[go: up one dir, main page]

AR004698A1 - Derivados de piperazina 1-(piperidinil -1,2- disustituido) -4- sustituida, composicion que los contiene, proceso para preparar dicha composicion y proceso para preparar dichos derivados - Google Patents

Derivados de piperazina 1-(piperidinil -1,2- disustituido) -4- sustituida, composicion que los contiene, proceso para preparar dicha composicion y proceso para preparar dichos derivados

Info

Publication number
AR004698A1
AR004698A1 ARP960104941A ARP960104941A AR004698A1 AR 004698 A1 AR004698 A1 AR 004698A1 AR P960104941 A ARP960104941 A AR P960104941A AR P960104941 A ARP960104941 A AR P960104941A AR 004698 A1 AR004698 A1 AR 004698A1
Authority
AR
Argentina
Prior art keywords
alkyl
6alkyl
substituted
formula
ar3c1
Prior art date
Application number
ARP960104941A
Other languages
English (en)
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=8220780&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AR004698(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of AR004698A1 publication Critical patent/AR004698A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/56—Nitrogen atoms
    • C07D211/58—Nitrogen atoms attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Neurology (AREA)
  • Anesthesiology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Neurosurgery (AREA)
  • Oncology (AREA)
  • Dermatology (AREA)
  • Hospice & Palliative Care (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

Derivados de piperazina 1-(piperidinil-1, 2-disustituido)-4-sustituidas de la fórmula (I), una forma de N-óxido, una sal de adición farmacéuticamenteaceptable o una forma estereoquímicamente isomérica del mismo, en el cual n es 0, 1 ó 2; m es 1 ó2 , siempre que si m es 2, luego n sea 1; p es 1 ó 2;=Q es =Oó =NR3; X es un enlace covalente o un radical bivalente de la fórmula -O-, -S-, -NR3-, R1 es Ar1, Ar1C1-6alquilo o di(Ar1)C1-6alquilo, donde cada grupo alquiloC1-6 es optativamentesustituido con hidroxi, alquiloxi C1-4, oxo o un sustituyente oxo cetalizado de la fórmula -O-CH2-CH2-O- ó -O-CH2-CH2-CH2-O-;R2 es Ar2, Ar2C1-6alquilo, Het1 ó Het1C1-6alquilo; R3 es H ó alquilo C1-6; L es H; Ar3, alquilo C1-6; alquilo C1-6 sustitui do con 1 ó 2 sustitutyentesseleccionados entre hidroxi, alquiloxi C1-6; Ar3, Ar3C1-6alquiloxi y Het2, alquenilo C3-6; Ar3, Ar3C1-6alquenilo; di(Ar3)C3-6alquenilo o un radical de lafórmula (a1-), (a-2), (a-3), (a4) ó (a-5), donde cadaq,independi entemente, es 2, 3 ó 4; cada r es 0,1, 2, 3 ó 4; cada Y1 es independientemente un enlacecovalente, -O- ó NR3; Y2 es un enlace covalente, alcanodiilo C1-4 ó C1-4alquil NR3-; cada -A=B independientemente, es un radical bivalente de lafórmula -CH=CH- ,-N=CH- ó -CH=N-; cada R4 independientemente, es H, alquilo C1-6; Ar2, Ar2 C1-6alquilo; R5 es H, alquilo C1-6; ó Ar3; R6 es alquilo C1-6; Ar3, ArC1-6alquilo; di(Ar3)C1-6alquilo, Ar3C3-7cicloalquilo, ó indolilo; R7 es Ar3 Ar3C1-6alquilo; di (Ar3)C1 -6alquilo; alquilo C1-6; cicloalquiloC3-7, cicloalquilo C3-7sustituido con Ar3, oxazolilo;oxazolilo sustituido con halo o alquilo C1-6; tiazolilo; tiazolilo sustituido con halo o alquilo C1-6; imidazolilo,imidazolilosustituído con Ar3, alquilo C 1-6, Ar3C1-6 alquilo, o halo; indolinilo, indolinilo sustituído con alquilo C1-4
ARP960104941A 1995-10-30 1996-10-28 Derivados de piperazina 1-(piperidinil -1,2- disustituido) -4- sustituida, composicion que los contiene, proceso para preparar dicha composicion y proceso para preparar dichos derivados AR004698A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP95202929 1995-10-30

Publications (1)

Publication Number Publication Date
AR004698A1 true AR004698A1 (es) 1999-03-10

Family

ID=8220780

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP960104941A AR004698A1 (es) 1995-10-30 1996-10-28 Derivados de piperazina 1-(piperidinil -1,2- disustituido) -4- sustituida, composicion que los contiene, proceso para preparar dicha composicion y proceso para preparar dichos derivados

Country Status (31)

