[go: up one dir, main page]

NO20034632D0 - 2-iminopyrrolidin-derivater - Google Patents

2-iminopyrrolidin-derivater

Info

Publication number
NO20034632D0
NO20034632D0 NO20034632A NO20034632A NO20034632D0 NO 20034632 D0 NO20034632 D0 NO 20034632D0 NO 20034632 A NO20034632 A NO 20034632A NO 20034632 A NO20034632 A NO 20034632A NO 20034632 D0 NO20034632 D0 NO 20034632D0
Authority
NO
Norway
Prior art keywords
isoindol
diethoxy
imino
fluoro
tert
Prior art date
Application number
NO20034632A
Other languages
English (en)
Other versions
NO20034632L (no
NO327849B1 (no
Inventor
Shuichi Suzuki
Makoto Kotake
Mitsuaki Miyamoto
Tetsuya Kawahara
Akiharu Kajiwara
Ieharu Hishinuma
Kazuo Okano
Syuhei Miyazawa
Richard Clark
Fumihiro Ozaki
Nobuaki Sato
Masanobu Shinoda
Atsushi Kamada
Itaru Tsukada
Fumiyoshi Matsuura
Yoshimitsu Naoe
Taro Terauchi
Yoshiaki Oohashi
Osamu Ito
Hiroshi Tanaka
Original Assignee
Jpkogushi Motoji
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Jpkogushi Motoji filed Critical Jpkogushi Motoji
Publication of NO20034632D0 publication Critical patent/NO20034632D0/no
Publication of NO20034632L publication Critical patent/NO20034632L/no
Publication of NO327849B1 publication Critical patent/NO327849B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pulmonology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Vascular Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyrrole Compounds (AREA)
  • Indole Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
NO20034632A 2001-04-19 2003-10-16 2-iminopyrrolidin-derivater, deres anvendelse samt farmakologisk preparat NO327849B1 (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2001121829 2001-04-19
JP2001269422 2001-09-05
PCT/JP2002/003961 WO2002085855A1 (fr) 2001-04-19 2002-04-19 Derives de 2-iminopyrrolidine

Publications (3)

Publication Number Publication Date
NO20034632D0 true NO20034632D0 (no) 2003-10-16
NO20034632L NO20034632L (no) 2003-12-19
NO327849B1 NO327849B1 (no) 2009-10-05

Family

ID=26613890

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20034632A NO327849B1 (no) 2001-04-19 2003-10-16 2-iminopyrrolidin-derivater, deres anvendelse samt farmakologisk preparat

Country Status (21)

Country Link
US (6) US7476688B2 (no)
EP (6) EP1386912B1 (no)
JP (6) JP4251872B2 (no)
KR (2) KR100749795B1 (no)
CN (3) CN1321996C (no)
AT (3) ATE538090T1 (no)
AU (1) AU2005202135B2 (no)
BR (1) BR0208985A (no)
CA (1) CA2446924C (no)
CZ (1) CZ303865B6 (no)
DE (2) DE60233043D1 (no)
ES (1) ES2462995T3 (no)
HU (1) HUP0400467A3 (no)
IL (2) IL158491A0 (no)
MX (1) MXPA03009497A (no)
NO (1) NO327849B1 (no)
NZ (1) NZ528820A (no)
PL (1) PL368109A1 (no)
RU (1) RU2270192C2 (no)
WO (4) WO2002085855A1 (no)
ZA (1) ZA200308064B (no)

