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DE60010596D1 - Pyridinderivate, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Zubereitungen - Google Patents

Pyridinderivate, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Zubereitungen

Info

Publication number
DE60010596D1
DE60010596D1 DE60010596T DE60010596T DE60010596D1 DE 60010596 D1 DE60010596 D1 DE 60010596D1 DE 60010596 T DE60010596 T DE 60010596T DE 60010596 T DE60010596 T DE 60010596T DE 60010596 D1 DE60010596 D1 DE 60010596D1
Authority
DE
Germany
Prior art keywords
alkyl
pyridine derivatives
preparation
attached
pharmaceutical compositions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE60010596T
Other languages
English (en)
Other versions
DE60010596T2 (de
Inventor
Jean-Louis Peglion
Aimee Dessinges
Christophe Poitevin
Mark Millan
Anne Dekeyne
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Les Laboratoires Servier SAS
Original Assignee
Les Laboratoires Servier SAS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Les Laboratoires Servier SAS filed Critical Les Laboratoires Servier SAS
Publication of DE60010596D1 publication Critical patent/DE60010596D1/de
Application granted granted Critical
Publication of DE60010596T2 publication Critical patent/DE60010596T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Immunology (AREA)
  • Anesthesiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyridine Compounds (AREA)
DE60010596T 1999-08-27 2000-08-25 Pyridinderivate, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Zubereitungen Expired - Fee Related DE60010596T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9910834 1999-08-27
FR9910834A FR2797874B1 (fr) 1999-08-27 1999-08-27 Nouveaux derives de la pyridine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Publications (2)

Publication Number Publication Date
DE60010596D1 true DE60010596D1 (de) 2004-06-17
DE60010596T2 DE60010596T2 (de) 2005-05-19

Family

ID=9549376

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60010596T Expired - Fee Related DE60010596T2 (de) 1999-08-27 2000-08-25 Pyridinderivate, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Zubereitungen

Country Status (22)

