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AR003441A1 - Compuestos para regular la meiosis y el uso de los mismos para preparar medicamentos. - Google Patents

Compuestos para regular la meiosis y el uso de los mismos para preparar medicamentos.

Info

Publication number
AR003441A1
AR003441A1 ARP960103295A AR10329596A AR003441A1 AR 003441 A1 AR003441 A1 AR 003441A1 AR P960103295 A ARP960103295 A AR P960103295A AR 10329596 A AR10329596 A AR 10329596A AR 003441 A1 AR003441 A1 AR 003441A1
Authority
AR
Argentina
Prior art keywords
compounds
themselves
prepare drugs
meiosis
regulating meiosis
Prior art date
Application number
ARP960103295A
Other languages
English (en)
Original Assignee
Novo Nordisk As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novo Nordisk As filed Critical Novo Nordisk As
Publication of AR003441A1 publication Critical patent/AR003441A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring the nitrogen atom being directly linked to the cyclopenta(a)hydro phenanthrene skeleton
    • C07J41/0016—Oximes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Urology & Nephrology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Epidemiology (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Ciertos compuestos (I), donde R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R12, R13, R14, R15,R16, R17, R18, R19, R20, R21 y R25 están definidos en lamemoria descriptiva estructuralmente relacionados con los compuestos naturales que puedenextraers e por ejemplo, de testículo de toro y de fluido folicularhumano, pueden usarse regulando la meiosis en los oocitos y en las células germen masculinas y el uso de dichos compuestos para preparar medicamentos.
ARP960103295A 1995-06-23 1996-06-24 Compuestos para regular la meiosis y el uso de los mismos para preparar medicamentos. AR003441A1 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DK72895 1995-06-23
DK73095 1995-06-23
DK146195 1995-12-22

Publications (1)

Publication Number Publication Date
AR003441A1 true AR003441A1 (es) 1998-08-05

Family

ID=27220892

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP960103295A AR003441A1 (es) 1995-06-23 1996-06-24 Compuestos para regular la meiosis y el uso de los mismos para preparar medicamentos.

Country Status (18)