Families Citing this family (99)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6346510B1 (en) 1995-10-23 2002-02-12 The Children's Medical Center Corporation Therapeutic antiangiogenic endostatin compositions
US7235567B2 (en) 2000-06-15 2007-06-26 Schering Corporation Crystalline polymorph of a bisulfate salt of a thrombin receptor antagonist
CZ20032850A3 (cs) 2001-04-18 2004-02-18 Euro-Celtique, S. A. Analogy nociceptinu
WO2002085855A1 (fr) 2001-04-19 2002-10-31 Eisai Co., Ltd. Derives de 2-iminopyrrolidine
US7186855B2 (en) 2001-06-11 2007-03-06 Xenoport, Inc. Prodrugs of GABA analogs, compositions and uses thereof
US7232924B2 (en) 2001-06-11 2007-06-19 Xenoport, Inc. Methods for synthesis of acyloxyalkyl derivatives of GABA analogs
US8048917B2 (en) 2005-04-06 2011-11-01 Xenoport, Inc. Prodrugs of GABA analogs, compositions and uses thereof
US6818787B2 (en) 2001-06-11 2004-11-16 Xenoport, Inc. Prodrugs of GABA analogs, compositions and uses thereof
US7049333B2 (en) * 2002-06-04 2006-05-23 Sanofi-Aventis Deutschland Gmbh Substituted thiophenes: compositions, processes of making, and uses in disease treatment and diagnosis
WO2004011429A1 (ja) * 2002-07-26 2004-02-05 Nihon Nohyaku Co., Ltd. 新規なハロアルキルスルホンアニリド誘導体及び除草剤並びにその使用方法
WO2004078721A1 (ja) * 2003-02-19 2004-09-16 Eisai Co., Ltd. 環状ベンズアミジン誘導体の製造方法
JP4786147B2 (ja) * 2003-06-26 2011-10-05 武田薬品工業株式会社 カンナビノイド受容体調節剤
WO2005007868A2 (en) * 2003-07-08 2005-01-27 Accumetrics, Inc. Controlled platelet activation to monitor therapy of adp antagonists
US20070243632A1 (en) * 2003-07-08 2007-10-18 Coller Barry S Methods for measuring platelet reactivity of patients that have received drug eluting stents
WO2005032464A2 (en) * 2003-09-30 2005-04-14 Merck & Co., Inc. Phenyl pyrrolidine ether tachykinin receptor antagonists
EP1677783A2 (en) 2003-10-08 2006-07-12 Nicholas Piramal India Limited Fibrinogen receptor antagonists and their use
JP4749702B2 (ja) * 2003-11-28 2011-08-17 第一三共株式会社 ヘテロアリール環を有する環状アミン誘導体
EP1695962A4 (en) * 2003-11-28 2007-03-28 Sankyo Co CYCLIC AMINE DERIVATIVE WITH HETEROARYLRING
AU2004312001B2 (en) * 2003-12-19 2009-08-27 Merck & Co., Inc. Cyclic guanidines, compositions containing such compounds and methods of use
US7612066B2 (en) 2004-03-04 2009-11-03 Eisai R&D Management Co., Ltd. Composition containing benzamidine derivative and method for stabilizing benzamidine derivative
JP2007538046A (ja) * 2004-05-19 2007-12-27 ノイロサーチ アクティーゼルスカブ 新規なアザビシクロアリール誘導体
EP1787983B1 (en) * 2004-08-16 2011-03-09 Eisai R&D Management Co., Ltd. Methods for producing isoindole derivatives
WO2006018954A1 (ja) * 2004-08-17 2006-02-23 Eisai R & D Management Co., Ltd. ジブロモフルオロベンゼン誘導体の製造方法
JP2008510726A (ja) * 2004-08-20 2008-04-10 エントレメッド インコーポレイテッド プロテイナーゼ活性化受容体アンタゴニストを含む組成物および方法
EP1810965A4 (en) * 2004-10-13 2009-10-28 Eisai R&D Man Co Ltd HYDRAZIDE DERIVATIVES
JP2007084440A (ja) * 2004-11-09 2007-04-05 Eisai R & D Management Co Ltd トロンビン受容体アンタゴニストを有効成分とするくも膜下出血に伴う血管攣縮の治療剤
WO2006051623A1 (ja) * 2004-11-09 2006-05-18 Eisai Co., Ltd. トロンビン受容体アンタゴニストを有効成分とするくも膜下出血に伴う血管攣縮の治療剤
EP1813282A4 (en) * 2004-11-09 2011-03-02 Eisai R&D Man Co Ltd MEANS FOR THE TREATMENT OF ANGIOSPASM IN SUBARACHO-OAL BLOODING WITH THROMBIN RECEPTOR ANTAGONIST AS AN ACTIVE AGENT
DE102004061748A1 (de) * 2004-12-22 2006-07-06 Bayer Healthcare Ag Azetidin-substituierte Pyrazoline
DE102004061750A1 (de) * 2004-12-22 2006-07-06 Bayer Healthcare Ag Heteroaryl-substituierte Pyrazoline
US7786330B2 (en) 2005-02-28 2010-08-31 Asahi Glass Company, Limited Process for producing 1,2-dialkoxy-3-fluorobenzene
