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AR008807A1 - Utilizacion de lipidos complejos como aditivos estabilizadores a preparados farmaceuticos de mezclas de enzimas digestivas - Google Patents

Utilizacion de lipidos complejos como aditivos estabilizadores a preparados farmaceuticos de mezclas de enzimas digestivas

Info

Publication number
AR008807A1
AR008807A1 ARP970103511A ARP970103511A AR008807A1 AR 008807 A1 AR008807 A1 AR 008807A1 AR P970103511 A ARP970103511 A AR P970103511A AR P970103511 A ARP970103511 A AR P970103511A AR 008807 A1 AR008807 A1 AR 008807A1
Authority
AR
Argentina
Prior art keywords
pharmaceutical preparations
complex lipids
digestive enzyme
stabilizing additives
enzyme mixtures
Prior art date
Application number
ARP970103511A
Other languages
English (en)
Original Assignee
Solvay Pharm Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Solvay Pharm Gmbh filed Critical Solvay Pharm Gmbh
Publication of AR008807A1 publication Critical patent/AR008807A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/683—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols
    • A61K31/685—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols one of the hydroxy compounds having nitrogen atoms, e.g. phosphatidylserine, lecithin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/465—Hydrolases (3) acting on ester bonds (3.1), e.g. lipases, ribonucleases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/24—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

Se describe la utilizacion de lípidos complejos, especialmente de lecitina, como aditivos que estabilizan contra una disminucion de actividadlipolítica bajo la influencia de la humedad, en preparados farmacéuticos solubles en aguade mezclas de enzimas digestivas que contienen lipasas yproteasas, especialmente mezclas de enzimas digestivas que contiene pancreatina los cuales son apropiados para la preparacion de soluciones acuosas para suintroduccion continua en el tractogastro ntestinal mediante una sonda.
ARP970103511A 1996-08-28 1997-08-01 Utilizacion de lipidos complejos como aditivos estabilizadores a preparados farmaceuticos de mezclas de enzimas digestivas AR008807A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19634752 1996-08-28
DE19724845A DE19724845A1 (de) 1996-08-28 1997-06-12 Verwendung von komplexen Lipiden als stabilisierende Zusätze zu pharmazeutischen Zubereitungen von Verdauungsenzymgemischen

Publications (1)

Publication Number Publication Date
AR008807A1 true AR008807A1 (es) 2000-02-23

Family

ID=26028823

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP970103511A AR008807A1 (es) 1996-08-28 1997-08-01 Utilizacion de lipidos complejos como aditivos estabilizadores a preparados farmaceuticos de mezclas de enzimas digestivas

Country Status (21)

Country Link
US (1) US5993806A (es)
EP (1) EP0826375B1 (es)
JP (1) JP4593697B2 (es)
CN (1) CN1199694C (es)
AR (1) AR008807A1 (es)
AT (1) ATE284225T1 (es)
AU (1) AU722151B2 (es)
BR (1) BR9704554B1 (es)
CA (1) CA2213151C (es)
CZ (1) CZ295329B6 (es)
DE (2) DE19724845A1 (es)
DK (1) DK0826375T3 (es)
EE (1) EE04179B1 (es)
ES (1) ES2235206T3 (es)
HU (1) HUP9701437A3 (es)
NO (1) NO973940L (es)
NZ (1) NZ328616A (es)
PL (1) PL190140B1 (es)
PT (1) PT826375E (es)
SK (1) SK284639B6 (es)
TR (1) TR199700872A2 (es)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6074689A (en) * 1998-03-10 2000-06-13 Immucell Corporation Colonic delivery of protein or peptide compositions
KR100367659B1 (ko) * 2000-05-08 2003-01-14 주식회사 바이넥스 선택적 안정화제의 첨가에 따른 자가분해(autolysis)를 통한 고역가 판크레아틴의 제조방법
GB0019118D0 (en) * 2000-08-03 2000-09-27 Danisco Solid phase glycerolysis
CA2427537A1 (en) * 2000-11-02 2002-05-10 Cilian Ag Use of enzymes obtained from ciliates as medicaments for promoting digestion
US20030099626A1 (en) * 2001-11-20 2003-05-29 Health Education Corporation Nutrient absorption enhancing compositions and methods
JP5032300B2 (ja) * 2004-03-22 2012-09-26 アボット プロダクツ ゲゼルシャフト ミット ベシュレンクテル ハフツング 界面活性剤を含有している、リパーゼを含有する生成物の、とりわけパンクレアチンの経口医薬組成物
US7153504B2 (en) * 2004-07-30 2006-12-26 Can Technologies, Inc. Stabilized pancreas product
EP1919293A4 (en) * 2005-07-20 2010-11-17 James S Brophy MODIFICATION OF PARTICLE MORPHOLOGY TO ENHANCE THE FUNCTIONALITY OF A PRODUCT
EP2278002B1 (en) * 2005-07-29 2017-07-12 Abbott Laboratories GmbH Pancreatin with reduced viral content
US9198871B2 (en) 2005-08-15 2015-12-01 Abbott Products Gmbh Delayed release pancreatin compositions
US11266607B2 (en) 2005-08-15 2022-03-08 AbbVie Pharmaceuticals GmbH Process for the manufacture and use of pancreatin micropellet cores
US10072256B2 (en) 2006-05-22 2018-09-11 Abbott Products Gmbh Process for separating and determining the viral load in a pancreatin sample
US20110183050A1 (en) * 2006-07-20 2011-07-28 Brophy James S Modification of particle morphology to improve product functionality
US8444967B2 (en) 2010-07-09 2013-05-21 Master Supplements, Inc. Treatment including prebiotic composition for use with probiotics
US20090130063A1 (en) * 2007-11-15 2009-05-21 Solvay Pharmaceuticals Gmbh Process for separating and determining the viral load in a pancreatin sample
DE102009006594A1 (de) 2009-01-29 2010-08-05 Nordmark Arzneimittel Gmbh & Co. Kg Pharmazeutisches Präparat
EP2391382B1 (de) 2009-01-29 2014-06-04 Nordmark Arzneimittel GmbH & Co.KG Pharmazeutisches präparat enthaltend lipase bakteriellen ursprungs
CN108187033A (zh) 2010-10-01 2018-06-22 阿普塔利斯制药有限公司 肠溶包衣的低强度胰脂肪酶制剂
WO2015069677A1 (en) * 2013-11-05 2015-05-14 Aptalis Pharma Ltd. High potency pancreatin pharmaceutical compositions
EP3030257B1 (en) 2013-08-09 2020-02-19 Allergan Pharmaceuticals International Limited Digestive enzyme composition suitable for enteral administration
JP2014193909A (ja) * 2014-06-04 2014-10-09 Nordmark Arzneimittel Gmbh & Co Kg 医薬調製物
US20160120964A1 (en) * 2014-11-05 2016-05-05 George Shlieout Processes for producing compositions with improved safety profile having lipase activity and compositions suitable for pharmaceutical use
US20180028454A1 (en) 2015-02-04 2018-02-01 Abbvie Inc. Pharmaceutical compositions and methods of use thereof to treat pancreatic enzyme insufficiency
DE102015114857A1 (de) 2015-09-04 2017-03-09 Nordmark Arzneimittel Gmbh & Co. Kg Getränk, enthaltend eine pharmazeutische Zusammensetzung
DE102015114862A1 (de) * 2015-09-04 2017-03-09 Nordmark Arzneimittel Gmbh & Co. Kg Pharmazeutische Zusammensetzung, enthaltend eine bakterielle Lipase

