AR001082A1 - Bencenosulfonilureas y bencenosulfoniltioureas sustituidas procedimiento para su preparación y su empleo para la producción de preparados farmacéuticos asi como preparados farmacéuticos que las contienen - Google Patents
Bencenosulfonilureas y bencenosulfoniltioureas sustituidas procedimiento para su preparación y su empleo para la producción de preparados farmacéuticos asi como preparados farmacéuticos que las contienenInfo
- Publication number
- AR001082A1 AR001082A1 AR33535596A AR33535596A AR001082A1 AR 001082 A1 AR001082 A1 AR 001082A1 AR 33535596 A AR33535596 A AR 33535596A AR 33535596 A AR33535596 A AR 33535596A AR 001082 A1 AR001082 A1 AR 001082A1
- Authority
- AR
- Argentina
- Prior art keywords
- atoms
- pharmaceutical preparations
- alkyl
- benzenesulfonylureas
- procedure
- Prior art date
Links
- 239000000825 pharmaceutical preparation Substances 0.000 title 2
- 238000004519 manufacturing process Methods 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 238000002360 preparation method Methods 0.000 title 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 9
- 125000000217 alkyl group Chemical group 0.000 abstract 5
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 239000001257 hydrogen Substances 0.000 abstract 3
- 229910052760 oxygen Inorganic materials 0.000 abstract 3
- 229910052717 sulfur Inorganic materials 0.000 abstract 3
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 2
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 2
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 2
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 2
- 239000001301 oxygen Substances 0.000 abstract 2
- 239000011593 sulfur Substances 0.000 abstract 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000004429 atom Chemical group 0.000 abstract 1
- 125000002541 furyl group Chemical group 0.000 abstract 1
- 125000005842 heteroatom Chemical group 0.000 abstract 1
- 125000001183 hydrocarbyl group Chemical group 0.000 abstract 1
- 125000005358 mercaptoalkyl group Chemical group 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 125000004076 pyridyl group Chemical group 0.000 abstract 1
- 125000000168 pyrrolyl group Chemical group 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- -1 thiazolylonaphthyl Chemical group 0.000 abstract 1
- 125000001544 thienyl group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C335/00—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C335/40—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of thiourea or isothiourea groups further bound to other hetero atoms
- C07C335/42—Sulfonylthioureas; Sulfonylisothioureas
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/50—Compounds containing any of the groups, X being a hetero atom, Y being any atom
- C07C311/52—Y being a hetero atom
- C07C311/54—Y being a hetero atom either X or Y, but not both, being nitrogen atoms, e.g. N-sulfonylurea
- C07C311/57—Y being a hetero atom either X or Y, but not both, being nitrogen atoms, e.g. N-sulfonylurea having sulfur atoms of the sulfonylurea groups bound to carbon atoms of six-membered aromatic rings
- C07C311/58—Y being a hetero atom either X or Y, but not both, being nitrogen atoms, e.g. N-sulfonylurea having sulfur atoms of the sulfonylurea groups bound to carbon atoms of six-membered aromatic rings having nitrogen atoms of the sulfonylurea groups bound to hydrogen atoms or to acyclic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Cardiology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Heart & Thoracic Surgery (AREA)
- Hospice & Palliative Care (AREA)
- Surgery (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Furan Compounds (AREA)
- Pyrrole Compounds (AREA)
- Pyridine Compounds (AREA)
Abstract
