AR001153A1 - Proceso reductivo de aminación para obtener n-(2(r)-hidroxi-(s)-indanil)-2(r)-fenilmetil-4(s)-hidroxi-5-(1-(4-(3-piridilmetil)-2(s)-n1-(t-butilcarboxamido)-piperazinil))pentanamida - Google Patents
Proceso reductivo de aminación para obtener n-(2(r)-hidroxi-(s)-indanil)-2(r)-fenilmetil-4(s)-hidroxi-5-(1-(4-(3-piridilmetil)-2(s)-n1-(t-butilcarboxamido)-piperazinil))pentanamidaInfo
- Publication number
- AR001153A1 AR001153A1 AR33563996A AR33563996A AR001153A1 AR 001153 A1 AR001153 A1 AR 001153A1 AR 33563996 A AR33563996 A AR 33563996A AR 33563996 A AR33563996 A AR 33563996A AR 001153 A1 AR001153 A1 AR 001153A1
- Authority
- AR
- Argentina
- Prior art keywords
- hydroxy
- butylcarboxamido
- pentanamide
- pyridylmethyl
- phenylmethyl
- Prior art date
Links
- -1 3-pyridylmethyl Chemical group 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- IPWFJLQDVFKJDU-UHFFFAOYSA-N pentanamide Chemical compound CCCCC(N)=O IPWFJLQDVFKJDU-UHFFFAOYSA-N 0.000 title abstract 2
- 238000006268 reductive amination reaction Methods 0.000 title abstract 2
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
Abstract
Un proceso reductivo de aminación que eficientemente produce N-(2(R)- hidroxi-(S)-indanil)-2(R)-fenilmetil-4(S)-hidroxi-S-(1-(4-(3-piridilmetil)-2(S)-N1-(t-butilcarboxamido)-piperazinil))pentanamida.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/404,776 US5508404A (en) | 1995-03-15 | 1995-03-15 | Reductive amination process |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR001153A1 true AR001153A1 (es) | 1997-09-24 |
Family
ID=23600989
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AR33563996A AR001153A1 (es) | 1995-03-15 | 1996-03-05 | Proceso reductivo de aminación para obtener n-(2(r)-hidroxi-(s)-indanil)-2(r)-fenilmetil-4(s)-hidroxi-5-(1-(4-(3-piridilmetil)-2(s)-n1-(t-butilcarboxamido)-piperazinil))pentanamida |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US5508404A (es) |
| EP (1) | EP0815102A1 (es) |
| CN (1) | CN1183780A (es) |
| AR (1) | AR001153A1 (es) |
| AU (1) | AU5175196A (es) |
| BR (1) | BR9607374A (es) |
| CZ (1) | CZ291035B6 (es) |
| EA (1) | EA000635B1 (es) |
| HR (1) | HRP960113A2 (es) |
| SK (1) | SK122797A3 (es) |
| TW (1) | TW349947B (es) |
| WO (1) | WO1996028440A1 (es) |
| YU (1) | YU15596A (es) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6576664B1 (en) * | 1997-08-18 | 2003-06-10 | Bristol-Myers Squibb Pharma Company | Inhibitors of aggrecanase and matrix metalloproteinases for the treatment of arthritis |
| US7199240B2 (en) * | 2002-12-11 | 2007-04-03 | Merck & Co., Inc. | Reductive alkylation of saturated cyclic amines |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB705979A (en) * | 1951-03-22 | 1954-03-24 | Henri Morren | 1.4-aralkyl piperazines and process for the preparation thereof |
| JPS57106681A (en) * | 1980-12-24 | 1982-07-02 | Dainippon Pharmaceut Co Ltd | 1,8-naphthyridine derivative and its salt |
| ES2112880T3 (es) * | 1991-11-08 | 1998-04-16 | Merck & Co Inc | Inhibidores de la proteasa de vih utiles para el tratamiento del sida. |
-
1995
- 1995-03-15 US US08/404,776 patent/US5508404A/en not_active Expired - Fee Related
-
1996
- 1996-03-05 AR AR33563996A patent/AR001153A1/es not_active Application Discontinuation
- 1996-03-06 TW TW085102720A patent/TW349947B/zh active
- 1996-03-11 HR HR08/404,776A patent/HRP960113A2/hr not_active Application Discontinuation
- 1996-03-11 WO PCT/US1996/002646 patent/WO1996028440A1/en not_active Ceased
- 1996-03-11 CN CN96193740A patent/CN1183780A/zh active Pending
- 1996-03-11 CZ CZ19972864A patent/CZ291035B6/cs not_active IP Right Cessation
- 1996-03-11 AU AU51751/96A patent/AU5175196A/en not_active Abandoned
- 1996-03-11 EA EA199700234A patent/EA000635B1/ru not_active IP Right Cessation
- 1996-03-11 EP EP96908541A patent/EP0815102A1/en not_active Withdrawn
- 1996-03-11 BR BR9607374A patent/BR9607374A/pt not_active Application Discontinuation
- 1996-03-11 SK SK1227-97A patent/SK122797A3/sk unknown
- 1996-03-15 YU YU15596A patent/YU15596A/sh unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US5508404A (en) | 1996-04-16 |
| YU15596A (sh) | 1999-07-28 |
| EA199700234A1 (ru) | 1998-04-30 |
| CZ291035B6 (cs) | 2002-12-11 |
| WO1996028440A1 (en) | 1996-09-19 |
| HRP960113A2 (en) | 1997-10-31 |
| CN1183780A (zh) | 1998-06-03 |
| TW349947B (en) | 1999-01-11 |
| BR9607374A (pt) | 1997-12-30 |
| SK122797A3 (en) | 1998-03-04 |
| EA000635B1 (ru) | 1999-12-29 |
| EP0815102A1 (en) | 1998-01-07 |
| AU5175196A (en) | 1996-10-02 |
| CZ286497A3 (cs) | 1998-02-18 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |