YU1299A - 1,4-disupstituisani derivati piperidina koji sadrže fluor - Google Patents
1,4-disupstituisani derivati piperidina koji sadrže fluorInfo
- Publication number
- YU1299A YU1299A YU1299A YU1299A YU1299A YU 1299 A YU1299 A YU 1299A YU 1299 A YU1299 A YU 1299A YU 1299 A YU1299 A YU 1299A YU 1299 A YU1299 A YU 1299A
- Authority
- YU
- Yugoslavia
- Prior art keywords
- substituted
- fluorine
- hydrogen atoms
- heteroarylalkenyl
- arylalkenyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/44—Oxygen atoms attached in position 4
- C07D211/46—Oxygen atoms attached in position 4 having a hydrogen atom as the second substituent in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/56—Nitrogen atoms
- C07D211/58—Nitrogen atoms attached in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pulmonology (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyridine Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Ovaj pronalazak se odnosi na nove 1,4-disupstituisane derivate piperidina koji sadrze fluor, opisane opstom formulom (I) i na njihove farmaceutski prihvatljive soli, pri cemu: Ar predstavlja aril- ili heteroaril-grupu sa 1 do 2 hetero-atoma odabrana iz grupe koja se sastoji od azota, kiseonika i sumpora (od 1 do 3 atoma vodonika u prstenu navedene aril- ili heteroaril-grupe mogu da budu supstituisani nizom alkil-grupom, itd.); R1 predstavlja cikloalkil-grupu sa 3 do 6 atoma ugljenika, cijih od 1 do 4 atoma vodonika mogu da budu supstituisani fluorom; R2 predstavlja zasicenu ili nezasicenu alifaticnu ugljovodonicnu grupu sa 5 do 15 ugljenikovih atoma, cijih od 1 do 6 atoma vodonika mogu da budu supstituisani fluorom, aralkil-, arilalkenil-, heteroarilalkil- ili heteroarilalkenil-grupu sa 1 do 2 hetero-atoma odabrana iz grupe koja se sastoji od azota, kiseonika i sumpora (opciono, od 1 do 3 atoma vodonika u prstenu navedene aralkil-, arilalkenil-, heteroarilalkil- ili heteroarilalkenil-grupe mogu da budu supstituisani nizom alkil-, trifluormetil-, cijano-, hidroksi-, nitro-, nizom alkoksikarbonil-, halo-, nizom alkoksi- ili amino-grupom itd.; a X predstavlja O ili NH, pod uslovom da barem jedna od grupa R1, odnosno R2 sadrzi jedan ili vise atoma fluora. Jedinjenja iz ovog pronalaska pokazuju selektivno antagonisticko dejstvo prema muskarinskim M3 receptorima, kao i i odlicnu oralnu aktivnost, trajanje dejstva i farmakokinetiku, imaju malo sporednih efekata, bezbedna su i efikasna. Zbog toga su korisna pri lecenju ili profilaksi respiratornih, digestivnih i urinarnih oboljenja.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP21943696 | 1996-08-01 | ||
| JP5397997 | 1997-02-21 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| YU1299A true YU1299A (sh) | 2002-03-18 |
Family
ID=26394715
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| YU1299A YU1299A (sh) | 1996-08-01 | 1997-07-28 | 1,4-disupstituisani derivati piperidina koji sadrže fluor |
Country Status (29)
| Country | Link |
|---|---|
| US (2) | US5948792A (sh) |
| EP (1) | EP0930298B1 (sh) |
| JP (1) | JP3063164B2 (sh) |
