IL125077A0 - Thrombin muteins as antidote for thrombin inhibitors - Google Patents

Thrombin muteins as antidote for thrombin inhibitors

Info

Publication number: IL125077A0
Authority: IL; Israel
Prior art keywords: thrombin; antidote; muteins; inhibitors; thrombin inhibitors
Prior art date: 1996-02-12

Application number

IL12507797A

Other languages

English (en)

Original Assignee

Basf Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-02-12

Filing date

1997-02-11

Publication date

1999-01-26

1997-02-11 Application filed by Basf Ag filed Critical Basf Ag

1999-01-26 Publication of IL125077A0 publication Critical patent/IL125077A0/xx

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/6429—Thrombin (3.4.21.5)
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21005—Thrombin (3.4.21.5)
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Genetics & Genomics (AREA)
Bioinformatics & Cheminformatics (AREA)
Zoology (AREA)
Wood Science & Technology (AREA)
Biomedical Technology (AREA)
General Health & Medical Sciences (AREA)
General Engineering & Computer Science (AREA)
Biochemistry (AREA)
Biotechnology (AREA)
Medicinal Chemistry (AREA)
Molecular Biology (AREA)
Microbiology (AREA)
Hematology (AREA)
Diabetes (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Public Health (AREA)
Physics & Mathematics (AREA)
Biophysics (AREA)
Plant Pathology (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Enzymes And Modification Thereof (AREA)
Peptides Or Proteins (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)

IL12507797A 1996-02-12 1997-02-11 Thrombin muteins as antidote for thrombin inhibitors IL125077A0 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DE19605126A DE19605126A1 (de)	1996-02-12	1996-02-12	Thrombinmuteine als Antidot für Thrombininhibitoren
PCT/EP1997/000612 WO1997029198A1 (de)	1996-02-12	1997-02-11	Thrombinmuteine als antidot für thrombininhibitoren

Publications (1)

Publication Number	Publication Date
IL125077A0 true IL125077A0 (en)	1999-01-26

Family

ID=7785198

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IL12507797A IL125077A0 (en)	1996-02-12	1997-02-11	Thrombin muteins as antidote for thrombin inhibitors

Country Status (18)

Country	Link
US (1)	US6060300A (xx)
EP (1)	EP0880591A1 (xx)
JP (1)	JPH11512621A (xx)
KR (1)	KR19990082479A (xx)
CN (1)	CN1211280A (xx)
AR (1)	AR005797A1 (xx)
AU (1)	AU1768497A (xx)
BR (1)	BR9707280A (xx)
CA (1)	CA2245546A1 (xx)
CO (1)	CO4600682A1 (xx)
CZ (1)	CZ247798A3 (xx)
DE (1)	DE19605126A1 (xx)
HR (1)	HRP970077A2 (xx)
HU (1)	HUP9900574A2 (xx)
IL (1)	IL125077A0 (xx)
NO (1)	NO983677D0 (xx)
WO (1)	WO1997029198A1 (xx)
ZA (1)	ZA971107B (xx)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP4426722B2 (ja)	1998-05-19	2010-03-03	ケルシウス，エルエルシー	フレーム部材と取外し可能に取付けられた膜とを備えたタオルマット
KR20000018933A (ko) *	1998-09-07	2000-04-06	김승수	내피세포 성장억제 활성을 가지는 사람 프로트롬빈 크링글단백질 및 이를 암호하는 유전자
GB2355161B (en) *	1999-10-05	2001-09-12	3Com Corp	Network device incorporating selective compression of stored data packets
KR20020008471A (ko) *	2000-07-20	2002-01-31	김승수	내피세포 성장 억제활성을 가지는 인간 프로트롬빈크링글, 그것의 재조합벡터 및 이를 발현하는 재조합 숙주
CN101501216B (zh) *	2006-03-06	2013-10-02	胡玛基因公司	制备重组人凝血酶的方法
KR102069498B1 (ko)	2007-09-28	2020-01-23	포톨라 파마슈티컬스, 인코포레이티드	인자 Ｘａ 저해제에 대한 안티도트 및 그것을 사용하는 방법
MX2011004907A (es)	2008-11-14	2011-07-29	Portola Pharm Inc	Antidotos para inhibidores del factor xa y metodos para el uso de los mismos en combinacion con agentes de coagulacion de sangre.
PL3604510T3 (pl)	2009-03-30	2025-07-28	Alexion Pharmaceuticals, Inc.	Antidota na inhibitory czynnika xa i sposoby ich stosowania
CN102625712B (zh)	2009-07-15	2017-07-25	博尔托拉制药公司	用于因子xa抑制剂的解毒剂的单位剂量制剂及其使用方法
ES2620421T3 (es)	2009-10-30	2017-06-28	Senova Gesellschaft für Biowissenschaft und Technik mbH	Peptidasas acopladas a polímero
AR079944A1 (es)	2010-01-20	2012-02-29	Boehringer Ingelheim Int	Anticuerpo neutralizante de la actividad de un anticoagulante
BR112013025031A2 (pt)	2011-03-30	2017-08-01	Boehringer Ingelheim Int	antídotos anticoagulantes
EA037991B1 (ru)	2014-05-26	2021-06-21	Академиш Зикенхёйс Лейден	Прогемостатические белки для лечения кровотечений
ES3020087T3 (en)	2020-09-21	2025-05-21	Instr Laboratory Co	Detecting and monitoring oral anticoagulants or intravenous direct thrombin inhibitors in a blood sample

