AR008391A1 - Derivados de catecol, su aplicacion terapeutica y medicamentos que los contienen - Google Patents
Derivados de catecol, su aplicacion terapeutica y medicamentos que los contienenInfo
- Publication number
- AR008391A1 AR008391A1 ARP970102549A ARP970102549A AR008391A1 AR 008391 A1 AR008391 A1 AR 008391A1 AR P970102549 A ARP970102549 A AR P970102549A AR P970102549 A ARP970102549 A AR P970102549A AR 008391 A1 AR008391 A1 AR 008391A1
- Authority
- AR
- Argentina
- Prior art keywords
- acids
- radicals
- compounds
- conjugates
- strains
- Prior art date
Links
- 239000003814 drug Substances 0.000 title abstract 3
- 230000001225 therapeutic effect Effects 0.000 title 1
- 239000002253 acid Substances 0.000 abstract 7
- 150000007513 acids Chemical class 0.000 abstract 7
- 150000001875 compounds Chemical class 0.000 abstract 5
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 abstract 2
- 239000013543 active substance Substances 0.000 abstract 2
- 150000001413 amino acids Chemical class 0.000 abstract 2
- 150000005415 aminobenzoic acids Chemical class 0.000 abstract 2
- 239000003242 anti bacterial agent Substances 0.000 abstract 2
- 229940088710 antibiotic agent Drugs 0.000 abstract 2
- 230000001580 bacterial effect Effects 0.000 abstract 2
- 229940079593 drug Drugs 0.000 abstract 2
- 150000005206 1,2-dihydroxybenzenes Chemical class 0.000 abstract 1
- 241000894006 Bacteria Species 0.000 abstract 1
- 108010016626 Dipeptides Proteins 0.000 abstract 1
- 208000016286 Iron metabolism disease Diseases 0.000 abstract 1
- 241000588748 Klebsiella Species 0.000 abstract 1
- 241000588769 Proteus <enterobacteria> Species 0.000 abstract 1
- RWRDLPDLKQPQOW-UHFFFAOYSA-N Pyrrolidine Chemical compound C1CCNC1 RWRDLPDLKQPQOW-UHFFFAOYSA-N 0.000 abstract 1
- 241000607142 Salmonella Species 0.000 abstract 1
- 239000000589 Siderophore Substances 0.000 abstract 1
- 230000004075 alteration Effects 0.000 abstract 1
- 230000000844 anti-bacterial effect Effects 0.000 abstract 1
- -1 benzhidrazones Chemical class 0.000 abstract 1
- 230000003115 biocidal effect Effects 0.000 abstract 1
- 239000002738 chelating agent Substances 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 208000015181 infectious disease Diseases 0.000 abstract 1
- 229910052742 iron Inorganic materials 0.000 abstract 1
- 238000002483 medication Methods 0.000 abstract 1
- NYCVCXMSZNOGDH-UHFFFAOYSA-N pyrrolidine-1-carboxylic acid Chemical compound OC(=O)N1CCCC1 NYCVCXMSZNOGDH-UHFFFAOYSA-N 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C251/00—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton
- C07C251/02—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton containing imino groups
- C07C251/04—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton containing imino groups having carbon atoms of imino groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C251/10—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton containing imino groups having carbon atoms of imino groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of an unsaturated carbon skeleton
- C07C251/16—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton containing imino groups having carbon atoms of imino groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of an unsaturated carbon skeleton containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
- A61K31/545—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/547—Chelates, e.g. Gd-DOTA or Zinc-amino acid chelates; Chelate-forming compounds, e.g. DOTA or ethylenediamine being covalently linked or complexed to the pharmacologically- or therapeutically-active agent
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/42—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C235/44—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
- C07C235/58—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring with carbon atoms of carboxamide groups and singly-bound oxygen atoms, bound in ortho-position to carbon atoms of the same non-condensed six-membered aromatic ring