CN100366595C (zh) * 2005-02-28 2008-02-06 北京金源化学集团有限公司 一种经由中间体2-氟-6-卤代苯酚制备1,2-二烷氧基-3-氟苯的方法
JPWO2006109846A1 (ja) * 2005-04-06 2008-11-20 武田薬品工業株式会社 トリアゾール誘導体およびその用途
US7595169B2 (en) * 2005-04-27 2009-09-29 Accumetrics, Inc. Method for determining percent platelet aggregation
US20090306059A1 (en) * 2005-05-13 2009-12-10 Tomio Kimura Cyclic amine derivative having substituted alkyl group
JP2007001974A (ja) * 2005-05-27 2007-01-11 Sankyo Co Ltd ヘテロアリール環を有する環状アミン誘導体を含有する医薬組成物
EP2308852A1 (de) 2005-08-21 2011-04-13 Abbott GmbH & Co. KG 5-Ring-Heteroaromaten-Verbindungen und ihre Verwendung als Bindungspartner für 5-HT5-Rezeptoren
EP1926710B1 (en) * 2005-09-15 2014-11-12 UCB Pharma S.A. 4-Substituted pyrrolidin-2-ones and their use
CN101371545A (zh) * 2006-01-12 2009-02-18 诺基亚公司 通信系统中的导频加扰
WO2007084728A2 (en) * 2006-01-19 2007-07-26 Abbott Laboratories 2-imino-benzimidazoles
WO2007102563A1 (ja) * 2006-03-02 2007-09-13 Eisai R & D Management Co., Ltd. 炎症性マーカー測定によるトロンビン受容体アンタゴニストの効果の判定方法
HRP20110054T1 (hr) * 2006-03-24 2011-02-28 Eisai R&D Management Co. Derivat triazolona
TWI367112B (en) 2006-06-30 2012-07-01 Schering Corp Immediate-release tablet formulations of a thrombin receptor antagonist
DE102006036023A1 (de) * 2006-08-02 2008-02-07 Sanofi-Aventis Imino-imidazo-pyridinderivate mit antithrombotischer Aktivität
JPWO2008023438A1 (ja) 2006-08-25 2010-01-07 旭硝子株式会社 １，２−ジアルコキシ−３−フルオロベンゼンの製造方法
WO2008026527A1 (fr) * 2006-08-28 2008-03-06 Kaneka Corporation Procédé de fabrication d'un dérivé de 3-cyanopyrrolidine ou d'un de ses sels
GB2446652A (en) * 2007-02-16 2008-08-20 Inion Ltd Osteogenic compounds
WO2008128038A2 (en) * 2007-04-13 2008-10-23 The Scripps Research Institute Methods and compositions for treating cardiac dysfunctions
WO2008137673A1 (en) * 2007-05-03 2008-11-13 Accumetrics, Inc. Methods of measuring inhibition of platelet aggregation by thrombin receptor antagonists
TWI417100B (zh) * 2007-06-07 2013-12-01 Astrazeneca Ab 二唑衍生物及其作為代謝型麩胺酸受體增效劑-８４２之用途
WO2009038157A1 (ja) * 2007-09-21 2009-03-26 Eisai R & D Management Co., Ltd. ２，３－ジヒドロ－イミノイソインドール誘導体
HRP20110510T1 (hr) * 2007-11-30 2011-08-31 Bayer Schering Pharma Aktiengesellschaft Heteroaril-supstituirani piperidini
CN101917990B (zh) * 2008-01-11 2012-11-28 卫材R&D管理有限公司 药物组合物、2-亚氨基吡咯烷衍生物用于制造药物组合物的用途和心脏病治疗用或改善用试剂盒
WO2009097973A2 (de) * 2008-02-05 2009-08-13 Sanofi-Aventis Imidazopyridazine als parl-inhibitoren, ihre herstellung und verwendung als arzneimittel
BRPI0907487A2 (pt) * 2008-02-05 2015-07-14 Sanofi Aventis Sais de triazólio como inibidores de par1, produção dos mesmos e uso como medicamentos
CA2713550C (en) * 2008-02-05 2016-06-14 Sanofi-Aventis Triazolopyridazines as par1 inhibitors, production thereof, and use as medicaments
JP2011511018A (ja) 2008-02-05 2011-04-07 サノフィ−アベンティス Ｐａｒ１阻害剤としてのｓｆ５誘導体、その製造、及び薬剤としての使用
JP2011515493A (ja) * 2008-03-27 2011-05-19 バーンハム インスティトゥート フォー メディカル リサーチ 抗原受容体により誘導されるＮＦ−κＢの活性化の阻害剤
US20100056519A1 (en) * 2008-07-15 2010-03-04 Serebruany Victor L Composition and method for reducing platelet activation and for the treatment of thrombotic events
KR20110097932A (ko) 2008-12-08 2011-08-31 베링거 인겔하임 인터내셔날 게엠베하 암 치료용 화합물
WO2011015381A1 (en) * 2009-08-05 2011-02-10 Celltrend Gmbh Method for prognosis of pulmonary arterial hypertension by detecting anti-par1-antibodies
ES2528948T3 (es) 2009-09-21 2015-02-13 Chemocentryx, Inc. Derivados de pirrolidinona carboxamida como moduladores de quemerina-R (ChemR23)
US8673890B2 (en) 2009-10-29 2014-03-18 Janssen Pharmaceutica Nv 2,3-dihydro-1H-isoindol-1-imine derivatives useful as thrombin PAR-1 receptor antagonist
