AR011190A1 - Empleo de derivados de pirimidina para la preparacion de un medicamento para la profilaxis de la formacion de tumores solos o en combinacion con otroscompuestos terapeuticos - Google Patents
Empleo de derivados de pirimidina para la preparacion de un medicamento para la profilaxis de la formacion de tumores solos o en combinacion con otroscompuestos terapeuticosInfo
- Publication number
- AR011190A1 AR011190A1 ARP980101097A ARP980101097A AR011190A1 AR 011190 A1 AR011190 A1 AR 011190A1 AR P980101097 A ARP980101097 A AR P980101097A AR P980101097 A ARP980101097 A AR P980101097A AR 011190 A1 AR011190 A1 AR 011190A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- heteroaryl
- aryl
- alkoxy
- trifluoromethyl
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Diabetes (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Empleo de un derivado de pirimidina de la formula (I) en donde R1 significa hidrogeno, halogeno, ciano, nitro, trifluorometilo, amino, alquilo (C1-C6),hidroxialquilo (C1-C6), alcoxi (C1-C6), arilo (C6-C12), alcoxi (C1-C6)- carbonilalquilo(C1 -C6), alquil (C1-C6)-S-alquilo (C1-C6), alquil (C1-C6)SO-alquilo (C1-C6), alquil (C1-C6)-SO2-alquilo (C1-C6), dihidroxi-alquilo (C1-C6), arilo, heteroarilo, heteroaril-alquilo (C1-C6) aril-alquilo (C1-C6) alcoxi(C1-C6)-carbonilarilo, aril-alcoxi(C1- C6) o heteroaril-alquiloxi (C1-C6), heteroarilo significa piridilo, furilo, tetrahidrofurilo, tienilo, imidazolilo,pirazolilo, triazolilo, tiazolilo, oxazolilo, benozotiazolilo; pudiendo arilo y heteroarilo, independientemente uno de otro,estar sustituidos con uno o variossustituyentes elegidos del grupo cloro, bromo, alquilo (C1-C6), alcoxi (C1-C6), -S-alquilo (C1-C6), -SO-alquilo (C1-C6), -SO2- alquilo (C1-C6), hidroxialquilo(C1-C6), trifluorometilo, o R1 significa (II), en dondela líne a de trazos discontínuos representa un doble enlace opcional; W, Q, Z significaindependientemente uno de otro, H, alquilo (C1-C6), trifluorometilo, fenilo, furilo, triazolilo, tiazolilo, tienilo, independientemente uno deotro,sustituidos de una a tres veces con alquilo (C1-C6), alcoxi (C1-C6), trifluorometilo, hidroxi o R1 significa -(C=O)-R6, R6 significa H, alquilo(C1-C6), arilo, heteroarilo, heteroarilo significa piridilo, furilo,tetrahidrofurilo, tienilo, imid azolilo, pirazolilo, triazolilo, tiazolilo,oxazolilo, benzotiazolilo<<, pudiendo estar arilo y heteroarilo, independiente uno del otro, sustituidos con uno a tres sustituyentes elegidos del grupocloro, bromo, nitro,trifluorometilo, alcoxi (C1-C6), -SO2-alquilo (C1-C6) o R1 significa (III), R7 significa arilo, heteroarilo, heteroarilo significa
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19710435A DE19710435A1 (de) | 1997-03-13 | 1997-03-13 | Verwendung von Pyrimidinderivaten zur Prävention von Krebs allein oder in Kombination mit anderen therapeutischen Maßnahmen |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR011190A1 true AR011190A1 (es) | 2000-08-02 |
Family
ID=7823277
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP980101097A AR011190A1 (es) | 1997-03-13 | 1998-03-11 | Empleo de derivados de pirimidina para la preparacion de un medicamento para la profilaxis de la formacion de tumores solos o en combinacion con otroscompuestos terapeuticos |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US6156755A (es) |
| EP (1) | EP0864327B1 (es) |
| JP (1) | JPH10279482A (es) |
| KR (1) | KR19980080148A (es) |
| CN (1) | CN1193513A (es) |
| AR (1) | AR011190A1 (es) |
| AT (1) | ATE227129T1 (es) |
