AR018177A1 - Compuestos calciliticos, una composicion farmaceutica que los comprende y el uso de los mismos para la manufactura de un medicamento. - Google Patents
Compuestos calciliticos, una composicion farmaceutica que los comprende y el uso de los mismos para la manufactura de un medicamento.Info
- Publication number
- AR018177A1 AR018177A1 ARP990101554A ARP990101554A AR018177A1 AR 018177 A1 AR018177 A1 AR 018177A1 AR P990101554 A ARP990101554 A AR P990101554A AR P990101554 A ARP990101554 A AR P990101554A AR 018177 A1 AR018177 A1 AR 018177A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- aryl
- heteroaryl
- group
- substituted
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 3
- 238000004519 manufacturing process Methods 0.000 title 1
- 229940126601 medicinal product Drugs 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 9
- 125000003118 aryl group Chemical group 0.000 abstract 5
- 125000002947 alkylene group Chemical group 0.000 abstract 4
- 229910052736 halogen Inorganic materials 0.000 abstract 4
- 150000002367 halogens Chemical class 0.000 abstract 4
- 125000001072 heteroaryl group Chemical group 0.000 abstract 4
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 abstract 3
- JCXJVPUVTGWSNB-UHFFFAOYSA-N Nitrogen dioxide Chemical compound O=[N]=O JCXJVPUVTGWSNB-UHFFFAOYSA-N 0.000 abstract 3
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 229910052760 oxygen Inorganic materials 0.000 abstract 3
- 229910052717 sulfur Inorganic materials 0.000 abstract 3
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 abstract 2
- 125000004206 2,2,2-trifluoroethyl group Chemical group [H]C([H])(*)C(F)(F)F 0.000 abstract 2
- 150000002576 ketones Chemical class 0.000 abstract 2
- 125000001424 substituent group Chemical group 0.000 abstract 2
- 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 abstract 2
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 2
- 101100244083 Arabidopsis thaliana PKL gene Proteins 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 230000001126 calcilytic effect Effects 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 abstract 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 1
- 125000001188 haloalkyl group Chemical group 0.000 abstract 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 125000000325 methylidene group Chemical group [H]C([H])=* 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/44—Iso-indoles; Hydrogenated iso-indoles
- C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
- C07C255/32—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring
- C07C255/33—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring with cyano groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by saturated carbon chains
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
- A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
- C07C217/02—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C217/04—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C217/06—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted
- C07C217/14—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted the oxygen atom of the etherified hydroxy group being further bound to a carbon atom of a six-membered aromatic ring
- C07C217/18—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted the oxygen atom of the etherified hydroxy group being further bound to a carbon atom of a six-membered aromatic ring the six-membered aromatic ring or condensed ring system containing that ring being further substituted
- C07C217/22—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted the oxygen atom of the etherified hydroxy group being further bound to a carbon atom of a six-membered aromatic ring the six-membered aromatic ring or condensed ring system containing that ring being further substituted by carbon atoms having at least two bonds to oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
