo t y metodos de uso de estos. |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9103862D0 (en) * | 1991-02-25 | 1991-04-10 | Glaxo Group Ltd | Chemical compounds |
| NZ243993A (en) * | 1991-08-20 | 1994-10-26 | Smithkline Beecham Plc | Pharmaceutical compositions having 5-ht4 receptor antagonist activity and selected compounds having such activity |
| IL117438A (en) * | 1995-03-16 | 2001-12-23 | Lilly Co Eli | Indazolecarboxamides, their preparation and pharmaceutical compositions containing them |
| EP0829474B1 (en) * | 1995-05-31 | 2003-04-09 | Nisshin Seifun Group Inc. | Indazole derivatives having monocyclic amino group |
| IT1291569B1 (it) * | 1997-04-15 | 1999-01-11 | Angelini Ricerche Spa | Indazolammidi come agenti serotoninergici |
-
1997
- 1997-04-15 IT IT97MI000867A patent/IT1291569B1/it active IP Right Grant
-
1998
- 1998-02-04 UA UA99116211A patent/UA58550C2/uk unknown
- 1998-04-02 CZ CZ19993625A patent/CZ295190B6/cs not_active IP Right Cessation
- 1998-04-02 DK DK98919257T patent/DK0975623T3/da active
- 1998-04-02 EP EP98919257A patent/EP0975623B1/en not_active Expired - Lifetime
- 1998-04-02 KR KR1019997009198A patent/KR100563867B1/ko not_active Expired - Fee Related
- 1998-04-02 US US09/403,007 patent/US6197769B1/en not_active Expired - Lifetime
- 1998-04-02 CN CNB988041987A patent/CN1318416C/zh not_active Expired - Fee Related
- 1998-04-02 DE DE69806141T patent/DE69806141T2/de not_active Expired - Lifetime
- 1998-04-02 CA CA002286870A patent/CA2286870C/en not_active Expired - Fee Related
- 1998-04-02 AT AT98919257T patent/ATE219490T1/de active
- 1998-04-02 IL IL13212798A patent/IL132127A/xx not_active IP Right Cessation
- 1998-04-02 PT PT98919257T patent/PT975623E/pt unknown
- 1998-04-02 HU HU0002057A patent/HU227973B1/hu not_active IP Right Cessation
- 1998-04-02 WO PCT/EP1998/002129 patent/WO1998046589A2/en not_active Ceased
- 1998-04-02 AU AU72159/98A patent/AU740360B2/en not_active Ceased
- 1998-04-02 GE GEAP19985083A patent/GEP20022654B/en unknown
- 1998-04-02 ES ES98919257T patent/ES2178205T3/es not_active Expired - Lifetime
- 1998-04-02 PL PL336348A patent/PL193308B1/pl unknown
- 1998-04-02 SK SK1423-99A patent/SK284731B6/sk not_active IP Right Cessation
- 1998-04-02 TR TR1999/02546T patent/TR199902546T2/xx unknown
- 1998-04-02 JP JP54347598A patent/JP4578581B2/ja not_active Expired - Fee Related
- 1998-04-02 EA EA199900935A patent/EA002352B1/ru not_active IP Right Cessation
- 1998-04-06 ZA ZA982926A patent/ZA982926B/xx unknown
- 1998-04-15 AR ARP980101721A patent/AR012426A1/es active IP Right Grant
-
1999
- 1999-11-05 BG BG103863A patent/BG64006B1/bg unknown
-
2010
- 2010-04-26 JP JP2010100701A patent/JP5237324B2/ja not_active Expired - Fee Related
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant, registration | ||
| FG | Grant, registration |