AR005797A1 - Trombinmuteinas como antidoto para los inhibidores de las trombinas - Google Patents
Trombinmuteinas como antidoto para los inhibidores de las trombinasInfo
- Publication number
- AR005797A1 AR005797A1 ARP970100548A ARP970100548A AR005797A1 AR 005797 A1 AR005797 A1 AR 005797A1 AR P970100548 A ARP970100548 A AR P970100548A AR P970100548 A ARP970100548 A AR P970100548A AR 005797 A1 AR005797 A1 AR 005797A1
- Authority
- AR
- Argentina
- Prior art keywords
- gly
- seq
- sequential
- antidote
- natural
- Prior art date
Links
- 239000000729 antidote Substances 0.000 title abstract 2
- 229940122388 Thrombin inhibitor Drugs 0.000 title 1
- 239000003868 thrombin inhibitor Substances 0.000 title 1
- 101000651439 Homo sapiens Prothrombin Proteins 0.000 abstract 3
- 229940039715 human prothrombin Drugs 0.000 abstract 3
- ANGAOPNEPIDLPO-XVYDVKMFSA-N Ala-His-Cys Chemical compound C[C@@H](C(=O)N[C@@H](CC1=CN=CN1)C(=O)N[C@@H](CS)C(=O)O)N ANGAOPNEPIDLPO-XVYDVKMFSA-N 0.000 abstract 1
- JSHVMZANPXCDTL-GMOBBJLQSA-N Arg-Asp-Ile Chemical compound [H]N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(O)=O JSHVMZANPXCDTL-GMOBBJLQSA-N 0.000 abstract 1
- KGHLGJAXYSVNJP-WHFBIAKZSA-N Asp-Ser-Gly Chemical compound OC(=O)C[C@H](N)C(=O)N[C@@H](CO)C(=O)NCC(O)=O KGHLGJAXYSVNJP-WHFBIAKZSA-N 0.000 abstract 1
- 108010094028 Prothrombin Proteins 0.000 abstract 1
- 102100027378 Prothrombin Human genes 0.000 abstract 1
- 108090000190 Thrombin Proteins 0.000 abstract 1
- NOOMDULIORCDNF-IRXDYDNUSA-N Tyr-Gly-Phe Chemical compound [H]N[C@@H](CC1=CC=C(O)C=C1)C(=O)NCC(=O)N[C@@H](CC1=CC=CC=C1)C(O)=O NOOMDULIORCDNF-IRXDYDNUSA-N 0.000 abstract 1
- 230000037430 deletion Effects 0.000 abstract 1
- 238000012217 deletion Methods 0.000 abstract 1
- 229940039716 prothrombin Drugs 0.000 abstract 1
- 229960004072 thrombin Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/6429—Thrombin (3.4.21.5)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21005—Thrombin (3.4.21.5)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Enzymes And Modification Thereof (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
Abstract
Trombinmeteínas, que en comparación con la trombina naatural presentan las siguientes diferencias secuenciales: (a) intercambio de un Gly después de Ala,hallándose el Gly en el entorno secuencial Tyr-Gly-Phe, y teniendo dicho Gly en la protombinahumana natural (SEQ ID NO:14) la posición 558; (b) por lomenos un intercambio o una supresión de los siguientes radicales: (b1) His, que se halla en el entorno secuencial Ala-His-Cys y que en la protombinanatural (SEQ ID NO:14) tiene la posición363; (b2) Asp, que se halla en el entorno sucuencial Arg-Asp-Ile y que en la protombina humana naturalSEQ ID NO:14) tiene la Posición 419; (b3) Ser, que se halla en el entorno secuencial Asp-Ser-Gly, y que en la protombina humana natural(SEQ ID NO:14)tiene la Posición 525; y su utilización como antídoto.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19605126A DE19605126A1 (de) | 1996-02-12 | 1996-02-12 | Thrombinmuteine als Antidot für Thrombininhibitoren |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR005797A1 true AR005797A1 (es) | 1999-07-14 |
Family
ID=7785198
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP970100548A AR005797A1 (es) | 1996-02-12 | 1997-02-12 | Trombinmuteinas como antidoto para los inhibidores de las trombinas |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US6060300A (es) |
| EP (1) | EP0880591A1 (es) |
| JP (1) | JPH11512621A (es) |
| KR (1) | KR19990082479A (es) |
| CN (1) | CN1211280A (es) |
| AR (1) | AR005797A1 (es) |
| AU (1) | AU1768497A (es) |
| BR (1) | BR9707280A (es) |
| CA (1) | CA2245546A1 (es) |
| CO (1) | CO4600682A1 (es) |
| CZ (1) | CZ247798A3 (es) |
| DE (1) | DE19605126A1 (es) |
| HR (1) | HRP970077A2 (es) |
| HU (1) | HUP9900574A2 (es) |
| IL (1) | IL125077A0 (es) |
| NO (1) | NO983677D0 (es) |
| WO (1) | WO1997029198A1 (es) |