| KR (1) | KR20000022214A (sh) |
| CN (1) | CN1226888A (sh) |
| AR (3) | AR008272A1 (sh) |
| AT (1) | ATE229941T1 (sh) |
| AU (1) | AU716050B2 (sh) |
| BG (1) | BG103114A (sh) |
| BR (1) | BR9711108A (sh) |
| CA (1) | CA2261680C (sh) |
| CO (1) | CO4960641A1 (sh) |
| CZ (1) | CZ33199A3 (sh) |
| DE (1) | DE69718026T2 (sh) |
| EE (1) | EE9900038A (sh) |
| ES (1) | ES2188961T3 (sh) |
| HR (1) | HRP970426A2 (sh) |
| HU (1) | HUP9902381A3 (sh) |
| ID (1) | ID17259A (sh) |
| IL (1) | IL127685A0 (sh) |
| IS (1) | IS4960A (sh) |
| NO (1) | NO990472D0 (sh) |
| NZ (1) | NZ333842A (sh) |
| PE (1) | PE92198A1 (sh) |
| PL (1) | PL331431A1 (sh) |
| SK (1) | SK12299A3 (sh) |
| TR (2) | TR199900204T2 (sh) |
| WO (1) | WO1998005641A1 (sh) |
| YU (1) | YU1299A (sh) |
Families Citing this family (56)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6180823B1 (en) | 1998-11-06 | 2001-01-30 | Sepracor Inc. | Stereoselective process for alkyl phenylglycolic acids |
| US6693202B1 (en) | 1999-02-16 | 2004-02-17 | Theravance, Inc. | Muscarinic receptor antagonists |
| WO2000061572A1 (en) * | 1999-04-08 | 2000-10-19 | Merck & Co., Inc. | Diastereoselective preparation of michael adducts |
| AU4314700A (en) * | 1999-04-28 | 2000-11-17 | Banyu Pharmaceutical Co., Ltd. | Processes for the preparation of piperidylmethylpyridine derivatives |
| AR025353A1 (es) * | 1999-08-23 | 2002-11-20 | Lundbeck & Co As H | Tratamiento de la incontinencia urinaria |
| EP1235802B1 (en) * | 1999-12-07 | 2005-07-13 | Theravance, Inc. | Carbamate derivatives having muscarinic receptor antagonist activity |
| UA73543C2 (uk) | 1999-12-07 | 2005-08-15 | Тераванс, Інк. | Похідні сечовини, фармацевтична композиція та застосування похідного при приготуванні лікарського засобу для лікування захворювання, яке опосередковується мускариновим рецептором |
| ATE356624T1 (de) * | 1999-12-17 | 2007-04-15 | Sanofi Aventis | Phenoxypropanolamin-derivate, ihre herstellung und therapeutische verwendung |
| US6403818B1 (en) | 2000-02-28 | 2002-06-11 | Eisai Co., Ltd. | Process for producing α-hydroxy-carbonyl compound |
| US6469172B2 (en) | 2000-03-08 | 2002-10-22 | Merck & Co., Inc. | Process for the preparation of chemical compounds |
| US6403584B1 (en) * | 2000-06-22 | 2002-06-11 | Merck & Co., Inc. | Substituted nipecotyl derivatives as inhibitors of cell adhesion |
| US6846835B2 (en) * | 2000-07-11 | 2005-01-25 | Banyu Pharmaceutical Co., Ltd. | Ester derivatives |
| ATE305468T1 (de) | 2000-12-22 | 2005-10-15 | Almirall Prodesfarma Ag | Chinuclidincarbamat derivate und deren verwendung als m3 antagonisten |
| SI1353919T1 (sl) | 2000-12-28 | 2006-12-31 | Almirall Prodesfarma Ag | Novi derivati kinuklidina in medicinske zmesi, kijih vsebujejo. |
| DE10111843A1 (de) * | 2001-03-13 | 2002-09-19 | Boehringer Ingelheim Pharma | Verbindungen zur Behandlung von inflammatorischen Erkrankungen |
| CN1558756A (zh) * | 2001-09-27 | 2004-12-29 | �ź㴫 | 用于治疗泌尿疾病的药物组合物 |
| ES2203327B1 (es) * | 2002-06-21 | 2005-06-16 | Almirall Prodesfarma, S.A. | Nuevos carbamatos de quinuclidina y composiciones farmaceuticas que los contienen. |