Bencenosulfonilureas y bencenosulfoniltioureas sustituidas de la fórmula (I), en donde: R(1) significa hidrógeno, alquilo con 1, 2, 3, 4, 5 ó 6 átomosde C o cicloalquilo con 1, 2, 3, 4, 5 ó 6 átomos de C; R(2) significa alquilo con 1, 2, 3, 4, 5ó 6 átomos de C, alcoxi con 3, 4, 5 ó 6 átomos de C,mercaptoalquilo con 1, 2, 3, 4, 5 ó 6 átomos de C; cicloalquilo con 3, 4, 5 ó 6 átomos de C, o cadenas de (C1-C3) en las que uno a tres átomos de C puedenestar reemplazados por heteroátomos O, NH yS; R(3) y R(4) (iguales o diferentes) significan hidrógeno, alquilo con 1, 2, 3, 4, 5 ó 6 átomos de C oforman juntos una cadena de (CH2)2-5; E significa oxígeno o azufre; X significa oxígeno o azufre; Y significa una cadena de hidrocarburos de la fórmula[CR(5)2]m; R(5) significa hidrógeno o alquilo con 1 ó 2 átomos de C; m significa 1 ó 2; Ar significa fenilo, tienilo, furilo, pirrolilo, tiazolilonaftilo, piridilo, que en cada caso está no sustituido o está sustituido conuno a 3 sustituyentes elegidos del grupo consistente en alquilo con 1 ó 2átomos de C, alcoxi; con 1 ó 2 átomos de C, Cl, Br ó F.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19504379A DE19504379A1 (de) | 1995-02-10 | 1995-02-10 | Substituierte Benzolsulfonylharnstoffe und -thioharnstoffe, Verfahren zu ihrer Herstellung und ihre Verwendung zur Herstellung pharmazeutischer Präparate sowie sie enthaltende pharmazeutische Präparate |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR001082A1 true AR001082A1 (es) | 1997-09-24 |
Family
ID=7753608
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AR33535596A AR001082A1 (es) | 1995-02-10 | 1996-02-08 | Bencenosulfonilureas y bencenosulfoniltioureas sustituidas procedimiento para su preparación y su empleo para la producción de preparados farmacéuticos asi como preparados farmacéuticos que las contienen |
Country Status (30)
| Country | Link |
|---|---|
| US (1) | US5607976A (es) |
| EP (1) | EP0726250B1 (es) |
| JP (1) | JP3774773B2 (es) |
| KR (1) | KR100446565B1 (es) |
| CN (1) | CN1064041C (es) |
| AR (1) | AR001082A1 (es) |
| AT (1) | ATE197291T1 (es) |
| AU (1) | AU700883B2 (es) |
| BR (1) | BR9600370A (es) |
| CA (1) | CA2169219C (es) |
| CZ (1) | CZ290809B6 (es) |
| DE (2) | DE19504379A1 (es) |
| DK (1) | DK0726250T3 (es) |
| ES (1) | ES2152440T3 (es) |
| FI (1) | FI120394B (es) |
| GR (1) | GR3034886T3 (es) |
| HR (1) | HRP960063B1 (es) |
| HU (1) | HU224211B1 (es) |
| IL (1) | IL117078A (es) |
| MY (1) | MY114693A (es) |
| NO (1) | NO305750B1 (es) |
| NZ (1) | NZ280954A (es) |
| PL (1) | PL181656B1 (es) |
| PT (1) | PT726250E (es) |
| RU (1) | RU2155750C2 (es) |
| SI (1) | SI9600040B (es) |
| SK (1) | SK281357B6 (es) |
| TR (1) | TR199600747A2 (es) |
| TW (1) | TW419457B (es) |
| ZA (1) | ZA961050B (es) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19832009A1 (de) | 1998-07-16 | 2000-01-20 | Hoechst Marion Roussel De Gmbh | 2,5-Substituierte Benzolsulfonylharnstoffe und -thioharnstoffe, Verfahren zu ihrer Herstellung, ihre Verwendung und sie enthaltende pharamazeutische Präparate |
| DE19858253A1 (de) * | 1998-12-17 | 2000-06-21 | Aventis Pharma Gmbh | Verwendung von Inhibitoren des KQt1-Kanals zur Herstellung eines Medikaments zur Behandlung von Krankheiten, die durch Helminthen und Ektoparasiten hervorgerufen werden |
| DE10060809A1 (de) * | 2000-12-07 | 2002-06-20 | Aventis Pharma Gmbh | Substituierte Anthranilsäuren, ihre Verwendung als Medikament oder Diagnostikum, sowie sie enthaltendes Medikament, sowie ein pharmazeutisches Kombinationspräparat mit einem Natrium/Wasserstoff-Austausch (NHE)-Blocker |
| DE10129704A1 (de) * | 2001-06-22 | 2003-01-02 | Aventis Pharma Gmbh | Verwendung von Benzolsulfonyl(thio)harnstoffen in der Behandlung des septischen Schocks |
| CN1330630C (zh) * | 2004-03-10 | 2007-08-08 | 中国药科大学 | 新的磺酰(硫)脲衍生物、其制备方法及含有它们的药物组合物 |
| UA87854C2 (en) * | 2004-06-07 | 2009-08-25 | Мерк Энд Ко., Инк. | N-(2-benzyl)-2-phenylbutanamides as androgen receptor modulators |