Country Link
EP (1) EP0857173B1 (es)
JP (1) JPH11507929A (es)
KR (1) KR19990028366A (es)
CN (1) CN1191543A (es)
AR (1) AR003441A1 (es)
AT (1) ATE254628T1 (es)
AU (1) AU718246B2 (es)
BR (1) BR9608968A (es)
CA (1) CA2224866A1 (es)
CZ (1) CZ408097A3 (es)
DE (1) DE69630802T2 (es)
HU (1) HUP9900454A3 (es)
IL (1) IL122609A0 (es)
NO (1) NO314231B1 (es)
PL (1) PL185622B1 (es)
RU (1) RU2182909C2 (es)
TW (1) TW474943B (es)
WO (1) WO1997000884A1 (es)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0984980B1 (en) * 1997-05-16 2002-12-04 Akzo Nobel N.V. 20-aralkyl-5alpha-pregnane derivatives
KR20010013401A (ko) 1997-06-04 2001-02-26 에프.지.엠. 헤르만스 감수분열 조절용 17β-알릴옥시(티오)알킬-안드로스탄유도체
ES2181321T3 (es) * 1997-12-18 2003-02-16 Akzo Nobel Nv Derivados 17beta-aril(arilmetil)oxi(tio)alquilandrostano.
EP0957108A1 (en) * 1998-05-14 1999-11-17 Schering Aktiengesellschaft Unsaturated cholestane derivatives, pharmaceutical compositions comprising them and use of these derivatives for the preparation of meiosis regulating medicaments
KR20010043558A (ko) 1998-05-13 2001-05-25 한센 핀 베네드, 안네 제헤르, 웨이콥 마리안느 감수분열 조절 화합물
KR20010053031A (ko) * 1998-06-19 2001-06-25 한센 핀 베네드, 안네 제헤르, 웨이콥 마리안느 감수분열 조절 화합물
AU759344B2 (en) 1998-12-11 2003-04-10 Akzo Nobel N.V. 22S-hydroxycholesta-8, 14-diene derivatives with meiosis regulating activity
WO2000036132A1 (en) * 1998-12-14 2000-06-22 Merck & Co., Inc. Hiv integrase inhibitors
PL350557A1 (en) * 1999-02-10 2002-12-16 Schering Ag Unsaturated cholestane derivatives and their use for the preparation of meiosis regulating medicaments
AU2794000A (en) * 1999-02-24 2000-09-14 Novo Nordisk A/S Treatment of infertility
CN1353617A (zh) 1999-02-24 2002-06-12 诺沃挪第克公司 不孕症的治疗
WO2001019354A2 (en) 1999-09-16 2001-03-22 Novo Nordisk A/S Composition for ivf
EP1127890A1 (en) 2000-02-22 2001-08-29 Schering Aktiengesellschaft Steroid derivatives with an additional ring annulated to ring A and use of these derivatives for the preparation of meiosis regulating medicaments
MXPA02007818A (es) * 2000-02-25 2002-10-23 Schering Ag Tasa de implantacion mejorada utilizando ff-mas.
EP1245572A1 (en) 2001-03-26 2002-10-02 Schering Aktiengesellschaft Aminosterol compounds, their use in the preparation of meiosis-regulating medicaments and method for their preparation
US8399441B2 (en) 2004-10-25 2013-03-19 Virginia Commonwealth University Nuclear sulfated oxysterol, potent regulator of lipid homeostasis, for therapy of hypercholesterolemia, hypertriglycerides, fatty liver diseases, and atherosclerosis
WO2006047022A1 (en) 2004-10-25 2006-05-04 Virginia Commonwealth University Nuclear sulfated oxysterol, potent regulator of cholesterol homeostasis, for therapy of hypercholesterolemia, hyperlipidemia, and atherosclerosis
FR2898272B1 (fr) * 2006-03-09 2008-07-04 Trophos Sa Utilisation de derives du 3,5-seco-4-nor-cholestrane pour l'obtention d'un medicament cytoprotecteur
CN102258004B (zh) * 2010-05-27 2013-07-17 中国科学院动物研究所 一种体外保存/培养卵母细胞以抑制卵母细胞生发泡破裂的方法
US9034859B2 (en) 2011-04-06 2015-05-19 Virginia Commonwealth University Sulfated oxysterol and oxysterol sulfation by hydroxysterol sulfotransferase promote lipid homeostasis and liver proliferation
AU2012304412A1 (en) 2011-09-08 2014-03-27 Sage Therapeutics, Inc. Neuroactive steroids, compositions, and uses thereof
DK3461834T3 (da) 2013-03-13 2021-08-23 Sage Therapeutics Inc Neuroaktive steroider
MX2021011641A (es) 2013-12-24 2023-03-10 Durect Corp Usos de sulfatos de colesterol oxigenados (soc).
JP6628745B2 (ja) 2014-06-18 2020-01-15 セージ セラピューティクス， インコーポレイテッド オキシステロールおよびその使用方法
EA024619B1 (ru) * 2014-11-21 2016-10-31 Эльвин Гаджи оглы Керимли ФРАКСИНОСТЕРИН - 24β-ЭТИЛХОЛЕСТА-20-КАРБОКСИ-6(7),8(9)-ДИЕН 3β-ОЛА И ЕГО ПРОИЗВОДНОЕ
HK1255500A1 (zh) 2015-07-06 2019-08-16 Sage Therapeutics, Inc. 氧固醇及其使用方法
MA54851A (fr) 2015-07-06 2021-12-08 Sage Therapeutics Inc Oxystérols et leurs procédés d'utilisation
HRP20210526T8 (hr) 2015-07-06 2021-08-20 Sage Therapeutics, Inc. Oksisteroli i postupci za njihovu uporabu
LT3436022T (lt) 2016-04-01 2022-06-27 Sage Therapeutics, Inc. Oksisteroliai ir jų panaudojimo būdai
WO2017193046A1 (en) 2016-05-06 2017-11-09 Sage Therapeutics, Inc. Oxysterols and methods of use thereof
MD3481846T2 (ro) 2016-07-07 2021-11-30 Sage Therapeutics Inc 24-Hidroxisteroli 11-substituiți pentru utilizare în tratamentul stărilor legate de NMDA
HUE059768T2 (hu) 2016-08-02 2022-12-28 Univ Virginia Commonwealth 5-kolesztén-3,25-diol, 3-szulfátot (25HC3S) vagy annak gyógyszerészetileg elfogadható sóját és legalább egy ciklikus oligoszacharidot tartalmazó készítmények
ES2935057T3 (es) 2016-09-30 2023-03-01 Sage Therapeutics Inc C7 oxisteroles sustituidos y estos compuestos para su uso como moduladores de la NMDA
IL297804A (en) 2016-10-18 2022-12-01 Sage Therapeutics Inc Oxysterols and methods of using them
TWI772331B (zh) 2016-10-18 2022-08-01 美商賽吉醫療公司 氧固醇(oxysterol)及其使用方法
CN112430251A (zh) * 2020-11-23 2021-03-02 广州瀚信通信科技股份有限公司 一种治疗白内障的化合物及其制备方法和应用

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5716777A (en) * 1994-06-23 1998-02-10 Novo Nordisk A/S Regulation of meiosis using sterols

Also Published As

Publication number Publication date
AU718246B2 (en) 2000-04-13
CN1191543A (zh) 1998-08-26
EP0857173B1 (en) 2003-11-19
HUP9900454A2 (hu) 1999-06-28
NO314231B1 (no) 2003-02-17
PL185622B1 (pl) 2003-06-30
CA2224866A1 (en) 1997-01-09
CZ408097A3 (cs) 1998-06-17
JPH11507929A (ja) 1999-07-13
DE69630802D1 (de) 2003-12-24
DE69630802T2 (de) 2004-08-12
HUP9900454A3 (en) 1999-11-29
BR9608968A (pt) 1999-06-29
KR19990028366A (ko) 1999-04-15
NO976044D0 (no) 1997-12-22
MX9800123A (es) 1998-03-29
EP0857173A1 (en) 1998-08-12
NO976044L (no) 1998-02-20
WO1997000884A1 (en) 1997-01-09
PL324219A1 (en) 1998-05-11
ATE254628T1 (de) 2003-12-15
IL122609A0 (en) 1998-08-16
TW474943B (en) 2002-02-01
AU6122796A (en) 1997-01-22
RU2182909C2 (ru) 2002-05-27

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