PT92494A - Processo para a preparacao de novos derivados do indol - Google Patents
Processo para a preparacao de novos derivados do indolInfo
- Publication number
- PT92494A PT92494A PT92494A PT9249489A PT92494A PT 92494 A PT92494 A PT 92494A PT 92494 A PT92494 A PT 92494A PT 9249489 A PT9249489 A PT 9249489A PT 92494 A PT92494 A PT 92494A
- Authority
- PT
- Portugal
- Prior art keywords
- lower alkyl
- linear
- denotes
- hydrogen atom
- alkyl group
- Prior art date
Links
- SIKJAQJRHWYJAI-UHFFFAOYSA-N Indole Chemical class C1=CC=C2NC=CC2=C1 SIKJAQJRHWYJAI-UHFFFAOYSA-N 0.000 title 1
- 229940054051 antipsychotic indole derivative Drugs 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 11
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 7
- 125000003545 alkoxy group Chemical group 0.000 abstract 3
- 125000003118 aryl group Chemical group 0.000 abstract 3
- 125000005843 halogen group Chemical group 0.000 abstract 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 2
- 229910052757 nitrogen Inorganic materials 0.000 abstract 2
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000005842 heteroatom Chemical group 0.000 abstract 1
- 229940126601 medicinal product Drugs 0.000 abstract 1
- 125000002950 monocyclic group Chemical group 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229920006395 saturated elastomer Polymers 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
- 239000011593 sulfur Substances 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Hospice & Palliative Care (AREA)
- Anesthesiology (AREA)
- Otolaryngology (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR8815937A FR2639944B1 (fr) | 1988-12-06 | 1988-12-06 | Nouveaux derives de l'indole, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| PT92494A true PT92494A (pt) | 1990-06-29 |
| PT92494B PT92494B (pt) | 1995-08-09 |
Family
ID=9372595
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT92494A PT92494B (pt) | 1988-12-06 | 1989-12-05 | Processo para a preparacao de novos derivados do indol |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US5030646A (pt) |
| EP (1) | EP0373061B1 (pt) |
| JP (1) | JPH064637B2 (pt) |
| AT (1) | ATE101610T1 (pt) |
| AU (1) | AU618648B2 (pt) |
| CA (1) | CA2004643A1 (pt) |
| DE (1) | DE68913167T2 (pt) |
| DK (1) | DK614989A (pt) |
| ES (1) | ES2063157T3 (pt) |
| FR (1) | FR2639944B1 (pt) |
| IE (1) | IE64209B1 (pt) |
| NZ (1) | NZ231634A (pt) |
| OA (1) | OA09147A (pt) |
| PT (1) | PT92494B (pt) |
| ZA (1) | ZA899321B (pt) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8928837D0 (en) * | 1989-12-21 | 1990-02-28 | Beecham Group Plc | Pharmaceuticals |
| HU211081B (en) * | 1990-12-18 | 1995-10-30 | Sandoz Ag | Process for producing indole derivatives as serotonin antagonists and pharmaceutical compositions containing the same |
| US5776962A (en) * | 1994-08-03 | 1998-07-07 | Cell Pathways, Inc. | Lactone compounds for treating patient with precancerous lesions |
| US5696159A (en) * | 1994-08-03 | 1997-12-09 | Cell Pathways, Inc. | Lactone compounds for treating patients with precancerous lesions |
| CN109438448B (zh) * | 2018-11-07 | 2021-08-27 | 成都大学 | 一种吲哚并七元环化合物及其制备方法和用途 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3971806A (en) * | 1974-05-09 | 1976-07-27 | Warner-Lambert Company | Indolothiopyrones |
| JPS557201A (en) * | 1978-05-23 | 1980-01-19 | Shionogi & Co Ltd | Derivative of tetrahydrothiopyrano(2,3-b)indole |
| JPS56120686A (en) * | 1980-02-27 | 1981-09-22 | Shionogi & Co Ltd | Tetrahydrothiopyrano 3,2-b indole derivative |
| HU193592B (en) * | 1984-01-25 | 1987-11-30 | Glaxo Group Ltd | Process for producing tetrahydro-carbazolone derivatives |
| JPH02131485A (ja) * | 1988-11-10 | 1990-05-21 | Yamanouchi Pharmaceut Co Ltd | ３−置換テトラヒドロチオピラノ〔２，３−ｂ〕インドール誘導体及びその中間体 |
-
1988
- 1988-12-06 FR FR8815937A patent/FR2639944B1/fr not_active Expired - Lifetime
-
1989
- 1989-12-05 ES ES89403356T patent/ES2063157T3/es not_active Expired - Lifetime
- 1989-12-05 PT PT92494A patent/PT92494B/pt not_active IP Right Cessation
- 1989-12-05 AU AU45834/89A patent/AU618648B2/en not_active Ceased
- 1989-12-05 NZ NZ231634A patent/NZ231634A/en unknown
- 1989-12-05 EP EP89403356A patent/EP0373061B1/fr not_active Expired - Lifetime
- 1989-12-05 AT AT89403356T patent/ATE101610T1/de not_active IP Right Cessation
- 1989-12-05 US US07/446,034 patent/US5030646A/en not_active Expired - Fee Related
- 1989-12-05 IE IE387189A patent/IE64209B1/en not_active IP Right Cessation
- 1989-12-05 CA CA002004643A patent/CA2004643A1/fr not_active Abandoned
- 1989-12-05 DE DE68913167T patent/DE68913167T2/de not_active Expired - Fee Related
- 1989-12-06 OA OA59690A patent/OA09147A/xx unknown
- 1989-12-06 ZA ZA899321A patent/ZA899321B/xx unknown
- 1989-12-06 DK DK614989A patent/DK614989A/da not_active Application Discontinuation
- 1989-12-06 JP JP1315531A patent/JPH064637B2/ja not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| ZA899321B (en) | 1990-08-29 |
| CA2004643A1 (fr) | 1990-06-06 |
| ATE101610T1 (de) | 1994-03-15 |
| FR2639944A1 (fr) | 1990-06-08 |
| DK614989D0 (da) | 1989-12-06 |
| EP0373061A1 (fr) | 1990-06-13 |
| DE68913167T2 (de) | 1994-09-01 |
| IE64209B1 (en) | 1995-07-26 |
| JPH064637B2 (ja) | 1994-01-19 |
| JPH02200685A (ja) | 1990-08-08 |
| ES2063157T3 (es) | 1995-01-01 |
| US5030646A (en) | 1991-07-09 |
| AU618648B2 (en) | 1992-01-02 |
| DK614989A (da) | 1990-06-07 |
| EP0373061B1 (fr) | 1994-02-16 |
| IE893871L (en) | 1990-06-06 |
| AU4583489A (en) | 1990-06-14 |
| PT92494B (pt) | 1995-08-09 |
| FR2639944B1 (fr) | 1991-01-18 |
| OA09147A (fr) | 1991-10-31 |
| NZ231634A (en) | 1991-06-25 |
| DE68913167D1 (de) | 1994-03-24 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG3A | Patent granted, date of granting |
Effective date: 19950404 |
|
| MM3A | Annulment or lapse |
Free format text: LAPSE DUE TO NON-PAYMENT OF FEES Effective date: 19961031 |