CO4980862A1 - Derivados de tetrahidropiridopirimidinona 3-sustituidos . - Google Patents
Derivados de tetrahidropiridopirimidinona 3-sustituidos .Info
- Publication number
- CO4980862A1 CO4980862A1 CO98061508A CO98061508A CO4980862A1 CO 4980862 A1 CO4980862 A1 CO 4980862A1 CO 98061508 A CO98061508 A CO 98061508A CO 98061508 A CO98061508 A CO 98061508A CO 4980862 A1 CO4980862 A1 CO 4980862A1
- Authority
- CO
- Colombia
- Prior art keywords
- alkyl
- branched
- substituted
- unbranched
- aromatic
- Prior art date
Links
- 125000000217 alkyl group Chemical group 0.000 abstract 4
- CXWXQJXEFPUFDZ-UHFFFAOYSA-N tetralin Chemical compound C1=CC=C2CCCCC2=C1 CXWXQJXEFPUFDZ-UHFFFAOYSA-N 0.000 abstract 3
- -1 3-substituted tetrahydropyridopyrimidinone Chemical class 0.000 abstract 2
- UFWIBTONFRDIAS-UHFFFAOYSA-N Naphthalene Chemical compound C1=CC=CC2=CC=CC=C21 UFWIBTONFRDIAS-UHFFFAOYSA-N 0.000 abstract 2
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 abstract 2
- 125000002947 alkylene group Chemical group 0.000 abstract 2
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 2
- 125000005842 heteroatom Chemical group 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- PQNFLJBBNBOBRQ-UHFFFAOYSA-N indane Chemical compound C1=CC=C2CCCC2=C1 PQNFLJBBNBOBRQ-UHFFFAOYSA-N 0.000 abstract 2
- 125000001570 methylene group Chemical group [H]C([H])([*:1])[*:2] 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 2
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 1
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 abstract 1
- FUFZNHHSSMCXCZ-UHFFFAOYSA-N 5-piperidin-4-yl-3-[3-(trifluoromethyl)phenyl]-1,2,4-oxadiazole Chemical compound FC(F)(F)C1=CC=CC(C=2N=C(ON=2)C2CCNCC2)=C1 FUFZNHHSSMCXCZ-UHFFFAOYSA-N 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 150000007513 acids Chemical class 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000005494 condensation Effects 0.000 abstract 1
- 238000009833 condensation Methods 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Endocrinology (AREA)
- Psychiatry (AREA)
- Diabetes (AREA)
- Cardiology (AREA)
- Obesity (AREA)
- Hospice & Palliative Care (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Child & Adolescent Psychology (AREA)
- Pain & Pain Management (AREA)
- Nutrition Science (AREA)
- Reproductive Health (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Structure And Mechanism Of Cameras (AREA)
Abstract
Derivados de tetrahidropiridopirimidinona 3-sustituidos de la fórmula (I)caracterizados porque uno de los radicales X, Y significa CH2 y el otro significa NR1 , R1 significa hidrógeno, (C1-6 ) alquilo ramificado o sin ramificar, CO-(C1-4 )-ALQUILO, CO2 -tBu, CO-arilo y un radical fenilalquilo C1-4 , que a su vez puede estar sustituido en el aromático por F, Cl, Br, Y, C1 -C4 alquilo, C1 -C4 alcoxi, trifluorometilo, hidroxi, amino, ciano o nitro. A Significa (C1 -10 )-alquiteno ramificado o sin ramificar, (C2 -10 )-alquileno lineal o ramificado, que comprende al menos un grupo 2, seleccionado de entre 0, S. NR2 ciclopropilo, CHOH, un enlace doble o triple, R2 significa hidrógeno y C1 -C4 alquilo B significa 4-piperidina, 4-tetrahidro- 1,2,3,6 piridina, 4-piperacina y los compuestos anulares correspondientes, amplios por un grupo metileno, realizándose el enlace entre A y B por vía de un átomo de N, y Ar significa fenilo, que eventualmente está sustituido por (C1-6 )alquilo ramificado o sin ramificar, O-(C1-6 )-alquilo ramificado o sin ramificar, OH, F, Cl, Br, I, trifluorometilo, NR2 2 , CO2 R2 , ciano o fenilo, tetralina, indano, aromáticos de alto grado de condensación como p. ej. naftalina, que eventualmente está sustituida por (C1-4 )-alquilo o O(C1-4 )-alquilo, entraceno o heterociclos aromáticos de 5 ó 6 miembros con 1 a 2 heteroátomos, heteroátomos seleccionados independientemente de entre O y N, y que pueden estar aún fusionados con otros radicales aromáticos, así como sus sales con ácidos fisiológicamente tolerados.