AR029374A1 - Compuestos derivados de benceno, su utilizacion, un procedimiento para su preparacion y una composicion farmaceutica que los contiene - Google Patents
Compuestos derivados de benceno, su utilizacion, un procedimiento para su preparacion y una composicion farmaceutica que los contieneInfo
- Publication number
- AR029374A1 AR029374A1 ARP000103334A ARP000103334A AR029374A1 AR 029374 A1 AR029374 A1 AR 029374A1 AR P000103334 A ARP000103334 A AR P000103334A AR P000103334 A ARP000103334 A AR P000103334A AR 029374 A1 AR029374 A1 AR 029374A1
- Authority
- AR
- Argentina
- Prior art keywords
- group
- hydrogen
- phenyl
- atom
- methyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/02—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements
- C07D295/027—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements containing only one hetero ring
- C07D295/03—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements containing only one hetero ring with the ring nitrogen atoms directly attached to acyclic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/06—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals
- C07D295/073—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals with the ring nitrogen atoms and the substituents separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/096—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2603/00—Systems containing at least three condensed rings
- C07C2603/56—Ring systems containing bridged rings
- C07C2603/58—Ring systems containing bridged rings containing three rings
- C07C2603/70—Ring systems containing bridged rings containing three rings containing only six-membered rings
- C07C2603/74—Adamantanes
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Hydrogenated Pyridines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Compuestos derivados de benceno caracterizados porque comprenden la formula (1) en la cual A representa un grupo elegido entre los siguientes -CsC-; -CHsCH-, -CH2CH2, n es igual a 1 o 2 X representa un átomo de hidrogeno, de cloro o de fluor o un grupo metilo o metoxi; Y representa un átomo de hidrogeno o un átomo de cloro o de fluor; R1 representa un grupo ciclohexilo monosustituido, disustituido, trisustituido o tetrasustituido por un grupo metilo; un grupo fenilo monosustituido o disustituido por un átomo de fluor o de cloro o por un grupo (C1-3)alcoxi o trifluorometilo; un grupo cicloheptilo, terbutilo, diciclopropilmetilo, biciclo [3.2.1] octanilo, 4-tetrahidropiranilo, 4-tetrahidrotiopiranilo o adamantilo 1 o 2; o R1 representa un grupo fenilo entendiéndose que en ese caso X o Y son diferentes del hidrogeno; o bien R1 representa un grupo ciclohexilo entendiéndose que en ese caso X e Y son diferentes del hidrogeno; R2 y R3 forman con el átomo de nitrogeno al cual están unidos una aminacíclica que comprende de 5 a 8 eslabones; un grupo morfolinilo eventualmente sustituido en posicion 3 y 5 por un metilo; o un grupo 4-fenil-1,2,3,6-tetrahidropiridinilo eventualmente substituido en el fenilo por un halogeno o un grupo trifluorometilo, (C1-4) alquilo o (C1-4)alcoxi; y las sales de adicion de esos compuestos con ácidos farmacéuticamente aceptables, así como sus solvatos e hidratos. También se divulga su utilizacion, un procedimiento para su preparacion y una composicion farmacéutica que los contienen.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR9908532A FR2795724B1 (fr) | 1999-07-02 | 1999-07-02 | Nouveaux derives du benzene, un procede pour leur preparation et les compositions pharmaceutiques les contenant |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR029374A1 true AR029374A1 (es) | 2003-06-25 |
