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AR002284A1 - Antagonistas del receptor endotelial, un procedimiento para su preparacion, su empleo para preparar un medicamento, preparaciones farmaceuticas que loscontienen y un procedimiento para obtener estas preparaciones farmaceuticas. - Google Patents

Antagonistas del receptor endotelial, un procedimiento para su preparacion, su empleo para preparar un medicamento, preparaciones farmaceuticas que loscontienen y un procedimiento para obtener estas preparaciones farmaceuticas.

Info

Publication number
AR002284A1
AR002284A1 ARP960101769A AR10176996A AR002284A1 AR 002284 A1 AR002284 A1 AR 002284A1 AR P960101769 A ARP960101769 A AR P960101769A AR 10176996 A AR10176996 A AR 10176996A AR 002284 A1 AR002284 A1 AR 002284A1
Authority
AR
Argentina
Prior art keywords
pharmaceutical preparations
procedure
prepare
obtaining
contain
Prior art date
Application number
ARP960101769A
Other languages
English (en)
Inventor
Mathias Dr Osswald
Werner Dr Mederski
Dieter Dr Dorsch
Claudia Wilm
Claus Dr Schmitges
Maria Christadler
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Publication of AR002284A1 publication Critical patent/AR002284A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
    • C07D285/01—Five-membered rings
    • C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
    • C07D285/14—Thiadiazoles; Hydrogenated thiadiazoles condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
    • C07D271/12—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pulmonology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

El invento se refiere a los nuevos compuestos de fórmula (I), en la que -A=B-C=D- representa un grupo -CH=CH-CH=CH-, en el cual 1 ó 2 CH también puedenestar reemplazados por N, Ar es fenilo o naftilo no sustituido o sustituido una, dos otres veces con H, Hal, Q, alquenilo de hasta 6 átomos de C, Ph, OPh,NO2, NR4R5, NHCOR4, CF3, OCF3, CN, OR4, COOR4, (CH2)nCOOR4, (CH2)nNR4R5, -N=C=O ó NHCONR4R5; R1, R2, R3 independientemente uno de los otros, estánausentes, o bien representanH, H al, Q, CF3, NO2, NR4R5, CN, COOR4 ó NHCOR4, R4, R5 representan independientemente H ó Q, o también forman juntos-CH2-(CH2)n-CH2-, Q representa alquilo de 1 a 6 átomos de C, Ph representa fenilo, X representa O ó S; Hal representa F, Cl,Br ó I; n es 1, 2 ó 3; y sussales aceptables desde el punto de vista fisiológico. También se refiere a un procedimiento para preparar dichos compuestos, a las preparacionesfarmacéuticas que los contienen y al empleo de los mismos para preparar un m edicamento y para combatir enfermedades, en particular la hipertonía y lainsuficiencia cardíaca. Los nuevos compuestos del invento poseen propiedades antagonistas del receptor endotelial.
ARP960101769A 1995-03-18 1996-03-15 Antagonistas del receptor endotelial, un procedimiento para su preparacion, su empleo para preparar un medicamento, preparaciones farmaceuticas que loscontienen y un procedimiento para obtener estas preparaciones farmaceuticas. AR002284A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19509950A DE19509950A1 (de) 1995-03-18 1995-03-18 Endothelin-Rezeptor-Antagonisten

Publications (1)

Publication Number Publication Date
AR002284A1 true AR002284A1 (es) 1998-03-11

Family

ID=7757094

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP960101769A AR002284A1 (es) 1995-03-18 1996-03-15 Antagonistas del receptor endotelial, un procedimiento para su preparacion, su empleo para preparar un medicamento, preparaciones farmaceuticas que loscontienen y un procedimiento para obtener estas preparaciones farmaceuticas.

Country Status (26)

