AR002016A1 - Derivados de 3-fenilisoquinoleina-1-(2h)-ona, procedimiento para su preparacion y medicamento y composicion farmaceutica que los contienen. - Google Patents
Derivados de 3-fenilisoquinoleina-1-(2h)-ona, procedimiento para su preparacion y medicamento y composicion farmaceutica que los contienen.Info
- Publication number
- AR002016A1 AR002016A1 ARP950100767A AR10076795A AR002016A1 AR 002016 A1 AR002016 A1 AR 002016A1 AR P950100767 A ARP950100767 A AR P950100767A AR 10076795 A AR10076795 A AR 10076795A AR 002016 A1 AR002016 A1 AR 002016A1
- Authority
- AR
- Argentina
- Prior art keywords
- group
- derivatives
- contain
- pharmaceutical composition
- alkyl group
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
- C07D217/24—Oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
Abstract
La presente invención se refiere a derivados de 3-fenilisoquinoleína-1-(2H) -ONA que responden a la fórmula general (I), en la cual X representa un átomode hidrógeno, un átomo de halógeno, un grupo trifluorometilo, un grupo alquilo, o bien uno o dosgrupos alcoxi, Y representa un átomo de hidrógeno, un átomode halógeno, un grupo alquilo o grupo alcoxi, R1 representa un grupo alquilo y R representa un grupo hidroxi, un grupo metoxi, un grupo etoxi, o bien ungrupo de la fórmula general NR2R3 enla cual R2 y R3 representan cada cual un átomo de hidrógeno o un grupo alquilo. Su aplicación es en la terapéutica.Además, se refiere a un procedimiento para preparar dichos derivados y a un medicamento y composición farmacéutica que los contienen.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR9415837A FR2728900B1 (fr) | 1994-12-29 | 1994-12-29 | Derives de 3-phenylisoquinolein-1(2h)-one, leur preparation et leur application en therapeutique |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR002016A1 true AR002016A1 (es) | 1998-01-07 |
Family
ID=9470390
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP950100767A AR002016A1 (es) | 1994-12-29 | 1995-12-27 | Derivados de 3-fenilisoquinoleina-1-(2h)-ona, procedimiento para su preparacion y medicamento y composicion farmaceutica que los contienen. |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US5665733A (es) |
| EP (1) | EP0719764B1 (es) |
| JP (1) | JPH08239365A (es) |
| KR (1) | KR960022472A (es) |
| CN (1) | CN1131150A (es) |
| AR (1) | AR002016A1 (es) |
| AT (1) | ATE172966T1 (es) |
| AU (1) | AU698595B2 (es) |
| BR (1) | BR9506106A (es) |
| CA (1) | CA2166234A1 (es) |
| CO (1) | CO4700298A1 (es) |
| CZ (1) | CZ348995A3 (es) |
| DE (1) | DE69505780D1 (es) |
| FI (1) | FI956298A7 (es) |
| FR (1) | FR2728900B1 (es) |
| HU (1) | HU215394B (es) |
| IL (1) | IL116590A0 (es) |
| NO (1) | NO955326L (es) |
| NZ (1) | NZ280765A (es) |
| PL (1) | PL312079A1 (es) |
| SK (1) | SK165795A3 (es) |
| ZA (1) | ZA9511046B (es) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2750427B1 (fr) * | 1996-06-28 | 1998-08-07 | Synthelabo | Derives de 1-oxo-1, 2-dihydroisoquinoleine-4-propanamide, leur preparation et leur application en therapeutique |
| FR2772758B1 (fr) * | 1997-12-22 | 2000-02-04 | Synthelabo | Derives de 1-oxo-1,2-dihydroisoquinoleine-4-propanamide, leur preparation et leur application en therapeutique |
| ES2361924T3 (es) * | 2002-12-20 | 2011-06-24 | X-Ceptor Therapeutics, Inc. | Derivados de isoquinolinona y su uso como agentes terapéuticos. |
| GB0420722D0 (en) * | 2004-09-17 | 2004-10-20 | Addex Pharmaceuticals Sa | Novel allosteric modulators |
| AU2007283570A1 (en) * | 2006-08-10 | 2008-02-14 | Ferrer Internacional S.A. | 1H-quinolin-4-one compounds, with affinity for the GABA receptor, processes, uses and compositions |
| EP1886996A1 (en) * | 2006-08-10 | 2008-02-13 | Ferrer Internacional, S.A. | 1H-Quinolin-4-one compounds, with affinity for the GABA receptor, processes, uses and compositions |
| EP2387564A1 (en) | 2009-01-15 | 2011-11-23 | Rutgers, The State University of New Jersey | Benzo ýc¨phenanthridines as antimicrobial agents |
