[go: up one dir, main page]

AR000772A1 - Proceso para la preparacion de derivados de ciclopropano. - Google Patents

Proceso para la preparacion de derivados de ciclopropano.

Info

Publication number
AR000772A1
AR000772A1 ARP960101101A AR10110196A AR000772A1 AR 000772 A1 AR000772 A1 AR 000772A1 AR P960101101 A ARP960101101 A AR P960101101A AR 10110196 A AR10110196 A AR 10110196A AR 000772 A1 AR000772 A1 AR 000772A1
Authority
AR
Argentina
Prior art keywords
product
preparation
acid
thiomethyl
contacting
Prior art date
Application number
ARP960101101A
Other languages
English (en)
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of AR000772A1 publication Critical patent/AR000772A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C327/00—Thiocarboxylic acids
    • C07C327/20—Esters of monothiocarboxylic acids
    • C07C327/32—Esters of monothiocarboxylic acids having sulfur atoms of esterified thiocarboxyl groups bound to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C253/00—Preparation of carboxylic acid nitriles
    • C07C253/16—Preparation of carboxylic acid nitriles by reaction of cyanides with lactones or compounds containing hydroxy groups or etherified or esterified hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
    • C07C319/02—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of thiols
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D327/00—Heterocyclic compounds containing rings having oxygen and sulfur atoms as the only ring hetero atoms
    • C07D327/10—Heterocyclic compounds containing rings having oxygen and sulfur atoms as the only ring hetero atoms two oxygen atoms and one sulfur atom, e.g. cyclic sulfates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/02—Systems containing only non-condensed rings with a three-membered ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Toxicology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

La presente invención provee un proceso novedoso para la preparación de ácido 1-(tiometil)-ciclopropanoacético el cual comprende: (a) poner en contacto1,1-ciclopropanodimetanol con dialquilsulfito en presencia de una base; y (b) remover de lam ezcla de reacción el alcohol subproducto de ella. Este procesose incorpora en el proceso novedoso adicional para la preparación de 1-(hidroximetil)ciclopropanoacetonitrilo y ácido1-(tiometil)ciclopropanoacético, en cuyo caso se agregaal p roducto proveniente del paso (b), cianuro de sodio y yoduro de sodio para obtener los mismos;comprendiendo, como etapas adicionales los siguientes:(d) convertir el producto proveniente del paso (c) en un remanente sulfonado; (e) poner encontacto elp roducto proveniente del paso (d) con ácido tiolacético y una base amínica para producir 1-(acetiltiometil)ciclopropanoacetonitrilo; y (f) hidrolizar elproducto del paso (e) en un sistema de solvente bifásico.
ARP960101101A 1995-01-23 1996-01-22 Proceso para la preparacion de derivados de ciclopropano. AR000772A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/376,715 US5523477A (en) 1995-01-23 1995-01-23 Process for the preparation of 1-(thiomethyl)-cyclopropaneacetic acid

Publications (1)

Publication Number Publication Date
AR000772A1 true AR000772A1 (es) 1997-08-06

Family

ID=23486169

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP960101101A AR000772A1 (es) 1995-01-23 1996-01-22 Proceso para la preparacion de derivados de ciclopropano.

Country Status (16)