Country Link
US (2) US6399616B1 (de)
EP (1) EP1078928B1 (de)
JP (1) JP3602780B2 (de)
KR (1) KR100450317B1 (de)
CN (1) CN1163495C (de)
AT (1) ATE266664T1 (de)
AU (1) AU765661B2 (de)
BR (1) BR0003848A (de)
CA (1) CA2317053A1 (de)
DE (1) DE60010596T2 (de)
DK (1) DK1078928T3 (de)
EA (1) EA004102B1 (de)
ES (1) ES2220359T3 (de)
FR (1) FR2797874B1 (de)
HU (1) HUP0003413A3 (de)
MX (1) MXPA00008241A (de)
NO (1) NO316651B1 (de)
NZ (1) NZ506560A (de)
PL (1) PL342178A1 (de)
PT (1) PT1078928E (de)
SI (1) SI1078928T1 (de)
ZA (1) ZA200004411B (de)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2797874B1 (fr) * 1999-08-27 2002-03-29 Adir Nouveaux derives de la pyridine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
DE10031391A1 (de) * 2000-07-03 2002-02-07 Knoll Ag Bicyclische Verbindungen und ihre Verwendung zur Prophylaxe und Therapie der zerebralen Ischämie
US20040106635A1 (en) * 2001-03-29 2004-06-03 Iwao Takamuro Spiroisoquinoline compound, a method for preparing the same and an intermediate thereof
DE10217006A1 (de) * 2002-04-16 2003-11-06 Merck Patent Gmbh Substituierte Indole
JP4897221B2 (ja) * 2002-12-20 2012-03-14 チバ ホールディング インコーポレーテッド アミン類の合成及びその合成のための中間体
JP4559749B2 (ja) * 2004-02-16 2010-10-13 あすか製薬株式会社 ピペラジニルピリジン誘導体
JP4596792B2 (ja) * 2004-02-24 2010-12-15 あすか製薬株式会社 ５−ｈｔ１ａ作動作用と５−ｈｔ３拮抗作用を併有する薬剤
JP4912145B2 (ja) 2004-02-26 2012-04-11 あすか製薬株式会社 ピリミジン誘導体
DE102004023506A1 (de) * 2004-05-10 2005-12-01 Grünenthal GmbH Kettenverlängerte substituierte Cyclohexyl-1,4-diamin-Derivate
DE102004023508A1 (de) * 2004-05-10 2005-12-08 Grünenthal GmbH Säurederivate substituierter Cyclohexyl-1,4-diamine
DE102004023501A1 (de) * 2004-05-10 2005-12-01 Grünenthal GmbH Oxosubstituierte Cyclohexyl-1,4-diamin-Derivate
EP1773777A1 (de) * 2004-07-23 2007-04-18 Bayer Cropscience Sa N-[2-(4-pyridinyl)ethyl]benzamidderivate als fungizide
ATE443707T1 (de) 2004-11-26 2009-10-15 Janssen Pharmaceutica Nv Isoxazolin-indol-derivate mit verbesserter antipsychotischer und anxiolytischer aktivität
FR2909670B1 (fr) * 2006-12-12 2010-07-30 Sanofi Aventis Derive fluore de quinoleine-2(1h)-one,son procede de preparation et son utilisation comme intermediaire de synthese
WO2015014256A1 (en) 2013-07-29 2015-02-05 Sunshine Lake Pharma Co., Ltd. Substituted heteroaryl compounds and methods of use thereof
CA2933466A1 (en) * 2013-12-13 2015-06-18 Takeda Pharmaceutical Company Limited Pyrrolo[3,2-c]pyridine derivatives as tlr inhibitors
US9968604B2 (en) 2015-04-16 2018-05-15 Chiesi Farmaceutici S.P.A. Chromene derivatives as phoshoinositide 3-kinases inhibitors
WO2016192657A1 (en) 2015-06-03 2016-12-08 Sunshine Lake Pharma Co., Ltd. Substituted piperazine compounds and methods of use and use thereof
CN106795160B (zh) * 2015-07-23 2019-04-19 广东东阳光药业有限公司 取代的吲哚化合物及其使用方法和用途
EP4308119A1 (de) * 2021-03-19 2024-01-24 Centre National de la Recherche Scientifique <sup2/>? <sub2/>?7?anwendungen von vorbelasteten serotonin 5-ht-rezeptor liganden zur behandlung von schmerzen, multipler sklerose und kontrolle der thermoregulation