- C07C217/54—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
- C07C217/56—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by singly-bound oxygen atoms
- C07C217/60—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by singly-bound oxygen atoms linked by carbon chains having two carbon atoms between the amino groups and the six-membered aromatic ring or the condensed ring system containing that ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
- C07C255/32—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring
- C07C255/37—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring the carbon skeleton being further substituted by etherified hydroxy groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C255/54—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and etherified hydroxy groups bound to the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C255/57—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and carboxyl groups, other than cyano groups, bound to the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/01—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms
- C07C311/02—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
- C07C311/03—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atoms of the sulfonamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C311/06—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atoms of the sulfonamide groups bound to hydrogen atoms or to acyclic carbon atoms to acyclic carbon atoms of hydrocarbon radicals substituted by carboxyl groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Endocrinology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Immunology (AREA)
- Diabetes (AREA)
- Pain & Pain Management (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Compuestos calcilíticos, que comprenden un compuesto de acuerdo con la formula (I), en la que: Y1 es un enlace covalente, alquileno o alquenileno dehasta 4 átomos de carbono, no sustituido o sustituido con alquilo C1-4, u O; Y2 es metileno, no sustituido o sustituido con alquilo o haloalquilo C1-4; Y3es un enlace covalente u O, S, N-Riv, o alquileno C1-4-O, alquileno C1-4-S, o alquileno C1-4-N-Riv; R3 y R4 son independientemente metilo o etilo, oforman conjuntamente ciclopropilo; R5 es arilo o arilo fusionado, dihidro- tetrahidro-arilo fusionado, no sustituido o sustituido con cualesquiersustituyentes seleccionados del grupo que consiste en OH, halogeno, alquilo C1-4, alcoxilo C1-4, cicloalquilo C3-6, OSO2Riv, CN, NO2, OCF3, CF3, CH2CF3,(CH2)nCO2Riv y O-(CH2)nCO2Riv, en los que n es un numero entero de 0 a 3 y Riv es seleccionado del grupo que consiste en H, alquilo C1-4 y cicloalquiloC3-6; o R5 es heteroarilo o heteroarilo fusionado, en el que el heteroarilo contiene N, O o S y es aromático, dihidrogenado o tetrahidrogenado, nosustituido o sustituido con cualesquier sustituyentes seleccionados del grupo que consiste en OH, OCH3, CH(CH3)2, halogeno, alquilo C1-4, alcoxiloC1-4, cicloalquilo C3-6, OSO2Riv, CN, NO2, OCF3, CF3, CH2CF3, (CH2)nCO2H, (CH2)nCO2Riv y O-(CH2)nCO2Riv, G es un enlace covalente, CHR6 o C-R6, en los queR6 es H, OH u O (formando una cetona); R7 es H, OH u O-alquilo C1-4; R8 es H o alquilo C1-4; o R7 y R8 forman conjuntamente una cetona, A y B sonindependientemente seleccionados del grupo que consiste en un enlace, CH2, NH, O, S y C=O, con tal que A o B sea seleccionado entre CH2 y NH; o A y B formanconjuntamente un enlace; o el grupo A-B es representado por CH=CH o C:::C; en la que: X1 y X5 son independientemente seleccionados del grupo que consisteen H, halogeno, CN, NO2, alquilo C1-4, cicloalquilo, CH2-arilo y CH2-heteroarilo; con tal que X1 o X5 sea H; X2, X3 y X4 son seleccionados del grupoque consiste en H, halogeno, O-alquilo C1-4, O-arilo,O-heteroarilo, CH2-arilo, CH2-heteroarilo, alquilo, C(O)arilo, C(O)heteroarilo, CH(OH)arilo,