| ES2204295B1 (es) * | 2002-07-02 | 2005-08-01 | Almirall Prodesfarma, S.A. | Nuevos derivados de quinuclidina-amida. |
| MXPA05000434A (es) * | 2002-07-08 | 2005-04-19 | Ranbaxy Lab Ltd | Derivados de hexano [3.1.0] azabiciclo 3,6-disustituido utiles como antagonistas de receptor muscarinico. |
| HK1079787A1 (zh) | 2002-07-31 | 2006-04-13 | Ranbaxy Laboratories Limited | 用作毒蕈碱受体拮抗剂的3，6-二取代的氮杂双环[3．1．0]己烷衍生物 |
| US6583103B1 (en) | 2002-08-09 | 2003-06-24 | S.C. Johnson & Son, Inc. | Two part cleaning formula resulting in an effervescent liquid |
| WO2004014363A1 (en) | 2002-08-09 | 2004-02-19 | Ranbaxy Laboratories Limited | 3,6-disubstituted azabicyclo [3.1.0] hexane derivatives useful as muscarinic receptor antagonist |
| EP1534675B1 (en) | 2002-08-23 | 2009-02-25 | Ranbaxy Laboratories, Ltd. | Fluoro and sulphonylamino containing 3,6-disubstituted azabicyclo¬3.1.0 hexane derivatives as muscarinic receptor antagonists |
| BR0315747A (pt) * | 2002-10-29 | 2005-09-06 | Pharmacia & Upjohn Co Llc | Compostos de amÈnio quaternário como antagonistas de receptor muscarìnico |
| TWI295669B (en) | 2002-10-30 | 2008-04-11 | Theravance Inc | Substituted 4-amino-1-(pyridylmethyl) piperidine and related compounds |
| WO2004052857A1 (en) * | 2002-12-10 | 2004-06-24 | Ranbaxy Laboratories Limited | 3,6-disubstituted azabicyclo [3.1.0] hexane derivatives as muscarinic receptor antagonists |
| PT1572173E (pt) | 2002-12-13 | 2010-05-10 | Warner Lambert Co | Ligando alfa-2-delta para tratar sintomas do tracto urinário inferior |
| AU2002347553A1 (en) | 2002-12-23 | 2004-07-14 | Ranbaxy Laboratories Limited | Flavaxate derivatives as muscarinic receptor antagonists |
| EP1583741A1 (en) * | 2002-12-23 | 2005-10-12 | Ranbaxy Laboratories, Limited | 1-substituted-3-pyrrolidine derivatives as muscarinic receptor antagonists |
| US7488748B2 (en) | 2003-01-28 | 2009-02-10 | Ranbaxy Laboratories Limited | 3,6-Disubstituted azabicyclo hexane derivatives as muscarinic receptor antagonists |
| PE20040950A1 (es) | 2003-02-14 | 2005-01-01 | Theravance Inc | DERIVADOS DE BIFENILO COMO AGONISTAS DE LOS RECEPTORES ADRENERGICOS ß2 Y COMO ANTAGONISTAS DE LOS RECEPTORES MUSCARINICOS |
| US7517905B2 (en) | 2003-04-09 | 2009-04-14 | Ranbaxy Laboratories Limited | Substituted azabicyclo hexane derivatives as muscarinic receptor antagonists |
| CN100406009C (zh) | 2003-04-10 | 2008-07-30 | 兰贝克赛实验室有限公司 | 作为毒蕈碱受体拮抗剂的取代的氮杂双环己烷衍生物 |
| AU2003223010A1 (en) | 2003-04-10 | 2004-11-01 | Ranbaxy Laboratories Limited | Substituted azabicyclo hexane derivatives as muscarinic receptor antagonists |
| EP1626957A1 (en) | 2003-04-11 | 2006-02-22 | Ranbaxy Laboratories Limited | Azabicyclo derivatives as muscarinic receptor antagonists |
| WO2004091597A2 (en) * | 2003-04-15 | 2004-10-28 | Pharmacia & Upjohn Company Llc | Method of treating irritable bowel syndrome (ibs) |
| US7368463B2 (en) | 2003-07-11 | 2008-05-06 | Theravance, Inc. | Substituted 4-amino-1-benzylpiperidine compounds |