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE4203965A1 (de) *	1992-02-11	1993-08-12	Max Planck Gesellschaft	Antidot fuer hirudin und synthetische thrombininhibitoren

1996
- 1996-02-12 DE DE19605126A patent/DE19605126A1/de not_active Withdrawn
1997
- 1997-02-11 IL IL12507797A patent/IL125077A0/xx unknown
- 1997-02-11 JP JP9528173A patent/JPH11512621A/ja active Pending
- 1997-02-11 ZA ZA971107A patent/ZA971107B/xx unknown
- 1997-02-11 CO CO97006960A patent/CO4600682A1/es unknown
- 1997-02-11 AU AU17684/97A patent/AU1768497A/en not_active Abandoned
- 1997-02-11 KR KR1019980706212A patent/KR19990082479A/ko not_active Withdrawn
- 1997-02-11 EP EP97903254A patent/EP0880591A1/de not_active Withdrawn
- 1997-02-11 CZ CZ982477A patent/CZ247798A3/cs unknown
- 1997-02-11 CN CN97192210A patent/CN1211280A/zh active Pending
- 1997-02-11 HR HR19605126.6A patent/HRP970077A2/hr not_active Application Discontinuation
- 1997-02-11 US US09/117,708 patent/US6060300A/en not_active Expired - Fee Related
- 1997-02-11 BR BR9707280A patent/BR9707280A/pt not_active Application Discontinuation
- 1997-02-11 HU HU9900574A patent/HUP9900574A2/hu unknown
- 1997-02-11 WO PCT/EP1997/000612 patent/WO1997029198A1/de not_active Ceased
- 1997-02-11 CA CA002245546A patent/CA2245546A1/en not_active Abandoned
- 1997-02-12 AR ARP970100548A patent/AR005797A1/es unknown
1998
- 1998-08-11 NO NO983677A patent/NO983677D0/no unknown

Also Published As

Publication number	Publication date
CZ247798A3 (cs)	1999-03-17
AR005797A1 (es)	1999-07-14
ZA971107B (en)	1998-08-11
JPH11512621A (ja)	1999-11-02
EP0880591A1 (de)	1998-12-02
BR9707280A (pt)	1999-07-20
US6060300A (en)	2000-05-09
DE19605126A1 (de)	1997-08-14
NO983677L (no)	1998-08-11
CA2245546A1 (en)	1997-08-14
CN1211280A (zh)	1999-03-17
AU1768497A (en)	1997-08-28
HRP970077A2 (en)	1998-04-30
KR19990082479A (ko)	1999-11-25
CO4600682A1 (es)	1998-05-08
NO983677D0 (no)	1998-08-11
WO1997029198A1 (de)	1997-08-14
HUP9900574A2 (hu)	1999-06-28

Publication	Publication Date	Title
PL331338A1 (en)	1999-07-05	Thiosulphonamidic metaloprotease inhibitors
AU3832895A (en)	1996-05-06	Thrombin inhibitors
HUP0001848A3 (en)	2002-03-28	6-phenylpyridyl-2-amine derivatives useful as nos inhibitors
HUP0001826A3 (en)	2002-01-28	Thrombin inhibitors
IL128664A0 (en)	2000-01-31	Heterocyclic metalloprotease inhibitors
AU3102397A (en)	1998-01-07	Metalloprotease inhibitors
PL328307A1 (en)	1999-01-18	Serinic protease inhibitors
IL128665A0 (en)	2000-01-31	Bidenatate metalloprotease inhibitors
PL328875A1 (en)	1999-03-01	Serinic protease inhibitors
IL125077A0 (en)	1999-01-26	Thrombin muteins as antidote for thrombin inhibitors
PL328223A1 (en)	1999-01-18	Aspartil protease inhibitors
IL136139A0 (en)	2001-05-20	Thrombin inhibitors
AU3396697A (en)	1998-04-14	Thrombin inhibitor
GB9613718D0 (en)	1996-08-28	Thrombin inhibitors
IL121474A0 (en)	1998-02-08	Thrombin inhibitors
AU2908197A (en)	1998-01-05	Thrombin inhibitors
EP1027333A4 (en)	2000-11-08	THROMBIN INHIBITORS
GB9624292D0 (en)	1997-01-08	Thrombin inhibitors
GB9625311D0 (en)	1997-01-22	Thrombin inhibitors
GB9624319D0 (en)	1997-01-08	Thrombin inhibitors
GB9624278D0 (en)	1997-01-08	Thrombin inhibitors
GB9605163D0 (en)	1996-05-15	Thrombin inhibitors
SI0956294T1 (en)	2004-10-31	Thrombin inhibitors
GB9704209D0 (en)	1997-04-16	Thrombin inhibitors
GB9716872D0 (en)	1997-10-15	Thrombin Inhibitors