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AR008272A1 - Derivados de piperidina 1,4-disustituida que contienen fluor, composicion farmaceutica compuesta de los mismos y un proceso para su preparacion - Google Patents

Derivados de piperidina 1,4-disustituida que contienen fluor, composicion farmaceutica compuesta de los mismos y un proceso para su preparacion

Info

Publication number
AR008272A1
AR008272A1 ARP970103516A ARP970103516A AR008272A1 AR 008272 A1 AR008272 A1 AR 008272A1 AR P970103516 A ARP970103516 A AR P970103516A AR P970103516 A ARP970103516 A AR P970103516A AR 008272 A1 AR008272 A1 AR 008272A1
Authority
AR
Argentina
Prior art keywords
group
substituted
hydrogen atoms
fluorine
derivatives
Prior art date
Application number
ARP970103516A
Other languages
English (en)
Original Assignee
Banyu Pharma Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Banyu Pharma Co Ltd filed Critical Banyu Pharma Co Ltd
Publication of AR008272A1 publication Critical patent/AR008272A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C07D211/44—Oxygen atoms attached in position 4
    • C07D211/46—Oxygen atoms attached in position 4 having a hydrogen atom as the second substituent in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/56—Nitrogen atoms
    • C07D211/58—Nitrogen atoms attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Urology & Nephrology (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Derivados de piperidina 1,4-disustituida que contienen flúor, un proceso para prepararlos y composiciones farmacéuticas que los contienen que se usancomo medicina, especialmente en el tratamiento o profilaxis de varias enfermedades delo s sistemas respiratorios, urinarias y digestsivas. Los nuevosderivados están representados por la fórmula general (I) y sus sales farmacéuticamente aceptables donde: Ar representa un grupo de arilo o un grupode heteroarilo que tieneentre 1 y 2 heteroátomos seleccionados de un grupo formado por nitrógeno, oxígeno y azufre (cualquiera de 1 a 3 átomos dehidrógeno sobre el anillo de dicho grupo de arilo o heteroarilo puede ser sustituido por un alquilo inferior,trifluormetilo, ciano, hidroxilo, nitroalcoxicaarbonilo inferior, halógeno, alcoxi inferior, amino o alquilamino inferior); R1 es cicloalquilo C3-C6 cuyos 1 a 4 átomos de hidrógeno puedenestar sustituidos con átomo(s) de flúor; R2 son gruposalifáticos satura dos o no saturados de C5-C15 cualquiera de cuyos 1 a 6 átomos de hidrógeno puedensustituirse con átomo(s) de flúor, grupos de aralquilo, arilalquenilo, heteroarilalquilo heteroarilalquenilo que tienen entre 1 y 2heteroátomosseleccionados del grupo formado por nitrógeno, oxígeno y azufre (opcionalmente cualquiera de 1 a 3 átomos de hidrógeno en el anillo en dicho grupo aralquilo,arilalquenilo, heteroarilquilo, o heteroarilalquenilo puede estar sustituídocon un alquilo inferior, t rifluorometilo, ciano, hidroxilo, nitroalcoxicarbonilo inferior, halógeno, alcoxi inferior, amino o alquilamino inferior), y X es O o NH, con la condición de que ppor lo menos uno de R1 y R2contenga uno o más átomosde flúor. Los compuestos no solo tienen un antagonismo potente y selectivo para los receptores M3 muscarínicos sino también tienen
ARP970103516A 1996-08-01 1997-08-01 Derivados de piperidina 1,4-disustituida que contienen fluor, composicion farmaceutica compuesta de los mismos y un proceso para su preparacion AR008272A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP21943696 1996-08-01
JP5397997 1997-02-21

Publications (1)

Publication Number Publication Date
AR008272A1 true AR008272A1 (es) 1999-12-29

Family

ID=26394715

Family Applications (3)

