AR002025A1 - Derivados de 4-(1h-indol-1-il)-1-piperidinilo, su uso y un procedimiento para su preparacion, una composicion farmaceutica que los contiene, unprocedimiento para la preparacion de dicha composicion farmaceutica. - Google Patents
Derivados de 4-(1h-indol-1-il)-1-piperidinilo, su uso y un procedimiento para su preparacion, una composicion farmaceutica que los contiene, unprocedimiento para la preparacion de dicha composicion farmaceutica.Info
- Publication number
- AR002025A1 AR002025A1 ARP960101210A AR10121096A AR002025A1 AR 002025 A1 AR002025 A1 AR 002025A1 AR P960101210 A ARP960101210 A AR P960101210A AR 10121096 A AR10121096 A AR 10121096A AR 002025 A1 AR002025 A1 AR 002025A1
- Authority
- AR
- Argentina
- Prior art keywords
- preparation
- procedure
- pharmaceutical composition
- alkyl
- indol
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Neurology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Psychiatry (AREA)
- Pharmacology & Pharmacy (AREA)
- Neurosurgery (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
La presente invención se refiere a los compuestos que tienen la fórmula (I) a sus sales de adición de ácido farmacéuticamente aceptable y a las formasestereoquímicamente isoméricas de los mismos donde la línea de trazos designa un enlace opcional;R1 y R2 son cada uno independientemente hidrógeno, alquiloC1-6, fenilo o fenilo sustituido con 1, 2 ó 3 sustituyentes seleccionados de halo, hidroxi, nitro, ciano, trifluormetilo, alquilo C1-6, alquiloxi C1-6,alquiltio C1-6, mercapto, amino, monoy di(alquilo C1-6)amino, carboxilo, alcoxicarbonilo C1-6 y alquilcarbinilo C1-6; Alk es alcanodiilo C1-4; D es unapirimidinona, piperidona o bencimidozolidinona; que tiene actividad antipsicótica; su preparación, las composiciones que lo contienen y su uso enmedicina.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP95200229 | 1995-01-31 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR002025A1 true AR002025A1 (es) | 1998-01-07 |
Family
ID=8219983
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP960101210A AR002025A1 (es) | 1995-01-31 | 1996-01-30 | Derivados de 4-(1h-indol-1-il)-1-piperidinilo, su uso y un procedimiento para su preparacion, una composicion farmaceutica que los contiene, unprocedimiento para la preparacion de dicha composicion farmaceutica. |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US5919788A (es) |
| EP (1) | EP0808313B1 (es) |
| JP (1) | JP3980054B2 (es) |
| KR (1) | KR100415391B1 (es) |
| CN (1) | CN1152874C (es) |
| AR (1) | AR002025A1 (es) |
| AT (1) | ATE247105T1 (es) |
| AU (1) | AU702931B2 (es) |
| BR (1) | BR9606815A (es) |
| CA (1) | CA2210913C (es) |
| DE (1) | DE69629454T2 (es) |
| ES (1) | ES2205015T3 (es) |
| FI (1) | FI973164A0 (es) |
| IL (1) | IL116930A (es) |
| MY (1) | MY130950A (es) |
| NO (1) | NO308537B1 (es) |
| NZ (1) | NZ301264A (es) |
| PL (1) | PL183291B1 (es) |
| TW (1) | TW421649B (es) |