| AU (1) | AU726089B2 (es) |
| BR (1) | BR9800884A (es) |
| CA (1) | CA2231765A1 (es) |
| CZ (1) | CZ74698A3 (es) |
| DE (2) | DE19710435A1 (es) |
| DK (1) | DK0864327T3 (es) |
| ES (1) | ES2182161T3 (es) |
| HU (1) | HUP9800535A1 (es) |
| PL (1) | PL325327A1 (es) |
| PT (1) | PT864327E (es) |
| RU (1) | RU2209629C2 (es) |
| TR (1) | TR199800436A3 (es) |
Families Citing this family (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2002523497A (ja) | 1998-08-29 | 2002-07-30 | アストラゼネカ・アクチエボラーグ | ピリミジン化合物 |
| JP2002523498A (ja) | 1998-08-29 | 2002-07-30 | アストラゼネカ・アクチエボラーグ | ピリミジン化合物 |
| GB9828511D0 (en) | 1998-12-24 | 1999-02-17 | Zeneca Ltd | Chemical compounds |
| GB9905075D0 (en) | 1999-03-06 | 1999-04-28 | Zeneca Ltd | Chemical compounds |
| GB9907658D0 (en) | 1999-04-06 | 1999-05-26 | Zeneca Ltd | Chemical compounds |
| GB9919778D0 (en) | 1999-08-21 | 1999-10-27 | Zeneca Ltd | Chemical compounds |
| GB0004886D0 (en) | 2000-03-01 | 2000-04-19 | Astrazeneca Uk Ltd | Chemical compounds |
| GB0004888D0 (en) | 2000-03-01 | 2000-04-19 | Astrazeneca Uk Ltd | Chemical compounds |
| GB0004890D0 (en) | 2000-03-01 | 2000-04-19 | Astrazeneca Uk Ltd | Chemical compounds |
| GB0004887D0 (en) | 2000-03-01 | 2000-04-19 | Astrazeneca Uk Ltd | Chemical compounds |
| GB0007371D0 (en) | 2000-03-28 | 2000-05-17 | Astrazeneca Uk Ltd | Chemical compounds |
| GB0016877D0 (en) | 2000-07-11 | 2000-08-30 | Astrazeneca Ab | Chemical compounds |
| GB0021726D0 (en) | 2000-09-05 | 2000-10-18 | Astrazeneca Ab | Chemical compounds |
| US6716851B2 (en) | 2000-12-12 | 2004-04-06 | Cytovia, Inc. | Substituted 2-aryl-4-arylaminopyrimidines and analogs as activators or caspases and inducers of apoptosis and the use thereof |
| MXPA03005609A (es) * | 2000-12-21 | 2003-10-06 | Vertex Pharma | Compuestos de pirazol utiles como inhibidores de la proteina cinasa. |
| GB0103926D0 (en) | 2001-02-17 | 2001-04-04 | Astrazeneca Ab | Chemical compounds |
| GB0113041D0 (en) | 2001-05-30 | 2001-07-18 | Astrazeneca Ab | Chemical compounds |
| US6825198B2 (en) * | 2001-06-21 | 2004-11-30 | Pfizer Inc | 5-HT receptor ligands and uses thereof |
| TWI330183B (es) * | 2001-10-22 | 2010-09-11 | Eisai R&D Man Co Ltd | |
| GB0205688D0 (en) | 2002-03-09 | 2002-04-24 | Astrazeneca Ab | Chemical compounds |
| US7442697B2 (en) | 2002-03-09 | 2008-10-28 | Astrazeneca Ab | 4-imidazolyl substituted pyrimidine derivatives with CDK inhibitory activity |
| GB0205693D0 (en) | 2002-03-09 | 2002-04-24 | Astrazeneca Ab | Chemical compounds |
| GB0205690D0 (en) | 2002-03-09 | 2002-04-24 | Astrazeneca Ab | Chemical compounds |
| RS51752B (sr) * | 2002-07-29 | 2011-12-31 | Rigel Pharmaceuticals | Metode tretiranja i prevencije autoimunih oboljenja jedinjenjima 2,4-pirimidindiamina |
| RU2376992C2 (ru) * | 2002-07-29 | 2009-12-27 | Райджел Фармасьютикалз, Инк. | Способы лечения или профилактики аутоиммунных заболеваний с помощью соединений 2,4-пиримидиндиамина |
| GB0311274D0 (en) | 2003-05-16 | 2003-06-18 | Astrazeneca Ab | Chemical compounds |
| GB0311276D0 (en) | 2003-05-16 | 2003-06-18 | Astrazeneca Ab | Chemical compounds |
| GB0323137D0 (en) * | 2003-10-03 | 2003-11-05 | Chang Lisa C W | 2,4,6- Trisubstituted pyrimidines and their different uses |
| BRPI0417478A (pt) * | 2003-12-15 | 2007-05-08 | Almirall Prodesfarma Ag | 2,6-bis-heteroaril-4-aminopirimidinas como antagonistas de receptor de adenosina |
| TW200528101A (en) | 2004-02-03 | 2005-09-01 | Astrazeneca Ab | Chemical compounds |