Family
ID=9547628
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP000103334A AR029374A1 (es) | 1999-07-02 | 2000-06-30 | Compuestos derivados de benceno, su utilizacion, un procedimiento para su preparacion y una composicion farmaceutica que los contiene |
Country Status (31)
| Country | Link |
|---|---|
| US (1) | US6908914B1 (es) |
| EP (1) | EP1196403B1 (es) |
| JP (1) | JP4931309B2 (es) |
| KR (1) | KR100760446B1 (es) |
| CN (1) | CN1156462C (es) |
| AR (1) | AR029374A1 (es) |
| AT (1) | ATE309231T1 (es) |
| AU (1) | AU778299B2 (es) |
| BG (1) | BG65209B1 (es) |
| BR (1) | BR0012463B1 (es) |
| CA (1) | CA2376691C (es) |
| CO (1) | CO5021196A1 (es) |
| CZ (1) | CZ300936B6 (es) |
| DE (1) | DE60023898T2 (es) |
| DK (1) | DK1196403T3 (es) |
| EA (1) | EA004048B1 (es) |
| ES (1) | ES2250160T3 (es) |
| FR (1) | FR2795724B1 (es) |
| HK (1) | HK1043122A1 (es) |
| HR (1) | HRP20010949B1 (es) |
| HU (1) | HU228983B1 (es) |
| IL (2) | IL147069A0 (es) |
| ME (1) | MEP25508A (es) |
| MX (1) | MXPA01013207A (es) |
| NO (1) | NO322230B1 (es) |
| NZ (1) | NZ516342A (es) |
| RS (1) | RS50266B (es) |
| TW (1) | TWI285640B (es) |
| UA (1) | UA71009C2 (es) |
| WO (1) | WO2001002380A1 (es) |
| ZA (1) | ZA200200018B (es) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE50207026D1 (de) * | 2001-08-23 | 2006-07-06 | Bayer Cropscience Sa | Substituierte propargylamine |
| JP2009512711A (ja) | 2005-10-21 | 2009-03-26 | ブレインセルス，インコーポレイティド | Ｐｄｅ阻害による神経新生の調節 |
| JP2009513672A (ja) | 2005-10-31 | 2009-04-02 | ブレインセルス，インコーポレイティド | 神経発生のｇａｂａ受容体媒介調節 |
| US20100216734A1 (en) | 2006-03-08 | 2010-08-26 | Braincells, Inc. | Modulation of neurogenesis by nootropic agents |
| AU2007249399A1 (en) | 2006-05-09 | 2007-11-22 | Braincells, Inc. | Neurogenesis by modulating angiotensin |
| WO2007134077A2 (en) | 2006-05-09 | 2007-11-22 | Braincells, Inc. | 5 ht receptor mediated neurogenesis |
| US20100184806A1 (en) | 2006-09-19 | 2010-07-22 | Braincells, Inc. | Modulation of neurogenesis by ppar agents |
| WO2010099217A1 (en) | 2009-02-25 | 2010-09-02 | Braincells, Inc. | Modulation of neurogenesis using d-cycloserine combinations |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE790971A (fr) * | 1971-11-09 | 1973-05-07 | Janssen Pharmaceutica Nv | Metode ter voorkoming van patologische reakties die de funktie van het komplement vereisen |
| JPS504086A (es) * | 1973-01-18 | 1975-01-16 | ||
| GB1475314A (en) * | 1973-11-02 | 1977-06-01 | Cm Ind | Phenyl-propylamine derivatives |
| US4104383A (en) * | 1973-11-02 | 1978-08-01 | C M Industries | Derivatives of phenylpropenylamine |
| EP0347123A3 (en) * | 1988-06-17 | 1991-07-03 | Fisons Corporation | Dibenzo-cycloheptenyl, -cycloheptyl and -oxepinyl amines having antihistaminic properties |
| US4855462A (en) * | 1988-06-17 | 1989-08-08 | Pennwalt Corporation | Antihistamines |
| US4912222A (en) * | 1988-06-17 | 1990-03-27 | Fisons Corporation | Antihistamines related to cyproheptadine |