Country Link
US (1) US5726194A (es)
EP (1) EP0733626B1 (es)
JP (1) JPH08269027A (es)
KR (1) KR100424045B1 (es)
CN (1) CN1061652C (es)
AR (1) AR002284A1 (es)
AT (1) ATE175666T1 (es)
AU (1) AU705559B2 (es)
BR (1) BR9601028A (es)
CA (1) CA2171934C (es)
CO (1) CO4700473A1 (es)
CZ (1) CZ288001B6 (es)
DE (2) DE19509950A1 (es)
DK (1) DK0733626T3 (es)
ES (1) ES2128117T3 (es)
FI (1) FI960953A7 (es)
GR (1) GR3029893T3 (es)
HU (1) HUP9600663A3 (es)
NO (1) NO305907B1 (es)
PL (1) PL184332B1 (es)
RU (1) RU2168503C2 (es)
SK (1) SK280926B6 (es)
TR (1) TR199600212A2 (es)
TW (1) TW363060B (es)
UA (1) UA48116C2 (es)
ZA (1) ZA962144B (es)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5962490A (en) 1987-09-25 1999-10-05 Texas Biotechnology Corporation Thienyl-, furyl- and pyrrolyl-sulfonamides and derivatives thereof that modulate the activity of endothelin
US6342610B2 (en) 1993-05-20 2002-01-29 Texas Biotechnology Corp. N-aryl thienyl-, furyl-, and pyrrolyl-sulfonamides and derivatives thereof that modulate the activity of endothelin
US6613804B2 (en) 1993-05-20 2003-09-02 Encysive Pharmaceuticals, Inc. Biphenylsulfonamides and derivatives thereof that modulate the activity of endothelin
US6376523B1 (en) 1994-05-20 2002-04-23 Texas Biotechnology Corporation Benzenesulfonamides and the use thereof to modulate the activity of endothelin
US6030991A (en) * 1993-05-20 2000-02-29 Texas Biotechnology Corp. Benzenesulfonamides and the use thereof to modulate the activity of endothelin
US6541498B2 (en) 1993-05-20 2003-04-01 Texas Biotechnology Benzenesulfonamides and the use thereof to modulate the activity of endothelin
US5612359A (en) * 1994-08-26 1997-03-18 Bristol-Myers Squibb Company Substituted biphenyl isoxazole sulfonamides
US5760038A (en) * 1995-02-06 1998-06-02 Bristol-Myers Squibb Company Substituted biphenyl sulfonamide endothelin antagonists
US5780473A (en) * 1995-02-06 1998-07-14 Bristol-Myers Squibb Company Substituted biphenyl sulfonamide endothelin antagonists
US5846990A (en) * 1995-07-24 1998-12-08 Bristol-Myers Squibb Co. Substituted biphenyl isoxazole sulfonamides
JPH09124620A (ja) * 1995-10-11 1997-05-13 Bristol Myers Squibb Co 置換ビフェニルスルホンアミドエンドセリン拮抗剤
DE19543639A1 (de) * 1995-11-23 1997-05-28 Merck Patent Gmbh Endothelin-Rezeptor-Antagonisten
AU717230B2 (en) 1996-02-20 2000-03-23 Bristol-Myers Squibb Company Methods for the preparation of biphenyl isoxazole sulfonamides
US5856507A (en) * 1997-01-21 1999-01-05 Bristol-Myers Squibb Co. Methods for the preparation of biphenyl isoxazole sulfonamides
DE19607096A1 (de) * 1996-02-24 1997-08-28 Merck Patent Gmbh Endothelin-Rezeptor-Antagonisten
DE19606980A1 (de) * 1996-02-24 1997-08-28 Merck Patent Gmbh Endothelin-Rezeptor-Antagonisten
US5939446A (en) * 1996-04-09 1999-08-17 Bristol-Myers Squibb Co. Heteroaryl substituted phenyl isoxazole sulfonamide endothelin antagonists
US5804585A (en) 1996-04-15 1998-09-08 Texas Biotechnology Corporation Thieno-pyridine sulfonamides derivatives thereof and related compounds that modulate the activity of endothelin
DE19653037A1 (de) * 1996-12-19 1998-06-25 Merck Patent Gmbh Endothelin-Rezeptor-Antagonisten
TW536540B (en) * 1997-01-30 2003-06-11 Bristol Myers Squibb Co Endothelin antagonists: N-[[2'-[[(4,5-dimethyl-3-isoxazolyl)amino]sulfonyl]-4-(2-oxazolyl)[1,1'-biphenyl]-2-yl]methyl]-N,3,3-trimethylbutanamide and N-(4,5-dimethyl-3-isoxazolyl)-2'-[(3,3-dimethyl-2-oxo-1-pyrrolidinyl)methyl]-4'-(2-oxazolyl)[1,1'-biphe
WO1998033781A1 (en) * 1997-01-30 1998-08-06 Bristol-Myers Squibb Company Method for preventing or treating low renin hypertension by administering an endothelin antagonist
DE19710831A1 (de) * 1997-03-15 1998-09-17 Merck Patent Gmbh Endothelin-Rezeptor-Antagonisten
DE19712141A1 (de) * 1997-03-22 1998-09-24 Merck Patent Gmbh Endothelin-Rezeptor-Antagonisten
TR200101905T2 (tr) 1997-04-28 2002-06-21 Texas Biotechnology Corporation Endotelin ile ilgili hastalıkların tedavisinde kullanılan sülfanoamidler.
US5783705A (en) 1997-04-28 1998-07-21 Texas Biotechnology Corporation Process of preparing alkali metal salys of hydrophobic sulfonamides
DE19731571A1 (de) * 1997-07-23 1999-01-28 Merck Patent Gmbh Endothelin-Rezeptor-Antagonisten
US6638937B2 (en) 1998-07-06 2003-10-28 Bristol-Myers Squibb Co. Biphenyl sulfonamides as dual angiotensin endothelin receptor antagonists
WO2000056685A1 (en) 1999-03-19 2000-09-28 Bristol-Myers Squibb Company Methods for the preparation of biphenyl isoxazole sulfonamides
DE10155076A1 (de) * 2001-11-09 2003-05-22 Merck Patent Gmbh Verwendung von Endothelin-Rezeptor-Antagonisten zur Behandlung von Tumorerkrankungen
JP2009530284A (ja) * 2006-03-13 2009-08-27 エンサイシブ・ファーマシューティカルズ・インコーポレイテッド 拡張期心不全を治療するための方法と組成物
MX2008011844A (es) * 2006-03-13 2008-10-02 Encysive Pharmaceuticals Inc Formulaciones de sitaxsentano de sodio.
US20080026061A1 (en) * 2006-06-22 2008-01-31 Reichwein John F Crystalline N-(4-chloro-3-methyl-5-isoxazolyl)-2-[2-methyl-4.5-(methylenedioxy)phenylacetyl]-thiophene-3-sulfonamide
JP2011510033A (ja) * 2008-01-25 2011-03-31 シンジェンタ パーティシペーションズ アクチェンゲゼルシャフト 化合物
US12398097B2 (en) 2019-07-29 2025-08-26 Vanderbilt University WDR5-MYC inhibitors