WO2011128420A1 (de) 2010-04-16 2011-10-20 Sanofi Pyridyl-vinyl-pyrazolo-chinoline als par1-inhibitoren
ES2532902T3 (es) 2010-04-16 2015-04-01 Sanofi Piridil-vinil-pirroles tricíclicos como inhibidores de PAR1
CN102241621A (zh) * 2010-05-11 2011-11-16 江苏恒瑞医药股份有限公司 5,5-双取代-2-亚氨基吡咯烷类衍生物、其制备方法及其在医药上的应用
WO2012014889A1 (ja) * 2010-07-29 2012-02-02 エーザイ・アール・アンド・ディー・マネジメント株式会社 フタロニトリル誘導体の製造方法
CN102442965B (zh) * 2010-09-30 2013-12-11 天津药物研究院 用于治疗血栓性疾病的par-1拮抗剂及其制备方法和用途
CN102757396B (zh) * 2011-04-28 2014-10-15 天津药物研究院 含苯并五元杂环的环外亚胺化合物、其制备方法和用途
SG10201608528YA (en) 2011-12-21 2016-12-29 Novira Therapeutics Inc Hepatitis b antiviral agents
WO2014046125A1 (ja) * 2012-09-20 2014-03-27 エーザイ・アール・アンド・ディー・マネジメント株式会社 トロンビン受容体アンタゴニストを有効成分とする肺高血圧症の予防治療剤
EP2961732B1 (en) 2013-02-28 2017-04-12 Janssen Sciences Ireland UC Sulfamoyl-arylamides and the use thereof as medicaments for the treatment of hepatitis b
CA2909742C (en) 2013-05-17 2020-08-04 Janssen Sciences Ireland Uc Sulphamoylthiophenamide derivatives and the use thereof as medicaments for the treatment of hepatitis b
JO3603B1 (ar) 2013-05-17 2020-07-05 Janssen Sciences Ireland Uc مشتقات سلفامويل بيرولاميد واستخدامها كادوية لمعالجة التهاب الكبد نوع بي
US9540324B2 (en) 2013-09-26 2017-01-10 Luc Therapeutics, Inc. Selective octahydro-cyclopenta[C] pyrrole negative modulators of NR2B
JP6466461B2 (ja) 2014-02-03 2019-02-06 ヴァイティー ファーマシューティカルズ，インコーポレイテッド Ｒｏｒガンマのジヒドロピロロピリジン阻害剤
CN104086501B (zh) * 2014-07-23 2016-02-17 张远强 一种par-1拮抗剂、其制备方法和用途
EP3207043B3 (en) 2014-10-14 2019-10-02 Vitae Pharmaceuticals, LLC Dihydropyrrolopyridine inhibitors of ror-gamma
US9663515B2 (en) 2014-11-05 2017-05-30 Vitae Pharmaceuticals, Inc. Dihydropyrrolopyridine inhibitors of ROR-gamma
US9845308B2 (en) 2014-11-05 2017-12-19 Vitae Pharmaceuticals, Inc. Isoindoline inhibitors of ROR-gamma
KR101657054B1 (ko) 2014-11-25 2016-09-19 기초과학연구원 N-헤테로고리 카벤 일산화질소 라디칼 화합물 및 그 응용
WO2016085224A2 (en) * 2014-11-25 2016-06-02 Institute For Basic Science N-heterocyclic carbene nitric oxide radical and application thereof
WO2016114386A1 (ja) * 2015-01-15 2016-07-21 国立研究開発法人国立精神・神経医療研究センター 進行型免疫性脱髄疾患治療剤
EP3331876B1 (en) 2015-08-05 2020-10-07 Vitae Pharmaceuticals, LLC Modulators of ror-gamma
JP6914257B2 (ja) 2015-11-20 2021-08-04 ヴァイティー ファーマシューティカルズ，エルエルシー Ｒｏｒ−ガンマのモジュレーター
TW202220968A (zh) 2016-01-29 2022-06-01 美商維它藥物有限責任公司 ＲＯＲ－γ調節劑
EP3848026A1 (en) 2016-04-15 2021-07-14 Novira Therapeutics Inc. Combinations and methods comprising a capsid assembly inhibitor
US9481674B1 (en) 2016-06-10 2016-11-01 Vitae Pharmaceuticals, Inc. Dihydropyrrolopyridine inhibitors of ROR-gamma
WO2019018975A1 (en) 2017-07-24 2019-01-31 Vitae Pharmaceuticals, Inc. INHIBITORS OF ROR GAMMA
WO2019023207A1 (en) 2017-07-24 2019-01-31 Vitae Pharmaceuticals, Inc. Inhibitors of rorϒ
US10844044B2 (en) 2018-06-14 2020-11-24 Vanderbilt University WDR5 inhibitors and modulators
CN109053546B (zh) * 2018-07-05 2021-04-27 中国科学院兰州化学物理研究所 一种苯酞类衍生物及其制备方法和应用
US10807959B2 (en) 2018-08-16 2020-10-20 Vanderbilt University WDR5-MLL1 inhibitors and modulators
WO2022051384A1 (en) * 2020-09-01 2022-03-10 Albert Einstein College Of Medicine Compounds and methods for inhibition of bax-mediated cell death
KR102517368B1 (ko) * 2020-09-03 2023-03-31 경희대학교 산학협력단 항진균 활성을 갖는 신규한 이미다졸 유도체의 염 및 이의 용도
CN114181088B (zh) * 2021-12-21 2024-05-17 大连大学 一种离子液体[TEA][TfOH]2催化制备α-卤代苯乙酮类化合物的方法
KR102782945B1 (ko) * 2022-05-24 2025-03-18 주식회사 이노보테라퓨틱스 벤조퓨라닐 히드록시페닐 메타논 옥심 유도체 및 이의 용도
CN115521266A (zh) * 2022-10-25 2022-12-27 广东医科大学 一种乙烯基异噁唑烷衍生物的制备方法
CN116675677B (zh) * 2023-08-02 2023-09-26 中国林业科学研究院林产化学工业研究所 一种c8漆酚衍生物及其制备方法和应用

