AR011680A1 - Un compuesto de esteroide, sus usos, procedimientos para prepararlo y una composicion farmaceutica que lo comprende. - Google Patents
Un compuesto de esteroide, sus usos, procedimientos para prepararlo y una composicion farmaceutica que lo comprende.Info
- Publication number
- AR011680A1 AR011680A1 ARP980100753A ARP980100753A AR011680A1 AR 011680 A1 AR011680 A1 AR 011680A1 AR P980100753 A ARP980100753 A AR P980100753A AR P980100753 A ARP980100753 A AR P980100753A AR 011680 A1 AR011680 A1 AR 011680A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- atoms
- group
- oocr
- alkenyl
- Prior art date
Links
- -1 STEROID COMPOUND Chemical class 0.000 title abstract 3
- 238000000034 method Methods 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 5
- 125000000217 alkyl group Chemical group 0.000 abstract 4
- 125000003342 alkenyl group Chemical group 0.000 abstract 3
- 125000001118 alkylidene group Chemical group 0.000 abstract 3
- 125000000304 alkynyl group Chemical group 0.000 abstract 3
- 125000001309 chloro group Chemical group Cl* 0.000 abstract 3
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 2
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 2
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 abstract 2
- 229910052799 carbon Inorganic materials 0.000 abstract 2
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 2
- 229910052731 fluorine Inorganic materials 0.000 abstract 2
- 239000011737 fluorine Substances 0.000 abstract 2
- 125000005843 halogen group Chemical group 0.000 abstract 2
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 abstract 1
- 125000001153 fluoro group Chemical group F* 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J53/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by condensation with a carbocyclic rings or by formation of an additional ring by means of a direct link between two ring carbon atoms, including carboxyclic rings fused to the cyclopenta(a)hydrophenanthrene skeleton are included in this class
- C07J53/002—Carbocyclic rings fused
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/18—Feminine contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/30—Oestrogens
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
- C07J1/0051—Estrane derivatives
- C07J1/0081—Substituted in position 17 alfa and 17 beta
- C07J1/0085—Substituted in position 17 alfa and 17 beta the substituent in position 17 alfa being a saturated hydrocarbon group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Endocrinology (AREA)
- Physical Education & Sports Medicine (AREA)
- Reproductive Health (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Diabetes (AREA)
- Rheumatology (AREA)
- Gynecology & Obstetrics (AREA)
- Urology & Nephrology (AREA)
- Steroid Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Un compuesto de esteroide que tiene la formula (I)en la cual: R3 es = O, -OH, =NOR, -OR u -OOCR, donde R es alquilo C1-6; R6 es H, =CH2 o (CH2)mH,siendo m 1 o 2; R7 es H, alquilo C1-4, alquenilo C2-5 o alquinilo C2-5, donde el grupoalquil o, alquenilo o alquinilo puede estar sustituido con 1 a 3átomos de halogeno, independientemente seleccionados del grupo que consiste en átomos fluor y cloro; R1 es H, alquilo C1-4, alquenilo C2-4, alquinilo C2-4o alquilideno C1-4, donde elgrupo alq uilo, alquenilo, alquinilo o alquilideno puede estar sustituido con 1 a 3 átomos de halogeno, independientementeseleccionados del grupo que consiste