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2761068A (en) * 1953-10-15 1956-08-28 Gen Electric Automatic pole figure recorder
FR2312498A1 (fr) * 1975-05-30 1976-12-24 Parcor Procede de preparation de la thieno (3,2-c) pyridine et de derives de celle-ci
FR2395271A1 (fr) * 1977-06-21 1979-01-19 Parcor Procede de preparation de thieno (2,3-c) et thieno (3,2-c) pyridines
KR830003481A (ko) * 1980-09-22 1983-06-20 미야다께 도꾸지로 6-플루오로-1,8-나프티리딘 유도체의 제조방법
AU553415B2 (en) * 1983-09-19 1986-07-17 Abbott Japan Co., Ltd. 6-fluoro-1-4-dihydro-4-oxo-7-substituted piperazinyl- quinoline-3-carboxylic acids
CA1278792C (en) * 1985-05-06 1991-01-08 Joseph P. Yevich Antipsychotic fused-ring pyridinylpiperazine derivatives
US5001130A (en) * 1988-02-18 1991-03-19 Bristol-Myers Company Psychotropic heterobicycloalkylpiperazine derivatives
JP2815126B2 (ja) * 1990-08-31 1998-10-27 日清製粉株式会社 ピリジンカルボン酸アミド誘導体
US5681954A (en) * 1993-05-14 1997-10-28 Daiichi Pharmaceutical Co., Ltd. Piperazine derivatives
US5300498A (en) * 1993-06-04 1994-04-05 Hoechst-Roussel Pharmaceuticals Incorporated 6-piperazinyl-1H-pyrazolo[3,4-b]pyridine-3-carboxylic acids, esters, amides and related compounds
FR2721800B1 (fr) * 1994-07-01 1997-12-26 Roussel Uclaf Nouveaux concentres emulsionnables renfermant un u plussieurs pesticides
JPH10502364A (ja) * 1994-07-06 1998-03-03 クウエスト・インターナシヨナル・ベー・ベー 昆虫誘引剤としてのリンゴ酸ジブチルの使用
DE4430593C2 (de) * 1994-08-20 1999-01-14 Max Delbrueck Centrum Verfahren zur Herstellung von Liposomal verkapseltem Taxol
PL184808B1 (pl) * 1995-09-15 2002-12-31 Sanofi Synthelabo Pochodne 2(1H)-chinolonu, sposób ich otrzymywania oraz ich zastosowanie terapeutyczne
FR2738823B1 (fr) * 1995-09-15 1997-10-31 Synthelabo Derives de 3-(omega-(4-(thieno(3,2-c)pyridin-4-yl)piperazin- 1-yl)alkyl)-3,4-dihydroquinolein-2(1h)-one,leur preparation et leur application en therapeutique
FR2761068B1 (fr) * 1997-03-20 1999-04-23 Synthelabo Derives de piperazin-4-ylthieno[3,2-c]pyridin-4-yl-2- carboxamide, leur preparation et leur application en therapeutique
FR2761071B1 (fr) * 1997-03-20 1999-12-03 Synthelabo Derives de quinolein-2(1h)-one et de dihydroquinolein-2(1h)- one, leur preparation et leur application en therapeutique
EP1020445B1 (de) * 1997-10-02 2008-08-13 Eisai R&D Management Co., Ltd. Kondensierte pyridinderivate
FR2797874B1 (fr) * 1999-08-27 2002-03-29 Adir Nouveaux derives de la pyridine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Also Published As

Publication number Publication date
JP3602780B2 (ja) 2004-12-15
PT1078928E (pt) 2004-09-30
FR2797874B1 (fr) 2002-03-29
NO20004295D0 (no) 2000-08-28
EP1078928B1 (de) 2004-05-12
AU765661B2 (en) 2003-09-25
KR100450317B1 (ko) 2004-09-30
HUP0003413A2 (hu) 2001-07-30
MXPA00008241A (es) 2002-08-20
US20020161228A1 (en) 2002-10-31
ZA200004411B (en) 2001-02-28
EA200000792A3 (ru) 2001-06-25
US6486171B2 (en) 2002-11-26
ES2220359T3 (es) 2004-12-16
US6399616B1 (en) 2002-06-04
NO20004295L (no) 2001-02-28
CA2317053A1 (fr) 2001-02-27
EA004102B1 (ru) 2003-12-25
CN1163495C (zh) 2004-08-25
KR20010050228A (ko) 2001-06-15
HUP0003413A3 (en) 2003-11-28
HK1034250A1 (en) 2001-10-19
ATE266664T1 (de) 2004-05-15
HU0003413D0 (en) 2000-08-25
CN1286255A (zh) 2001-03-07
PL342178A1 (en) 2001-03-12
SI1078928T1 (en) 2004-08-31
EA200000792A2 (ru) 2001-04-23
DK1078928T3 (da) 2004-09-13
FR2797874A1 (fr) 2001-03-02
DE60010596T2 (de) 2005-05-19
NO316651B1 (no) 2004-03-22
BR0003848A (pt) 2001-04-03
JP2001097978A (ja) 2001-04-10
AU5364200A (en) 2001-03-01
EP1078928A1 (de) 2001-02-28
NZ506560A (en) 2001-06-29

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