Family Cites Families (63)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR8129E (fr) 1906-03-09 1908-01-20 Zeiss Carl Soc Garniture de canon munie d'une lunette de visée
US6087380A (en) * 1949-11-24 2000-07-11 Boehringer Ingelheim Pharma Kg Disubstituted bicyclic heterocycles, the preparations and the use thereof as pharmaceutical compositions
JPS4842875B1 (no) 1969-01-29 1973-12-14
US3717648A (en) * 1970-10-21 1973-02-20 Sterling Drug Inc 1-phenyl-azacarbocyclic-2-imines
US4118504A (en) 1970-11-05 1978-10-03 Carlo Erba Isoindoline derivatives for treating pain
DE2154525A1 (de) * 1970-11-05 1972-06-15 Carlo Erba S.P.A., Mailand (Italien) Isoindolinderivate und Verfahren zu ihrer Herstellung
GB1344663A (en) 1970-11-10 1974-01-23 Erba Carlo Spa Isoindoline compounds
ZA722407B (en) * 1971-05-13 1973-01-31 Richardson Merrell Inc Substituted cycloalkyl lactamimides
JPS512868B2 (no) 1971-09-30 1976-01-29
US3773788A (en) 1971-11-26 1973-11-20 Standard Oil Co Method for the preparation of n-(substituted phenyl)-2-iminopyrrolidines
US3920688A (en) * 1973-02-05 1975-11-18 Monsanto Co 2-imino derivatives of substituted imidazoles
US3859302A (en) * 1973-02-05 1975-01-07 Monsanto Co Preparation of 2-imino-imidazole derivatives
US3904395A (en) * 1973-02-05 1975-09-09 Monsanto Co 2-Imino derivatives of substituted imidazoles
US3887577A (en) * 1973-07-05 1975-06-03 Monsanto Co Process for the preparation of 2-imino derivatives of substituted imidazoles
US4126611A (en) * 1973-08-09 1978-11-21 Richardson-Merrell Inc. Substituted cycloalkyl lactamimides
DE2430354A1 (de) 1974-06-25 1976-01-15 Basf Ag Neue substituierte 1-amino-isoindole, verfahren zu deren herstellung sowie diese enthaltende pharmazeutische zubereitungen
JPS5122720A (ja) 1974-08-19 1976-02-23 Sumitomo Chemical Co Jukyobaifuanteigatadofutaroshianinganryono seizoho
GB1476949A (en) 1974-11-20 1977-06-16 Wyeth John & Brother Ltd Imidazo-1,2-a-benzimidazole and pyrimido-1,2-a-benzimidazole derivatives their preparation and their pharmaceutical compositions
GB1484615A (en) * 1974-11-23 1977-09-01 Lepetit Spa Tricyclic n-containing derivatives
US4004016A (en) * 1975-08-11 1977-01-18 E. R. Squibb & Sons, Inc. Amino-benzimidazole derivatives
JPS5371063A (en) * 1976-12-03 1978-06-24 Grelan Pharmaceut Co Ltd Preparation of 4-(1-9x9-2-isoindolinyl)acetophenone
WO1983002920A1 (fr) 1982-02-27 1983-09-01 Kabashima, Kazuo Procede de coloration et materiau de formation de couleur
JPS6222760A (ja) * 1985-07-24 1987-01-30 Sankyo Co Ltd イソインドリン誘導体及びそれを有効成分とする農園芸用殺菌剤
US5002941A (en) 1985-12-12 1991-03-26 Smithkline Beecham Corporation Pyrrolo(1,2-a)imidazole and imidazo(1,2-a)pyridine derivatives and their use as 5-lipoxygenase pathway inhibitors
FR2595521B1 (fr) * 1986-03-07 1988-10-21 Electricite De France Dispositif de telecomptage
ES2005450A6 (es) 1987-11-16 1989-03-01 Gema Sa Procedimiento para la preparacion de derivados n(4-etil-2,3-dioxo)-piperacin-1-iln-carbonilo.
JP2805867B2 (ja) 1989-07-19 1998-09-30 日本電気株式会社 電子写真感光体
US5145818A (en) * 1989-12-29 1992-09-08 Mitsui Petrochemical Industries, Ltd. Olefin polymerization catalyst and process for the polymerization of olefins
US5258387A (en) 1990-08-21 1993-11-02 Hoffmann-La Roche Inc. Tricyclic pyridone derivatives
CA2048003A1 (en) 1990-08-21 1992-02-22 Serge Burner Tricyclic pyridone derivatives