| JP4851937B2 (ja) | 2003-11-21 | 2012-01-11 | セラヴァンス， インコーポレーテッド | β２アドレナリン作動性受容体作動薬活性およびムスカリン受容体拮抗薬活性を有する化合物 |
| RU2329261C2 (ru) * | 2003-12-29 | 2008-07-20 | Баниу Фармасьютикал Ко., Лтд. | Новое 2-гетероарил-замещенное производное бензимидазола |
| ATE419246T1 (de) * | 2004-06-16 | 2009-01-15 | Ranbaxy Lab Ltd | Als antagonisten des muscarinrezeptors geeignete xanthinderivate |
| WO2006018708A2 (en) * | 2004-08-19 | 2006-02-23 | Ranbaxy Laboratories Limited | Pyrrolidine derivatives as muscarinic receptor antagonists |
| EP1794161A2 (en) * | 2004-09-24 | 2007-06-13 | Ranbaxy Laboratories Limited | Muscarinic receptor antagonists |
| WO2006035303A1 (en) * | 2004-09-29 | 2006-04-06 | Ranbaxy Laboratories Limited | Muscarinic receptor antagonists |
| WO2006049304A1 (ja) | 2004-11-02 | 2006-05-11 | Banyu Pharmaceutical Co., Ltd | アリールオキシ置換ベンズイミダゾール誘導体 |
| WO2006054162A1 (en) * | 2004-11-19 | 2006-05-26 | Ranbaxy Laboratories Limited | Azabicyclic muscarinic receptor antagonists |
| WO2006064304A1 (en) * | 2004-12-15 | 2006-06-22 | Ranbaxy Laboratories Limited | Acid addition salts of muscarinic receptor antagonists |
| WO2006117754A1 (en) * | 2005-05-03 | 2006-11-09 | Ranbaxy Laboratories Limited | 3,6-disubstituted azabicyclo [3.1.0] hexane derivatives as muscarinic receptor antagonists |
| US7799820B2 (en) * | 2005-09-30 | 2010-09-21 | Banyu Pharmaceutical Co., Ltd. | 2-Heterocycle-substituted indole derivatives for treating diabetes and associated conditions |
| EP1934184A1 (en) * | 2005-10-05 | 2008-06-25 | Ranbaxy Laboratories, Ltd. | 3 -azabicyclooctane derivatives as muscarinic receptor antagonists |
| WO2007045979A1 (en) | 2005-10-19 | 2007-04-26 | Ranbaxy Laboratories Limited | Pharmaceutical compositions of muscarinic receptor antagonists |
| GB0602778D0 (en) | 2006-02-10 | 2006-03-22 | Glaxo Group Ltd | Novel compound |
| JP2008081492A (ja) | 2006-08-31 | 2008-04-10 | Banyu Pharmaceut Co Ltd | オーロラａ選択的阻害作用を有する新規アミノピリジン誘導体 |
| US20090010923A1 (en) * | 2007-04-24 | 2009-01-08 | University Of Maryland, Baltimore | Treatment of cancer with anti-muscarinic receptor agents |
| DK2197841T3 (da) | 2007-09-07 | 2012-02-06 | Theravance Inc | Guanidinholdige forbindelser anvendelige som muscariniske receptorantagonister |
| DK2234600T3 (da) * | 2007-12-21 | 2014-09-08 | Hoffmann La Roche | Antistofformulering |
| CN104876854B (zh) * | 2015-04-16 | 2017-03-01 | 御盛隆堂药业有限责任公司 | 羟基乙酸酯衍生物及其用途 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6018661B2 (ja) * | 1976-01-01 | 1985-05-11 | 太田製薬株式会社 | １−（１，３−ジオキソラン−４−イルメチル）ピペリジノ−ル誘導体 |
| JPS5679688A (en) * | 1979-12-04 | 1981-06-30 | Ota Seiyaku Kk | 4-acyloxy-1- 1,3-dioxoran-2-ylmethyl piperidine derivative and its production |
| IT1231238B (it) * | 1987-09-21 | 1991-11-26 | Angeli Inst Spa | Derivati ammidinici |
| GB8825505D0 (en) * | 1988-11-01 | 1988-12-07 | Pfizer Ltd | Therapeutic agents |
| GB9023023D0 (en) * | 1990-10-23 | 1990-12-05 | Barlow Richard B | Pharmaceutical compositions |
| CA2123728A1 (en) * | 1993-05-21 | 1994-11-22 | Noriyoshi Sueda | Urea derivatives and their use as acat inhibitors |
