MX9705821A - Derivados antipsicoticos de piperidina 4-(1h-indolil-1-il)-1-substituida. - Google Patents
Derivados antipsicoticos de piperidina 4-(1h-indolil-1-il)-1-substituida.Info
- Publication number
- MX9705821A MX9705821A MX9705821A MX9705821A MX9705821A MX 9705821 A MX9705821 A MX 9705821A MX 9705821 A MX9705821 A MX 9705821A MX 9705821 A MX9705821 A MX 9705821A MX 9705821 A MX9705821 A MX 9705821A
- Authority
- MX
- Mexico
- Prior art keywords
- 6alkyl
- substituted
- 6alkyloxy
- halogen
- indolil
- Prior art date
Links
- 230000000561 anti-psychotic effect Effects 0.000 title abstract 2
- NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical class C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 title 1
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 3
- -1 C1-6alkyloxy Chemical group 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical group 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- 125000004916 (C1-C6) alkylcarbonyl group Chemical group 0.000 abstract 1
- 125000006700 (C1-C6) alkylthio group Chemical group 0.000 abstract 1
- YCIPQJTZJGUXND-UHFFFAOYSA-N Aglaia odorata Alkaloid Natural products C1=CC(OC)=CC=C1C1(C(C=2C(=O)N3CCCC3=NC=22)C=3C=CC=CC=3)C2(O)C2=C(OC)C=C(OC)C=C2O1 YCIPQJTZJGUXND-UHFFFAOYSA-N 0.000 abstract 1
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 125000004663 dialkyl amino group Chemical group 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- XUWHAWMETYGRKB-UHFFFAOYSA-N piperidin-2-one Chemical compound O=C1CCCCN1 XUWHAWMETYGRKB-UHFFFAOYSA-N 0.000 abstract 1
- VTGOHKSTWXHQJK-UHFFFAOYSA-N pyrimidin-2-ol Chemical compound OC1=NC=CC=N1 VTGOHKSTWXHQJK-UHFFFAOYSA-N 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Psychiatry (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
La presente invencion se refiere a compuestos de la formula (I): sales de adicion farmacéuticamente aceptables y las formas estereoquímicamente isoméricas de los mismos, en donde la línea punteada designa un enlace opcional; R1 y R2 son independientemente cada uno hidrogeno, halogeno, alquilo de C1-6 o alquiloxi de C1-6; R3 y R4 son cada uno independientemente hidrogeno, alquilo de C1-6, fenilo o fenilo substituido con 1, 2 o 3 substituyentes seleccionados entre halogeno, hidroxi, nitro, ciano, tirfluorometilo, alquilo de C1-6, alquiloxi de C1-6, alquiltio de C1-6, mercapto, amino, mono- y dialquilamino de C1-6, carboxilo, alquiloxicarbonilo de C1-6 y alquilcarbonilo de C1-6; Alk es alcanodiilo de C1-4; D es una pirimidinona, piperidona o una bencimidozolidinona; que tiene actividad antisicotica; su preparacion, las composiciones que los contienen y su uso como medicamento.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP95200229.3 | 1995-01-31 | ||
| EP95200229 | 1995-01-31 | ||
| PCT/EP1996/000363 WO1996023784A1 (en) | 1995-01-31 | 1996-01-23 | Antipsychotic 4-(1h-indolyl-1-yl)-1-substituted piperidine derivatives |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MX9705821A true MX9705821A (es) | 1997-10-31 |
| MXPA97005821A MXPA97005821A (es) | 1998-07-03 |
Family
ID=
Also Published As
| Publication number | Publication date |
|---|---|
| CA2210913C (en) | 2008-10-21 |
| PL183291B1 (pl) | 2002-06-28 |
| EP0808313B1 (en) | 2003-08-13 |
| FI973164A0 (fi) | 1997-07-30 |
| MY130950A (en) | 2007-07-31 |
| NO973508L (no) | 1997-07-30 |
| FI973164A7 (fi) | 1997-07-30 |
| AR002025A1 (es) | 1998-01-07 |
| CN1172482A (zh) | 1998-02-04 |
| JPH10512893A (ja) | 1998-12-08 |
| WO1996023784A1 (en) | 1996-08-08 |
| US5919788A (en) | 1999-07-06 |
| ZA96702B (en) | 1997-07-30 |
| DE69629454T2 (de) | 2004-06-17 |
| NO308537B1 (no) | 2000-09-25 |
| EP0808313A1 (en) | 1997-11-26 |
| KR100415391B1 (ko) | 2004-05-06 |
| ES2205015T3 (es) | 2004-05-01 |
| KR19980701692A (ko) | 1998-06-25 |
| PL321565A1 (en) | 1997-12-08 |
| IL116930A (en) | 2000-06-29 |
| CN1152874C (zh) | 2004-06-09 |
| TW421649B (en) | 2001-02-11 |
| NZ301264A (en) | 1998-07-28 |
| ATE247105T1 (de) | 2003-08-15 |
| NO973508D0 (no) | 1997-07-30 |
| DE69629454D1 (en) | 2003-09-18 |
| IL116930A0 (en) | 1996-05-14 |
| AU702931B2 (en) | 1999-03-11 |
| AU4664596A (en) | 1996-08-21 |
| CA2210913A1 (en) | 1996-08-08 |
| JP3980054B2 (ja) | 2007-09-19 |
| FI973164L (fi) | 1997-07-30 |
| BR9606815A (pt) | 1997-12-30 |
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