| US7875636B2 (en) | 2006-04-12 | 2011-01-25 | Merck Sharp & Dohme Corp. | Pyridyl amide T-type calcium channel antagonists |
| CA2701594C (en) * | 2007-10-24 | 2014-02-18 | Merck Sharp & Dohme Corp. | Heterocycle phenyl amide t-type calcium channel antagonists |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE243821C (es) * | ||||
| DE1493672C3 (de) * | 1964-08-01 | 1974-05-02 | Farbwerke Hoechst Ag, Vormals Meister Lucius & Bruening, 6000 Frankfurt | Verfahren zur Herstellung von Benzolsulfonylharnstoffen |
| DE1518874C3 (de) * | 1964-10-07 | 1975-03-13 | Farbwerke Hoechst Ag, Vormals Meister Lucius & Bruening, 6000 Frankfurt | Benzolsulfonylharnstoffe und Verfahren zu ihrer Herstellung |
| DE1443919C3 (de) * | 1964-12-28 | 1973-11-29 | Farbwerke Hoechst Ag, Vormals Meister Lucius & Bruening, 6000 Frankfurt | Benzolsulfonylharnstoffe, Ver fahren zu ihrer Herstellung und diese enthaltende pharmazeutische Zubereitun gen |
| US3917690A (en) * | 1966-11-29 | 1975-11-04 | Hoechst Ag | Benzenesulfonyl ureas and process for their manufacture |
| DE1568648C3 (de) * | 1966-12-19 | 1975-03-27 | Farbwerke Hoechst Ag, Vormals Meister Lucius & Bruening, 6000 Frankfurt | Benzolsulfonylharnstoffe, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Präparate |
| BE754454A (fr) * | 1969-08-06 | 1971-02-05 | Bayer Ag | Nouveaux composes hypoglycemiques du type d'arylsulfonylurees et d'arylsulfonylsemicarbazides contenant des groupes carbonamide |
| DE2413514C3 (de) * | 1974-03-21 | 1982-03-04 | Hoechst Ag, 6000 Frankfurt | N-Acylaminoathylbenzolsulfonyl-N'-methylharnstoffe, Verfahren zu ihrer Herstellung und deren Verwendung |
| DE3011153A1 (de) * | 1980-03-22 | 1981-10-15 | Hoechst Ag, 6000 Frankfurt | Verwendung von n-(4- spitze klammer auf 2-(5-chlor-2-methoxy-benzamido)-aethylspitze klammer zu -benzolsulfonyl)-n'-methyl-harnstoff |
| US5215985A (en) * | 1990-07-20 | 1993-06-01 | E. R. Squibb & Sons, Inc. | Method for treating ischemic insult to neurons employing an ATP-sensitive potassium channel blocker |
| ATE146775T1 (de) * | 1993-02-23 | 1997-01-15 | Hoechst Ag | Substituierte benzolsulfonylharnstoffe und - thioharnstoffe- verfahren zu ihrer herstellung und ihre verwendung als pharmazeutika |
-
1995
- 1995-02-10 DE DE19504379A patent/DE19504379A1/de not_active Withdrawn
- 1995-12-29 HU HU9503932A patent/HU224211B1/hu not_active IP Right Cessation
-
1996
- 1996-01-29 PL PL96312531A patent/PL181656B1/pl not_active IP Right Cessation
- 1996-02-05 TW TW085101375A patent/TW419457B/zh not_active IP Right Cessation
- 1996-02-05 DE DE59606062T patent/DE59606062D1/de not_active Expired - Lifetime
- 1996-02-05 AT AT96101585T patent/ATE197291T1/de active
- 1996-02-05 EP EP96101585A patent/EP0726250B1/de not_active Expired - Lifetime
- 1996-02-05 PT PT96101585T patent/PT726250E/pt unknown
- 1996-02-05 ES ES96101585T patent/ES2152440T3/es not_active Expired - Lifetime
- 1996-02-05 DK DK96101585T patent/DK0726250T3/da active
- 1996-02-06 SI SI9600040A patent/SI9600040B/sl not_active IP Right Cessation
- 1996-02-07 CN CN96101370A patent/CN1064041C/zh not_active Expired - Fee Related
- 1996-02-08 US US08/598,319 patent/US5607976A/en not_active Expired - Lifetime
- 1996-02-08 SK SK175-96A patent/SK281357B6/sk not_active IP Right Cessation
- 1996-02-08 CZ CZ1996382A patent/CZ290809B6/cs not_active IP Right Cessation
- 1996-02-08 FI FI960587A patent/FI120394B/fi not_active IP Right Cessation
- 1996-02-08 HR HR960063A patent/HRP960063B1/xx not_active IP Right Cessation
- 1996-02-08 NZ NZ280954A patent/NZ280954A/en not_active IP Right Cessation
- 1996-02-08 IL IL11707896A patent/IL117078A/xx not_active IP Right Cessation
- 1996-02-08 AR AR33535596A patent/AR001082A1/es unknown
- 1996-02-08 MY MYPI96000472A patent/MY114693A/en unknown
- 1996-02-08 AU AU44429/96A patent/AU700883B2/en not_active Ceased
- 1996-02-08 TR TR96/00102A patent/TR199600747A2/xx unknown
