AR005347A1 - Compuestos 4,5-di-hidronaf[1,2-c]isoxasoles, derivados y composiciones farmaceuticas, metodo de preparacion, uso como substancia farmaceuticamenteactiva y usos para la fabricacion de medicamentos para el tratamiento de la ansiedad, alteraciones psiquiatricas, nausea, vomitos, dependencia de farmacos - Google Patents
Compuestos 4,5-di-hidronaf[1,2-c]isoxasoles, derivados y composiciones farmaceuticas, metodo de preparacion, uso como substancia farmaceuticamenteactiva y usos para la fabricacion de medicamentos para el tratamiento de la ansiedad, alteraciones psiquiatricas, nausea, vomitos, dependencia de farmacosInfo
- Publication number
- AR005347A1 AR005347A1 ARP970100015A ARP970100015A AR005347A1 AR 005347 A1 AR005347 A1 AR 005347A1 AR P970100015 A ARP970100015 A AR P970100015A AR P970100015 A ARP970100015 A AR P970100015A AR 005347 A1 AR005347 A1 AR 005347A1
- Authority
- AR
- Argentina
- Prior art keywords
- compounds
- pharmaceutical
- hydroxy
- manufacture
- dependence
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 4
- 208000019901 Anxiety disease Diseases 0.000 title abstract 2
- 230000036506 anxiety Effects 0.000 title abstract 2
- 239000003814 drug Substances 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- 239000013543 active substance Substances 0.000 title 1
- 230000004075 alteration Effects 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 5
- 125000003545 alkoxy group Chemical group 0.000 abstract 4
- 150000002431 hydrogen Chemical class 0.000 abstract 3
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 239000001257 hydrogen Substances 0.000 abstract 3
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical group 0.000 abstract 2
- 206010028813 Nausea Diseases 0.000 abstract 1
- 206010047700 Vomiting Diseases 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 206010013663 drug dependence Diseases 0.000 abstract 1
- 125000001072 heteroaryl group Chemical group 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 230000008693 nausea Effects 0.000 abstract 1
- 230000003287 optical effect Effects 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 208000020016 psychiatric disease Diseases 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 208000011117 substance-related disease Diseases 0.000 abstract 1
- 238000006467 substitution reaction Methods 0.000 abstract 1
- 230000008673 vomiting Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/20—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Otolaryngology (AREA)
- Addiction (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Se desciben compuestos de fórmula (I) donde A es hidrógeno, hidroxi, donde R1 es hidrógeno, un grupo alquilo de 1 a 6 carbonos eventualmente substituídocon substitución hidroxi, alcoxi, o amino; arilo o heteroarilo eventualmente substituído conh alógeno, hidroxi o alcoxi; o bencilo eventualmente substituídocon halógeno, hidroxi o alcoxi; n es un número entero de 1 o 2 ; Z es N, CH o C(CH); m es un número entero de 1 a 3 , y X es hidrógeno, hidroxi o alcoxi, ysus sales farmacéuticamenteace ptables y sus isómeros geométricos u ópticos o las mezclas racémicas, cuando sea aplicable. Los compuestos de fórmula (I) seobtienen mediante el siguiente esquema de reacción de fórmula (II) También se describe uso de dichos copuestos I parala f abricación de medicamentos para eltratamiento de la ansiedad, de alteraciones psiquiatricas, de la náusea, el vómito y de la dependencia de fármacos.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US58331996A | 1996-01-05 | 1996-01-05 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR005347A1 true AR005347A1 (es) | 1999-04-28 |
Family
ID=24332609
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP970100015A AR005347A1 (es) | 1996-01-05 | 1997-01-03 | Compuestos 4,5-di-hidronaf[1,2-c]isoxasoles, derivados y composiciones farmaceuticas, metodo de preparacion, uso como substancia farmaceuticamenteactiva y usos para la fabricacion de medicamentos para el tratamiento de la ansiedad, alteraciones psiquiatricas, nausea, vomitos, dependencia de farmacos |
Country Status (14)
| Country | Link |
|---|---|
| EP (1) | EP0874833A1 (es) |