- C07C235/60—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring with carbon atoms of carboxamide groups and singly-bound oxygen atoms, bound in ortho-position to carbon atoms of the same non-condensed six-membered aromatic ring having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/42—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C235/44—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
- C07C235/58—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring with carbon atoms of carboxamide groups and singly-bound oxygen atoms, bound in ortho-position to carbon atoms of the same non-condensed six-membered aromatic ring
- C07C235/64—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring with carbon atoms of carboxamide groups and singly-bound oxygen atoms, bound in ortho-position to carbon atoms of the same non-condensed six-membered aromatic ring having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
- C07C237/22—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton having nitrogen atoms of amino groups bound to the carbon skeleton of the acid part, further acylated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C245/00—Compounds containing chains of at least two nitrogen atoms with at least one nitrogen-to-nitrogen multiple bond
- C07C245/02—Azo compounds, i.e. compounds having the free valencies of —N=N— groups attached to different atoms, e.g. diazohydroxides
- C07C245/06—Azo compounds, i.e. compounds having the free valencies of —N=N— groups attached to different atoms, e.g. diazohydroxides with nitrogen atoms of azo groups bound to carbon atoms of six-membered aromatic rings
- C07C245/08—Azo compounds, i.e. compounds having the free valencies of —N=N— groups attached to different atoms, e.g. diazohydroxides with nitrogen atoms of azo groups bound to carbon atoms of six-membered aromatic rings with the two nitrogen atoms of azo groups bound to carbon atoms of six-membered aromatic rings, e.g. azobenzene
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C251/00—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton
- C07C251/02—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton containing imino groups
- C07C251/24—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton containing imino groups having carbon atoms of imino groups bound to carbon atoms of six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C251/00—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton
- C07C251/72—Hydrazones
- C07C251/74—Hydrazones having doubly-bound carbon atoms of hydrazone groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C251/78—Hydrazones having doubly-bound carbon atoms of hydrazone groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of an unsaturated carbon skeleton
- C07C251/80—Hydrazones having doubly-bound carbon atoms of hydrazone groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of an unsaturated carbon skeleton the carbon skeleton containing rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C251/00—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton
- C07C251/72—Hydrazones
- C07C251/86—Hydrazones having doubly-bound carbon atoms of hydrazone groups bound to carbon atoms of six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/04—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D263/06—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by oxygen atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
- C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
- C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
- C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
- C07D501/26—Methylene radicals, substituted by oxygen atoms; Lactones thereof with the 2-carboxyl group
- C07D501/34—Methylene radicals, substituted by oxygen atoms; Lactones thereof with the 2-carboxyl group with the 7-amino radical acylated by carboxylic acids containing hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Pyrrole Compounds (AREA)
