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AR006513A1 - Adn que codifica el receptor de ecdisona; un polipeptido que comprende el receptor; un polipeptido de fusion; un adn recombinante; una construccion deadn recombinante; una celula transformada; un vegetal, un hongo o mamifero que comprende la construccion de adn; un metodo para seleccionar compuestos - Google Patents

Adn que codifica el receptor de ecdisona; un polipeptido que comprende el receptor; un polipeptido de fusion; un adn recombinante; una construccion deadn recombinante; una celula transformada; un vegetal, un hongo o mamifero que comprende la construccion de adn; un metodo para seleccionar compuestos

Info

Publication number
AR006513A1
AR006513A1 ARP960102733A AR10273396A AR006513A1 AR 006513 A1 AR006513 A1 AR 006513A1 AR P960102733 A ARP960102733 A AR P960102733A AR 10273396 A AR10273396 A AR 10273396A AR 006513 A1 AR006513 A1 AR 006513A1
Authority
AR
Argentina
Prior art keywords
dna
polypeptide
construction
receiver
recombinant
Prior art date
Application number
ARP960102733A
Other languages
English (en)
Original Assignee
Zeneca Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9510759.5A external-priority patent/GB9510759D0/en
Priority claimed from GBGB9513882.2A external-priority patent/GB9513882D0/en
Priority claimed from GBGB9517316.7A external-priority patent/GB9517316D0/en
Priority claimed from GBGB9605656.9A external-priority patent/GB9605656D0/en
Application filed by Zeneca Ltd filed Critical Zeneca Ltd
Publication of AR006513A1 publication Critical patent/AR006513A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/72—Receptors; Cell surface antigens; Cell surface determinants for hormones
    • C07K14/721—Steroid/thyroid hormone superfamily, e.g. GR, EcR, androgen receptor, oestrogen receptor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8216—Methods for controlling, regulating or enhancing expression of transgenes in plant cells
    • C12N15/8237—Externally regulated expression systems
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8216—Methods for controlling, regulating or enhancing expression of transgenes in plant cells
    • C12N15/8237—Externally regulated expression systems
    • C12N15/8238—Externally regulated expression systems chemically inducible, e.g. tetracycline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Cell Biology (AREA)
  • Molecular Biology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Toxicology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Endocrinology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Steroid Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Se refiere a un ADN que codifica parte del receptor de ecdisona que comprende la secuencia que se muestra en Seq.ID Bro.2; Seq DE Nro.3; Seg. IDNro.4 o Seq. ID Nro.6 o una secuencia que muestra homología a una de éstas, o la cual hibridizaa una de éstas, o la cual es degenerada como el resultadodel código genético. Estos receptores esteroides son factores regulatorios transcripcionales eucaróticos, los cuales, en respuesta a la unión de lahormona esteroidea, unen elementosespecí ficos al ADN y activan la transcripción. El receptor esteroide de ecdisona de Helothis virescens (HEcR)puede ser inducido por inductores no esteroides. El uso de un no esteroide como inductor permite que el sistema sea utilizadoen aplic aciones agroquímicas yfarmacéuticas. Otro objeto es entonces, un polipéptido que comprende el receptor de ecdisona o fragmento del mismo. Se refiere también a unpolipéptido de fusión que comprende el anterior polipéptido; a un ADN r ecombinante o una construcción de ADN recombinante que comprende el ADN quecodifica al menos parte del receptor de ecdisona; a una célula transformada y que es capaz de expresar el polipéptido; a un vegetal, un hongo o mamíferoquecomprende la co nstrucción de ADN recombinante; a un método para seleccionar compuestos capaces de unirse a receptores esteroides; a dichoscompuestos; una composición agrícola o farmacéutica; el uso del compuesto y a un método paraproducir una prote ína, un péptido o un polipéptido.
ARP960102733A 1995-05-26 1996-05-24 Adn que codifica el receptor de ecdisona; un polipeptido que comprende el receptor; un polipeptido de fusion; un adn recombinante; una construccion deadn recombinante; una celula transformada; un vegetal, un hongo o mamifero que comprende la construccion de adn; un metodo para seleccionar compuestos AR006513A1 (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GBGB9510759.5A GB9510759D0 (en) 1995-05-26 1995-05-26 A gene switch
GBGB9513882.2A GB9513882D0 (en) 1995-07-07 1995-07-07 A gene switch
GBGB9517316.7A GB9517316D0 (en) 1995-08-24 1995-08-24 A gene switch
GBGB9605656.9A GB9605656D0 (en) 1996-03-18 1996-03-18 A gene switch

Publications (1)

Publication Number Publication Date
AR006513A1 true AR006513A1 (es) 1999-09-08

Family

ID=27451286

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP960102733A AR006513A1 (es) 1995-05-26 1996-05-24 Adn que codifica el receptor de ecdisona; un polipeptido que comprende el receptor; un polipeptido de fusion; un adn recombinante; una construccion deadn recombinante; una celula transformada; un vegetal, un hongo o mamifero que comprende la construccion de adn; un metodo para seleccionar compuestos

Country Status (17)

Country Link
US (1) US6379945B1 (es)
EP (1) EP0828829A1 (es)
JP (1) JPH11506319A (es)
CN (1) CN1191568A (es)
AR (1) AR006513A1 (es)
AU (1) AU711391B2 (es)
BG (1) BG102124A (es)
CA (1) CA2219121A1 (es)
CZ (1) CZ372297A3 (es)
HU (1) HUP9802225A3 (es)
MX (1) MX9709156A (es)
NO (1) NO975419L (es)
NZ (1) NZ308162A (es)
PL (1) PL323587A1 (es)
RU (1) RU97121687A (es)
TR (2) TR200003861T2 (es)
WO (1) WO1996037609A1 (es)

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CA2219121A1 (en) 1996-11-28
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EP0828829A1 (en) 1998-03-18
HUP9802225A3 (en) 2000-03-28
TR199701436T1 (xx) 1998-03-21
US6379945B1 (en) 2002-04-30
NO975419L (no) 1998-01-22
NZ308162A (en) 2000-02-28
RU97121687A (ru) 2005-01-20
TR200003861T2 (tr) 2001-04-20
PL323587A1 (en) 1998-04-14
AU711391B2 (en) 1999-10-14
MX9709156A (es) 1998-03-31
WO1996037609A1 (en) 1996-11-28
JPH11506319A (ja) 1999-06-08
NO975419D0 (no) 1997-11-25
CN1191568A (zh) 1998-08-26
BG102124A (en) 1998-11-30

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