| WO2006110884A2 (en) * | 2005-04-11 | 2006-10-19 | Neurocrine Biosciences, Inc. | 2, 6-di (hetero) aryl -4-amido-pyrimidines as adenosine receptor antagonists |
| US20060293343A1 (en) * | 2005-05-18 | 2006-12-28 | Asahi Kasei Pharma Corporation | Pyrimidine derivatives |
| US7745428B2 (en) | 2005-09-30 | 2010-06-29 | Astrazeneca Ab | Imidazo[1,2-A]pyridine having anti-cell-proliferation activity |
| WO2008070661A1 (en) * | 2006-12-04 | 2008-06-12 | Neurocrine Biosciences, Inc. | Substituted pyrimidines as adenosine receptor antagonists |
| US20100249084A1 (en) * | 2007-03-21 | 2010-09-30 | Youngsheng Chen | Substituted pyrimidines as adenosine receptor antagonists |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB884772A (en) * | 1958-01-16 | 1961-12-20 | Merck & Co Inc | 2-alkoxy-4-amino pyrimidines |
| DE3905364A1 (de) * | 1989-02-22 | 1990-08-23 | Hoechst Ag | Substituierte pyrimidin-derivate, verfahren zu ihrer herstellung und ihre verwendung als tool |
| DE4025387A1 (de) * | 1990-08-10 | 1992-02-13 | Hoechst Ag | Substituierte pyrimidin-derivate, verfahren zu ihrer herstellung und ihre verwendung als reagenzien |
| KR950703539A (ko) * | 1992-09-28 | 1995-09-20 | 알렌 제이. 스피겔 | 당뇨병 합병증 치료용 치환된 피리미딘(substituted pyrimidines for control or diabetic complications) |
-
1997
- 1997-03-13 DE DE19710435A patent/DE19710435A1/de not_active Withdrawn
-
1998
- 1998-02-27 DK DK98103410T patent/DK0864327T3/da active
- 1998-02-27 PT PT98103410T patent/PT864327E/pt unknown
- 1998-02-27 EP EP98103410A patent/EP0864327B1/de not_active Expired - Lifetime
- 1998-02-27 AT AT98103410T patent/ATE227129T1/de not_active IP Right Cessation
- 1998-02-27 ES ES98103410T patent/ES2182161T3/es not_active Expired - Lifetime
- 1998-02-27 DE DE59806139T patent/DE59806139D1/de not_active Expired - Fee Related
- 1998-03-11 CZ CZ98746A patent/CZ74698A3/cs unknown
- 1998-03-11 AR ARP980101097A patent/AR011190A1/es unknown
- 1998-03-11 TR TR1998/00436A patent/TR199800436A3/tr unknown
- 1998-03-11 HU HU9800535A patent/HUP9800535A1/hu unknown
- 1998-03-11 US US09/038,156 patent/US6156755A/en not_active Expired - Fee Related
- 1998-03-11 CA CA002231765A patent/CA2231765A1/en not_active Abandoned
- 1998-03-12 AU AU58350/98A patent/AU726089B2/en not_active Ceased
- 1998-03-12 JP JP10060757A patent/JPH10279482A/ja active Pending
- 1998-03-12 CN CN98105543A patent/CN1193513A/zh active Pending
- 1998-03-12 KR KR1019980008179A patent/KR19980080148A/ko not_active Ceased
- 1998-03-12 BR BR9800884-6A patent/BR9800884A/pt not_active IP Right Cessation
- 1998-03-12 RU RU98105512/14A patent/RU2209629C2/ru not_active IP Right Cessation
- 1998-03-13 PL PL98325327A patent/PL325327A1/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU5835098A (en) | 1998-09-17 |
| HU9800535D0 (en) | 1998-04-28 |
| PL325327A1 (en) | 1998-09-14 |
| RU2209629C2 (ru) | 2003-08-10 |
| TR199800436A2 (xx) | 1998-10-21 |
| AU726089B2 (en) | 2000-11-02 |
| BR9800884A (pt) | 1999-12-07 |
| US6156755A (en) | 2000-12-05 |
| KR19980080148A (ko) | 1998-11-25 |
| DE19710435A1 (de) | 1998-09-17 |
| EP0864327A1 (de) | 1998-09-16 |
| ATE227129T1 (de) | 2002-11-15 |
| EP0864327B1 (de) | 2002-11-06 |
| TR199800436A3 (tr) | 1998-10-21 |
| DE59806139D1 (de) | 2002-12-12 |
| CA2231765A1 (en) | 1998-09-13 |
| PT864327E (pt) | 2003-03-31 |
| JPH10279482A (ja) | 1998-10-20 |
| ES2182161T3 (es) | 2003-03-01 |
| DK0864327T3 (da) | 2003-02-17 |
| CN1193513A (zh) | 1998-09-23 |
| CZ74698A3 (cs) | 1998-09-16 |
| HUP9800535A1 (hu) | 2000-11-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |