AR007776A1 - Analogos de vitamina d3 fluorados, composicion farmaceutica, procedimiento para prepararlos y uso de los mismos para la preparacion de medicamentos. - Google Patents
Analogos de vitamina d3 fluorados, composicion farmaceutica, procedimiento para prepararlos y uso de los mismos para la preparacion de medicamentos.Info
- Publication number
- AR007776A1 AR007776A1 ARP970102159A ARP970102159A AR007776A1 AR 007776 A1 AR007776 A1 AR 007776A1 AR P970102159 A ARP970102159 A AR P970102159A AR P970102159 A ARP970102159 A AR P970102159A AR 007776 A1 AR007776 A1 AR 007776A1
- Authority
- AR
- Argentina
- Prior art keywords
- hydrogen
- double bond
- carbon atoms
- analogs
- vitamin
- Prior art date
Links
- QYSXJUFSXHHAJI-YRZJJWOYSA-N vitamin D3 Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C\C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-YRZJJWOYSA-N 0.000 title abstract 2
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 title 1
- 239000003814 drug Substances 0.000 title 1
- 229910052731 fluorine Inorganic materials 0.000 title 1
- 239000011737 fluorine Substances 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 10
- 125000004432 carbon atom Chemical group C* 0.000 abstract 6
- 239000001257 hydrogen Substances 0.000 abstract 6
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 6
- 125000000217 alkyl group Chemical group 0.000 abstract 4
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 2
- 125000003709 fluoroalkyl group Chemical group 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Nutrition Science (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Análogos de vitamina D3 fluorados, que comprenden un compuesto de fórmula (I), en donde: X es (H,H) o =CH2; R1 y R2, son independientemente entre sí,hidrógeno, alquilo o fluoroalquilo de 1 a 4 átomos de carbono o R1 y R2 juntamente con elc arbono 20 forman un cicloalquilo o ciclofluoroalquilo de3 a 6 átomos de carbono, o R1 y R2 juntos forman =CH2; R3 y R4 son independientemente entre sí, un alquilo o fluoroalquilo de 1 a 4 átomos decarbono, o R3 y R4 juntamente con elcar bono 25 forman un cicloalquilo o ciclofluoroalquilo de 3 a 9 átomos de carbono; A es un enlace simple o undoble enlace; y B es un doble enlace o un enlace triple; excepto; (i) cuando X es =CH2, R3 y R4 son cada uno CF3, A es un dobleenlace y uno de R1 o R2 eshidrógeno, entonces el otro R1 o R2 no puede ser CH3; (ii) cuando X es =CH2, R3 y R4 son cada uno un alquilo de 1 a 2 átomos de carbono, A es un dobleenlace y R2 es hidrógeno, entonces R1 no puede ser CH3; (iii) cuando Xes =CH2, R3 y R4 son cada uno un alquilo de 1 a 4 átomos de carbono, A es undoble enlace y R1 es hidrógeno, entonces R2 no puede ser CH3; (iv) cuando X es =CH2, uno de R3 o R4 son cada uno CF3, A es un doble enlace, R1 es CH3 y R2es hidrógeno,en tonces el otro de R3 o R4 no puede ser CH3; y (v) cuando X es (H,H), R3 y R4 son cada uno CF3, A es un doble enlace, B es un enlace triple yR2 es hidrógeno, entonces R1 no puede ser CH3.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US1821996P | 1996-05-23 | 1996-05-23 | |
| US3990197P | 1997-03-19 | 1997-03-19 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR007776A1 true AR007776A1 (es) | 1999-11-24 |
Family
ID=26690870
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP970102159A AR007776A1 (es) | 1996-05-23 | 1997-05-21 | Analogos de vitamina d3 fluorados, composicion farmaceutica, procedimiento para prepararlos y uso de los mismos para la preparacion de medicamentos. |
Country Status (26)
| Country | Link |
|---|---|
| EP (1) | EP0808832B1 (es) |
| JP (1) | JP2859248B2 (es) |
| KR (1) | KR100253961B1 (es) |
| CN (1) | CN100402497C (es) |
| AR (1) | AR007776A1 (es) |
| AT (1) | ATE238278T1 (es) |
| AU (1) | AU733970B2 (es) |
| BR (1) | BR9703385A (es) |
| CA (1) | CA2205315C (es) |
| CO (1) | CO4940503A1 (es) |
| CZ (1) | CZ157797A3 (es) |
| DE (1) | DE69721123T2 (es) |
| DK (1) | DK0808832T3 (es) |
| ES (1) | ES2195049T3 (es) |
| HR (1) | HRP970272A2 (es) |
| HU (1) | HUP9700928A3 (es) |
| IL (1) | IL120844A0 (es) |
| MA (1) | MA24250A1 (es) |
