AR006593A1 - Compuestos derivados de acidos carboxilicos, utiles como inhibidores de la endotelina y las composiciones farmaceuticas que los contienen - Google Patents
Compuestos derivados de acidos carboxilicos, utiles como inhibidores de la endotelina y las composiciones farmaceuticas que los contienenInfo
- Publication number
- AR006593A1 AR006593A1 ARP970101432A ARP970101432A AR006593A1 AR 006593 A1 AR006593 A1 AR 006593A1 AR P970101432 A ARP970101432 A AR P970101432A AR P970101432 A ARP970101432 A AR P970101432A AR 006593 A1 AR006593 A1 AR 006593A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkoxy
- alkylthio
- carry
- pharmaceutical compositions
- compositions containing
- Prior art date
Links
- -1 CARBOXYL ACIDS Chemical class 0.000 title abstract 3
- 150000001875 compounds Chemical class 0.000 title abstract 2
- 239000003112 inhibitor Substances 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 239000002253 acid Substances 0.000 title 1
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 abstract 3
- 125000005843 halogen group Chemical group 0.000 abstract 3
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 2
- 239000004215 Carbon black (E152) Substances 0.000 abstract 2
- 229930195733 hydrocarbon Natural products 0.000 abstract 2
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 2
- 125000000951 phenoxy group Chemical group [H]C1=C([H])C([H])=C(O*)C([H])=C1[H] 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- 125000004767 (C1-C4) haloalkoxy group Chemical group 0.000 abstract 1
- 125000004765 (C1-C4) haloalkyl group Chemical group 0.000 abstract 1
- 102000002045 Endothelin Human genes 0.000 abstract 1
- 108050009340 Endothelin Proteins 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 abstract 1
- ZUBDGKVDJUIMQQ-UBFCDGJISA-N endothelin-1 Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(O)=O)NC(=O)[C@H]1NC(=O)[C@H](CC=2C=CC=CC=2)NC(=O)[C@@H](CC=2C=CC(O)=CC=2)NC(=O)[C@H](C(C)C)NC(=O)[C@H]2CSSC[C@@H](C(N[C@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@H](CC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N2)=O)NC(=O)[C@@H](CO)NC(=O)[C@H](N)CSSC1)C1=CNC=N1 ZUBDGKVDJUIMQQ-UBFCDGJISA-N 0.000 abstract 1
- FONOSWYYBCBQGN-UHFFFAOYSA-N ethylene dione Chemical group O=C=C=O FONOSWYYBCBQGN-UHFFFAOYSA-N 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000002883 imidazolyl group Chemical group 0.000 abstract 1
- 150000002825 nitriles Chemical class 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000004430 oxygen atom Chemical group O* 0.000 abstract 1
- 125000003226 pyrazolyl group Chemical group 0.000 abstract 1
- 125000000168 pyrrolyl group Chemical group 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
- 239000011593 sulfur Substances 0.000 abstract 1
- 150000003536 tetrazoles Chemical class 0.000 abstract 1
- 125000001425 triazolyl group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
- C07D215/22—Oxygen atoms attached in position 2 or 4
- C07D215/227—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
- C07D215/22—Oxygen atoms attached in position 2 or 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/34—One oxygen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/60—Three or more oxygen or sulfur atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Quinoline Compounds (AREA)
Abstract