| ZA (1) | ZA971107B (es) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4426722B2 (ja) | 1998-05-19 | 2010-03-03 | ケルシウス，エルエルシー | フレーム部材と取外し可能に取付けられた膜とを備えたタオルマット |
| KR20000018933A (ko) * | 1998-09-07 | 2000-04-06 | 김승수 | 내피세포 성장억제 활성을 가지는 사람 프로트롬빈 크링글단백질 및 이를 암호하는 유전자 |
| GB2355161B (en) * | 1999-10-05 | 2001-09-12 | 3Com Corp | Network device incorporating selective compression of stored data packets |
| KR20020008471A (ko) * | 2000-07-20 | 2002-01-31 | 김승수 | 내피세포 성장 억제활성을 가지는 인간 프로트롬빈크링글, 그것의 재조합벡터 및 이를 발현하는 재조합 숙주 |
| CA2644926A1 (en) * | 2006-03-06 | 2007-09-13 | Humagene, Inc. | A method for the preparation of recombinant human thrombin and fibrinogen |
| EP3078743B1 (en) | 2007-09-28 | 2020-06-24 | Portola Pharmaceuticals, Inc. | Antidotes for factor xa inhibitors and methods of using the same |
| JP5709316B2 (ja) | 2008-11-14 | 2015-04-30 | ポートラ ファーマシューティカルズ， インコーポレイテッド | 第Ｘａ因子阻害剤のための解毒剤および血液凝固剤と組み合わせて該解毒剤を使用する方法 |
| FI3604510T3 (fi) | 2009-03-30 | 2025-06-26 | Alexion Pharma Inc | Vastalääkkeitä tekijä xa:n estäjille ja menetelmiä niiden käyttämiseksi |
| WO2011008885A1 (en) | 2009-07-15 | 2011-01-20 | Portola Pharmaceuticals, Inc. | Unit dose formulation of antidotes for factor xa inhibitors and methods of using the same |
| EP2316931B1 (de) | 2009-10-30 | 2016-12-28 | Senova Gesellschaft für Biowissenschaft und Technik mbH | Polymergekoppelte Peptidasen |
| TWI513466B (zh) | 2010-01-20 | 2015-12-21 | Boehringer Ingelheim Int | 抗凝血劑解毒劑 |
| PH12013501924A1 (en) | 2011-03-30 | 2017-10-25 | Boehringer Ingelheim Int | Anticoagulant antidotes |
| CA2949349A1 (en) | 2014-05-26 | 2015-12-03 | Academisch Ziekenhuis Leiden | Prohemostatic proteins for the treatment of bleeding |
| US12073926B2 (en) | 2020-09-21 | 2024-08-27 | Instrumentation Laboratory Company | Detecting and monitoring oral anticoagulants or intravenous direct thrombin inhibitors in a blood sample |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4203965A1 (de) * | 1992-02-11 | 1993-08-12 | Max Planck Gesellschaft | Antidot fuer hirudin und synthetische thrombininhibitoren |
-
1996
- 1996-02-12 DE DE19605126A patent/DE19605126A1/de not_active Withdrawn
-
1997
- 1997-02-11 HU HU9900574A patent/HUP9900574A2/hu unknown
- 1997-02-11 CA CA002245546A patent/CA2245546A1/en not_active Abandoned
- 1997-02-11 JP JP9528173A patent/JPH11512621A/ja active Pending
- 1997-02-11 HR HR19605126.6A patent/HRP970077A2/hr not_active Application Discontinuation
- 1997-02-11 CO CO97006960A patent/CO4600682A1/es unknown
- 1997-02-11 IL IL12507797A patent/IL125077A0/xx unknown
- 1997-02-11 KR KR1019980706212A patent/KR19990082479A/ko not_active Withdrawn
- 1997-02-11 CZ CZ982477A patent/CZ247798A3/cs unknown
- 1997-02-11 AU AU17684/97A patent/AU1768497A/en not_active Abandoned
- 1997-02-11 EP EP97903254A patent/EP0880591A1/de not_active Withdrawn
- 1997-02-11 ZA ZA971107A patent/ZA971107B/xx unknown
- 1997-02-11 US US09/117,708 patent/US6060300A/en not_active Expired - Fee Related
- 1997-02-11 CN CN97192210A patent/CN1211280A/zh active Pending
- 1997-02-11 WO PCT/EP1997/000612 patent/WO1997029198A1/de not_active Ceased
- 1997-02-11 BR BR9707280A patent/BR9707280A/pt not_active Application Discontinuation
- 1997-02-12 AR ARP970100548A patent/AR005797A1/es unknown
-
1998
- 1998-08-11 NO NO983677A patent/NO983677D0/no unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CZ247798A3 (cs) | 1999-03-17 |
| JPH11512621A (ja) | 1999-11-02 |
| NO983677L (no) | 1998-08-11 |
| CN1211280A (zh) | 1999-03-17 |
| ZA971107B (en) | 1998-08-11 |
| KR19990082479A (ko) | 1999-11-25 |
| CA2245546A1 (en) | 1997-08-14 |
| US6060300A (en) | 2000-05-09 |
| HUP9900574A2 (hu) | 1999-06-28 |
| DE19605126A1 (de) | 1997-08-14 |
| CO4600682A1 (es) | 1998-05-08 |
| HRP970077A2 (en) | 1998-04-30 |
| AU1768497A (en) | 1997-08-28 |
| IL125077A0 (en) | 1999-01-26 |
| EP0880591A1 (de) | 1998-12-02 |
| WO1997029198A1 (de) | 1997-08-14 |
| NO983677D0 (no) | 1998-08-11 |
| BR9707280A (pt) | 1999-07-20 |
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