| JP (1) | JP3161737B2 (es) |
| KR (1) | KR100308748B1 (es) |
| CN (1) | CN1214046A (es) |
| AR (1) | AR005347A1 (es) |
| AU (1) | AU710059B2 (es) |
| BR (1) | BR9612578A (es) |
| CA (1) | CA2241845C (es) |
| HU (1) | HUP9903706A3 (es) |
| IL (1) | IL125197A0 (es) |
| NO (1) | NO983100L (es) |
| NZ (1) | NZ325587A (es) |
| WO (1) | WO1997025317A1 (es) |
| ZA (1) | ZA9725B (es) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2420235A1 (en) * | 2000-08-21 | 2002-02-28 | Georgetown University | 2-3-disubstituted quinuclidines as modulators of monoamine transporters and therapeutic and diagnostic methods based thereon |
| CA2480113C (en) * | 2002-04-02 | 2012-04-24 | Janssen Pharmaceutica N.V. | Substituted amino isoxazoline derivatives and their use as anti-depressants |
| TW200409777A (en) * | 2002-08-12 | 2004-06-16 | Janssen Pharmaceutica Nv | C-substituted tricyclic isoxazoline derivatives and their use as anti-depressants |
| EP1554286B1 (en) * | 2002-08-15 | 2010-01-27 | Janssen Pharmaceutica N.V. | Fused heterocyclic isoxazoline derivatives and their use as anti-depressants |
| ATE387455T1 (de) * | 2002-08-21 | 2008-03-15 | Janssen Pharmaceutica Nv | C6- und c9-substituierte chromeno(4,3- c)isoxazoline und ihre verwendung als anti- depressiva |
| US8025859B2 (en) | 2007-05-18 | 2011-09-27 | Cesl Limited | Process for gold and silver recovery from a sulphide concentrate |
| MX336881B (es) | 2009-10-29 | 2016-02-04 | Bristol Myers Squibb Co | Compuestos heterociclicos triciclicos. |
| JP7029445B2 (ja) | 2016-09-02 | 2022-03-03 | ブリストル－マイヤーズ スクイブ カンパニー | 置換された三環式ヘテロ環化合物 |
| US11059784B2 (en) | 2017-08-09 | 2021-07-13 | Bristol-Myers Squibb Company | Oxime ether compounds |
| US11046646B2 (en) | 2017-08-09 | 2021-06-29 | Bristol-Myers Squibb Company | Alkylphenyl compounds |
| KR102002633B1 (ko) | 2018-07-19 | 2019-07-22 | 김태효 | 완충이격부가 구비된 논슬립 발의류 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2119977A1 (en) * | 1971-04-23 | 1971-12-16 | Teikoku Hormone Manufacturing Co , Ltd, Tokio | Antiphlogistic and antisecretory napththisoxazoles - from 1-hydroxyim - 2-carbonyl derivs by intramolecular condensation |
| DK0402644T3 (da) * | 1989-05-19 | 1996-01-02 | Hoechst Roussel Pharma | N-(Aryloxyalkyl)-heteroarylpiperidiner og -heteroarylpiperaziner, fremgangsmåde til deres fremstilli ng samt deres anvendelse som medikamenter |
| EP0665840A1 (en) * | 1992-10-23 | 1995-08-09 | MERCK SHARP & DOHME LTD. | Dopamine receptor subtype ligands |
-
1996
- 1996-12-12 EP EP96944274A patent/EP0874833A1/en not_active Withdrawn
- 1996-12-12 WO PCT/US1996/019569 patent/WO1997025317A1/en not_active Ceased
- 1996-12-12 KR KR1019980705166A patent/KR100308748B1/ko not_active Expired - Fee Related
- 1996-12-12 CA CA002241845A patent/CA2241845C/en not_active Expired - Fee Related
- 1996-12-12 BR BR9612578A patent/BR9612578A/pt not_active Application Discontinuation
- 1996-12-12 CN CN96180175A patent/CN1214046A/zh active Pending
- 1996-12-12 JP JP52519797A patent/JP3161737B2/ja not_active Expired - Fee Related
- 1996-12-12 AU AU14126/97A patent/AU710059B2/en not_active Ceased
- 1996-12-12 IL IL12519796A patent/IL125197A0/xx unknown
- 1996-12-12 NZ NZ325587A patent/NZ325587A/xx unknown
- 1996-12-12 HU HU9903706A patent/HUP9903706A3/hu unknown
-
1997
- 1997-01-02 ZA ZA9725A patent/ZA9725B/xx unknown
- 1997-01-03 AR ARP970100015A patent/AR005347A1/es unknown
-
1998
- 1998-07-03 NO NO983100A patent/NO983100L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| NO983100D0 (no) | 1998-07-03 |
| IL125197A0 (en) | 1999-03-12 |
| EP0874833A1 (en) | 1998-11-04 |
| JP3161737B2 (ja) | 2001-04-25 |
| AU1412697A (en) | 1997-08-01 |
| WO1997025317A1 (en) | 1997-07-17 |
| CN1214046A (zh) | 1999-04-14 |
| BR9612578A (pt) | 1999-07-27 |
| AU710059B2 (en) | 1999-09-09 |
| NO983100L (no) | 1998-09-04 |
| KR100308748B1 (ko) | 2001-12-12 |
| NZ325587A (en) | 1999-02-25 |
| CA2241845C (en) | 2002-10-01 |
| KR19990077033A (ko) | 1999-10-25 |
| HUP9903706A2 (hu) | 2000-08-28 |
| ZA9725B (en) | 1997-07-07 |
| JPH11510816A (ja) | 1999-09-21 |
| HUP9903706A3 (en) | 2000-09-28 |
| CA2241845A1 (en) | 1997-07-17 |
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