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19747063A DE19747063A1 (de) | 1997-10-24 | 1997-10-24 | 3-substituierte Tetrahydropyridopyrimidinon-Derivate, ihre Herstellung und Verwendung |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CO4980862A1 true CO4980862A1 (es) | 2000-11-27 |
Family
ID=7846539
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CO98061508A CO4980862A1 (es) | 1997-10-24 | 1998-10-22 | Derivados de tetrahidropiridopirimidinona 3-sustituidos . |
Country Status (27)
| Country | Link |
|---|---|
| US (1) | US6414157B1 (es) |
| EP (1) | EP1025100B1 (es) |
| JP (1) | JP2001521035A (es) |
| KR (1) | KR20010015787A (es) |
| CN (1) | CN1277611A (es) |
| AR (1) | AR015466A1 (es) |
| AT (1) | ATE212346T1 (es) |
| AU (1) | AU748666B2 (es) |
| BG (1) | BG104291A (es) |
| BR (1) | BR9812970A (es) |
| CA (1) | CA2305258A1 (es) |
| CO (1) | CO4980862A1 (es) |
| DE (2) | DE19747063A1 (es) |
| DK (1) | DK1025100T3 (es) |
| ES (1) | ES2172222T3 (es) |
| HR (1) | HRP980554A2 (es) |
| HU (1) | HUP0004648A3 (es) |
| ID (1) | ID24633A (es) |
| NO (1) | NO20001934L (es) |
| NZ (1) | NZ503486A (es) |
| PL (1) | PL340034A1 (es) |
| PT (1) | PT1025100E (es) |
| SK (1) | SK3872000A3 (es) |
| TR (1) | TR200001102T2 (es) |
| TW (1) | TW432063B (es) |
| WO (1) | WO1999021857A1 (es) |
| ZA (1) | ZA989664B (es) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19900544A1 (de) * | 1999-01-11 | 2000-07-13 | Basf Ag | Verwendung von Verbindungen der Formel I zur Prophylaxe und Therapie der zerebralen Ischämie |
| WO2004014909A1 (en) * | 2002-08-13 | 2004-02-19 | Warner-Lambert Company Llc | Fused tetrahydropyridine derivatives as matrix metalloproteinase inhibitors |
| US20040127501A1 (en) * | 2002-09-24 | 2004-07-01 | Zhengming Chen | Therapeutic agents useful for treating pain |
| JP4654035B2 (ja) | 2002-11-05 | 2011-03-16 | グラクソスミスクライン・リミテッド・ライアビリティ・カンパニー | 抗菌剤 |
| CL2004000409A1 (es) * | 2003-03-03 | 2005-01-07 | Vertex Pharma | Compuestos derivados de 2-(cilo sustituido)-1-(amino u oxi sustituido)-quinazolina, inhibidores de canales ionicos de sodio y calcio dependientes de voltaje; composicion farmaceutica; y uso del compuesto en el tratamiento de dolor agudo, cronico, neu |
| US7160888B2 (en) * | 2003-08-22 | 2007-01-09 | Warner Lambert Company Llc | [1,8]naphthyridin-2-ones and related compounds for the treatment of schizophrenia |
| US20050165025A1 (en) * | 2004-01-22 | 2005-07-28 | Recordati Ireland Ltd. | Combination therapy with 5HT 1A and 5HT 1B-receptor antagonists |
| DE102004020908A1 (de) | 2004-04-28 | 2005-11-17 | Grünenthal GmbH | Substituierte 5,6,7,8,-Tetrahydro-pyrido[4,3-d]pyrimidin-2-yl- und 5,6,7,8,-Tetrahydro-chinazolin-2-yl-Verbindungen |
| CN101189237A (zh) * | 2005-04-01 | 2008-05-28 | 沃尼尔·朗伯有限责任公司 | 用于治疗精神分裂症的四氢－吡啶并氮杂䓬－8－酮和相关化合物 |
| CA2621164A1 (en) * | 2005-08-26 | 2007-03-01 | Shionogi & Co., Ltd. | Derivative having ppar agonistic activity |
| CN102952129B (zh) * | 2011-08-16 | 2015-09-23 | 上海师范大学 | 四氢吡啶并二氢嘧啶酮衍生物及其制备方法和应用 |