WO1992012590A1 (en) * 1991-01-03 1992-07-23 Sasktel Data collection network apparatus and method
DE69213296T2 (de) * 1991-04-16 1997-03-20 Philips Electronics Nv SMD-Widerstand
ATE212018T1 (de) 1993-02-26 2002-02-15 Otsuka Pharma Co Ltd Thiazole oder imidazole derivate als maillard reaktion inhibitoren
JPH0732103A (ja) 1993-07-19 1995-02-03 Sumitomo Metal Ind Ltd 溶融金属の鋳造用ノズル
KR100342275B1 (ko) * 1993-10-21 2002-12-05 지.디. 썰 엘엘씨 산화질소신타제저해제로서유용한아미디노유도체
WO1996005192A1 (en) 1994-08-12 1996-02-22 Toyama Chemical Co., Ltd. Novel quinolone- or naphthyridonecarboxylic acid derivative or salt thereof
US5629322A (en) 1994-11-15 1997-05-13 Merck & Co., Inc. Cyclic amidine analogs as inhibitors of nitric oxide synthase
JP3666922B2 (ja) 1995-02-21 2005-06-29 山本化成株式会社 カルボン酸塩、その製造方法および該塩化合物を用いる感熱記録材料
TW401408B (en) 1995-07-21 2000-08-11 Fujisawa Pharmaceutical Co Heterocyclic compounds having prostaglandin I2 agonism
AU3440597A (en) 1996-07-02 1998-01-21 Novartis Ag N-phenylimino heterocyclic derivatives and their use as herbicides
JP2707239B2 (ja) 1996-07-26 1998-01-28 日本バイエルアグロケム株式会社 シアノアルキルーヘテロ環式化合物及び殺虫剤
WO1998014432A1 (en) 1996-10-02 1998-04-09 Janssen Pharmaceutica N.V. Pde iv inhibiting 2-cyanoiminoimidazole derivatives
US5977134A (en) * 1996-12-05 1999-11-02 Merck & Co., Inc. Inhibitors of farnesyl-protein transferase
FR2757053B1 (fr) * 1996-12-12 1999-01-22 Oreal Utilisation de derives de la di-imino-isoindoline ou de la 3-amino-isoindolone pour la teinture des fibres keratiniques et compositions de teinture les renfermant
PE121699A1 (es) * 1997-02-18 1999-12-08 Boehringer Ingelheim Pharma Heterociclos biciclicos disustituidos como inhibidores de la trombina
US6187799B1 (en) 1997-05-23 2001-02-13 Onyx Pharmaceuticals Inhibition of raf kinase activity using aryl ureas
IL133625A0 (en) * 1997-06-26 2001-04-30 Lilly Co Eli Antithrombotic agents
US6465484B1 (en) * 1997-09-26 2002-10-15 Merck & Co., Inc. Angiogenesis inhibitors
PE133799A1 (es) 1997-11-25 2000-01-10 Schering Corp Antagonistas del receptor de trombina
WO1999040072A1 (de) 1998-02-03 1999-08-12 Boehringer Ingelheim Pharma Kg 5-gliedrige benzokondensierte heterocyclen als antithrombotika
US6114532A (en) * 1998-02-03 2000-09-05 Boehringer Ingelheim Pharma Kg Bicyclic heterocycles, the preparation thereof, and their use as pharmaceuticals
US6194447B1 (en) * 1998-07-02 2001-02-27 Neurosearch A/S Bis (benzimidazole) derivatives serving as potassium blocking agents
WO2000001676A1 (en) 1998-07-02 2000-01-13 Neurosearch A/S Potassium channel blocking agents
WO2000053582A1 (fr) 1999-03-05 2000-09-14 Suntory Limited COMPOSES HETEROCYCLIQUES POSSEDANT UN EFFET D'ACTIVATION DU RECEPTEUR α4β2 DE L'ACETYLCHOLINE NICOTINIQUE
US6376530B1 (en) * 1999-05-10 2002-04-23 Merck & Co., Inc. Cyclic amidines useful as NMDA NR2B antagonists
JP3647338B2 (ja) * 1999-11-11 2005-05-11 富士通株式会社 画像信号解像度変換方法及び装置
CA2421594A1 (en) * 2000-11-10 2002-05-16 John Arnold Werner 3-substituted oxindole beta 3 agonists
JP2002155060A (ja) * 2000-11-15 2002-05-28 Japan Tobacco Inc イミダゾール化合物及びその用途
WO2002085855A1 (fr) 2001-04-19 2002-10-31 Eisai Co., Ltd. Derives de 2-iminopyrrolidine
JP4151310B2 (ja) 2001-05-22 2008-09-17 Ｄｉｃ株式会社 硬化性不飽和樹脂組成物
US6726177B2 (en) 2002-07-02 2004-04-27 Value Valves Co., Ltd. Valve with improved junk ring structure
JP3725843B2 (ja) * 2002-07-05 2005-12-14 ローム株式会社 反射型センサ
WO2004078721A1 (ja) 2003-02-19 2004-09-16 Eisai Co., Ltd. 環状ベンズアミジン誘導体の製造方法