| WO2010127307A1 (en) | 2009-04-30 | 2010-11-04 | Rutgers, The State University Of New Jersey | Antimicrobial agents |
| FR2956816B1 (fr) * | 2010-03-01 | 2012-05-18 | Univ Joseph Fourier | Utilisation de quinolones pour la preparation de medicaments, nouvelles quinolones et leur procede de synthese |
| CA2810162A1 (en) | 2010-06-09 | 2011-12-15 | Rutgers, The State University Of New Jersey | Antimicrobial agents |
| CA2803890A1 (en) | 2010-06-25 | 2011-12-29 | Rutgers, The State University Of New Jersey | Antimicrobial agents |
| WO2013106756A2 (en) | 2012-01-13 | 2013-07-18 | Rutgers, The State University Of New Jersey | Antimicrobial agents |
| WO2013142712A1 (en) | 2012-03-21 | 2013-09-26 | Rutgers, The State University Of New Jersey | Antimicrobial agents |
| US9458150B2 (en) | 2013-11-08 | 2016-10-04 | Rutgers, The State University Of New Jersey | Antimicrobial agents |
| CN109195957A (zh) | 2016-02-25 | 2019-01-11 | 塔克西斯医药股份有限公司 | 合成方法和中间体 |
| US10774093B2 (en) | 2017-03-30 | 2020-09-15 | Taxis Pharmaceuticals, Inc. | Synthetic processes and synthetic intermediates |
| US20240043418A1 (en) * | 2020-03-26 | 2024-02-08 | Richter Gedeon Nyrt. | 1,3-dihydro-2h-pyrrolo[3,4-c]pyridine derivatives as gabaa a5 receptor modulators |
| TWI901650B (zh) * | 2020-03-26 | 2025-10-21 | 匈牙利商羅特格登公司 | 啶及吡啶并〔３，４－ｃ〕嗒衍生物 |
-
1994
- 1994-12-29 FR FR9415837A patent/FR2728900B1/fr not_active Expired - Fee Related
-
1995
- 1995-12-18 DE DE69505780T patent/DE69505780D1/de not_active Expired - Lifetime
- 1995-12-18 AT AT95402842T patent/ATE172966T1/de not_active IP Right Cessation
- 1995-12-18 EP EP95402842A patent/EP0719764B1/fr not_active Expired - Lifetime
- 1995-12-21 NZ NZ280765A patent/NZ280765A/en unknown
- 1995-12-27 JP JP7340607A patent/JPH08239365A/ja active Pending
- 1995-12-27 AR ARP950100767A patent/AR002016A1/es unknown
- 1995-12-28 HU HU9503848A patent/HU215394B/hu not_active IP Right Cessation
- 1995-12-28 KR KR1019950061341A patent/KR960022472A/ko not_active Withdrawn
- 1995-12-28 BR BR9506106A patent/BR9506106A/pt not_active Application Discontinuation
- 1995-12-28 CZ CZ953489A patent/CZ348995A3/cs unknown
- 1995-12-28 FI FI956298A patent/FI956298A7/fi not_active Application Discontinuation
- 1995-12-28 CA CA002166234A patent/CA2166234A1/en not_active Abandoned
- 1995-12-28 ZA ZA9511046A patent/ZA9511046B/xx unknown
- 1995-12-28 PL PL95312079A patent/PL312079A1/xx unknown
- 1995-12-28 SK SK1657-95A patent/SK165795A3/sk unknown
- 1995-12-28 CN CN95120638A patent/CN1131150A/zh active Pending
- 1995-12-28 AU AU40712/95A patent/AU698595B2/en not_active Ceased
- 1995-12-28 NO NO955326A patent/NO955326L/no unknown
- 1995-12-28 CO CO95062144A patent/CO4700298A1/es unknown
- 1995-12-28 US US08/579,677 patent/US5665733A/en not_active Expired - Fee Related
- 1995-12-28 IL IL11659095A patent/IL116590A0/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP0719764A1 (fr) | 1996-07-03 |
| IL116590A0 (en) | 1996-03-31 |
| NZ280765A (en) | 1996-08-27 |
| HU9503848D0 (en) | 1996-02-28 |
| CN1131150A (zh) | 1996-09-18 |
| FI956298L (fi) | 1996-06-30 |
| SK165795A3 (en) | 1996-07-03 |
| NO955326L (no) | 1996-07-01 |
| CZ348995A3 (en) | 1996-07-17 |
| FI956298A0 (fi) | 1995-12-28 |
| NO955326D0 (no) | 1995-12-28 |
| CA2166234A1 (en) | 1996-06-30 |
| KR960022472A (ko) | 1996-07-18 |
| BR9506106A (pt) | 1997-12-23 |
| PL312079A1 (en) | 1996-07-08 |
| ZA9511046B (en) | 1996-07-11 |
| CO4700298A1 (es) | 1998-12-29 |
| DE69505780D1 (de) | 1998-12-10 |
| EP0719764B1 (fr) | 1998-11-04 |
| HUT74187A (en) | 1996-11-28 |
| JPH08239365A (ja) | 1996-09-17 |
| HU215394B (hu) | 1998-12-28 |
| US5665733A (en) | 1997-09-09 |
| AU4071295A (en) | 1996-07-04 |
| FR2728900A1 (fr) | 1996-07-05 |
| FR2728900B1 (fr) | 1997-01-31 |
| FI956298A7 (fi) | 1996-06-30 |
| AU698595B2 (en) | 1998-11-05 |
| ATE172966T1 (de) | 1998-11-15 |
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