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3956483A (en) * 1968-10-24 1976-05-11 Wilson Pharmaceutical & Chemical Corporation Preparing pancreatin
US3991180A (en) * 1972-03-06 1976-11-09 Rohm And Haas Company Stabilization of internally administered pancreatic lipase
DE2512746C3 (de) * 1975-03-22 1980-04-24 Kali-Chemie Pharma Gmbh, 3000 Hannover Verfahren zur Herstellung von keimarmem, faserfreiem Pankreatin
GB1603640A (en) * 1977-07-20 1981-11-25 Gist Brocades Nv Enzyme particles
JPS58148814A (ja) * 1982-03-01 1983-09-05 Fujimoto Seiyaku Kk 消化酵素軟カプセル剤
JPS59169491A (ja) * 1983-03-15 1984-09-25 Duskin Franchise Co Ltd 酵素の安定化法
JPH0229950A (ja) * 1988-07-18 1990-01-31 Nec Corp 光ディスク
JP2679852B2 (ja) * 1989-11-29 1997-11-19 株式会社サム研究所 経口及び局所投与用生物活性蛋白組成物
GB9007052D0 (en) * 1990-03-29 1990-05-30 Skua Investments Ltd Pharmaceutical formulations
EP1961312A3 (en) * 1991-01-24 2010-03-31 Martek Biosciences Corporation Microbial oil mixture and uses thereof
DE4200002A1 (de) * 1992-01-02 1993-07-08 Rudolf V Dipl Chem Dr Noronha Reinigungstablette fuer die zahnprothesen
EP0719133A1 (en) * 1993-09-15 1996-07-03 Unilever Plc Skin care method and composition
JPH09125096A (ja) * 1995-10-30 1997-05-13 Koei Sangyo:Kk 液状天然油脂洗剤

Also Published As

Publication number Publication date
DE59712108D1 (de) 2005-01-13
TR199700872A3 (tr) 1999-04-21
HUP9701437A3 (en) 2001-03-28
NZ328616A (en) 1999-01-28
EP0826375A3 (de) 2002-08-14
DE19724845A1 (de) 1998-03-05
CA2213151C (en) 2008-04-01
AU722151B2 (en) 2000-07-20
NO973940L (no) 1998-03-02
JPH1077236A (ja) 1998-03-24
EE9700249A (et) 1998-04-15
SK115997A3 (en) 1998-07-08
ES2235206T3 (es) 2005-07-01
CN1174743A (zh) 1998-03-04
PL321825A1 (en) 1998-03-02
JP4593697B2 (ja) 2010-12-08
CN1199694C (zh) 2005-05-04
EP0826375B1 (de) 2004-12-08
PT826375E (pt) 2005-02-28
CA2213151A1 (en) 1998-02-28
EP0826375A2 (de) 1998-03-04
US5993806A (en) 1999-11-30
CZ218497A3 (cs) 1998-03-18
DK0826375T3 (da) 2005-01-24
HK1005224A1 (en) 1998-12-31
NO973940D0 (no) 1997-08-27
EE04179B1 (et) 2003-12-15
HU9701437D0 (en) 1997-10-28
HUP9701437A2 (hu) 1998-03-30
CZ295329B6 (cs) 2005-07-13
PL190140B1 (pl) 2005-11-30
BR9704554B1 (pt) 2011-12-27
ATE284225T1 (de) 2004-12-15
TR199700872A2 (xx) 1999-04-21
SK284639B6 (sk) 2005-08-04
AU3530997A (en) 1998-03-05
BR9704554A (pt) 1998-09-15

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