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MX9300031A - Derivados de piperazina, procedimiento para su preparacion y composicion farmaucetica que los contiene. - Google Patents

Derivados de piperazina, procedimiento para su preparacion y composicion farmaucetica que los contiene.

Info

Publication number
MX9300031A
MX9300031A MX9300031A MX9300031A MX9300031A MX 9300031 A MX9300031 A MX 9300031A MX 9300031 A MX9300031 A MX 9300031A MX 9300031 A MX9300031 A MX 9300031A MX 9300031 A MX9300031 A MX 9300031A
Authority
MX
Mexico
Prior art keywords
piperazine
derivatives
procedure
preparation
pharmaceutical composition
Prior art date
Application number
MX9300031A
Other languages
English (en)
Inventor
Ian Anthony Cliffe
Original Assignee
Wyeth John & Brother Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth John & Brother Ltd filed Critical Wyeth John & Brother Ltd
Publication of MX9300031A publication Critical patent/MX9300031A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/125—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/13—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Cardiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Diabetes (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Child & Adolescent Psychology (AREA)
  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)

Abstract

Compuestos de la fórmula (I). En la cual A, es un cadena de alquileno de 2 a 5 átomos de carbono opcionalmente substituida por uno o más grupos alquilo inferior, R representa hidrógeno o uno o dos grupos alquilo inferior iguales o diferentes, R1 es un radical arilo o heteroarilo monocíclicos, R2 es un radical arilo- o bicíclico y R3 es cicloalquilo, así como las sales farmacéuticamente aceptables formadas por adición de ácido, todos los cuales son nuevos. Dichos compuestos son antagonistas 5-HT1A que se pueden utilizar, por ejemplo, en el tratamiento de la ansiedad.
MX9300031A 1992-01-08 1993-01-07 Derivados de piperazina, procedimiento para su preparacion y composicion farmaucetica que los contiene. MX9300031A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB929200293A GB9200293D0 (en) 1992-01-08 1992-01-08 Piperazine derivatives

Publications (1)

Publication Number Publication Date
MX9300031A true MX9300031A (es) 1993-07-01

Family

ID=10708249

Family Applications (1)

Application Number Title Priority Date Filing Date
MX9300031A MX9300031A (es) 1992-01-08 1993-01-07 Derivados de piperazina, procedimiento para su preparacion y composicion farmaucetica que los contiene.

Country Status (21)

Country Link
US (1) US5532242A (es)
EP (1) EP0620817B1 (es)
JP (1) JP3274865B2 (es)
KR (1) KR100283345B1 (es)
AT (1) ATE183504T1 (es)
AU (1) AU668901B2 (es)
BR (1) BR9207030A (es)
CA (1) CA2125182A1 (es)
DE (1) DE69229834T2 (es)
ES (1) ES2134835T3 (es)
FI (1) FI106200B (es)
GB (2) GB9200293D0 (es)
HU (1) HUT70513A (es)
IL (1) IL104305A (es)
MX (1) MX9300031A (es)
NZ (1) NZ246205A (es)
PH (1) PH30268A (es)
RU (1) RU2128653C1 (es)
TW (1) TW265337B (es)
WO (1) WO1993014076A1 (es)
ZA (1) ZA93141B (es)