- Cephalosporin Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Derivados de catecol de la formula general I en que radicales de ácidos azometincarboxílicos, ácidos azobencenoscarboxílicos, benzhidrazonas, ácidosaminobenzoicos, aminoácidos o dipéptidos, ácidos pirrolidin carboxílicos y/ooxazolidincarboxíl icos así como radicales de formilcarboximetiloximas actuancomo elementos estructurales y sus conjugados con sustancias activas, particularmente antibioticos. La invencion se refiere también a la aplicacionde estoscompuestos como sideroforo s en el caso de cepas bacterianas gram negativas, partivularmente pseudomonadáceas, cepas de E. colil, salmonella,klebsiella y proteus y en forma de sus conjugados con sustancias aactivas, por ejemplo antibioticos(como conjugados de siderofor o o antibiotico) puedenintroducir éstas en la célula bacteriana y mejorar su eficacia antibacteriana o promoverla en parte también frene a otras cepas de bacterias resistentes abeta-lactamas. Además estos compuestosson adecuados como quelatantes d e hierro para la utilizacion en enfermedades producidas en trastornos del metabolismodel hierro. Donde en la formula I R1=OH u O-acilo y R2 en posicion 3 y/o 4 radicales de ácidos azometincarboxílicos aromáticosradicales deazobencenocarboxílico s, radicales de benzohidrazona, radicales de ácidos aminobenzoicos, radicales de aminoácidos, radicales de ácidos pirrolidin y/ooxazolidincarboxílicos y radicales de formilcarboximetiloxima y /o susconjugados con sustancias activas, particularmente antibioticos. Estoscompuestos pueden existir en forma de ácidos libres en forma de sus sales o como ésteres facilmente disociables, aplicados en medicamentos que loscontienen. Se refiere tambiéna dichos medicamentos, así como a l a aplicacion de los mismos en el caso de trastornos infecciosos o producidos por alteraciones
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19625524A DE19625524C2 (de) | 1996-06-26 | 1996-06-26 | Neue synthetische Catechol-Antibiotika-Konjugate und diese enthaltende Arzneimittel |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR008391A1 true AR008391A1 (es) | 2000-01-19 |
Family
ID=7798042
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP970102549A AR008391A1 (es) | 1996-06-26 | 1997-06-11 | Derivados de catecol, su aplicacion terapeutica y medicamentos que los contienen |
Country Status (29)
| Country | Link |
|---|---|
| US (1) | US6380181B1 (es) |
| EP (1) | EP0907633B1 (es) |
| JP (1) | JP2000514042A (es) |
| KR (1) | KR20000022120A (es) |
| CN (1) | CN1106380C (es) |
| AR (1) | AR008391A1 (es) |
| AT (1) | ATE204563T1 (es) |
| AU (1) | AU728669B2 (es) |
| BR (1) | BR9709964A (es) |
| CA (1) | CA2252809A1 (es) |
| CO (1) | CO4900028A1 (es) |
| CZ (1) | CZ9804297A3 (es) |
| DE (2) | DE19654920A1 (es) |
| DK (1) | DK0907633T3 (es) |
| ES (1) | ES2163161T3 (es) |
| GR (1) | GR3036667T3 (es) |
| HU (1) | HUP0001746A3 (es) |
| IL (1) | IL126703A0 (es) |
| NO (1) | NO311975B1 (es) |
| NZ (1) | NZ332519A (es) |
| PE (1) | PE70098A1 (es) |
| PL (1) | PL330899A1 (es) |
| PT (1) | PT907633E (es) |
| RU (1) | RU2180898C2 (es) |
| SK (1) | SK283560B6 (es) |
| UA (1) | UA54437C2 (es) |
| UY (1) | UY24596A1 (es) |
| WO (1) | WO1997049670A1 (es) |
| ZA (1) | ZA975638B (es) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19708846A1 (de) * | 1997-03-05 | 1998-09-17 | Gruenenthal Gmbh | Neue Benzoxazindionderivate, Verfahren zu ihrer Herstellung und ihre Verwendung |
| US6613942B1 (en) | 1997-07-01 | 2003-09-02 | Novo Nordisk A/S | Glucagon antagonists/inverse agonists |
| WO1999042435A2 (de) * | 1998-02-21 | 1999-08-26 | Analyticon Ag Biotechnologie Pharmazie | Myxocheline |
| US20040186087A1 (en) * | 2003-03-20 | 2004-09-23 | Ceramoptec Industries, Inc. | Siderophore conjugates of photoactive dyes for photodynamic therapy |
| DE102004030987A1 (de) * | 2004-06-26 | 2006-01-12 | Merck Patent Gmbh | Ortho-substituierte (3-Hydroxyphenyl)-essigsäure-benzyliden-hydrazide |
| US20100240713A1 (en) * | 2007-06-05 | 2010-09-23 | Xenon Pharmaceuticals Inc. | Aromatic and heteroaromatic compounds useful in treating iron disorders |
| US20090233972A1 (en) * | 2008-03-12 | 2009-09-17 | Yat Sun Or | Substituted heterocycles as anti-infectives |
| EP3265130B1 (en) * | 2014-08-19 | 2024-05-22 | Hsiri Therapeutics, LLC | Antibacterial sideromycins |