en átomos fluor y cloro; E representa -junto con los átomos de carbono 16 y 17 de lacadena cer rada D- una cadenacerrada de cuatro a siete miembros, siendo dicha cadena cerrada alfa con respecto a la cadena cerrada D, sustituida con RE y que comprende opcionalmenteuno o dos enlaces dobles endocíclicos; RE es H, alquilo C1-6,alquenilo C 2-6, alquilideno C1-6, cicloalquilo espiro-anillado C2-6, -OR, -SR, -OOCR, -NHR,-NRR, -NHCOR, donde R (y en el caso que RE sea -NRR, cada R independientemente de la otra) es un alquilo con 1 a 6 átomos de carbono, -NCO, -(CH2)n-N3o(CH2)n-CN, sien do n de 0 a 5, donde el grupo alquilo, alquenilo, alquinilo, alquilideno o cicloalquilo puede estar sustituido con 1 a 3 sustituyentes,independientemente seleccionados del grupo que consiste en -OR, -SR, OOCR, -NHR y -NHCOR, donde R es tal c omo se la ha definido anteriormente, átomos defluor y átomos de cloro; R17 es -OH, OCH2OR, -OR u OOCR, donde R es un alquilo con 1 a 6 átomos de carbono; en donde el compuesto de esteroide puede teneropcionalmente uno o másenlaces dobles, estando d icho enlace doble presente entre el átomo de carbono de la posicion 9 y el átomo de carbono de la
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP97102884 | 1997-02-21 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR011680A1 true AR011680A1 (es) | 2000-08-30 |
Family
ID=8226513
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP980100753A AR011680A1 (es) | 1997-02-21 | 1998-02-20 | Un compuesto de esteroide, sus usos, procedimientos para prepararlo y una composicion farmaceutica que lo comprende. |
Country Status (26)
| Country | Link |
|---|---|
| US (2) | US6077873A (es) |
| EP (1) | EP0869132B1 (es) |
| JP (1) | JP4392066B2 (es) |
| KR (1) | KR19980071540A (es) |
| CN (2) | CN100522984C (es) |
| AR (1) | AR011680A1 (es) |
| AT (1) | ATE205217T1 (es) |
| AU (1) | AU723713B2 (es) |
| BR (1) | BR9800718B1 (es) |
| CA (1) | CA2229960C (es) |
| CZ (1) | CZ50598A3 (es) |
| DE (1) | DE69801539T2 (es) |
| DK (1) | DK0869132T3 (es) |
| ES (1) | ES2164400T3 (es) |
| HU (1) | HU223755B1 (es) |
| ID (1) | ID19947A (es) |
| IL (1) | IL123195A (es) |
| NO (1) | NO310724B1 (es) |
| NZ (1) | NZ329789A (es) |
| PL (1) | PL188079B1 (es) |
| PT (1) | PT869132E (es) |
| RU (1) | RU2182153C2 (es) |
| SG (1) | SG60203A1 (es) |
| TR (1) | TR199800282A1 (es) |
| TW (1) | TW403736B (es) |
| ZA (1) | ZA981344B (es) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL123195A (en) * | 1997-02-21 | 2002-11-10 | Akzo Nobel Nv | Steroid compounds with anti-pregnancy activity and against bone thinning, preparation and pharmaceutical preparations containing them |
| US6667299B1 (en) * | 2000-03-16 | 2003-12-23 | Hollis-Eden Pharmaceuticals, Inc. | Pharmaceutical compositions and treatment methods |
| US6756366B1 (en) * | 1999-04-06 | 2004-06-29 | Akzo Nobel N.V. | Orally active androgens |
| CO5271709A1 (es) | 2000-01-12 | 2003-04-30 | Pfizer Prod Inc | Composiciones y procedimientos para el y tratamiento de afecciones que responden a estrogenos |
| TWI225068B (en) | 2000-06-06 | 2004-12-11 | Akzo Nobel Nv | Anellated steroid compounds having contraceptive and anti-osteoporosis activity |
| JP2002241395A (ja) * | 2001-02-16 | 2002-08-28 | Taiho Yakuhin Kogyo Kk | エストラ−４，６−ジエン−３，１７−ジオンの製造方法 |
| US7250289B2 (en) | 2002-11-20 | 2007-07-31 | Affymetrix, Inc. | Methods of genetic analysis of mouse |