| NO (1) | NO972278L (es) |
| NZ (1) | NZ314840A (es) |
| PE (1) | PE66798A1 (es) |
| PL (1) | PL320130A1 (es) |
| PT (1) | PT808832E (es) |
| SG (1) | SG70010A1 (es) |
| TR (1) | TR199700416A2 (es) |
| YU (1) | YU20097A (es) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6008209A (en) * | 1997-04-28 | 1999-12-28 | Hoffmann-La Roche Inc. | Method of using vitamin D3 analogs with bis C-20 side chains |
| DE19935771A1 (de) | 1999-07-23 | 2001-02-01 | Schering Ag | Neue Vitamin D-Derivate mit cyclischen Substrukturen in den Seitenketten, Verfahren und Zwischenprodukte zu ihrer Herstellung und die Verwendung zur Herstellung von Arzneimitteln |
| AU2001278744A1 (en) * | 2000-08-17 | 2002-02-25 | Chugai Seiyaku Kabushiki Kaisha | Remedial agent for osteoporosis |
| WO2003027065A1 (en) * | 2001-09-21 | 2003-04-03 | F. Hoffmann-La Roche Ag | 3-desoxy-vitamin d3 analog esters |
| SG110107A1 (en) | 2003-09-24 | 2005-04-28 | Bioxell Spa | Compound and use in treatment |
| US20080318911A1 (en) * | 2004-09-24 | 2008-12-25 | Bioxell S.P.A. | 20-Cyclopropyl, 26,27-Alkyl/Haloalkyl Vitamin D3 Compounds and Methods of Use Thereof |
| US20090099140A1 (en) * | 2005-03-23 | 2009-04-16 | Bioxell S.P.A. | 20-Alkyl, Gemini Vitamin D3 Compounds and Methods of Use Thereof |
| DK2634171T3 (en) * | 2010-10-25 | 2015-07-13 | Teijin Pharma Ltd | 23-yne-vitamin D 3 DERIVATIVE |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4141746A1 (de) * | 1991-12-13 | 1993-06-17 | Schering Ag | 20-methyl-substituierte vitamin d-derivate |
| DE4220757A1 (de) * | 1992-06-24 | 1994-01-05 | Schering Ag | Derivate in der Vitamin D-Reihe mit Modifikationen in der 20-Position, Verfahren zu ihrer Herstellung, Zwischenprodukte für dieses Verfahren, diese Derivate enthaltende pharmazeutische Präparate sowie deren Verwendung zur Herstellung von Arzneimitteln |
| US5428029A (en) * | 1993-11-24 | 1995-06-27 | Hoffmann-La Roche Inc. | Vitamin D3 fluorinated analogs |
| US5384314B1 (en) * | 1994-03-11 | 1997-08-05 | Hoffmann La Roche | 1alpha-fluoro-25-hydroxy-16-ene-23-yne-cholecalciferol |
| WO1997016193A1 (en) * | 1995-10-27 | 1997-05-09 | F. Hoffmann-La Roche Ag | Pharmaceutical composition for treating osteoporosis |
-
1997
- 1997-05-12 SG SG1997001484A patent/SG70010A1/en unknown
- 1997-05-14 CA CA002205315A patent/CA2205315C/en not_active Expired - Fee Related
- 1997-05-14 AT AT97107868T patent/ATE238278T1/de not_active IP Right Cessation
- 1997-05-14 ES ES97107868T patent/ES2195049T3/es not_active Expired - Lifetime
- 1997-05-14 EP EP97107868A patent/EP0808832B1/en not_active Expired - Lifetime
- 1997-05-14 DE DE69721123T patent/DE69721123T2/de not_active Expired - Lifetime
- 1997-05-14 DK DK97107868T patent/DK0808832T3/da active
- 1997-05-14 PT PT97107868T patent/PT808832E/pt unknown
- 1997-05-16 PE PE1997000387A patent/PE66798A1/es not_active Application Discontinuation
- 1997-05-16 IL IL12084497A patent/IL120844A0/xx unknown
- 1997-05-16 NZ NZ314840A patent/NZ314840A/en unknown
- 1997-05-20 HR HR60/039,901A patent/HRP970272A2/xx not_active Application Discontinuation
- 1997-05-20 NO NO972278A patent/NO972278L/no unknown
- 1997-05-20 YU YU20097A patent/YU20097A/sh unknown
- 1997-05-21 AR ARP970102159A patent/AR007776A1/es active IP Right Grant
- 1997-05-21 MA MA24631A patent/MA24250A1/fr unknown
- 1997-05-21 HU HU9700928A patent/HUP9700928A3/hu unknown
- 1997-05-22 PL PL97320130A patent/PL320130A1/xx unknown
- 1997-05-22 CN CNB971134324A patent/CN100402497C/zh not_active Expired - Fee Related
- 1997-05-22 CO CO97028096A patent/CO4940503A1/es unknown
- 1997-05-22 AU AU23576/97A patent/AU733970B2/en not_active Ceased
- 1997-05-22 CZ CZ971577A patent/CZ157797A3/cs unknown
- 1997-05-22 JP JP9131810A patent/JP2859248B2/ja not_active Expired - Fee Related
- 1997-05-22 KR KR1019970020029A patent/KR100253961B1/ko not_active Expired - Fee Related
- 1997-05-23 TR TR97/00416A patent/TR199700416A2/xx unknown
- 1997-05-23 BR BR9703385A patent/BR9703385A/pt not_active Application Discontinuation
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant, registration |