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US5464853A (en) * 1993-05-20 1995-11-07 Immunopharmaceutics, Inc. N-(5-isoxazolyl)biphenylsulfonamides, N-(3-isoxazolyl)biphenylsulfonamides and derivatives thereof that modulate the activity of endothelin
US5591761A (en) * 1993-05-20 1997-01-07 Texas Biotechnology Corporation Thiophenyl-, furyl-and pyrrolyl-sulfonamides and derivatives thereof that modulate the activity of endothelin
US5032604A (en) * 1989-12-08 1991-07-16 Merck & Co., Inc. Class III antiarrhythmic agents
US5378715A (en) * 1992-02-24 1995-01-03 Bristol-Myers Squibb Co. Sulfonamide endothelin antagonists
NZ247440A (en) * 1992-05-06 1995-04-27 Squibb & Sons Inc Phenyl sulphonamide derivatives, preparation and pharmaceutical compositions thereof

Also Published As

Publication number Publication date
AU705559B2 (en) 1999-05-27
NO961072L (no) 1996-09-19
ATE175666T1 (de) 1999-01-15
TR199600212A2 (tr) 1997-01-21
DK0733626T3 (da) 1999-08-09
CZ288001B6 (cs) 2001-03-14
FI960953L (fi) 1996-09-19
UA48116C2 (uk) 2002-08-15
JPH08269027A (ja) 1996-10-15
ZA962144B (en) 1996-09-26
DE19509950A1 (de) 1996-09-19
SK280926B6 (sk) 2000-09-12
TW363060B (en) 1999-07-01
EP0733626A1 (de) 1996-09-25
BR9601028A (pt) 1997-12-30
KR960034189A (ko) 1996-10-22
RU2168503C2 (ru) 2001-06-10
CZ80096A3 (en) 1996-10-16
KR100424045B1 (ko) 2004-06-26
GR3029893T3 (en) 1999-07-30
AU4803996A (en) 1996-09-26
US5726194A (en) 1998-03-10
DE59601122D1 (de) 1999-02-25
PL184332B1 (pl) 2002-10-31
NO961072D0 (no) 1996-03-15
NO305907B1 (no) 1999-08-16
HU9600663D0 (en) 1996-05-28
CA2171934C (en) 2007-04-24
CN1141919A (zh) 1997-02-05
ES2128117T3 (es) 1999-05-01
FI960953A0 (fi) 1996-02-29
CO4700473A1 (es) 1998-12-29
EP0733626B1 (de) 1999-01-13
FI960953A7 (fi) 1996-09-19
CA2171934A1 (en) 1996-09-19
SK36396A3 (en) 1997-02-05
HUP9600663A3 (en) 1998-07-28
HUP9600663A2 (en) 1997-01-28
CN1061652C (zh) 2001-02-07
PL313280A1 (en) 1996-09-30

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