Se refiere a inhibidores de la endotelina que tienen la fórmula (I), en la cual R significa tetrazol, nitrilo o un grupo (II) en la cual R1 tieneel siguiente significado: a)hidrógeno; b) un grupo succinilimidoxi; c)un hidrocarburoheter oaromático de 5 eslabones enlazado en un átomo de nitrógeno,como pirrolilo, pirazolilo, imidazolilo y triazolilo, que puede portar de uno a dos átomos de halógeno, o de uno a dos grupos C1-C4-alquilo o de unoa dos grupos C1-C4-alcoxi;halógenoa lcoxi, fenoxi, C1-C4-alquiltio, C1-C4- alquilamino, C1-C4-dialquilamino, dioxometileno o dioxoetileno; unhidrocarburo heteroaromático de cinco o seis eslabones que contiene de uno a tres átomos de nitrógeno y/o un átomo de azufre ode oxígeno, que puedeportar de uno a cuatro átomos de halógeno y/o de uno a dos de los siguientes restos: C1-C4-alquilo, C1-C4-halógenoalquilo, C1-C4-alcoxi, C1-C4-halógenoalcoxi, C1-C4-alquiltio, fenilo, fenoxi o fenilcarbonilo, dondelos res tos fenilo a su vez pueden portar de uno a cinco átomos de halógeno y/o deuno a tres de los siguientes restos: C1-C4-alquilo, C1-C4-halógenoalquilo, C1-C4-alcoxi, C1-C4-halógenoalcoxi y/o C1-C4-alquiltio. También se refiereacomposiciones farmac éuticas que contienen dichos compuestos.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19614542A DE19614542A1 (de) | 1996-04-12 | 1996-04-12 | Neue Carbonsäurederivate, ihre Herstellung und Verwendung |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR006593A1 true AR006593A1 (es) | 1999-09-08 |
Family
ID=7791123
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP970101432A AR006593A1 (es) | 1996-04-12 | 1997-04-10 | Compuestos derivados de acidos carboxilicos, utiles como inhibidores de la endotelina y las composiciones farmaceuticas que los contienen |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US6103732A (es) |
| EP (1) | EP0892788A1 (es) |
| JP (1) | JP2000508325A (es) |
| KR (1) | KR20000005366A (es) |
| CN (1) | CN1216042A (es) |
| AR (1) | AR006593A1 (es) |
| AU (1) | AU711293B2 (es) |
| BG (1) | BG63202B1 (es) |
| BR (1) | BR9708614A (es) |
| CA (1) | CA2250764A1 (es) |
| CO (1) | CO4900038A1 (es) |
| DE (1) | DE19614542A1 (es) |
| HR (1) | HRP970200A2 (es) |
| ID (1) | ID19050A (es) |
| IL (1) | IL126026A0 (es) |
| NO (1) | NO311802B1 (es) |
| NZ (1) | NZ331704A (es) |
| PL (1) | PL329240A1 (es) |
| SK (1) | SK127698A3 (es) |
| TR (1) | TR199802042T2 (es) |
| TW (1) | TW419465B (es) |
| WO (1) | WO1997038982A1 (es) |
| ZA (1) | ZA973096B (es) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU740351B2 (en) * | 1996-12-18 | 2001-11-01 | Abbott Gmbh & Co. Kg | Heterocyclic carboxylic acid derivatives, their preparation ans use as endothelin receptor antagonists |
| US6030975A (en) * | 1997-03-14 | 2000-02-29 | Basf Aktiengesellschaft | Carboxylic acid derivatives, their preparation and use in treating cancer |
| HUP0004935A3 (en) * | 1997-09-04 | 2001-12-28 | Basf Ag | Novel carboxylic acid derivatives, their production and their use as mixed eta/etb endothelin-receptor antagonists |
| HU0900792D0 (en) * | 1997-10-17 | 2010-03-01 | Ark Therapeutics Ltd | Use of renin-angiotensin inhibitors |
| US7566452B1 (en) | 1999-05-04 | 2009-07-28 | New York University | Cancer treatment with endothelin receptor antagonists |
| PT1243262E (pt) * | 2001-03-20 | 2006-10-31 | Sanol Arznei Schwarz Gmbh | Nova utilizacao de uma classe de compostos peptideos para o tratamento da dor inflamatoria nao neuropatica |
| ES2185606T3 (es) * | 2001-03-21 | 2003-05-01 | Sanol Arznei Schwarz Gmbh | Nuevo uso de una clase de compuestos peptidicos para tratamiento de la alodinia u otros tipos diferentes de dolor cronico o fantasma. |
| CN1950101B (zh) | 2004-04-16 | 2011-03-30 | 舒沃茨药物股份公司 | 肽化合物用于预防和治疗慢性头痛的用途 |
