AR011614A1 - Derivados (4-piperidinil)-1h-2-benzopirano utiles como agentes antipsicoticos, composicion farmaceutica, usos en la fabricacion de medicamentos y metodo de preparacion - Google Patents
Derivados (4-piperidinil)-1h-2-benzopirano utiles como agentes antipsicoticos, composicion farmaceutica, usos en la fabricacion de medicamentos y metodo de preparacionInfo
- Publication number
- AR011614A1 AR011614A1 ARP980100456A ARP980100456A AR011614A1 AR 011614 A1 AR011614 A1 AR 011614A1 AR P980100456 A ARP980100456 A AR P980100456A AR P980100456 A ARP980100456 A AR P980100456A AR 011614 A1 AR011614 A1 AR 011614A1
- Authority
- AR
- Argentina
- Prior art keywords
- derivatives
- alkyl
- benzopyran
- piperidinyl
- useful
- Prior art date
Links
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- BGQDJILSOPGZQP-UHFFFAOYSA-N 4-(1h-isochromen-1-yl)piperidine Chemical compound C1CNCCC1C1C2=CC=CC=C2C=CO1 BGQDJILSOPGZQP-UHFFFAOYSA-N 0.000 title 1
- 239000000164 antipsychotic agent Substances 0.000 title 1
- 239000003814 drug Substances 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- 238000002360 preparation method Methods 0.000 title 1
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 4
- PQNFLJBBNBOBRQ-UHFFFAOYSA-N indane Chemical group C1=CC=C2CCCC2=C1 PQNFLJBBNBOBRQ-UHFFFAOYSA-N 0.000 abstract 2
- 125000000325 methylidene group Chemical group [H]C([H])=* 0.000 abstract 2
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 1
- RAVIMLUKVSFJHZ-UHFFFAOYSA-N 5,5-dimethyl-1,1-dioxo-1,3-thiazolidin-4-one Chemical group CC1(C)C(=O)NCS1(=O)=O RAVIMLUKVSFJHZ-UHFFFAOYSA-N 0.000 abstract 1
- XOTGAFSNNZVNTO-UHFFFAOYSA-N C(CNCC1)C1C1OC(C=CC=C2)=C2C=C1 Chemical compound C(CNCC1)C1C1OC(C=CC=C2)=C2C=C1 XOTGAFSNNZVNTO-UHFFFAOYSA-N 0.000 abstract 1
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 abstract 1
- 208000028017 Psychotic disease Diseases 0.000 abstract 1
- DHKHKXVYLBGOIT-UHFFFAOYSA-N acetaldehyde Diethyl Acetal Natural products CCOC(C)OCC DHKHKXVYLBGOIT-UHFFFAOYSA-N 0.000 abstract 1
- 125000004423 acyloxy group Chemical group 0.000 abstract 1
- 125000004390 alkyl sulfonyl group Chemical group 0.000 abstract 1
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 1
- 125000000051 benzyloxy group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])O* 0.000 abstract 1
- 150000005676 cyclic carbonates Chemical group 0.000 abstract 1
- 125000002485 formyl group Chemical group [H]C(*)=O 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 125000004446 heteroarylalkyl group Chemical group 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- -1 methylene acetal Chemical class 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000004044 trifluoroacetyl group Chemical group FC(C(=O)*)(F)F 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/453—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with oxygen as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/10—Spiro-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Psychiatry (AREA)
