SI9600040B - Substituted benzensulphonyl ureas and thioureas, process for the preparation thereof and use thereof for the preparation of pharmaceutical preparations as well as pharmaceutical preparations containing them - Google Patents
Substituted benzensulphonyl ureas and thioureas, process for the preparation thereof and use thereof for the preparation of pharmaceutical preparations as well as pharmaceutical preparations containing them Download PDFInfo
- Publication number
- SI9600040B SI9600040B SI9600040A SI9600040A SI9600040B SI 9600040 B SI9600040 B SI 9600040B SI 9600040 A SI9600040 A SI 9600040A SI 9600040 A SI9600040 A SI 9600040A SI 9600040 B SI9600040 B SI 9600040B
- Authority
- SI
- Slovenia
- Prior art keywords
- formula
- atoms
- alkyl
- substituted
- carbon atoms
- Prior art date
Links
- 238000002360 preparation method Methods 0.000 title claims 8
- -1 benzensulphonyl ureas Chemical class 0.000 title claims 5
- 238000000034 method Methods 0.000 title claims 2
- 239000000825 pharmaceutical preparation Substances 0.000 title 2
- 235000013877 carbamide Nutrition 0.000 title 1
- 150000003585 thioureas Chemical class 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 claims abstract 20
- 229910052760 oxygen Inorganic materials 0.000 claims abstract 13
- 125000003545 alkoxy group Chemical group 0.000 claims abstract 11
- 229910052717 sulfur Inorganic materials 0.000 claims abstract 10
- GHDLZGOOOLEJKI-UHFFFAOYSA-N benzenesulfonylurea Chemical compound NC(=O)NS(=O)(=O)C1=CC=CC=C1 GHDLZGOOOLEJKI-UHFFFAOYSA-N 0.000 claims abstract 9
- 125000000753 cycloalkyl group Chemical group 0.000 claims abstract 6
- 125000002541 furyl group Chemical group 0.000 claims abstract 5
- 125000001624 naphthyl group Chemical group 0.000 claims abstract 5
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims abstract 5
- 125000004076 pyridyl group Chemical group 0.000 claims abstract 5
- 125000000168 pyrrolyl group Chemical group 0.000 claims abstract 5
- 125000000335 thiazolyl group Chemical group 0.000 claims abstract 5
- 125000001544 thienyl group Chemical group 0.000 claims abstract 5
- 125000004432 carbon atom Chemical group C* 0.000 claims 32
- 229910052739 hydrogen Inorganic materials 0.000 claims 12
- 239000001257 hydrogen Substances 0.000 claims 12
- 150000001875 compounds Chemical class 0.000 claims 11
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 9
- 239000001301 oxygen Substances 0.000 claims 9
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 7
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims 6
- 239000003814 drug Substances 0.000 claims 6
- 239000011593 sulfur Substances 0.000 claims 6
- 125000001183 hydrocarbyl group Chemical group 0.000 claims 5
- 150000002431 hydrogen Chemical class 0.000 claims 5
- 150000003839 salts Chemical class 0.000 claims 5
- 125000001424 substituent group Chemical group 0.000 claims 5
- KHBQMWCZKVMBLN-UHFFFAOYSA-N Benzenesulfonamide Chemical compound NS(=O)(=O)C1=CC=CC=C1 KHBQMWCZKVMBLN-UHFFFAOYSA-N 0.000 claims 3
- PVMBGVAQRSHDBB-UHFFFAOYSA-N benzenesulfonylthiourea Chemical compound NC(=S)NS(=O)(=O)C1=CC=CC=C1 PVMBGVAQRSHDBB-UHFFFAOYSA-N 0.000 claims 3
- 239000012948 isocyanate Substances 0.000 claims 3
- 150000001412 amines Chemical class 0.000 claims 2
- 125000003118 aryl group Chemical group 0.000 claims 2
- 239000004202 carbamide Substances 0.000 claims 2
- 229910052799 carbon Inorganic materials 0.000 claims 2
- 125000005842 heteroatom Chemical group 0.000 claims 2
- 150000002513 isocyanates Chemical class 0.000 claims 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 2
