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AR015007A1 - Compuestos de 12,13-ciclopropano epotilona y sales, solvatos e hidratos de los mismos - Google Patents

Compuestos de 12,13-ciclopropano epotilona y sales, solvatos e hidratos de los mismos

Info

Publication number
AR015007A1
AR015007A1 ARP990101833A ARP990101833A AR015007A1 AR 015007 A1 AR015007 A1 AR 015007A1 AR P990101833 A ARP990101833 A AR P990101833A AR P990101833 A ARP990101833 A AR P990101833A AR 015007 A1 AR015007 A1 AR 015007A1
Authority
AR
Argentina
Prior art keywords
alkyl
substituted
aryl
group
compounds
Prior art date
Application number
ARP990101833A
Other languages
English (en)
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of AR015007A1 publication Critical patent/AR015007A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Se trata de compuestos de epotilona modificados de la posicion 12, 13, de la formulas (I) y (II) en las cuales: B1 y B2 se seleccionan del grupo queconsiste de H, u OR6; R1, R2, R3, y R4, se seleccionan de H, alquilo inferior; R5 se selecciona del grupo que consiste de H, alquilo, alquilo sustituido; R8 esheterociclo; R9 es hidrogeno o alquilo inferior; R6, es hidrogeno o alquilo, M es CR10R11. R10 y R11 se seleccionan del grupo que consiste de H, halogeno,alquilo, alquilo sustituido, arilo, arilo sustituido, cicloalquilo, heterociclo, R12C=O, R13OC=O, R14NHC=O, O-alquilo u O-alquilo sustituido NR15R16; R12, R13,R14, R15, R17, R18, R19 se seleccionan del grupo que consiste de H, alquilo, alquilo sustituido, arilo, acilo o arilo sustituido.R16 se selecciona del grupoque consiste en H, alquilo, alquilo sustituido, arilo, arilo sustituido, cicloalquilo, heterociclo, R17C=O, R18OC=O, R19SO2, hidroxi, O-alquilo, u O-alquilosustituido y cualquiera de las sales, solvatos o hidratos de los mismos. Dichos compuestos I y II son macrolidos de aplicacion en el campo farmacéutico.Específicamente son agentes estabilizantes de los microtubulos y por tanto utiles para el tratamiento del cáncer, y otras enfermedades tales como artritis,esclerosis, infecciones virales, trastornos neumodegenerativos, SIDA, etc.
ARP990101833A 1998-04-21 1999-04-21 Compuestos de 12,13-ciclopropano epotilona y sales, solvatos e hidratos de los mismos AR015007A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US8256498P 1998-04-21 1998-04-21

Publications (1)

Publication Number Publication Date
AR015007A1 true AR015007A1 (es) 2001-04-11

Family

ID=22171978

Family Applications (2)

Application Number Title Priority Date Filing Date
ARP990101833A AR015007A1 (es) 1998-04-21 1999-04-21 Compuestos de 12,13-ciclopropano epotilona y sales, solvatos e hidratos de los mismos
ARP990101834A AR015774A1 (es) 1998-04-21 1999-04-21 Derivados de epotilona 12,13-modificados y sus sales

Family Applications After (1)

Application Number Title Priority Date Filing Date
ARP990101834A AR015774A1 (es) 1998-04-21 1999-04-21 Derivados de epotilona 12,13-modificados y sus sales

Country Status (17)

Country Link
US (2) US6399638B1 (es)
EP (3) EP1073648B1 (es)
JP (2) JP4476483B2 (es)
CN (1) CN1142923C (es)
AR (2) AR015007A1 (es)
AT (2) ATE435861T1 (es)
AU (2) AU757733B2 (es)
BR (1) BR9909795A (es)
CA (2) CA2329181C (es)
CY (2) CY1105836T1 (es)
DE (2) DE69941083D1 (es)
DK (3) DK1589017T3 (es)
ES (3) ES2327803T3 (es)
PE (1) PE20000460A1 (es)
PT (3) PT1073647E (es)
TR (1) TR200003036T2 (es)
WO (2) WO1999054318A1 (es)

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Also Published As

Publication number Publication date
EP1073648B1 (en) 2006-09-20
DE69941083D1 (en) 2009-08-20
DE69933287T2 (de) 2007-05-03
ES2400049T3 (es) 2013-04-05
EP1073647A4 (en) 2003-01-02
EP1589017B1 (en) 2012-12-05
ES2273484T3 (es) 2007-05-01
EP1589017A2 (en) 2005-10-26
EP1073647B1 (en) 2009-07-08
CA2323609A1 (en) 1999-10-28
CN1298398A (zh) 2001-06-06
US6399638B1 (en) 2002-06-04
EP1073648A1 (en) 2001-02-07
JP2002512238A (ja) 2002-04-23
ES2327803T3 (es) 2009-11-03
DK1073647T3 (da) 2009-11-09
CN1142923C (zh) 2004-03-24
DE69933287D1 (de) 2006-11-02
ATE435861T1 (de) 2009-07-15
PT1589017E (pt) 2013-03-04
EP1073648A4 (en) 2003-01-02
AU748526B2 (en) 2002-06-06
CA2329181C (en) 2011-02-22
TR200003036T2 (tr) 2001-01-22
BR9909795A (pt) 2000-12-26
DK1073648T3 (da) 2007-01-08
JP4476483B2 (ja) 2010-06-09
WO1999054319A1 (en) 1999-10-28
DK1589017T3 (da) 2013-03-18
ATE340177T1 (de) 2006-10-15
CY1105836T1 (el) 2011-02-02
PT1073647E (pt) 2009-07-17
JP2002512239A (ja) 2002-04-23
WO1999054318A1 (en) 1999-10-28
EP1073647A1 (en) 2001-02-07
AR015774A1 (es) 2001-05-16
PT1073648E (pt) 2006-12-29
US6380395B1 (en) 2002-04-30
CY1109593T1 (el) 2014-08-13
AU3471699A (en) 1999-11-08
EP1589017A3 (en) 2009-04-22
CA2329181A1 (en) 1999-10-28
PE20000460A1 (es) 2000-06-09
AU3382799A (en) 1999-11-08
AU757733B2 (en) 2003-03-06

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