| FR2663328B1 (fr) | 1990-06-14 | 1994-08-05 | Sanofi Sa | Derives d'hexahydroazepines, un procede pour leur preparation et compositions pharmaceutiques les contenant. |
| PT100639A (pt) * | 1991-06-27 | 1993-09-30 | Univ Virginia Commonwealth | Metodo para o tratamento terapeutico com compostos que sao ligandos ao receptor sigma e compostos ai utilizados, nomeadamente derivados fenilalquil-amina, aminotetralina,piperazina e piperidina |
| JP3199405B2 (ja) * | 1991-08-30 | 2001-08-20 | 生化学工業株式会社 | 肝細胞球状集塊化剤及び球状集塊化肝細胞の製造方法 |
| US5486517A (en) * | 1994-05-10 | 1996-01-23 | Warner-Lambert Company | Benzimidazoles and imidazopyridines as central nervous system agents |
| FR2751645B1 (fr) * | 1996-07-29 | 1998-12-24 | Sanofi Sa | Amines pour la fabrication de medicaments destines a empecher la proliferation de cellules tumorales |
| JP3690423B2 (ja) * | 1997-03-18 | 2005-08-31 | スミスクライン ビーチャム パブリック リミテッド カンパニー | 置換イソキノリン誘導体およびその抗痙攣薬としての使用 |
-
1999
- 1999-07-02 FR FR9908532A patent/FR2795724B1/fr not_active Expired - Fee Related
-
2000
- 2000-06-27 BR BRPI0012463-0A patent/BR0012463B1/pt not_active IP Right Cessation
- 2000-06-27 HU HU0202200A patent/HU228983B1/hu not_active IP Right Cessation
- 2000-06-27 IL IL14706900A patent/IL147069A0/xx active IP Right Grant
- 2000-06-27 AT AT00946022T patent/ATE309231T1/de active
- 2000-06-27 CN CNB008111413A patent/CN1156462C/zh not_active Expired - Fee Related
- 2000-06-27 WO PCT/FR2000/001790 patent/WO2001002380A1/fr not_active Ceased
- 2000-06-27 NZ NZ516342A patent/NZ516342A/en not_active IP Right Cessation
- 2000-06-27 DE DE60023898T patent/DE60023898T2/de not_active Expired - Lifetime
- 2000-06-27 KR KR1020017016966A patent/KR100760446B1/ko not_active Expired - Fee Related
- 2000-06-27 DK DK00946022T patent/DK1196403T3/da active
- 2000-06-27 HR HR20010949A patent/HRP20010949B1/xx not_active IP Right Cessation
- 2000-06-27 US US10/019,205 patent/US6908914B1/en not_active Expired - Lifetime
- 2000-06-27 JP JP2001507818A patent/JP4931309B2/ja not_active Expired - Fee Related
- 2000-06-27 CA CA002376691A patent/CA2376691C/en not_active Expired - Fee Related
- 2000-06-27 CZ CZ20014697A patent/CZ300936B6/cs not_active IP Right Cessation
- 2000-06-27 EP EP00946022A patent/EP1196403B1/fr not_active Expired - Lifetime
- 2000-06-27 AU AU59924/00A patent/AU778299B2/en not_active Ceased
- 2000-06-27 EA EA200101209A patent/EA004048B1/ru not_active IP Right Cessation
- 2000-06-27 UA UA2001128823A patent/UA71009C2/uk unknown
- 2000-06-27 ME MEP-255/08A patent/MEP25508A/xx unknown
- 2000-06-27 HK HK02104681.4A patent/HK1043122A1/zh unknown
- 2000-06-27 MX MXPA01013207A patent/MXPA01013207A/es active IP Right Grant
- 2000-06-27 ES ES00946022T patent/ES2250160T3/es not_active Expired - Lifetime
- 2000-06-27 RS YU91101A patent/RS50266B/sr unknown
- 2000-06-27 TW TW089112618A patent/TWI285640B/zh not_active IP Right Cessation
- 2000-06-28 CO CO00048530A patent/CO5021196A1/es unknown
- 2000-06-30 AR ARP000103334A patent/AR029374A1/es active IP Right Grant
-
2001
- 2001-12-12 IL IL147069A patent/IL147069A/en not_active IP Right Cessation
- 2001-12-20 BG BG106255A patent/BG65209B1/bg unknown
- 2001-12-27 NO NO20016392A patent/NO322230B1/no not_active IP Right Cessation
-
2002
- 2002-01-02 ZA ZA200200018A patent/ZA200200018B/en unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant, registration |