Also Published As

Publication number Publication date
US7244730B2 (en) 2007-07-17
EP1391451B1 (en) 2011-11-23
CA2446924C (en) 2011-02-08
JPWO2002085850A1 (ja) 2004-08-12
JP4220249B2 (ja) 2009-02-04
US20040254376A1 (en) 2004-12-16
CN1321996C (zh) 2007-06-20
EP1391451A4 (en) 2006-02-01
KR100749794B1 (ko) 2007-08-17
CN1733725A (zh) 2006-02-15
IL158491A0 (en) 2004-05-12
EP2385039A1 (en) 2011-11-09
JP4251872B2 (ja) 2009-04-08
WO2002088094A1 (fr) 2002-11-07
US20050004197A1 (en) 2005-01-06
JP4516922B2 (ja) 2010-08-04
PL368109A1 (en) 2005-03-21
JP4445201B2 (ja) 2010-04-07
CZ303865B6 (cs) 2013-05-29
EP1386912A1 (en) 2004-02-04
JP2006225393A (ja) 2006-08-31
WO2002088092A1 (fr) 2002-11-07
RU2270192C2 (ru) 2006-02-20
EP1391456B1 (en) 2009-07-22
NO20034632L (no) 2003-12-19
ES2462995T3 (es) 2014-05-27
HUP0400467A3 (en) 2012-08-28
RU2003133664A (ru) 2005-05-10
EP1386912A4 (en) 2006-02-01
CN1243735C (zh) 2006-03-01
EP1386912B1 (en) 2009-03-18
CZ20032824A3 (en) 2004-04-14
CN100402499C (zh) 2008-07-16
EP1391451A1 (en) 2004-02-25
EP1394152A4 (en) 2005-02-02
KR20050059343A (ko) 2005-06-17
EP1391456A1 (en) 2004-02-25
EP1394152A1 (en) 2004-03-03
JP4464928B2 (ja) 2010-05-19
HUP0400467A2 (hu) 2005-02-28
KR100749795B1 (ko) 2007-08-17
EP2385039B1 (en) 2014-03-12
HK1086269A1 (zh) 2006-09-15
NZ528820A (en) 2007-01-26
CN1503784A (zh) 2004-06-09
IL158491A (en) 2010-12-30
EP1614680A2 (en) 2006-01-11
KR20030090764A (ko) 2003-11-28
ATE425964T1 (de) 2009-04-15
DE60231608D1 (de) 2009-04-30
AU2002255269B2 (en) 2007-03-15
JPWO2002088092A1 (ja) 2004-08-12
MXPA03009497A (es) 2004-05-24
US20050004204A1 (en) 2005-01-06
EP1391456A4 (en) 2006-02-01
EP1614680B1 (en) 2011-12-21
JP2006206595A (ja) 2006-08-10
US20050245592A1 (en) 2005-11-03
JPWO2002088094A1 (ja) 2004-08-12
AU2005202135B2 (en) 2007-11-15
CA2446924A1 (en) 2002-10-31
US20040242627A1 (en) 2004-12-02
DE60233043D1 (de) 2009-09-03
NO327849B1 (no) 2009-10-05
US7476688B2 (en) 2009-01-13
JPWO2002085855A1 (ja) 2004-08-12
AU2005202135A1 (en) 2005-06-09
US7304083B2 (en) 2007-12-04
ZA200308064B (en) 2005-04-26
WO2002085855A1 (fr) 2002-10-31
ATE534627T1 (de) 2011-12-15
WO2002085850A1 (en) 2002-10-31
EP1614680A3 (en) 2006-02-01
ATE538090T1 (de) 2012-01-15
BR0208985A (pt) 2004-03-09
CN1754880A (zh) 2006-04-05
US20090215795A1 (en) 2009-08-27
JP3795458B2 (ja) 2006-07-12