- Epidemiology (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Abstract
Derivados (4-piperidinil)-1H-benzopirano de la formula (I), un estereoisomero o una sal farmacéuticamente aceptable del mismo, donde R1 es H,alquilo C1-6, aralquilo eventualmente substituido, heteroarilalquilo eventualmentesu bstituido, 5,5-dimetil-1,1-dioxo-4-tiazolidinona, indano,alquilsulfonilo, trifluoroacetilo o fenilo eventualmente substituido con (CH2)mZ-(CH2)t, donde Z es O o C=O; cada R2 y R3 son independientemente H,alquilo C1-6, -C(O)alquilo C1-6,CHO o alquenilo C2-6; cada uno de X e Y son independientemente H, hidroxi, alquilo C1-6, halogeno, aciloxi o alcoxi C1-6,benciloxi o X e Y juntos forman un difenilmetilencetal, ciclohexilidencetal, metilenacetal o grupo carbonato cíclico,siempre que X e Y están en posicionadyacente, y n es un numero entero 1, 2 o 3; m es un numero entero 0, 1, 2 o 3, y t es un numero entero 0, 1, 2 o 3. Los referidos derivados se incluyen encomposiciones farmacéuticas y son utiles en el tratamientode la psicos is.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US79710797A | 1997-02-07 | 1997-02-07 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR011614A1 true AR011614A1 (es) | 2000-08-30 |
Family
ID=25169927
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP980100456A AR011614A1 (es) | 1997-02-07 | 1998-02-03 | Derivados (4-piperidinil)-1h-2-benzopirano utiles como agentes antipsicoticos, composicion farmaceutica, usos en la fabricacion de medicamentos y metodo de preparacion |
Country Status (21)
| Country | Link |
|---|---|
| EP (1) | EP1015446B1 (es) |
| JP (1) | JP4177461B2 (es) |
| KR (1) | KR100509878B1 (es) |
| CN (1) | CN1092653C (es) |
| AR (1) | AR011614A1 (es) |
| AT (1) | ATE236150T1 (es) |
| AU (1) | AU725301B2 (es) |
| BR (1) | BRPI9807312B8 (es) |
| CA (1) | CA2281702C (es) |
| CY (1) | CY2324B1 (es) |
| DE (1) | DE69812980T2 (es) |
| DK (1) | DK1015446T3 (es) |
| ES (1) | ES2194303T3 (es) |
| HU (1) | HUP0001308A3 (es) |
| IL (1) | IL131243A (es) |
| NO (1) | NO318936B1 (es) |
| NZ (1) | NZ336719A (es) |
| PT (1) | PT1015446E (es) |
| TW (1) | TW518333B (es) |
| WO (1) | WO1998034933A1 (es) |
| ZA (1) | ZA98831B (es) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK1749001T3 (da) | 2004-04-29 | 2010-06-28 | Aventis Pharma Inc | 3-piperidinylisochroman-5-ol som dopaminagonister |
| WO2005117849A1 (en) | 2004-05-28 | 2005-12-15 | Unigen Pharmaceuticals, Inc. | Diarylalkanes as potent inhibitors of binuclear enzymes |
| RU2480466C2 (ru) | 2007-07-26 | 2013-04-27 | Ф.Хоффманн-Ля Рош Аг | Двойные модуляторы 5-ht2a и d3-рецепторов |
| KR101849695B1 (ko) | 2008-07-21 | 2018-04-17 | 유니젠, 인크. | 일련의 피부-화이트닝(라이트닝) 화합물 |
| US8877778B2 (en) | 2010-12-15 | 2014-11-04 | Hoffmann-La Roche Inc. | Benzofurane compounds |
| CN102079720B (zh) * | 2011-01-20 | 2013-02-06 | 蚌埠丰原医药科技发展有限公司 | 一种制备1-苄基-4-哌啶甲醛的方法 |
| CN109896935A (zh) | 2011-03-24 | 2019-06-18 | 尤尼根公司 | 用于制备二芳基丙烷的化合物和方法 |