- QGZKDVFQNNGYKY-UHFFFAOYSA-O Ammonium Chemical compound [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 claims 1
- 206010049418 Sudden Cardiac Death Diseases 0.000 claims 1
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 claims 1
- 229910001413 alkali metal ion Inorganic materials 0.000 claims 1
- 229910052784 alkaline earth metal Inorganic materials 0.000 claims 1
- 150000001342 alkaline earth metals Chemical class 0.000 claims 1
- 125000004429 atom Chemical group 0.000 claims 1
- 239000002585 base Substances 0.000 claims 1
- 125000001246 bromo group Chemical group Br* 0.000 claims 1
- 230000000747 cardiac effect Effects 0.000 claims 1
- 125000001309 chloro group Chemical group Cl* 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 208000035475 disorder Diseases 0.000 claims 1
- 125000001153 fluoro group Chemical group F* 0.000 claims 1
- 230000004217 heart function Effects 0.000 claims 1
- 230000001771 impaired effect Effects 0.000 claims 1
- 239000012442 inert solvent Substances 0.000 claims 1
- 230000000302 ischemic effect Effects 0.000 claims 1
- 150000002540 isothiocyanates Chemical class 0.000 claims 1
- ZACBJJDJJBGIDC-UHFFFAOYSA-N n-(sulfanylidenemethylidene)benzenesulfonamide Chemical compound S=C=NS(=O)(=O)C1=CC=CC=C1 ZACBJJDJJBGIDC-UHFFFAOYSA-N 0.000 claims 1
- 239000007800 oxidant agent Substances 0.000 claims 1
- 230000033764 rhythmic process Effects 0.000 claims 1
- 229910052710 silicon Inorganic materials 0.000 claims 1
- 239000010703 silicon Substances 0.000 claims 1
- RISUTSCZAANJJQ-UHFFFAOYSA-N sulfinylurea Chemical compound NC(=O)N=S=O RISUTSCZAANJJQ-UHFFFAOYSA-N 0.000 claims 1
- 229940124530 sulfonamide Drugs 0.000 claims 1
- UVVUGWBBCDFNSD-UHFFFAOYSA-N tetraisocyanatosilane Chemical compound O=C=N[Si](N=C=O)(N=C=O)N=C=O UVVUGWBBCDFNSD-UHFFFAOYSA-N 0.000 claims 1
- 238000002054 transplantation Methods 0.000 claims 1
- 125000004665 trialkylsilyl group Chemical group 0.000 claims 1
- 150000003672 ureas Chemical class 0.000 claims 1
- 125000005358 mercaptoalkyl group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C335/00—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C335/40—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of thiourea or isothiourea groups further bound to other hetero atoms
- C07C335/42—Sulfonylthioureas; Sulfonylisothioureas
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/50—Compounds containing any of the groups, X being a hetero atom, Y being any atom
- C07C311/52—Y being a hetero atom
- C07C311/54—Y being a hetero atom either X or Y, but not both, being nitrogen atoms, e.g. N-sulfonylurea
- C07C311/57—Y being a hetero atom either X or Y, but not both, being nitrogen atoms, e.g. N-sulfonylurea having sulfur atoms of the sulfonylurea groups bound to carbon atoms of six-membered aromatic rings
- C07C311/58—Y being a hetero atom either X or Y, but not both, being nitrogen atoms, e.g. N-sulfonylurea having sulfur atoms of the sulfonylurea groups bound to carbon atoms of six-membered aromatic rings having nitrogen atoms of the sulfonylurea groups bound to hydrogen atoms or to acyclic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Cardiology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Heart & Thoracic Surgery (AREA)
- Hospice & Palliative Care (AREA)
- Surgery (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Furan Compounds (AREA)
- Pyrrole Compounds (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19504379A DE19504379A1 (de) | 1995-02-10 | 1995-02-10 | Substituierte Benzolsulfonylharnstoffe und -thioharnstoffe, Verfahren zu ihrer Herstellung und ihre Verwendung zur Herstellung pharmazeutischer Präparate sowie sie enthaltende pharmazeutische Präparate |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| SI9600040A SI9600040A (en) | 1996-10-31 |