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US8109398P | 1998-04-08 | 1998-04-08 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR018177A1 true AR018177A1 (es) | 2001-10-31 |
Family
ID=22162059
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP990101554A AR018177A1 (es) | 1998-04-08 | 1999-04-06 | Compuestos calciliticos, una composicion farmaceutica que los comprende y el uso de los mismos para la manufactura de un medicamento. |
Country Status (33)
| Country | Link |
|---|---|
| US (1) | US6395919B1 (es) |
| EP (1) | EP1070048B1 (es) |
| JP (1) | JP2002510671A (es) |
| KR (1) | KR20010042526A (es) |
| CN (1) | CN1304401A (es) |
| AP (1) | AP1271A (es) |
| AR (1) | AR018177A1 (es) |
| AT (1) | ATE303358T1 (es) |
| AU (1) | AU752389B2 (es) |
| BG (1) | BG104916A (es) |
| BR (1) | BR9909486A (es) |
| CA (1) | CA2327279A1 (es) |
| CO (1) | CO5031246A1 (es) |
| DE (1) | DE69927008T2 (es) |
| DZ (1) | DZ2751A1 (es) |
| EA (1) | EA200001039A1 (es) |
| EG (1) | EG24178A (es) |
| ES (1) | ES2247795T3 (es) |
| HU (1) | HUP0101346A3 (es) |
| ID (1) | ID27004A (es) |
| IL (1) | IL138918A0 (es) |
| MX (1) | MXPA00009844A (es) |
| MY (1) | MY121054A (es) |
| NO (1) | NO20005006D0 (es) |
| NZ (1) | NZ507288A (es) |
| OA (1) | OA11499A (es) |
| PE (1) | PE20000415A1 (es) |
| PL (1) | PL343357A1 (es) |
| SK (1) | SK14852000A3 (es) |
| TR (1) | TR200002896T2 (es) |
| UA (1) | UA58586C2 (es) |
| WO (1) | WO1999051569A1 (es) |
| ZA (1) | ZA200005369B (es) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ECSP003590A (es) * | 1999-07-31 | 2002-02-25 | Smithkline Beecham Corp | Compuestos calcioliticos |
| MY159417A (en) * | 2000-01-24 | 2017-01-13 | Smithkline Beecham Corp | Calcilytic compounds |
| US20030018203A1 (en) | 2002-07-17 | 2003-01-23 | Largo Maria Amparo | Calcilytic compounds |
| FR2812875B1 (fr) | 2000-08-08 | 2003-12-12 | Centre Nat Rech Scient | Nouvelles diamines possedant une activite modulatrice des casr et leur mode de preparation |
| US6916956B2 (en) | 2000-08-11 | 2005-07-12 | Japan Tobacco, Inc. | Calcium receptor antagonist |
| AU2002230579A1 (en) * | 2000-10-25 | 2002-05-06 | Smithkline Beecham Corp | Calcilytic compounds |
| MY143244A (en) | 2002-11-26 | 2011-04-15 | Smithkline Beecham Corp | Calcilytic compounds |
| US7105537B2 (en) | 2003-01-28 | 2006-09-12 | Bristol-Myers Squibb Company | 2-substituted cyclic amines as calcium sensing receptor modulators |
| US7205322B2 (en) | 2003-02-12 | 2007-04-17 | Bristol-Myers Squibb Company | Thiazolidine compounds as calcium sensing receptor modulators |
| CA2513738C (en) * | 2003-04-23 | 2010-04-06 | Japan Tobacco Inc. | Casr antagonist |
| US7265145B2 (en) | 2003-05-28 | 2007-09-04 | Bristol-Myers Squibb Company | Substituted piperidines and pyrrolidines as calcium sensing receptor modulators and method |
| JPWO2004106280A1 (ja) | 2003-05-28 | 2006-07-20 | 日本たばこ産業株式会社 | ＣａＳＲアンタゴニスト |
| US20070155819A1 (en) * | 2004-02-06 | 2007-07-05 | Marquis Robert W Jr | Calcilytic compounds |
| US7648965B2 (en) | 2004-05-14 | 2010-01-19 | Unigene Laboratories Inc. | Method for fostering bone formation and preservation |
| US7531518B2 (en) * | 2004-05-14 | 2009-05-12 | Unigene Laboratories Inc. | Method for fostering bone formation and preservation |
| US20060293667A1 (en) * | 2005-05-19 | 2006-12-28 | Agnes Vignery | Bone implant device and methods of using same |