| EP4232450A4 (en) | 2020-10-21 | 2024-09-04 | Aligos Therapeutics, Inc. | BICYCLIC COMPOUNDS |
| WO2022266193A1 (en) | 2021-06-18 | 2022-12-22 | Aligos Therapeutics, Inc. | Bicyclic compounds |
| AU2023257365A1 (en) | 2022-04-20 | 2024-10-17 | Aligos Therapeutics, Inc. | Bicyclic compounds |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0827149A (ja) * | 1994-07-08 | 1996-01-30 | Meiji Seika Kaisha Ltd | ピリミジノン誘導体およびその塩 |
-
1997
- 1997-10-24 DE DE19747063A patent/DE19747063A1/de not_active Withdrawn
-
1998
- 1998-10-05 PT PT98951491T patent/PT1025100E/pt unknown
- 1998-10-05 AU AU97484/98A patent/AU748666B2/en not_active Ceased
- 1998-10-05 BR BR9812970-8A patent/BR9812970A/pt not_active IP Right Cessation
- 1998-10-05 DE DE59802922T patent/DE59802922D1/de not_active Expired - Fee Related
- 1998-10-05 NZ NZ503486A patent/NZ503486A/en unknown
- 1998-10-05 PL PL98340034A patent/PL340034A1/xx unknown
- 1998-10-05 KR KR1020007004362A patent/KR20010015787A/ko not_active Withdrawn
- 1998-10-05 TR TR2000/01102T patent/TR200001102T2/xx unknown
- 1998-10-05 HU HU0004648A patent/HUP0004648A3/hu unknown
- 1998-10-05 SK SK387-2000A patent/SK3872000A3/sk unknown
- 1998-10-05 EP EP98951491A patent/EP1025100B1/de not_active Expired - Lifetime
- 1998-10-05 AT AT98951491T patent/ATE212346T1/de not_active IP Right Cessation
- 1998-10-05 CN CN98810525A patent/CN1277611A/zh active Pending
- 1998-10-05 ES ES98951491T patent/ES2172222T3/es not_active Expired - Lifetime
- 1998-10-05 CA CA002305258A patent/CA2305258A1/en not_active Abandoned
- 1998-10-05 JP JP2000517967A patent/JP2001521035A/ja active Pending
- 1998-10-05 DK DK98951491T patent/DK1025100T3/da active
- 1998-10-05 ID IDW20000762D patent/ID24633A/id unknown
- 1998-10-05 WO PCT/EP1998/006305 patent/WO1999021857A1/de not_active Ceased
- 1998-10-20 TW TW087117332A patent/TW432063B/zh not_active IP Right Cessation
- 1998-10-21 HR HR19747063.7A patent/HRP980554A2/hr not_active Application Discontinuation
- 1998-10-22 CO CO98061508A patent/CO4980862A1/es unknown
- 1998-10-23 ZA ZA9809664A patent/ZA989664B/xx unknown
- 1998-10-23 AR ARP980105297A patent/AR015466A1/es not_active Application Discontinuation
-
2000
- 2000-04-03 BG BG104291A patent/BG104291A/xx unknown
- 2000-04-10 US US09/529,231 patent/US6414157B1/en not_active Expired - Lifetime
- 2000-04-13 NO NO20001934A patent/NO20001934L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| AU9748498A (en) | 1999-05-17 |
| TW432063B (en) | 2001-05-01 |
| HUP0004648A3 (en) | 2001-11-28 |
| BR9812970A (pt) | 2000-08-08 |
| ID24633A (id) | 2000-07-27 |
| CN1277611A (zh) | 2000-12-20 |
| ZA989664B (en) | 2000-04-25 |
| EP1025100B1 (de) | 2002-01-23 |
| PL340034A1 (en) | 2001-01-15 |
| HUP0004648A2 (hu) | 2001-05-28 |
| DK1025100T3 (da) | 2002-05-06 |
| HRP980554A2 (en) | 1999-08-31 |
| DE19747063A1 (de) | 1999-04-29 |
| PT1025100E (pt) | 2002-07-31 |
| US6414157B1 (en) | 2002-07-02 |
| TR200001102T2 (tr) | 2000-08-21 |
| KR20010015787A (ko) | 2001-02-26 |
| NO20001934D0 (no) | 2000-04-13 |
| NO20001934L (no) | 2000-04-13 |
| NZ503486A (en) | 2001-04-27 |
| SK3872000A3 (en) | 2000-09-12 |
| WO1999021857A1 (de) | 1999-05-06 |
| AR015466A1 (es) | 2001-05-02 |
| AU748666B2 (en) | 2002-06-06 |
| ATE212346T1 (de) | 2002-02-15 |
| BG104291A (en) | 2001-05-31 |
| CA2305258A1 (en) | 1999-05-06 |
| JP2001521035A (ja) | 2001-11-06 |
| DE59802922D1 (de) | 2002-03-14 |
| ES2172222T3 (es) | 2002-09-16 |
| EP1025100A1 (de) | 2000-08-09 |
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