| SI9600040B true SI9600040B (en) | 2001-12-31 |
Family
ID=7753608
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SI9600040A SI9600040B (en) | 1995-02-10 | 1996-02-06 | Substituted benzensulphonyl ureas and thioureas, process for the preparation thereof and use thereof for the preparation of pharmaceutical preparations as well as pharmaceutical preparations containing them |
Country Status (30)
| Country | Link |
|---|---|
| US (1) | US5607976A (es) |
| EP (1) | EP0726250B1 (es) |
| JP (1) | JP3774773B2 (es) |
| KR (1) | KR100446565B1 (es) |
| CN (1) | CN1064041C (es) |
| AR (1) | AR001082A1 (es) |
| AT (1) | ATE197291T1 (es) |
| AU (1) | AU700883B2 (es) |
| BR (1) | BR9600370A (es) |
| CA (1) | CA2169219C (es) |
| CZ (1) | CZ290809B6 (es) |
| DE (2) | DE19504379A1 (es) |
| DK (1) | DK0726250T3 (es) |
| ES (1) | ES2152440T3 (es) |
| FI (1) | FI120394B (es) |
| GR (1) | GR3034886T3 (es) |
| HR (1) | HRP960063B1 (es) |
| HU (1) | HU224211B1 (es) |
| IL (1) | IL117078A (es) |
| MY (1) | MY114693A (es) |
| NO (1) | NO305750B1 (es) |
| NZ (1) | NZ280954A (es) |
| PL (1) | PL181656B1 (es) |
| PT (1) | PT726250E (es) |
| RU (1) | RU2155750C2 (es) |
| SI (1) | SI9600040B (es) |
| SK (1) | SK281357B6 (es) |
| TR (1) | TR199600747A2 (es) |
| TW (1) | TW419457B (es) |
| ZA (1) | ZA961050B (es) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19832009A1 (de) | 1998-07-16 | 2000-01-20 | Hoechst Marion Roussel De Gmbh | 2,5-Substituierte Benzolsulfonylharnstoffe und -thioharnstoffe, Verfahren zu ihrer Herstellung, ihre Verwendung und sie enthaltende pharamazeutische Präparate |
| DE19858253A1 (de) * | 1998-12-17 | 2000-06-21 | Aventis Pharma Gmbh | Verwendung von Inhibitoren des KQt1-Kanals zur Herstellung eines Medikaments zur Behandlung von Krankheiten, die durch Helminthen und Ektoparasiten hervorgerufen werden |
| DE10060809A1 (de) * | 2000-12-07 | 2002-06-20 | Aventis Pharma Gmbh | Substituierte Anthranilsäuren, ihre Verwendung als Medikament oder Diagnostikum, sowie sie enthaltendes Medikament, sowie ein pharmazeutisches Kombinationspräparat mit einem Natrium/Wasserstoff-Austausch (NHE)-Blocker |
| DE10129704A1 (de) * | 2001-06-22 | 2003-01-02 | Aventis Pharma Gmbh | Verwendung von Benzolsulfonyl(thio)harnstoffen in der Behandlung des septischen Schocks |
| CN1330630C (zh) * | 2004-03-10 | 2007-08-08 | 中国药科大学 | 新的磺酰(硫)脲衍生物、其制备方法及含有它们的药物组合物 |
| UA87854C2 (en) * | 2004-06-07 | 2009-08-25 | Мерк Энд Ко., Инк. | N-(2-benzyl)-2-phenylbutanamides as androgen receptor modulators |
| US7875636B2 (en) | 2006-04-12 | 2011-01-25 | Merck Sharp & Dohme Corp. | Pyridyl amide T-type calcium channel antagonists |
| CA2701594C (en) * | 2007-10-24 | 2014-02-18 | Merck Sharp & Dohme Corp. | Heterocycle phenyl amide t-type calcium channel antagonists |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE243821C (es) * | ||||
| DE1493672C3 (de) * | 1964-08-01 | 1974-05-02 | Farbwerke Hoechst Ag, Vormals Meister Lucius & Bruening, 6000 Frankfurt | Verfahren zur Herstellung von Benzolsulfonylharnstoffen |
| DE1518874C3 (de) * | 1964-10-07 | 1975-03-13 | Farbwerke Hoechst Ag, Vormals Meister Lucius & Bruening, 6000 Frankfurt | Benzolsulfonylharnstoffe und Verfahren zu ihrer Herstellung |
| DE1443919C3 (de) * | 1964-12-28 | 1973-11-29 | Farbwerke Hoechst Ag, Vormals Meister Lucius & Bruening, 6000 Frankfurt | Benzolsulfonylharnstoffe, Ver fahren zu ihrer Herstellung und diese enthaltende pharmazeutische Zubereitun gen |
| US3917690A (en) * | 1966-11-29 | 1975-11-04 | Hoechst Ag | Benzenesulfonyl ureas and process for their manufacture |