| US11857052B2 (en) * | 2020-04-01 | 2024-01-02 | Omachron Intellectual Property Inc. | Water separator for a hair dryer |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SU520351A1 (ru) * | 1973-10-03 | 1976-07-05 | Уральский Ордена Трудового Красного Знамени Политехнический Институт Имени С.М.Кирова | Способ плучени азометинов |
| DE3215085A1 (de) | 1982-04-22 | 1983-10-27 | Bayer Ag, 5090 Leverkusen | Ss-lactam-antibiotika, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel |
| JPS59193822A (ja) | 1983-04-15 | 1984-11-02 | Kureha Chem Ind Co Ltd | 腎炎治療剤 |
| US4610824A (en) | 1984-10-09 | 1986-09-09 | E. R. Squibb & Sons, Inc. | Hydrazide derivatives of monocyclic beta-lactam antibiotics |
| SU1520064A1 (ru) * | 1985-01-14 | 1989-11-07 | Эйсай Ко., Лтд (Фирма) | Производные цефалоспорина в виде син-изомеров, про вл ющие антибактериальную активность |
| EP0189287B1 (en) * | 1985-01-21 | 1992-12-16 | Nippon Pharmaceutical Development Institute Company Limited | Novel b-lactam antibiotics |
| ZA877987B (en) * | 1986-11-12 | 1988-08-31 | Ici Pharma | Antibiotic compounds |
| GB8811055D0 (en) * | 1988-05-10 | 1988-06-15 | Ici Plc | Antibiotic compounds |
| AU644008B2 (en) * | 1990-08-10 | 1993-12-02 | Sumitomo Pharmaceuticals Company, Limited | Beta-lactam compounds, and their production and use |
| EP0544166A3 (en) | 1991-11-26 | 1993-11-03 | Hoffmann La Roche | Cephalosporinderivatives |
| JPWO9318062A1 (en) * | 1992-03-11 | 1994-03-03 | Kyowa Hakko Kogyo Kk | Peptide which inhibits phospholipase c. |
| DE4231295A1 (de) | 1992-09-18 | 1994-03-24 | Knoell Hans Forschung Ev | Neue alpha-Aminoacylpenicilline mit substituierten Dicarboxamoyl-Seitenketten, Verfahren zu ihrer Herstellung und ihre Verwendung |
| DE4313946A1 (de) | 1993-04-28 | 1994-11-03 | Knoell Hans Forschung Ev | Neue O-Acyl-N-(diacyloxybenzoyl)-amoxicillinderivate, Verfahren zu ihrer Herstellung und ihre Verwendung |
-
1996
- 1996-06-26 DE DE19654920A patent/DE19654920A1/de not_active Withdrawn
-
1997
- 1997-05-14 JP JP10502161A patent/JP2000514042A/ja active Pending
- 1997-05-14 BR BR9709964A patent/BR9709964A/pt not_active IP Right Cessation
- 1997-05-14 SK SK1788-98A patent/SK283560B6/sk unknown
- 1997-05-14 ES ES97923887T patent/ES2163161T3/es not_active Expired - Lifetime
- 1997-05-14 NZ NZ332519A patent/NZ332519A/xx unknown
- 1997-05-14 PT PT97923887T patent/PT907633E/pt unknown
- 1997-05-14 IL IL12670397A patent/IL126703A0/xx unknown
- 1997-05-14 RU RU99101045/04A patent/RU2180898C2/ru not_active IP Right Cessation
- 1997-05-14 WO PCT/EP1997/002453 patent/WO1997049670A1/de not_active Ceased
- 1997-05-14 KR KR1019980710534A patent/KR20000022120A/ko not_active Ceased
- 1997-05-14 UA UA99010372A patent/UA54437C2/uk unknown
- 1997-05-14 US US09/202,955 patent/US6380181B1/en not_active Expired - Fee Related
- 1997-05-14 AU AU29542/97A patent/AU728669B2/en not_active Ceased
- 1997-05-14 CZ CZ19984297A patent/CZ9804297A3/cs unknown
- 1997-05-14 CN CN97195765A patent/CN1106380C/zh not_active Expired - Fee Related
- 1997-05-14 HU HU0001746A patent/HUP0001746A3/hu unknown
- 1997-05-14 PL PL97330899A patent/PL330899A1/xx unknown
- 1997-05-14 DK DK97923887T patent/DK0907633T3/da active
- 1997-05-14 EP EP97923887A patent/EP0907633B1/de not_active Expired - Lifetime
- 1997-05-14 AT AT97923887T patent/ATE204563T1/de not_active IP Right Cessation
- 1997-05-14 DE DE59704380T patent/DE59704380D1/de not_active Expired - Fee Related
- 1997-05-14 CA CA002252809A patent/CA2252809A1/en not_active Abandoned
- 1997-06-11 AR ARP970102549A patent/AR008391A1/es unknown
- 1997-06-13 PE PE1997000491A patent/PE70098A1/es not_active Application Discontinuation
- 1997-06-24 CO CO97035121A patent/CO4900028A1/es unknown
- 1997-06-24 UY UY24596A patent/UY24596A1/es unknown
- 1997-06-25 ZA ZA9705638A patent/ZA975638B/xx unknown
-
1998
- 1998-12-14 NO NO19985858A patent/NO311975B1/no not_active IP Right Cessation
-
2001
- 2001-09-18 GR GR20010401527T patent/GR3036667T3/el not_active IP Right Cessation
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