| WO (1) | WO1996023784A1 (es) |
| ZA (1) | ZA96702B (es) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI242011B (en) * | 1997-03-31 | 2005-10-21 | Eisai Co Ltd | 1,4-substituted cyclic amine derivatives |
| US7189753B1 (en) | 1997-11-06 | 2007-03-13 | Cady Roger K | Preemptive prophylaxis of migraine |
| US6204274B1 (en) | 1998-04-29 | 2001-03-20 | American Home Products Corporation | Indolyl derivatives as serotonergic agents |
| TW528754B (en) * | 1998-04-29 | 2003-04-21 | Wyeth Corp | Indolyl derivatibes as serotonergic agents |
| GB9810886D0 (en) * | 1998-05-13 | 1998-07-22 | Lilly Industries Ltd | Pharmaceutical compounds |
| EP1791839B1 (en) * | 2004-09-09 | 2015-06-10 | Janssen Pharmaceutica NV | Preparation of 9-hydroxy-3-(2-hydroxyethyl)-2-methyl-4h-pyrido[1,2-a]pyrimidin-4-one and crystalls thereof |
| JP2009524574A (ja) * | 2006-08-23 | 2009-07-02 | テバ ファーマシューティカル インダストリーズ リミティド | Ｃｍｈｔｐ及びその中間体の合成方法 |
| US7820816B2 (en) | 2006-08-23 | 2010-10-26 | Teva Pharmaceutical Industries Ltd. | Process for the synthesis of CMHTP and intermediates thereof |
| CN101600716A (zh) * | 2007-01-08 | 2009-12-09 | 阿特维斯集团公司 | 用于制备9-羟基-3-(2-氯乙基)-2-甲基-4H-吡啶并[1,2-a]嘧啶-4-酮盐酸盐的改进方法 |
| WO2008126886A1 (ja) * | 2007-04-12 | 2008-10-23 | Taisho Pharmaceutical Co., Ltd. | インドール又はインドリン誘導体 |
| WO2009010988A1 (en) * | 2007-07-19 | 2009-01-22 | Natco Pharma Limited | An improved, industrially viable process for the preparation of high purity paliperidone |
| WO2012177708A1 (en) | 2011-06-20 | 2012-12-27 | Ratiopharm Gmbh | Paliperidone oleate |
| WO2014102588A2 (en) * | 2012-12-27 | 2014-07-03 | Purdue Pharma L.P. | Indole and indoline-type piperidine compounds and uses thereof |
| US9951038B2 (en) | 2012-12-27 | 2018-04-24 | Purdue Pharma L.P. | Quinazolin-4(3H)-one-type piperidine compounds and uses thereof |
| CN117700410B (zh) * | 2023-05-20 | 2025-07-04 | 山东康诺生物工程有限公司 | 一种3-(2-氯乙基)-2-甲基-9-羟基-4H-吡啶并[1,2-a]嘧啶-4-酮的制备方法 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4342870A (en) * | 1980-03-28 | 1982-08-03 | Janssen Pharmaceutica N.V. | Novel 3-(1-piperidinylalkyl)-4H-pyrido[1,2-a]pyrimidin-4-one derivatives |
| US4443451A (en) * | 1981-07-15 | 1984-04-17 | Janssen Pharmaceutica N.V. | Bicyclic pyrimidin-5-one derivatives |
| US5140029A (en) * | 1989-01-09 | 1992-08-18 | Janssen Pharmaceutica N.V. | 2-aminopyrimidinone derivatives |
| US5256659A (en) * | 1989-01-09 | 1993-10-26 | Janssen Pharmaceutica N.V. | 2-aminopyrimidinone derivatives |
| GB8900382D0 (en) * | 1989-01-09 | 1989-03-08 | Janssen Pharmaceutica Nv | 2-aminopyrimidinone derivatives |
| JP2800953B2 (ja) * | 1990-07-06 | 1998-09-21 | 住友製薬株式会社 | 新規なイミド誘導体 |
| US5360807A (en) * | 1990-07-19 | 1994-11-01 | Janssen Pharmaceutica N.V. | Substituted thiazolyl and substituted pyridinyl derivatives |
| DK181190D0 (da) * | 1990-07-30 | 1990-07-30 | Lundbeck & Co As H | 3-aryl-indol- eller 3-aryl-indazolderivater |