| DE1568648C3 (de) * | 1966-12-19 | 1975-03-27 | Farbwerke Hoechst Ag, Vormals Meister Lucius & Bruening, 6000 Frankfurt | Benzolsulfonylharnstoffe, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Präparate |
| BE754454A (fr) * | 1969-08-06 | 1971-02-05 | Bayer Ag | Nouveaux composes hypoglycemiques du type d'arylsulfonylurees et d'arylsulfonylsemicarbazides contenant des groupes carbonamide |
| DE2413514C3 (de) * | 1974-03-21 | 1982-03-04 | Hoechst Ag, 6000 Frankfurt | N-Acylaminoathylbenzolsulfonyl-N'-methylharnstoffe, Verfahren zu ihrer Herstellung und deren Verwendung |
| DE3011153A1 (de) * | 1980-03-22 | 1981-10-15 | Hoechst Ag, 6000 Frankfurt | Verwendung von n-(4- spitze klammer auf 2-(5-chlor-2-methoxy-benzamido)-aethylspitze klammer zu -benzolsulfonyl)-n'-methyl-harnstoff |
| US5215985A (en) * | 1990-07-20 | 1993-06-01 | E. R. Squibb & Sons, Inc. | Method for treating ischemic insult to neurons employing an ATP-sensitive potassium channel blocker |
| ATE146775T1 (de) * | 1993-02-23 | 1997-01-15 | Hoechst Ag | Substituierte benzolsulfonylharnstoffe und - thioharnstoffe- verfahren zu ihrer herstellung und ihre verwendung als pharmazeutika |
-
1995
- 1995-02-10 DE DE19504379A patent/DE19504379A1/de not_active Withdrawn
- 1995-12-29 HU HU9503932A patent/HU224211B1/hu not_active IP Right Cessation
-
1996
- 1996-01-29 PL PL96312531A patent/PL181656B1/pl not_active IP Right Cessation
- 1996-02-05 TW TW085101375A patent/TW419457B/zh not_active IP Right Cessation
- 1996-02-05 DE DE59606062T patent/DE59606062D1/de not_active Expired - Lifetime
- 1996-02-05 AT AT96101585T patent/ATE197291T1/de active
- 1996-02-05 EP EP96101585A patent/EP0726250B1/de not_active Expired - Lifetime
- 1996-02-05 PT PT96101585T patent/PT726250E/pt unknown
- 1996-02-05 ES ES96101585T patent/ES2152440T3/es not_active Expired - Lifetime
- 1996-02-05 DK DK96101585T patent/DK0726250T3/da active
- 1996-02-06 SI SI9600040A patent/SI9600040B/sl not_active IP Right Cessation
- 1996-02-07 CN CN96101370A patent/CN1064041C/zh not_active Expired - Fee Related
- 1996-02-08 US US08/598,319 patent/US5607976A/en not_active Expired - Lifetime
- 1996-02-08 SK SK175-96A patent/SK281357B6/sk not_active IP Right Cessation
- 1996-02-08 CZ CZ1996382A patent/CZ290809B6/cs not_active IP Right Cessation
- 1996-02-08 FI FI960587A patent/FI120394B/fi not_active IP Right Cessation
- 1996-02-08 HR HR960063A patent/HRP960063B1/xx not_active IP Right Cessation
- 1996-02-08 NZ NZ280954A patent/NZ280954A/en not_active IP Right Cessation
- 1996-02-08 IL IL11707896A patent/IL117078A/xx not_active IP Right Cessation
- 1996-02-08 AR AR33535596A patent/AR001082A1/es unknown
- 1996-02-08 MY MYPI96000472A patent/MY114693A/en unknown
- 1996-02-08 AU AU44429/96A patent/AU700883B2/en not_active Ceased
- 1996-02-08 TR TR96/00102A patent/TR199600747A2/xx unknown
- 1996-02-09 JP JP02392796A patent/JP3774773B2/ja not_active Expired - Fee Related
- 1996-02-09 ZA ZA961050A patent/ZA961050B/xx unknown
- 1996-02-09 BR BR9600370A patent/BR9600370A/pt not_active Application Discontinuation
- 1996-02-09 CA CA002169219A patent/CA2169219C/en not_active Expired - Fee Related
- 1996-02-09 RU RU96102420/04A patent/RU2155750C2/ru not_active IP Right Cessation
- 1996-02-09 NO NO960529A patent/NO305750B1/no not_active IP Right Cessation
- 1996-02-10 KR KR1019960003232A patent/KR100446565B1/ko not_active Expired - Fee Related
-
2000
- 2000-11-22 GR GR20000402575T patent/GR3034886T3/el unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| IF | Valid on the event date | ||
| KO00 | Lapse of patent |
Effective date: 20120926 |