AR007291A1 - Nuevos derivados de 10,11-dihidro-10-oxo-5h-dibenz/b, f/azepina-5-carboxamida, metodo de preparacion y su uso en la preparacion de una composicion farmaceutica - Google Patents
Nuevos derivados de 10,11-dihidro-10-oxo-5h-dibenz/b, f/azepina-5-carboxamida, metodo de preparacion y su uso en la preparacion de una composicion farmaceuticaInfo
- Publication number
- AR007291A1 AR007291A1 ARP970102233A ARP970102233A AR007291A1 AR 007291 A1 AR007291 A1 AR 007291A1 AR P970102233 A ARP970102233 A AR P970102233A AR P970102233 A ARP970102233 A AR P970102233A AR 007291 A1 AR007291 A1 AR 007291A1
- Authority
- AR
- Argentina
- Prior art keywords
- group
- preparation
- alkyl
- alkylaryl
- alkylcycloalkyl
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 125000002877 alkyl aryl group Chemical group 0.000 abstract 5
- 125000000217 alkyl group Chemical group 0.000 abstract 5
- 125000005119 alkyl cycloalkyl group Chemical group 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 3
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 239000001257 hydrogen Substances 0.000 abstract 3
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 3
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 2
- AVXURJPOCDRRFD-UHFFFAOYSA-N Hydroxylamine Chemical compound ON AVXURJPOCDRRFD-UHFFFAOYSA-N 0.000 abstract 1
- 125000004448 alkyl carbonyl group Chemical group 0.000 abstract 1
- 125000005213 alkyl heteroaryl group Chemical group 0.000 abstract 1
- 125000005129 aryl carbonyl group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 210000003169 central nervous system Anatomy 0.000 abstract 1
- 125000001072 heteroaryl group Chemical group 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 210000001428 peripheral nervous system Anatomy 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D223/18—Dibenzazepines; Hydrogenated dibenzazepines
- C07D223/22—Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines
- C07D223/30—Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines with hetero atoms directly attached to the ring nitrogen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
Abstract
Se describen los compuestos de la fórmula general (I); R es un grupo hidroxi, alquilo, cicloalquilo, alquilcicloalquilo, alquilarilo o unalquilheteroarilo o R es el grupo -O-CO-R1 en donde R1 es un grupo hidrógeno, alquilo, cicloalquilo,alq uilcicloalquilo, alquilarilo, arilo o heteroarilo oR es el grupo -O-CO-OR1 en donde R1 substituyente se designa arriba o R es el grupo -O-R2 en donde R2 es un grupo alquilo o alquilarilo, o R es el grupo-NR3R4 en donde R3 eshidrógeno,-NH-CO-NH2, N H-CS-NH2, grupo alquilo o alquilarilo y R4 es un grupo de hidrógeno, alquilo, alquilcicloalquilo,alquilarilo, alquilcarbonilo o arilcarbonilo; así como un proceso para su preparación el cual consiste en lareacción de un compuesto de l a fórmula (II),con hidroxilamina o sus derivados de la fórmula (III) donde R2 ya fue especificado anteriormente: H2NOR2 (III). Los compuestos citados tienenvaliosas propiedades farmacéuticas es decir en eltratamiento de algunas pert urbaciones en el sistema nervioso central y periférico.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PT101876A PT101876B (pt) | 1996-05-27 | 1996-05-27 | Novos derivados de 10,11-di-hidro-10-oxo-5h-dibenzo(b,f)azepina-5-carboxamida |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR007291A1 true AR007291A1 (es) | 1999-10-27 |
Family
ID=20085604
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP970102233A AR007291A1 (es) | 1996-05-27 | 1997-05-26 | Nuevos derivados de 10,11-dihidro-10-oxo-5h-dibenz/b, f/azepina-5-carboxamida, metodo de preparacion y su uso en la preparacion de una composicion farmaceutica |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US5866566A (es) |
| EP (1) | EP0810216B1 (es) |
| JP (1) | JP3592892B2 (es) |
| CN (1) | CN1101382C (es) |
| AR (1) | AR007291A1 (es) |
| AT (1) | ATE199901T1 (es) |
| AU (1) | AU713807B2 (es) |
| BR (1) | BR9703403B1 (es) |
| CA (1) | CA2206172C (es) |
| DE (1) | DE69704297T2 (es) |
| DK (1) | DK0810216T3 (es) |
| ES (1) | ES2156319T3 (es) |
| GR (1) | GR3035910T3 (es) |
| PL (1) | PL189298B1 (es) |
| PT (1) | PT101876B (es) |
| RU (1) | RU2187503C2 (es) |
| SI (1) | SI0810216T1 (es) |
| TR (1) | TR199802462T2 (es) |
| WO (1) | WO1997045416A1 (es) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2004203644B2 (en) * | 1999-12-20 | 2008-04-17 | Novartis Ag | Pharmaceutical compositions |