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CZ315098A3 (cs) * 1996-04-05 1999-04-14 Société De Conseils De Recherches Et D'applications Scientifiques (S. C. R. A. S.) Antagonisté alfa1-adrenergických receptorů
US5610164A (en) * 1996-07-24 1997-03-11 American Home Products Corporation (Thiophen-2-yl)-piperidin or tetrahydropyridin azabicyclocarboxamides
IT1293807B1 (it) * 1997-08-01 1999-03-10 Recordati Chem Pharm Derivati 1- (n-fenilaminoalchil) piperazinici sostituiti alla posizione 2 dell'anello fenilico
US6399614B1 (en) 1997-08-01 2002-06-04 Recordati S.A. Chemical And Pharmaceutical Company 1-(N-phenylaminoalkyl)piperazine derivatives substituted at position 2 of the phenyl ring
IT1293804B1 (it) 1997-08-01 1999-03-10 Recordati Chem Pharm Diarilalchilpiperazine attive sulle basse vie urinarie
RU2161614C2 (ru) * 1998-03-17 2001-01-10 Тульский государственный педагогический университет им. Л.Н. Толстого Способ получения динатриевой соли n,n,-бис-(4-амино-2-сульфофенил)пиперазина
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CA2351860A1 (en) * 1998-12-17 2000-06-22 Wyeth Piperazine ethylamide derivatives with 5-ht1a receptor activity
WO2001068104A1 (en) 2000-03-16 2001-09-20 The Mclean Hospital Corporation Compounds for the treatment of psychiatric or substance abuse disorders
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EP1765075A4 (en) 2004-06-10 2010-11-10 Mclean Hospital Corp PYRIMIDINES, AS FORM. uridine; IN THE TREATMENT OF PATIENTS WITH MANIC-DEPRESSIVE PSYCHOSIS
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US7731940B2 (en) 2006-01-25 2010-06-08 The Regents Of The University Of California Compositions and methods related to serotonin 5-HT1A receptors
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MY152078A (en) 2007-09-14 2014-08-15 Ortho Mcneil Janssen Pharm 1',3'-disubstituted-4-phenyl-3,4,5,6-tetrahydro-2h,1'h-[1,4']bipyridinyl-2'-ones
CA2697399C (en) 2007-09-14 2016-01-19 Ortho-Mcneil-Janssen Pharmaceuticals, Inc. 1,3-disubstituted 4-(aryl-x-phenyl)-1h-pyridin-2-ones
NZ584148A (en) * 2007-09-14 2011-05-27 Ortho Mcneil Janssen Pharm 1,3-disubstituted-4-phenyl-1 h-pyridin-2-ones
RU2492170C9 (ru) * 2007-11-14 2013-12-27 Орто-Макнейл-Янссен Фармасьютикалз, Инк. Имидазо[1,2-а]пиридиновые производные и их применение в качестве положительных аллостерических модуляторов рецепторов mglur2
AU2009289784B2 (en) 2008-09-02 2012-03-22 Addex Pharma S.A. 3-azabicyclo[3.1.0]hexyl derivatives as modulators of metabotropic glutamate receptors
ES2466341T3 (es) 2008-10-16 2014-06-10 Janssen Pharmaceuticals, Inc. Derivados de indol y benzomorfolina como moduladores de receptores de glutamato metabotrópicos
WO2010060589A1 (en) 2008-11-28 2010-06-03 Ortho-Mcneil-Janssen Pharmaceuticals, Inc. Indole and benzoxazine derivatives as modulators of metabotropic glutamate receptors
NZ596053A (en) 2009-05-12 2013-05-31 Janssen Pharmaceuticals Inc 1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors
AU2010246609B2 (en) 2009-05-12 2013-09-05 Addex Pharma S.A. 1,2,4-triazolo [4,3-a] pyridine derivatives and their use for the treatment or prevention of neurological and psychiatric disorders
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JO3367B1 (ar) 2013-09-06 2019-03-13 Janssen Pharmaceutica Nv مركبات 2،1، 4- ثلاثي زولو [3،4-a] بيريدين واستخدامها بصفة منظمات تفارغية موجبة لمستقبلات ميجلور 2
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KR20220038826A (ko) 2014-01-21 2022-03-29 얀센 파마슈티카 엔.브이. 대사 조절형 글루탐산 작동성 수용체 제2아형의 양성 알로스테릭 조절제 또는 오르토스테릭 작동제를 포함하는 조합 및 그 용도

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Also Published As

Publication number Publication date
HU9402042D0 (en) 1994-09-28
ES2134835T3 (es) 1999-10-16
GB9200293D0 (en) 1992-02-26
JPH07502739A (ja) 1995-03-23
GB2263110A (en) 1993-07-14
JP3274865B2 (ja) 2002-04-15
RU94039542A (ru) 1996-08-10
DE69229834D1 (de) 1999-09-23
EP0620817B1 (en) 1999-08-18
GB2263110B (en) 1995-08-09
IL104305A0 (en) 1993-05-13
EP0620817A1 (en) 1994-10-26
FI943247A0 (fi) 1994-07-07
KR100283345B1 (ko) 2001-03-02
US5532242A (en) 1996-07-02
NZ246205A (en) 1996-12-20
AU668901B2 (en) 1996-05-23
AU3169793A (en) 1993-08-03
HUT70513A (en) 1995-10-30
BR9207030A (pt) 1995-12-05
FI943247L (fi) 1994-07-07
ZA93141B (en) 1994-07-08
FI106200B (fi) 2000-12-15
DE69229834T2 (de) 2000-01-13
TW265337B (es) 1995-12-11
GB9227001D0 (en) 1993-02-17
IL104305A (en) 1998-04-05
WO1993014076A1 (en) 1993-07-22
CA2125182A1 (en) 1993-07-22
PH30268A (en) 1997-02-20
RU2128653C1 (ru) 1999-04-10
ATE183504T1 (de) 1999-09-15

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