| US8921397B2 (en) | 2011-05-04 | 2014-12-30 | Hoffmann-La Roche Inc. | Benzofurane-piperidine compounds |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1552004A (en) * | 1976-05-26 | 1979-09-05 | Takeda Chemical Industries Ltd | Isochroman derivatives |
| US4963568A (en) * | 1989-05-31 | 1990-10-16 | Abbott Laboratories | Dopamine agonists |
-
1998
- 1998-01-20 PT PT98902628T patent/PT1015446E/pt unknown
- 1998-01-20 ES ES98902628T patent/ES2194303T3/es not_active Expired - Lifetime
- 1998-01-20 IL IL13124398A patent/IL131243A/en not_active IP Right Cessation
- 1998-01-20 JP JP53461798A patent/JP4177461B2/ja not_active Expired - Fee Related
- 1998-01-20 CN CN98802357A patent/CN1092653C/zh not_active Expired - Lifetime
- 1998-01-20 KR KR10-1999-7007127A patent/KR100509878B1/ko not_active Expired - Fee Related
- 1998-01-20 WO PCT/US1998/000979 patent/WO1998034933A1/en not_active Ceased
- 1998-01-20 DE DE69812980T patent/DE69812980T2/de not_active Expired - Lifetime
- 1998-01-20 HU HU0001308A patent/HUP0001308A3/hu unknown
- 1998-01-20 DK DK98902628T patent/DK1015446T3/da active
- 1998-01-20 AT AT98902628T patent/ATE236150T1/de active
- 1998-01-20 AU AU59237/98A patent/AU725301B2/en not_active Expired
- 1998-01-20 NZ NZ336719A patent/NZ336719A/xx unknown
- 1998-01-20 EP EP98902628A patent/EP1015446B1/en not_active Expired - Lifetime
- 1998-01-20 BR BRPI9807312A patent/BRPI9807312B8/pt not_active IP Right Cessation
- 1998-01-20 CA CA002281702A patent/CA2281702C/en not_active Expired - Lifetime
- 1998-02-02 ZA ZA98831A patent/ZA98831B/xx unknown
- 1998-02-03 AR ARP980100456A patent/AR011614A1/es active IP Right Grant
- 1998-02-03 TW TW087101327A patent/TW518333B/zh not_active IP Right Cessation
-
1999
- 1999-08-06 NO NO19993812A patent/NO318936B1/no unknown
-
2003
- 2003-04-30 CY CY0300037A patent/CY2324B1/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| IL131243A (en) | 2004-02-19 |
| NO318936B1 (no) | 2005-05-30 |
| NZ336719A (en) | 2000-10-27 |
| CY2324B1 (en) | 2003-11-14 |
| DK1015446T3 (da) | 2003-07-14 |
| KR20000070862A (ko) | 2000-11-25 |
| HUP0001308A3 (en) | 2001-07-30 |
| AU5923798A (en) | 1998-08-26 |
| TW518333B (en) | 2003-01-21 |
| KR100509878B1 (ko) | 2005-08-25 |
| EP1015446A1 (en) | 2000-07-05 |
| CN1246859A (zh) | 2000-03-08 |
| DE69812980D1 (de) | 2003-05-08 |
| BR9807312A (pt) | 2000-05-02 |
| JP4177461B2 (ja) | 2008-11-05 |
| BR9807312B1 (pt) | 2013-10-29 |
| DE69812980T2 (de) | 2003-11-13 |
| CA2281702C (en) | 2006-04-11 |
| ATE236150T1 (de) | 2003-04-15 |
| BRPI9807312B8 (pt) | 2016-09-13 |
| HK1027812A1 (en) | 2001-01-23 |
| HUP0001308A2 (hu) | 2001-06-28 |
| WO1998034933A1 (en) | 1998-08-13 |
| IL131243A0 (en) | 2001-01-28 |
| EP1015446B1 (en) | 2003-04-02 |
| CA2281702A1 (en) | 1998-08-13 |
| PT1015446E (pt) | 2003-08-29 |
| NO993812D0 (no) | 1999-08-06 |
| ZA98831B (en) | 1998-08-07 |
| NO993812L (no) | 1999-10-05 |
| CN1092653C (zh) | 2002-10-16 |
| AU725301B2 (en) | 2000-10-12 |
| ES2194303T3 (es) | 2003-11-16 |
| JP2001512436A (ja) | 2001-08-21 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant, registration |