Country Link
US (1) US5523477A (es)
EP (1) EP0805808A1 (es)
CN (1) CN1072218C (es)
AR (1) AR000772A1 (es)
AU (1) AU4657396A (es)
BR (1) BR9607083A (es)
CZ (1) CZ234897A3 (es)
EA (2) EA000090B1 (es)
FI (1) FI973085A0 (es)
HR (1) HRP960028A2 (es)
RO (1) RO118131B1 (es)
SK (1) SK99897A3 (es)
TW (1) TW322475B (es)
UA (1) UA50730C2 (es)
WO (1) WO1996022987A1 (es)
YU (1) YU3596A (es)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5904068A (en) 1996-04-30 1999-05-18 Eaton Corporation Semi-automatic shift implementation with synchronized transmission emulation
WO2003066582A1 (en) * 2002-02-06 2003-08-14 Delmar Chemicals Inc. Process for the preparation of 1-(mercaptomethyl)-cyclopropaneacetic acid
CA2371048C (en) 2002-02-06 2011-01-04 Delmar Chemicals Inc. Process for the preparation of 1-(mercaptomethyl)-cyclopropaneacetic acid
US7560559B2 (en) * 2003-04-15 2009-07-14 Merck & Co., Inc. Polymorphic form of montelukast sodium
PT1678139E (pt) 2003-10-10 2011-11-28 Synhton B V Montelucaste em estado sólido
JP2007518826A (ja) * 2004-01-30 2007-07-12 テバ ファーマシューティカル インダストリーズ リミティド モンテルカスト遊離酸多形体
EP1760077A1 (en) * 2004-01-30 2007-03-07 Teva Pharmaceutical Industries Ltd. Montelukast free acid polymorphs
CA2554789A1 (en) * 2004-01-30 2005-08-18 Teva Pharmaceutical Industries, Ltd. Montelukast sodium polymorphs
DE602005015174D1 (de) * 2004-04-21 2009-08-13 Teva Pharma Verfahren zur herstellung von montelukast-natrium
US7829716B2 (en) * 2004-04-30 2010-11-09 Synthon Pharmaceuticals, Inc. Process for making montelukast and intermediates therefor
US7501517B2 (en) * 2004-04-30 2009-03-10 Synthon Ip, Inc. Process for making montelukast and intermediates therefor
EP1812394B1 (en) * 2004-07-19 2011-03-02 Matrix Laboratories Ltd Process for the preparation of montelukast and its salts
KR20090015186A (ko) * 2005-07-05 2009-02-11 테바 파마슈티컬 인더스트리즈 리미티드 몬테루카스트의 정제
KR20080033425A (ko) * 2005-07-20 2008-04-16 닥터 레디스 래보러토리즈, 인코포레이티드 몬테루캐스트의 제조 공정
US20070161796A1 (en) * 2005-11-16 2007-07-12 Ilan Kor-Sade Drying methods of montelukast sodium by azeotropic removal of the solvent
AR056815A1 (es) * 2005-11-18 2007-10-24 Synthon Bv PROCESO PARA PREPARAR MONTELUKAST, INTERMEDIARIOS DEL MISMO Y SUS SALES DE ADICIoN Y PROCEDIMIENTO DE PURIFICACIoN DE ÉSTOS Y DE MONTELUKAST
US20070213365A1 (en) * 2006-02-21 2007-09-13 Chemagis Ltd. Novel polymorphs of montelukast ammonium salts and processes for preparation therefor
IL181607A0 (en) * 2006-02-27 2007-07-04 Chemagis Ltd Novel process for preparing montelukast and salts thereof
EP1996552A1 (en) * 2006-03-17 2008-12-03 Synthon B.V. Montelukast amantadine salt
US20090326232A1 (en) * 2006-06-26 2009-12-31 Uttam Kumar Ray Process for the Preparation of Leukotriene Receptor Antagonist (Montelukast Sodium)
GB0618703D0 (en) * 2006-09-22 2006-11-01 Almac Sciences Ltd Synthesis of leikotriene compounds
US7700776B2 (en) * 2006-10-24 2010-04-20 Formosa Laboratories, Inc. Compounds and preparation for montelukast sodium
US7271268B1 (en) 2006-12-22 2007-09-18 Formosa Laboratories Inc. Process for preparation of [1-(mercaptomethyl)cyclopropyl]acetic acid and related derivatives
US20080188664A1 (en) * 2007-01-15 2008-08-07 Chemagis Ltd. Process for preparing montelukast sodium containing controlled levels of impurities
KR101072896B1 (ko) 2007-10-09 2011-10-17 한미홀딩스 주식회사 이온성 액체 매개체를 이용한 몬테루카스트산의 제조 방법
CN102046602A (zh) * 2008-04-25 2011-05-04 斯索恩有限公司 制备孟鲁司特中间体的方法
WO2009144742A2 (en) 2008-05-26 2009-12-03 Aptuit Laurus Pvt Limited An improved process for preparing montelukast and salts thereof
CN101880270B (zh) * 2009-05-07 2012-10-03 上海华升生物科技有限公司 一种制备1,1-环丙烷二甲醇环亚硫酸酯的方法
WO2011004298A1 (en) 2009-07-09 2011-01-13 Alembic Limited Montelukast hexamethylenediamine salt and its use for the preparation of montelukast sodium
US8471030B2 (en) 2010-12-06 2013-06-25 Orochem Technologies Inc. Purification of montelukast using simulated moving bed
KR101431678B1 (ko) 2012-01-10 2014-08-22 (주)위즈켐 1-(1'-(카복시메틸)시클로프로판메틸디설파닐메틸)시클로프로판아세트산과 그 유도체의 제조방법
CN103058884B (zh) * 2012-12-14 2014-10-29 武汉赛狮药物化学有限公司 1-羟甲基环丙基乙腈的合成方法
CN111170939A (zh) * 2019-12-20 2020-05-19 牡丹江恒远药业股份有限公司 一种高纯度孟鲁司特钠及其中间体的制备方法
CN112094212B (zh) * 2020-09-07 2025-08-01 江苏阿尔法集团盛基药业(宿迁)有限公司 一种孟鲁司特钠侧链的制备方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK304185A (da) * 1984-07-27 1986-01-28 Hoffmann La Roche Fremgangsmaade til fremstilling af furanon
CA2053209C (en) * 1990-10-12 1998-12-08 Michel L. Belley Unsaturated hydroxyalkylquinoline acids as leukotriene antagonists
US5270324A (en) * 1992-04-10 1993-12-14 Merck Frosst Canada, Inc. Fluorinated hydroxyalkylquinoline acids as leukotriene antagonists
CA2111372C (en) * 1992-12-22 2007-01-16 Robert N. Young Diaryl 5,6-fusedheterocyclic acids as leukotriene antagonists
US5438141A (en) * 1993-05-21 1995-08-01 Merck Frosst Canada, Inc. Heteroaryl and haloaryl quinoline derivatives of cyclopropaneacetic acid as leukotriene antagonists
US5350760A (en) * 1993-08-04 1994-09-27 Merck Frosst Canada, Inc. Aza-5,5-fused hetrocyclic acids as leukotriene antagonists
TW416948B (en) * 1993-12-28 2001-01-01 Merck & Co Inc Process for the preparation of leukotriene antagonists