| UA89964C2 (ru) | 2004-09-08 | 2010-03-25 | Н.В. Органон | 15β-ЗАМЕЩЕННЫЕ СТЕРОИДЫ, КОТОРЫЕ ИМЕЮТ СЕЛЕКТИВНУЮ ЭСТРОГЕННУЮ АКТИВНОСТЬ |
| EP2127656A4 (en) * | 2006-12-20 | 2010-03-03 | Landsteiner Scient S A De C V | COMPOSITIONS OF RISEDRONATE AND VITAMIN D3 |
| US8367648B2 (en) | 2009-06-10 | 2013-02-05 | Msd Oss B.V. | Substituted 16,17-annellated steroid compounds for use in womens healthcare |
| TW201109346A (en) * | 2009-06-10 | 2011-03-16 | Organon Nv | Substituted 16,17-annellated steroid compounds for use in women's healthcare |
| WO2023000135A1 (en) * | 2021-07-19 | 2023-01-26 | Context Biopharma Inc. | Processes of making onapristone and intermediates thereof |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK0411733T3 (da) * | 1989-08-04 | 1999-06-28 | Schering Ag | 11-beta-aryl-gona-4,9-dien-3-oner |
| EP0411736B1 (de) * | 1989-08-04 | 1994-05-04 | Schering Aktiengesellschaft | 11 Beta-substituierte 16 alpha, 17alpha-Methylen-estra-4,9-dien-3-one |
| US5407928A (en) * | 1990-08-15 | 1995-04-18 | Schering Aktiengesellschaft | 11β-aryl-gona-4,9-dien-3-ones |
| ZA94715B (en) * | 1993-02-08 | 1994-10-24 | Akzo Nv | Steroids for treating menopausal complaints |
| IL123195A (en) * | 1997-02-21 | 2002-11-10 | Akzo Nobel Nv | Steroid compounds with anti-pregnancy activity and against bone thinning, preparation and pharmaceutical preparations containing them |
-
1998
- 1998-02-05 IL IL12319598A patent/IL123195A/en not_active IP Right Cessation
- 1998-02-05 TW TW087101457A patent/TW403736B/zh not_active IP Right Cessation
- 1998-02-18 DK DK98200518T patent/DK0869132T3/da active
- 1998-02-18 AT AT98200518T patent/ATE205217T1/de not_active IP Right Cessation
- 1998-02-18 PT PT98200518T patent/PT869132E/pt unknown
- 1998-02-18 DE DE69801539T patent/DE69801539T2/de not_active Expired - Lifetime
- 1998-02-18 NZ NZ329789A patent/NZ329789A/en unknown
- 1998-02-18 EP EP98200518A patent/EP0869132B1/en not_active Expired - Lifetime
- 1998-02-18 ES ES98200518T patent/ES2164400T3/es not_active Expired - Lifetime
- 1998-02-18 ZA ZA981344A patent/ZA981344B/xx unknown
- 1998-02-19 US US09/026,348 patent/US6077873A/en not_active Expired - Lifetime
- 1998-02-19 SG SG1998000359A patent/SG60203A1/en unknown
- 1998-02-20 JP JP03945598A patent/JP4392066B2/ja not_active Expired - Lifetime
- 1998-02-20 CZ CZ98505A patent/CZ50598A3/cs unknown
- 1998-02-20 HU HU9800373A patent/HU223755B1/hu not_active IP Right Cessation
- 1998-02-20 ID IDP980243A patent/ID19947A/id unknown
- 1998-02-20 CN CNB981085954A patent/CN100522984C/zh not_active Expired - Fee Related
- 1998-02-20 TR TR1998/00282A patent/TR199800282A1/xx unknown
- 1998-02-20 AR ARP980100753A patent/AR011680A1/es active IP Right Grant
- 1998-02-20 KR KR1019980005273A patent/KR19980071540A/ko not_active Ceased
- 1998-02-20 BR BRPI9800718-1A patent/BR9800718B1/pt not_active IP Right Cessation
- 1998-02-20 CA CA002229960A patent/CA2229960C/en not_active Expired - Fee Related
- 1998-02-20 CN CNA2007101064034A patent/CN101092442A/zh active Pending
- 1998-02-20 AU AU55412/98A patent/AU723713B2/en not_active Ceased
- 1998-02-20 NO NO19980737A patent/NO310724B1/no not_active IP Right Cessation
- 1998-02-20 RU RU98103023/04A patent/RU2182153C2/ru not_active IP Right Cessation
- 1998-02-20 PL PL98324939A patent/PL188079B1/pl not_active IP Right Cessation
-
2000
- 2000-03-30 US US09/538,783 patent/US6313180B1/en not_active Expired - Lifetime
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant, registration |