- 1996-02-09 JP JP02392796A patent/JP3774773B2/ja not_active Expired - Fee Related
- 1996-02-09 ZA ZA961050A patent/ZA961050B/xx unknown
- 1996-02-09 BR BR9600370A patent/BR9600370A/pt not_active Application Discontinuation
- 1996-02-09 CA CA002169219A patent/CA2169219C/en not_active Expired - Fee Related
- 1996-02-09 RU RU96102420/04A patent/RU2155750C2/ru not_active IP Right Cessation
- 1996-02-09 NO NO960529A patent/NO305750B1/no not_active IP Right Cessation
- 1996-02-10 KR KR1019960003232A patent/KR100446565B1/ko not_active Expired - Fee Related
-
2000
- 2000-11-22 GR GR20000402575T patent/GR3034886T3/el unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ES2196344T3 (es) | Derivados de sulfonamida y su uso en el tratamiento de trastornos de snc. | |
| NZ335396A (en) | Methods and compositions for stimulating neurite growth using compounds with affinity for fkbp12 in combination with neurotrophic factors | |
| ES2146741T3 (es) | Derivados de rapamicina utiles como inmunosupresores. | |
| AR042572A1 (es) | Derivados de acido lipoico, procedimiento para su preparacion, medicamentos y composiciones farmaceuticas que los contienen y utilizacion de dichos derivados para la preparacion de los referidos medicamentos | |
| TW200613290A (en) | Substituted urea compounds | |
| ATE411285T1 (de) | Prolin-derivate und deren verwendung als medikamente | |
| AR048080A2 (es) | Metodo para el control de enfermedades y horticolas de plantas | |
| EA199800288A1 (ru) | Производные 5-o-дезозаминил-6-o-метилэритронолида а, способ их получения и их применение для получения биологически активных продуктов | |
| ES2090855T3 (es) | Derivados de naftaleno, procedimientos para su preparacion y productos intermediarios apropiados. | |
| AR001082A1 (es) | Bencenosulfonilureas y bencenosulfoniltioureas sustituidas procedimiento para su preparación y su empleo para la producción de preparados farmacéuticos asi como preparados farmacéuticos que las contienen | |
| ATE46157T1 (de) | Benzo(b>thiophen und benzo(b>furancarboxamidderivate, ihre verfahren zur herstellung und sie enthaltende arzneimittel. | |
| ES2077070T3 (es) | Intermedio de sintesis de 2-alquiniladenosina, produccion de dicho intermedio, produccion de 2-alquiniladenosina a partir de dicho intermedio, y derivado de 2-alquiniladenosina estable. | |
| ES521191A0 (es) | Procedimiento de preparacion de polimetileno-iminas disustituidas y de sus sales de adicion con acidos apropiados. | |
| EA200200096A1 (ru) | Новые производные витамина d с циклическими субструктурами в боковых цепях, способ и промежуточные продукты для их получения и их применение для получения лекарственных средств | |
| ATE211474T1 (de) | Galanthamin derivate, verfahren zu ihrer herstellung und ihre verwendung als medikamente | |
| ES2138660T3 (es) | Derivados de brasinosteroides y regulador del crecimiento de las plantas que contiene los mismos. | |
| ES2089709T3 (es) | Derivados de pirrolidina y procedimiento para prepararlos. | |
| ATE194851T1 (de) | Amidinophenylalaninderivate, verfahren zu deren herstellung, deren verwendung und diese enthaltende mittel als antikoagulantien | |
| DE69030052D1 (de) | Lösliche, nichttoxische Derivate von basischen Polyenmakroliden, ihre Herstellung und Verwendung | |
| EA199800949A1 (ru) | Антибактериальные соединения карбапенема, содержащие их фармацевтические композиции и способы лечения | |
| IT1071500B (it) | Processo per la produzione di idrocarburi aromatici da idrocarburi a catena aperta in presenza di un catalizzatore al gallio | |
| ES2068497T3 (es) | Derivados de urea, su produccion, y composiciones farmaceuticas que los contienen. | |
| ES480602A1 (es) | Un procedimiento para la preparacion de nuevos derivados de indol. | |
| ES2149871T3 (es) | Taxanos que tienen una cadena lateral de substitucion amino. | |
| AR033004A1 (es) | Procedimiento para elaborar 2,6-dialquilmorfolinas n-sustituidas |