Also Published As

Publication number Publication date
WO1996022987A1 (en) 1996-08-01
EA000090B1 (ru) 1998-06-25
CN1072218C (zh) 2001-10-03
UA50730C2 (uk) 2002-11-15
US5523477A (en) 1996-06-04
BR9607083A (pt) 1997-11-11
FI973085A7 (fi) 1997-07-22
CN1172481A (zh) 1998-02-04
HRP960028A2 (en) 1997-10-31
FI973085L (fi) 1997-07-22
FI973085A0 (fi) 1997-07-22
AU4657396A (en) 1996-08-14
EP0805808A1 (en) 1997-11-12
TW322475B (es) 1997-12-11
EA199700137A1 (ru) 1997-12-30
CZ234897A3 (cs) 1998-02-18
RO118131B1 (ro) 2003-02-28
YU3596A (sh) 1998-07-10
SK99897A3 (en) 1998-04-08

Similar Documents

Publication Publication Date Title
AR000772A1 (es) Proceso para la preparacion de derivados de ciclopropano.
MX222918B (es) Procedimiento para la reaccion de un compuesto organico con un hidroperoxido.
AR047746A1 (es) Un procedimiento para la sintesis del (1s)-4,5-dimetoxi-1-(metilaminometil)-benzo-ciclobutano y sus sales de adicion, un metodo para la resolucion de su intermediario de sintesis racemico y su aplicacion a la sintesis de la ivabradina y sus sales de adicion con un acido farmaceuticamente aceptable
CL2009001529A1 (es) Sistema para generar ester de alquilo que comprende un primer reactor con una primera enzima que recibe un primer reactivo, un segundo reactivo y solvente inerte, cuyo producto de reaccion delprimer reactor se alimenta a un segundo reactor con una segunda enzima que recibe segundo reactivo adicional y solvente inerte (divisional de la sol. 2416-05).
UY37172A (es) Procedimiento para la preparación de imidazotriazinonas sustituidas con sulfonamida
ATE249420T1 (de) Herstellung von iodixanol
ES2139908T3 (es) Procedimiento para la produccion de 1,1,1,2,3,3,3-heptafluoropropano.
ES2087790T3 (es) Un procedimiento para la produccion de dimeros de cetena.
AR247878A1 (es) Procedimiento para preparar antagonistas receptores fibrinogenos
EA200400736A1 (ru) Способ извлечения капролактама
CY1108120T1 (el) Μια μεθοδος για την παρασκευη α-χλωροκετονων
MX9300473A (es) Procedimiento para la separacion del racemato de verapamil.
ID27149A (id) Proses pembuatan asam hidroksimetiltiobutirat
Kobus‐Bartoszewicz et al. Photoinduced Metal‐Free Hydrocarboxylation of Allylamines
EE200200460A (et) Meetod tuntud tetrasooli derivaadi sünteesiks
ES2174345T3 (es) Procedimiento para la preparacion de esteres del acido 2,6 piridindicarboxilicos.
NO20044608L (no) Fremgangsmate for a fremstille konjugert linolsyre
PT98519A (pt) Processo para a preparacao de 4-amino-delta 4,6-esteroides com accao inibidora da 5-alfa-redutase
ATE409687T1 (de) Verbesserte neutralisation von isophoronnitril- syntheseausträgen
EA200000413A1 (ru) Способ синтеза пирроламидов
EA199801084A1 (ru) Спосб получения фенилгетероциклических соединений, используемых в качестве ингибиторов циклооксигеназы-2
ES2055089T3 (es) Procedimiento para preparar 4-metilpirazoles.
ATE349545T1 (de) Enzymatisches verfahren zur herstellung von substituierter 2-amino-3-(2-amino-phenylsulfanyl)-propionsäure
TWI255812B (en) A process for the preparation of r-(+)-6-carboxamido-3-n-methylamino-1,2,3,4-tetrahydrocarbazole
ES2090731T3 (es) Preparacion de derivados insaturados del acido carbamico.

Legal Events

Date Code Title Description
FG Grant, registration