Similar Documents

Publication Publication Date Title
ATE534627T1 (de) 2-iminopyrrolidin-derivate
DE68907921D1 (de) Substituierte pyrrol-, pyrazol- und triazol-angiotensin ii-antagonisten.
EA199900953A1 (ru) ЗАМЕЩЕННЫЕ ПИРАЗОЛЫ, КАК ИНГИБИТОРЫ p38 КИНАЗЫ
DE59401924D1 (de) Substituierte heterocyclische Carbonsäureamide, ihre Herstellung und ihre Verwendung als Arzneimittel
NO307884B1 (no) Substituerte pyrazoler som CRF antagonister
FI933804A0 (fi) Monohydrat av 5-(2-(4-(1,2-bensisotiazol-3-yl)-1-piperazinyl)etyl-6-klor-1,3-dihydro-2h-indol-2-onkhydroklorid
DE60226469D1 (de) Biphenylkarbonsäureamidderivate als p38 kinase-inhibitoren
HRP20080226T3 (en) Quinoline and quinazoline derivatives having affinity for 5ht1-type receptors
DK0957099T3 (da) Heterocykliske carboxamider
FI956279L (fi) Menetelmiä ja välituotteita 5-/2-(4-(bentsoisotiatsol-3-yyli)piperatsin-1-yyli)etyyli/-6-kloori-1,3-dihydroindol-2-onin valmistamiseksi
NO982222L (no) 3-(4-Subst.-piperidinyl-1)-1-(3,4-diklorfenyl)propylkarbamater og -ureaer og derivater som neurokinin-antagonister
TR200201128T2 (tr) PDE4 inhibitörleri olarak tetrahidrotiyopiranfitalazinon türevleri.
DE3880077D1 (de) Mittel gegen angst.
FI914906L (fi) 1-(3,4-dihydro-2-oxo-1h-kinolin-6-yl) -2-(4-(2-fenyletyl) piperidin-1-yl)etanol och -etanon, deras framstaellning och anvaendning inom terapi.
ATE223404T1 (de) Monoargininylsalz der (e)-3-(1-n-butyl-5-((2-(2- carboxyphenyl)methoxy-4-chlorphenyl)-1h-pyrazol 4-yl)-2-((5-methoxy-2,3-dihydrobenzofuran-6- yl)methyl)-prop-2-en carbonsäure
CA2423357A1 (en) Fused heterocyclic derivatives as phosphodiesterase inhibitors
NO971991L (no) Heterosyklus-substituerte propensyrederivater som NMDA-antagonister
ATE278667T1 (de) Tetramsäure-derivate zur verwendung in medizin und lebensmitteltechnologie
DK0687257T3 (da) 4-amino-2-(hetero)aryl-butanamider anvendelige som 5HT1A-antagonister
ATE247092T1 (de) Arylsulfonamid-substituierte benzimidazolderivate ihre verwendung als tryptase-inhibitoren
ATE264312T1 (de) (2-piperidin-1-yl-4-substituierte)-4-amino-2- chinazolin-derivate mit antihypertensiver wirkung,verfahren zu ihrer herstellung und ihrem pharmazeutischen gebrauch
ATE236887T1 (de) Arylsulfonamid-substituierte benzimidazolderivate und ihre verwendung als tryptase-inhibitoren
ATE388710T1 (de) Phthalazinderivate als phosphodiesterase-4-hemmer

Legal Events

Date Code Title Description
MM1K Lapsed by not paying the annual fees