| AU7545894A (en) * | 1993-09-02 | 1995-03-22 | Yamanouchi Pharmaceutical Co., Ltd. | Carbamate derivative and medicine containing the same |
| JP3294961B2 (ja) * | 1993-12-10 | 2002-06-24 | 杏林製薬株式会社 | 新規イミダゾール誘導体及びその製造法 |
| JPH07258250A (ja) * | 1994-03-25 | 1995-10-09 | Yamanouchi Pharmaceut Co Ltd | エステル誘導体 |
| US5750540A (en) * | 1995-04-28 | 1998-05-12 | Banyu Pharmaceutical Co., Ltd. | 1,4-di-substituted piperidine derivatives |
| CA2179574A1 (en) * | 1995-06-26 | 1996-12-27 | Tomomi Okada | Substituted piperidine derivative and medicine comprising the same |
| EP0863141B1 (en) * | 1995-10-13 | 2001-09-12 | Banyu Pharmaceutical Co., Ltd. | Substituted heteroaromatic derivatives |
-
1997
- 1997-07-24 PE PE1997000659A patent/PE92198A1/es not_active Application Discontinuation
- 1997-07-28 AU AU36351/97A patent/AU716050B2/en not_active Ceased
- 1997-07-28 YU YU1299A patent/YU1299A/sh unknown
- 1997-07-28 SK SK122-99A patent/SK12299A3/sk unknown
- 1997-07-28 WO PCT/JP1997/002600 patent/WO1998005641A1/ja not_active Ceased
- 1997-07-28 HU HU9902381A patent/HUP9902381A3/hu unknown
- 1997-07-28 BR BR9711108A patent/BR9711108A/pt not_active IP Right Cessation
- 1997-07-28 CN CN97196911A patent/CN1226888A/zh active Pending
- 1997-07-28 PL PL97331431A patent/PL331431A1/xx unknown
- 1997-07-28 AT AT97933037T patent/ATE229941T1/de not_active IP Right Cessation
- 1997-07-28 CZ CZ99331A patent/CZ33199A3/cs unknown
- 1997-07-28 ES ES97933037T patent/ES2188961T3/es not_active Expired - Lifetime
- 1997-07-28 DE DE69718026T patent/DE69718026T2/de not_active Expired - Lifetime
- 1997-07-28 IL IL12768597A patent/IL127685A0/xx unknown
- 1997-07-28 EP EP97933037A patent/EP0930298B1/en not_active Expired - Lifetime
- 1997-07-28 KR KR1019980710633A patent/KR20000022214A/ko not_active Ceased
- 1997-07-28 EE EEP199900038A patent/EE9900038A/xx unknown
- 1997-07-28 CA CA002261680A patent/CA2261680C/en not_active Expired - Fee Related
- 1997-07-28 TR TR1999/00204T patent/TR199900204T2/xx unknown
- 1997-07-28 JP JP10507794A patent/JP3063164B2/ja not_active Expired - Fee Related
- 1997-07-28 TR TR2000/01482T patent/TR200001482T2/xx unknown
- 1997-07-30 HR HR53,979/97A patent/HRP970426A2/hr not_active Application Discontinuation
- 1997-07-31 US US08/903,768 patent/US5948792A/en not_active Expired - Lifetime
- 1997-07-31 ID IDP972666A patent/ID17259A/id unknown
- 1997-08-01 AR ARP970103516A patent/AR008272A1/es not_active Application Discontinuation
- 1997-08-01 CO CO97044382A patent/CO4960641A1/es unknown
-
1998
- 1998-08-25 AR ARP980104218A patent/AR016877A2/es unknown
- 1998-08-25 AR ARP980104219A patent/AR017021A1/es unknown
-
1999
- 1999-01-25 BG BG103114A patent/BG103114A/xx unknown
- 1999-01-28 NZ NZ333842A patent/NZ333842A/en unknown
- 1999-01-29 IS IS4960A patent/IS4960A/is unknown
- 1999-02-01 NO NO990472A patent/NO990472D0/no not_active Application Discontinuation
- 1999-04-13 US US09/290,607 patent/US6040449A/en not_active Expired - Fee Related
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