| GB9930058D0 (en) | 1999-12-20 | 2000-02-09 | Novartis Ag | Organic compounds |
| GB0111566D0 (en) * | 2001-05-11 | 2001-07-04 | Portela & Ca Sa | Method for preparation of (s)-(+)-and (r)-(-)-10,11-dihydro-10-hydroxy-5h-dibenz/b,f/azephine-5-carboxamide |
| GB0112812D0 (en) * | 2001-05-25 | 2001-07-18 | Portela & Ca Sa | Mthd for preparation of 10, 11-dihydro-10-hydroxy-5H-dibenz/B,F/azepine-5-c arboxamide and 10,11-dihydro-10-oxo-5H-dibenz/B,F/azepine-5-carb oxamide therefrom |
| GB2401605A (en) * | 2003-05-12 | 2004-11-17 | Portela & Ca Sa | Method for racemisation of (S)-(+)- and (R)-(-)-10,11-dihydro-10-hydroxy-5H-dibenz[b,f]azepine-5-carboxamide and optically enriched mixtures thereof |
| GB2416167A (en) * | 2004-07-13 | 2006-01-18 | Portela & Ca Sa | Chiral inversion and esterification of (S)- and (R)-10-hydroxy-dibenzazepine carboxamides |
| GB2422149A (en) * | 2005-01-14 | 2006-07-19 | Portela & Ca Sa | Process for the preparation of 10,11-dihydro-10-hydroxy-5H-dibenz[b,f]azepine-5-carboxamide |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH500196A (de) * | 1969-03-10 | 1970-12-15 | Ciba Geigy Ag | Verfahren zur Herstellung von neuen Azepinderivaten |
| FI75561C (fi) * | 1979-10-30 | 1988-07-11 | Ciba Geigy Ag | Foerfarande foer framstaellning av 5- karbamoyl-10-oxo-10,11-dihydro-5h-dibens/b,f/azepin och daertill noedvaendiga mellanprodukter. |
| CH649080A5 (de) * | 1981-04-16 | 1985-04-30 | Ciba Geigy Ag | 5h-dibenz(b,f)azepin-5-carboxamide als mittel zur prophylaxe und behandlung von zerebraler leistungsinsuffizienz. |
| US5173486A (en) * | 1991-08-26 | 1992-12-22 | Bristol-Myers Squibb Company | Dibenz[b,f][1,4]oxazepin-11(10H)-ones for multidrug resistance reversing agents |
| US5466683A (en) * | 1994-08-25 | 1995-11-14 | Teva Pharmaceutical Industries Ltd. | Water-soluble analogs of carbamazepine |
-
1996
- 1996-05-27 PT PT101876A patent/PT101876B/pt not_active IP Right Cessation
-
1997
- 1997-05-23 US US08/862,196 patent/US5866566A/en not_active Expired - Fee Related
- 1997-05-26 AR ARP970102233A patent/AR007291A1/es active IP Right Grant
- 1997-05-26 DK DK97108465T patent/DK0810216T3/da active
- 1997-05-26 EP EP97108465A patent/EP0810216B1/en not_active Expired - Lifetime
- 1997-05-26 SI SI9730129T patent/SI0810216T1/xx unknown
- 1997-05-26 DE DE69704297T patent/DE69704297T2/de not_active Expired - Fee Related
- 1997-05-26 ES ES97108465T patent/ES2156319T3/es not_active Expired - Lifetime
- 1997-05-26 AT AT97108465T patent/ATE199901T1/de not_active IP Right Cessation
- 1997-05-27 CN CN97196803A patent/CN1101382C/zh not_active Expired - Fee Related
- 1997-05-27 RU RU98123571/04A patent/RU2187503C2/ru not_active IP Right Cessation
- 1997-05-27 WO PCT/IB1997/000691 patent/WO1997045416A1/en not_active Ceased
- 1997-05-27 PL PL97330141A patent/PL189298B1/pl not_active IP Right Cessation
- 1997-05-27 JP JP13716397A patent/JP3592892B2/ja not_active Expired - Fee Related
- 1997-05-27 CA CA002206172A patent/CA2206172C/en not_active Expired - Fee Related
- 1997-05-27 AU AU29740/97A patent/AU713807B2/en not_active Ceased
- 1997-05-27 TR TR1998/02462T patent/TR199802462T2/xx unknown
- 1997-05-27 BR BRPI9703403-7A patent/BR9703403B1/pt not_active IP Right Cessation
-
2001
- 2001-05-22 GR GR20010400764T patent/GR3035910T3/el not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| PT101876A (pt) | 1997-12-31 |
| PL330141A1 (en) | 1999-04-26 |
| DE69704297T2 (de) | 2001-09-20 |
| GR3035910T3 (en) | 2001-08-31 |
| RU2187503C2 (ru) | 2002-08-20 |
| CN1101382C (zh) | 2003-02-12 |
| AU713807B2 (en) | 1999-12-09 |
| PT101876B (pt) | 1999-09-30 |
| US5866566A (en) | 1999-02-02 |
| BR9703403B1 (pt) | 2010-06-29 |
| TR199802462T2 (xx) | 2000-07-21 |
| DK0810216T3 (da) | 2001-07-23 |
| DE69704297D1 (de) | 2001-04-26 |
| JP3592892B2 (ja) | 2004-11-24 |
| WO1997045416A1 (en) | 1997-12-04 |
| CA2206172A1 (en) | 1997-11-27 |
| CA2206172C (en) | 2002-07-16 |
| SI0810216T1 (es) | 2001-08-31 |
| EP0810216B1 (en) | 2001-03-21 |
| MX9703846A (es) | 1998-06-30 |
| PL189298B1 (pl) | 2005-07-29 |
| EP0810216A1 (en) | 1997-12-03 |
| JPH1081669A (ja) | 1998-03-31 |
| ATE199901T1 (de) | 2001-04-15 |
| ES2156319T3 (es) | 2001-06-16 |
| AU2974097A (en) | 1998-01-05 |
| BR9703403A (pt) | 1998-09-15 |
| CN1226234A (zh) | 1999-08-18 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant, registration |