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AR002247A1 - Eleuterobina y analogos de la misma y composiciones que las comprenden. - Google Patents

Eleuterobina y analogos de la misma y composiciones que las comprenden.

Info

Publication number
AR002247A1
AR002247A1 ARP950100096A AR10009695A AR002247A1 AR 002247 A1 AR002247 A1 AR 002247A1 AR P950100096 A ARP950100096 A AR P950100096A AR 10009695 A AR10009695 A AR 10009695A AR 002247 A1 AR002247 A1 AR 002247A1
Authority
AR
Argentina
Prior art keywords
analogs
compositions
eleuterobina
same
eleutherobine
Prior art date
Application number
ARP950100096A
Other languages
English (en)
Original Assignee
Univ California
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ California filed Critical Univ California
Publication of AR002247A1 publication Critical patent/AR002247A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/26—Acyclic or carbocyclic radicals, substituted by hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/7056—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing five-membered rings with nitrogen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

La presente invención comprende la eleuterobina que es un diterpeno glicosilado que tiene la fórmula estructural (I), que es un agente citotóxico,y que es tóxico para los carcinomas de las células cancerosas; los análogos de la eleuterobinay composiciones que las comprenden.
ARP950100096A 1994-11-09 1995-11-08 Eleuterobina y analogos de la misma y composiciones que las comprenden. AR002247A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/336,518 US5473057A (en) 1994-11-09 1994-11-09 Eleutherobin and analogs thereof

Publications (1)

Publication Number Publication Date
AR002247A1 true AR002247A1 (es) 1998-03-11

Family

ID=23316461

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP950100096A AR002247A1 (es) 1994-11-09 1995-11-08 Eleuterobina y analogos de la misma y composiciones que las comprenden.

Country Status (16)

Country Link
US (1) US5473057A (es)
EP (1) EP0790769A4 (es)
JP (1) JPH10508611A (es)
KR (1) KR970706732A (es)
AR (1) AR002247A1 (es)
AU (1) AU688177B2 (es)
BR (1) BR9510357A (es)
CZ (1) CZ288170B6 (es)
HU (1) HUT77882A (es)
IL (1) IL116190A (es)
NO (1) NO306347B1 (es)
NZ (1) NZ296728A (es)
PL (1) PL181693B1 (es)
RU (1) RU2146089C1 (es)
WO (1) WO1996014745A1 (es)
ZA (1) ZA959517B (es)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5965718A (en) * 1997-10-24 1999-10-12 The Scripps Research Institute Analogs of sarcodictyin and eleutherobin
US6172205B1 (en) * 1997-12-11 2001-01-09 The Trustees Of Columbia In The City Of New York Synthetic process toward total synthesis of eleutherobin and its analogues and uses thereof
US6833373B1 (en) 1998-12-23 2004-12-21 G.D. Searle & Co. Method of using an integrin antagonist and one or more antineoplastic agents as a combination therapy in the treatment of neoplasia
US6858598B1 (en) 1998-12-23 2005-02-22 G. D. Searle & Co. Method of using a matrix metalloproteinase inhibitor and one or more antineoplastic agents as a combination therapy in the treatment of neoplasia
US6066635A (en) * 1999-03-23 2000-05-23 University Of California, San Diego Avrainvillamide, a cytotoxic marine natural product, and derivatives thereof
CA2290316A1 (en) 1999-11-24 2001-05-24 The University Of British Columbia Novel source of eleutherobin and related antimitotic diterpenes
US6946283B2 (en) * 2001-01-05 2005-09-20 William Marsh Rice University Ginkgo biloba levopimaradiene synthase
US7238514B2 (en) * 2001-01-05 2007-07-03 William Marsh Rice University Diterpene-producing unicellular organism
US7067494B2 (en) 2001-06-22 2006-06-27 The University Of British Columbia Antimitotic eleuthesides
CA2607940C (en) 2005-05-18 2009-12-15 Aegera Therapeutics Inc. Bir domain binding compounds
AU2007250443B2 (en) 2006-05-16 2013-06-13 Pharmascience Inc. IAP BIR domain binding compounds
EP2534170B1 (en) 2010-02-12 2017-04-19 Pharmascience Inc. Iap bir domain binding compounds
KR20160058960A (ko) 2013-10-04 2016-05-25 압토스 바이오사이언시스 인코포레이티드 암을 치료하기 위한 조성물과 방법
WO2023287071A1 (ko) * 2021-07-16 2023-01-19 주식회사 엘지화학 항균 조성물

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2021809C1 (ru) * 1987-11-30 1994-10-30 Институт химии поверхности АН Украины Вещество, обладающее противоопухолевым действием
RU2003330C1 (ru) * 1989-12-15 1993-11-30 Виктор Николаевич Чернов Способ лечени рака молочной железы
RU2008001C1 (ru) * 1992-06-04 1994-02-28 Борис Иванович Блескин Способ профилактики и лечения рака различной локализации

Also Published As

Publication number Publication date
CZ288170B6 (en) 2001-05-16
AU688177B2 (en) 1998-03-05
RU2146089C1 (ru) 2000-03-10
PL320089A1 (en) 1997-09-15
NZ296728A (en) 1998-03-25
EP0790769A4 (en) 1998-10-21
IL116190A (en) 1999-12-22
MX9703414A (es) 1997-07-31
NO306347B1 (no) 1999-10-25
AU4140996A (en) 1996-06-06
PL181693B1 (pl) 2001-09-28
JPH10508611A (ja) 1998-08-25
EP0790769A1 (en) 1997-08-27
CZ139697A3 (en) 1997-09-17
HUT77882A (hu) 1998-09-28
KR970706732A (ko) 1997-12-01
IL116190A0 (en) 1996-01-31
US5473057A (en) 1995-12-05
ZA959517B (en) 1996-06-20
NO972103D0 (no) 1997-05-07
WO1996014745A1 (en) 1996-05-23
NO972103L (no) 1997-05-07
BR9510357A (pt) 1997-12-23

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Legal Events

Date Code Title Description
FA Abandonment or withdrawal