Application Number Title Priority Date Filing Date
ARP970103516A AR008272A1 (es) 1996-08-01 1997-08-01 Derivados de piperidina 1,4-disustituida que contienen fluor, composicion farmaceutica compuesta de los mismos y un proceso para su preparacion
ARP980104218A AR016877A2 (es) 1996-08-01 1998-08-25 6-ter-butiloxicarbonilaminopiridinas 2-sustituidas y sus sales
ARP980104219A AR017021A1 (es) 1996-08-01 1998-08-25 Acido 2-hidroxiacetico

Family Applications After (2)

Application Number Title Priority Date Filing Date
ARP980104218A AR016877A2 (es) 1996-08-01 1998-08-25 6-ter-butiloxicarbonilaminopiridinas 2-sustituidas y sus sales
ARP980104219A AR017021A1 (es) 1996-08-01 1998-08-25 Acido 2-hidroxiacetico

Country Status (29)

Country Link
US (2) US5948792A (es)
EP (1) EP0930298B1 (es)
JP (1) JP3063164B2 (es)
KR (1) KR20000022214A (es)
CN (1) CN1226888A (es)
AR (3) AR008272A1 (es)
AT (1) ATE229941T1 (es)
AU (1) AU716050B2 (es)
BG (1) BG103114A (es)
BR (1) BR9711108A (es)
CA (1) CA2261680C (es)
CO (1) CO4960641A1 (es)
CZ (1) CZ33199A3 (es)
DE (1) DE69718026T2 (es)
EE (1) EE9900038A (es)
ES (1) ES2188961T3 (es)
HR (1) HRP970426A2 (es)
HU (1) HUP9902381A3 (es)
ID (1) ID17259A (es)
IL (1) IL127685A0 (es)
IS (1) IS4960A (es)
NO (1) NO990472D0 (es)
NZ (1) NZ333842A (es)
PE (1) PE92198A1 (es)
PL (1) PL331431A1 (es)
SK (1) SK12299A3 (es)
TR (2) TR199900204T2 (es)
WO (1) WO1998005641A1 (es)
YU (1) YU1299A (es)

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Also Published As

Publication number Publication date
ATE229941T1 (de) 2003-01-15
PE92198A1 (es) 1999-01-09
CA2261680A1 (en) 1998-02-12
EP0930298B1 (en) 2002-12-18
ES2188961T3 (es) 2003-07-01
CZ33199A3 (cs) 1999-07-14
US5948792A (en) 1999-09-07
IS4960A (is) 1999-01-29
TR200001482T2 (tr) 2000-11-21
PL331431A1 (en) 1999-07-19
DE69718026D1 (de) 2003-01-30
AU716050B2 (en) 2000-02-17
US6040449A (en) 2000-03-21
TR199900204T2 (xx) 2000-01-21
ID17259A (id) 1997-12-11
CA2261680C (en) 2005-03-08
CN1226888A (zh) 1999-08-25
SK12299A3 (en) 2000-05-16
IL127685A0 (en) 1999-10-28
NO990472L (no) 1999-02-01
EP0930298A1 (en) 1999-07-21
HRP970426A2 (en) 1998-08-31
HUP9902381A2 (hu) 1999-11-29
KR20000022214A (ko) 2000-04-25
AU3635197A (en) 1998-02-25
NO990472D0 (no) 1999-02-01
JP3063164B2 (ja) 2000-07-12
NZ333842A (en) 2001-05-25
WO1998005641A1 (en) 1998-02-12
EP0930298A4 (en) 2000-06-07
CO4960641A1 (es) 2000-09-25
AR017021A1 (es) 2001-08-22
AR016877A2 (es) 2001-08-01
BR9711108A (pt) 1999-08-17
BG103114A (en) 1999-11-30
HUP9902381A3 (en) 2000-06-28
DE69718026T2 (de) 2003-07-10
EE9900038A (et) 1999-08-16
YU1299A (sh) 2002-03-18

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