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AR041262A1 - Metodos para tratar los trastornos de ojo seco - Google Patents

Metodos para tratar los trastornos de ojo seco

Info

Publication number
AR041262A1
AR041262A1 ARP030103339A ARP030103339A AR041262A1 AR 041262 A1 AR041262 A1 AR 041262A1 AR P030103339 A ARP030103339 A AR P030103339A AR P030103339 A ARP030103339 A AR P030103339A AR 041262 A1 AR041262 A1 AR 041262A1
Authority
AR
Argentina
Prior art keywords
norleucil
inhibitors
kinase inhibitors
dry eye
trifluomethyl
Prior art date
Application number
ARP030103339A
Other languages
English (en)
Original Assignee
Alcon Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alcon Inc filed Critical Alcon Inc
Publication of AR041262A1 publication Critical patent/AR041262A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/60—Salicylic acid; Derivatives thereof
    • A61K31/612—Salicylic acid; Derivatives thereof having the hydroxy group in position 2 esterified, e.g. salicylsulfuric acid
    • A61K31/616—Salicylic acid; Derivatives thereof having the hydroxy group in position 2 esterified, e.g. salicylsulfuric acid by carboxylic acids, e.g. acetylsalicylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/416—1,2-Diazoles condensed with carbocyclic ring systems, e.g. indazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/08—Peptides having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Reivindicación 1: El uso de una composición que comprende un vehículo farmacéuticamente aceptable y una cantidad farmacéuticamente efectiva de un inhibidor de la síntesis de citocinas seleccionado entre el grupo que consiste en inhibidores de lascinasas activadas por mitógenos, inhibidores de la cinasa C-jun N terminal e inhibidores de la cinasa I-kappa, inhibidores de la síntesis de IL-1beta, inhibidores de la síntesis de TNFalfa, inhibidores de la tirosina cinasa de la familia Janus,inhibidores de transductores de senal y activadores de la transcripción y ligandos de los receptores de retinoides X para la elaboración de un medicamento para el tratamiento del ojo seco y otros trastornos que requieren la humectación el ojo en unmamífero. Reivindicación 3: El uso de acuerdo con la reivindicación 1, en el cual el inhibidor de la síntesis de citocinas es seleccionado entre el grupo que consiste en (5-(2-amino-4-pirimidinil)-4-(4-fluofenil)-1-(4-piperidinil)imidazol),antra[1,9-cd]pirazol-6-(2H)-ona, (D)Arginil-(D)Norleucil-(D)Norleucil-(D)Arginil-(D)Norleucil-(D)Norleucil-(D)Norleucil-Glicina-(D)Tirosina-amida, sal de acetato, 2-cloro-N-[3,5-di(trifluometil)fenil]-4-(trifluometil)pirimidin-5-carboxamida,trifusal y bexaroteno.
ARP030103339A 2002-09-20 2003-09-15 Metodos para tratar los trastornos de ojo seco AR041262A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US41246302P 2002-09-20 2002-09-20

Publications (1)

Publication Number Publication Date
AR041262A1 true AR041262A1 (es) 2005-05-11

Family

ID=32030872

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP030103339A AR041262A1 (es) 2002-09-20 2003-09-15 Metodos para tratar los trastornos de ojo seco

Country Status (14)

Country Link
US (2) US7026296B2 (es)
EP (1) EP1542768A1 (es)
JP (1) JP2006502183A (es)
KR (1) KR20050057175A (es)
CN (1) CN1684738A (es)
AR (1) AR041262A1 (es)
AU (1) AU2003278727A1 (es)
BR (1) BR0314603A (es)
CA (1) CA2497977A1 (es)
MX (1) MXPA05003063A (es)
PL (1) PL374700A1 (es)
TW (1) TW200404534A (es)
WO (1) WO2004026406A1 (es)
ZA (1) ZA200502119B (es)

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US20060189541A1 (en) 2006-08-24
KR20050057175A (ko) 2005-06-16
US7026296B2 (en) 2006-04-11
US20040058875A1 (en) 2004-03-25
AU2003278727A1 (en) 2004-04-08
BR0314603A (pt) 2005-07-26
CN1684738A (zh) 2005-10-19
CA2497977A1 (en) 2004-04-01
JP2006502183A (ja) 2006-01-19
ZA200502119B (en) 2006-09-27
EP1542768A1 (en) 2005-06-22
TW200404534A (en) 2004-04-01

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