| GB9305641D0 (en) * | 1993-03-18 | 1993-05-05 | Merck Sharp & Dohme | Therapeutic agents |
-
1996
- 1996-01-09 TW TW085100173A patent/TW421649B/zh not_active IP Right Cessation
- 1996-01-23 KR KR1019970705088A patent/KR100415391B1/ko not_active Expired - Fee Related
- 1996-01-23 WO PCT/EP1996/000363 patent/WO1996023784A1/en not_active Ceased
- 1996-01-23 JP JP52324396A patent/JP3980054B2/ja not_active Expired - Lifetime
- 1996-01-23 AT AT96902258T patent/ATE247105T1/de not_active IP Right Cessation
- 1996-01-23 BR BR9606815A patent/BR9606815A/pt not_active IP Right Cessation
- 1996-01-23 US US08/860,380 patent/US5919788A/en not_active Expired - Fee Related
- 1996-01-23 DE DE69629454T patent/DE69629454T2/de not_active Expired - Fee Related
- 1996-01-23 PL PL96321565A patent/PL183291B1/pl not_active IP Right Cessation
- 1996-01-23 FI FI973164A patent/FI973164A0/fi not_active Application Discontinuation
- 1996-01-23 EP EP96902258A patent/EP0808313B1/en not_active Expired - Lifetime
- 1996-01-23 CA CA002210913A patent/CA2210913C/en not_active Expired - Fee Related
- 1996-01-23 AU AU46645/96A patent/AU702931B2/en not_active Ceased
- 1996-01-23 CN CNB961917016A patent/CN1152874C/zh not_active Expired - Fee Related
- 1996-01-23 NZ NZ301264A patent/NZ301264A/en not_active IP Right Cessation
- 1996-01-23 ES ES96902258T patent/ES2205015T3/es not_active Expired - Lifetime
- 1996-01-29 IL IL11693096A patent/IL116930A/xx not_active IP Right Cessation
- 1996-01-30 ZA ZA9600702A patent/ZA96702B/xx unknown
- 1996-01-30 AR ARP960101210A patent/AR002025A1/es unknown
- 1996-01-31 MY MYPI96000364A patent/MY130950A/en unknown
-
1997
- 1997-07-30 NO NO973508A patent/NO308537B1/no not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| AU4664596A (en) | 1996-08-21 |
| FI973164L (fi) | 1997-07-30 |
| ES2205015T3 (es) | 2004-05-01 |
| DE69629454D1 (en) | 2003-09-18 |
| MX9705821A (es) | 1997-10-31 |
| MY130950A (en) | 2007-07-31 |
| WO1996023784A1 (en) | 1996-08-08 |
| NZ301264A (en) | 1998-07-28 |
| KR19980701692A (ko) | 1998-06-25 |
| BR9606815A (pt) | 1997-12-30 |
| PL321565A1 (en) | 1997-12-08 |
| FI973164A7 (fi) | 1997-07-30 |
| EP0808313A1 (en) | 1997-11-26 |
| DE69629454T2 (de) | 2004-06-17 |
| CA2210913A1 (en) | 1996-08-08 |
| CN1152874C (zh) | 2004-06-09 |
| NO973508L (no) | 1997-07-30 |
| ATE247105T1 (de) | 2003-08-15 |
| PL183291B1 (pl) | 2002-06-28 |
| CN1172482A (zh) | 1998-02-04 |
| AU702931B2 (en) | 1999-03-11 |
| TW421649B (en) | 2001-02-11 |
| KR100415391B1 (ko) | 2004-05-06 |
| CA2210913C (en) | 2008-10-21 |
| EP0808313B1 (en) | 2003-08-13 |
| FI973164A0 (fi) | 1997-07-30 |
| JP3980054B2 (ja) | 2007-09-19 |
| IL116930A (en) | 2000-06-29 |
| NO308537B1 (no) | 2000-09-25 |
| JPH10512893A (ja) | 1998-12-08 |
| US5919788A (en) | 1999-07-06 |
| IL116930A0 (en) | 1996-05-14 |
| NO973508D0 (no) | 1997-07-30 |
| ZA96702B (en) | 1997-07-30 |
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