| EP1781276B1 (en) * | 2004-08-27 | 2010-06-23 | UCB Pharma GmbH | Use of peptide compounds for treating bone cancer pain, chemotherapy- and nucleoside-induced pain |
| US20070043120A1 (en) * | 2005-08-18 | 2007-02-22 | Bettina Beyreuther | Therapeutic combination for painful medical conditions |
| EP1754476A1 (en) * | 2005-08-18 | 2007-02-21 | Schwarz Pharma Ag | Lacosamide (SPM 927) for treating myalgia, e.g. fibromyalgia |
| US20070048372A1 (en) * | 2005-08-18 | 2007-03-01 | Srz Properties, Inc. | Method for treating non-inflammatory osteoarthritic pain |
| PT2462990E (pt) | 2006-06-15 | 2014-04-02 | Ucb Pharma Gmbh | Composição farmacêutica com efeito anticonvulsivo sinergístico |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4411225A1 (de) * | 1994-03-31 | 1995-10-05 | Basf Ag | Verwendung von Carbonsäurederivaten als Arzneimittel |
| WO1996000219A1 (en) * | 1994-06-27 | 1996-01-04 | Ciba-Geigy Ag | Pyrimidinyl- and triazinyl-oxy and thio-3-haloalkyl-propionic acid derivatives as herbicides |
-
1996
- 1996-04-12 DE DE19614542A patent/DE19614542A1/de not_active Withdrawn
-
1997
- 1997-04-04 BR BR9708614A patent/BR9708614A/pt not_active IP Right Cessation
- 1997-04-04 SK SK1276-98A patent/SK127698A3/sk unknown
- 1997-04-04 US US09/155,948 patent/US6103732A/en not_active Expired - Fee Related
- 1997-04-04 WO PCT/EP1997/001687 patent/WO1997038982A1/de not_active Ceased
- 1997-04-04 TR TR1998/02042T patent/TR199802042T2/xx unknown
- 1997-04-04 NZ NZ331704A patent/NZ331704A/en unknown
- 1997-04-04 EP EP97918109A patent/EP0892788A1/de not_active Withdrawn
- 1997-04-04 JP JP9536698A patent/JP2000508325A/ja active Pending
- 1997-04-04 KR KR1019980708088A patent/KR20000005366A/ko not_active Ceased
- 1997-04-04 IL IL12602697A patent/IL126026A0/xx unknown
- 1997-04-04 CN CN97193737A patent/CN1216042A/zh active Pending
- 1997-04-04 CA CA002250764A patent/CA2250764A1/en not_active Abandoned
- 1997-04-04 AU AU26364/97A patent/AU711293B2/en not_active Ceased
- 1997-04-04 PL PL97329240A patent/PL329240A1/xx unknown
- 1997-04-10 AR ARP970101432A patent/AR006593A1/es not_active Application Discontinuation
- 1997-04-11 ZA ZA973096A patent/ZA973096B/xx unknown
- 1997-04-11 TW TW086104674A patent/TW419465B/zh not_active IP Right Cessation
- 1997-04-11 HR HR19614542.2A patent/HRP970200A2/xx not_active Application Discontinuation
- 1997-04-11 CO CO97018895A patent/CO4900038A1/es unknown
- 1997-04-14 ID IDP971240A patent/ID19050A/id unknown
-
1998
- 1998-09-15 BG BG102770A patent/BG63202B1/bg unknown
- 1998-10-09 NO NO19984713A patent/NO311802B1/no not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| BG102770A (en) | 1999-11-30 |
| ID19050A (id) | 1998-06-04 |
| BR9708614A (pt) | 1999-08-03 |
| IL126026A0 (en) | 1999-05-09 |
| CO4900038A1 (es) | 2000-03-27 |
| NO311802B1 (no) | 2002-01-28 |
| KR20000005366A (ko) | 2000-01-25 |
| NO984713L (no) | 1998-10-09 |
| US6103732A (en) | 2000-08-15 |
| ZA973096B (en) | 1998-10-12 |
| BG63202B1 (bg) | 2001-06-29 |
| TW419465B (en) | 2001-01-21 |
| NO984713D0 (no) | 1998-10-09 |
| PL329240A1 (en) | 1999-03-15 |
| EP0892788A1 (de) | 1999-01-27 |
| TR199802042T2 (xx) | 2000-09-21 |
| AU711293B2 (en) | 1999-10-07 |
| WO1997038982A1 (de) | 1997-10-23 |
| AU2636497A (en) | 1997-11-07 |
| HRP970200A2 (en) | 1998-04-30 |
| JP2000508325A (ja) | 2000-07-04 |
| CN1216042A (zh) | 1999-05-05 |
| NZ331704A (en) | 2000-06-23 |
| DE19614542A1 (de) | 1997-10-16 |
| CA2250764A1 (en) | 1997-10-23 |
| SK127698A3 (en) | 2000-03-13 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC | Refusal |