| AU2006285080B2 (en) * | 2005-09-02 | 2012-05-03 | Amgen Inc. | Methods of modulating intestinal fluid balance |
| WO2008121386A2 (en) * | 2007-03-30 | 2008-10-09 | Amgen Inc. | Calcimimetic compounds for use in the treatment of bowel disorders |
| ES2412408T3 (es) * | 2008-12-24 | 2013-07-11 | Daiichi Sankyo Company, Limited | Compuestos de indanilo |
| WO2010103429A1 (en) | 2009-03-10 | 2010-09-16 | Pfizer Inc. | 1,1-(Dimethyl-Ethylamino)-2-Hydroxy-Propoxy]-Ethyl}-3-Methyl-Biphenyl-4- Carboxylic Acid Derivatives As Calcium Receptor Antagonists |
| GB201217330D0 (en) | 2012-09-28 | 2012-11-14 | Univ Cardiff | Therapeutic for treating inflammatory lung disorders |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2533210A1 (fr) * | 1982-09-17 | 1984-03-23 | Lyon I Universite Claude | Edulcorants de synthese |
| DE3301198A1 (de) * | 1983-01-15 | 1984-07-19 | Hoechst Ag, 6230 Frankfurt | N-arylalkylamin-3-propoxypyridin-derivate, verfahren zu ihrer herstellung, sie enthaltende pharmazeutische praeparate und deren verwendung |
| US5541204A (en) * | 1994-12-02 | 1996-07-30 | Bristol-Myers Squibb Company | Aryloxypropanolamine β 3 adrenergic agonists |
| WO1997010822A1 (en) | 1995-09-21 | 1997-03-27 | Eli Lilly And Company | SELECTIVE β3 ADRENERGIC AGONISTS |
| BR9708632A (pt) * | 1996-04-09 | 2000-01-18 | Nps Pharma Inc | Composto calcilìticos |
-
1999
- 1999-04-06 AR ARP990101554A patent/AR018177A1/es unknown
- 1999-04-06 MY MYPI99001327A patent/MY121054A/en unknown
- 1999-04-06 PE PE1999000275A patent/PE20000415A1/es not_active Application Discontinuation
- 1999-04-07 EG EG36999A patent/EG24178A/xx active
- 1999-04-07 DZ DZ990052A patent/DZ2751A1/xx active
- 1999-04-08 PL PL99343357A patent/PL343357A1/xx not_active Application Discontinuation
- 1999-04-08 US US09/647,793 patent/US6395919B1/en not_active Expired - Lifetime
- 1999-04-08 JP JP2000542291A patent/JP2002510671A/ja not_active Withdrawn
- 1999-04-08 AT AT99916516T patent/ATE303358T1/de not_active IP Right Cessation
- 1999-04-08 CA CA002327279A patent/CA2327279A1/en not_active Abandoned
- 1999-04-08 ID IDW20002001A patent/ID27004A/id unknown
- 1999-04-08 ZA ZA200005369A patent/ZA200005369B/xx unknown
- 1999-04-08 EA EA200001039A patent/EA200001039A1/ru unknown
- 1999-04-08 HU HU0101346A patent/HUP0101346A3/hu unknown
- 1999-04-08 DE DE69927008T patent/DE69927008T2/de not_active Expired - Lifetime
- 1999-04-08 EP EP99916516A patent/EP1070048B1/en not_active Expired - Lifetime
- 1999-04-08 KR KR1020007011166A patent/KR20010042526A/ko not_active Ceased
- 1999-04-08 AP APAP/P/2000/001931A patent/AP1271A/en active
- 1999-04-08 WO PCT/US1999/007722 patent/WO1999051569A1/en not_active Ceased
- 1999-04-08 NZ NZ507288A patent/NZ507288A/en not_active IP Right Cessation
- 1999-04-08 MX MXPA00009844A patent/MXPA00009844A/es unknown
- 1999-04-08 SK SK1485-2000A patent/SK14852000A3/sk unknown
- 1999-04-08 IL IL13891899A patent/IL138918A0/xx unknown
- 1999-04-08 ES ES99916516T patent/ES2247795T3/es not_active Expired - Lifetime
- 1999-04-08 CO CO99020604A patent/CO5031246A1/es unknown
- 1999-04-08 CN CN99807083A patent/CN1304401A/zh active Pending
- 1999-04-08 TR TR2000/02896T patent/TR200002896T2/xx unknown
- 1999-04-08 AU AU34819/99A patent/AU752389B2/en not_active Ceased
- 1999-04-08 BR BR9909486-0A patent/BR9909486A/pt not_active Application Discontinuation
- 1999-08-04 UA UA2000105670A patent/UA58586C2/uk unknown
-
2000
- 2000-10-04 NO NO20005006A patent/NO20005006D0/no not_active Application Discontinuation
- 2000-10-06 OA OA1200000277A patent/OA11499A/en unknown
- 2000-11-07 BG BG104916A patent/BG104916A/xx unknown
Also Published As
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