Country Link
US (3) US6197772B1 (es)
EP (1) EP0862566B1 (es)
JP (1) JP3073238B2 (es)
KR (1) KR100407067B1 (es)
CN (2) CN100415716C (es)
AR (1) AR004698A1 (es)
AT (1) ATE188691T1 (es)
AU (1) AU704155B2 (es)
BR (1) BR9611184B8 (es)
CA (1) CA2234096C (es)
CY (1) CY2177B1 (es)
CZ (1) CZ291794B6 (es)
DE (1) DE69606196T2 (es)
DK (1) DK0862566T3 (es)
EA (1) EA000909B1 (es)
ES (1) ES2143238T3 (es)
GR (1) GR3033154T3 (es)
HR (1) HRP960507B1 (es)
HU (1) HU227341B1 (es)
IL (1) IL123962A (es)
MX (1) MX9803407A (es)
MY (1) MY116575A (es)
NO (1) NO310232B1 (es)
NZ (1) NZ321575A (es)
PL (1) PL185029B1 (es)
PT (1) PT862566E (es)
SI (1) SI0862566T1 (es)
TR (1) TR199800756T2 (es)
TW (1) TW460473B (es)
WO (1) WO1997016440A1 (es)
ZA (1) ZA969090B (es)

Families Citing this family (48)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ321575A (en) * 1995-10-30 1999-05-28 Janssen Pharmaceutica Nv 1-(1,2-disubstituted piperidinyl)-4- substituted piperazine derivatives
TW382017B (en) 1995-12-27 2000-02-11 Janssen Pharmaceutica Nv 1-(1,2-disubstituted piperidinyl)-4-(fused imidazole)-piperidine derivatives
TW429256B (en) * 1995-12-27 2001-04-11 Janssen Pharmaceutica Nv 1-(1,2-disubstituted piperidinyl)-4-(benzimidazolyl- and imidazopyridinyl)-piperidine derivatives
TW531537B (en) 1995-12-27 2003-05-11 Janssen Pharmaceutica Nv 1-(1,2-disubstituted piperidinyl)-4-substituted piperidine derivatives
AU2307899A (en) * 1997-12-23 1999-07-12 Alcon Laboratories, Inc. Muscarinic agents and use thereof to treat glaucoma, myopia and various other conditions
US6689765B2 (en) 1999-05-04 2004-02-10 Schering Corporation Piperazine derivatives useful as CCR5 antagonists
US6391865B1 (en) 1999-05-04 2002-05-21 Schering Corporation Piperazine derivatives useful as CCR5 antagonists
GB9923748D0 (en) * 1999-10-07 1999-12-08 Glaxo Group Ltd Chemical compounds
USRE39921E1 (en) 1999-10-07 2007-11-13 Smithkline Beecham Corporation Chemical compounds
WO2001030348A1 (en) * 1999-10-25 2001-05-03 Janssen Pharmaceutica N.V. Use of substance p antagonists for influencing the circadian timing system
GB0025354D0 (en) 2000-10-17 2000-11-29 Glaxo Group Ltd Chemical compounds
AU2002255947B8 (en) 2001-03-29 2005-11-17 Schering Corporation CCR5 antagonists useful for treating AIDS
GB0108594D0 (en) * 2001-04-05 2001-05-23 Glaxo Group Ltd Chemical compounds
GB0203020D0 (en) * 2002-02-08 2002-03-27 Glaxo Group Ltd Chemical compounds
EP1472222A1 (en) 2002-02-08 2004-11-03 Glaxo Group Limited Piperidylcarboxamide derivatives and their use in the treatment of tachykinim-mediated diseases
GB0203022D0 (en) * 2002-02-08 2002-03-27 Glaxo Group Ltd Chemical compounds
CA2487141C (en) 2002-06-24 2011-08-02 Janssen Pharmaceutica N.V. Process for the production of n-(2,6-dimethyl-phenyl)-2-piperazin-1-yl-acetamide
WO2004056772A1 (en) * 2002-12-23 2004-07-08 Janssen Pharmaceutica N.V. Substituted 1,4-di-piperidin-4-yl-piperazine derivatives and their use as tachykinin antagonists
MY141736A (en) * 2002-10-08 2010-06-15 Elanco Animal Health Ireland Substituted 1,4-di-piperidin-4-yi-piperazine derivatives and their use as neurokinin antagonists
UA81918C2 (uk) * 2002-10-08 2008-02-25 Янссен Фармацевтика Н.В. Заміщені похідні 1,4-дипіперидин-4-ілпіперазину та їх застосування як нейрокінінових антагоністів
MXPA05003948A (es) * 2002-10-17 2005-06-17 Amgen Inc Derivados de bencimidazol y su uso como ligandos de receptor vaniloide.
JO2485B1 (en) 2002-12-23 2009-01-20 شركة جانسين فارماسوتيكا ان. في 1-Piperidine-3-Yl-4-Piperidine-4-Yl-Piperazine derivatives substituted and used as quinine antagonists
CA2509406C (en) 2002-12-23 2012-07-03 Janssen Pharmaceutica N.V. Substituted 1-piperidin-4-yl-4-azetidin-3-yl-piperazine derivatives and their use as neurokinin antagonists
JO2696B1 (en) 2002-12-23 2013-03-03 شركة جانسين فارماسوتيكا ان. في Derivatives of 1-piperdine-4-yl-4-biprolidine-3-yl-piperazine substituted and used as quinine antagonists
AU2003298369B2 (en) * 2002-12-23 2009-08-27 Janssen Pharmaceutica N.V. Substituted 4-(4-piperidin-4-yl-piperazin-1-yl)-azepane derivatives and their use as neurokinin antagonists
MXPA05013295A (es) * 2003-06-10 2006-03-09 Janssen Pharmaceutica Nv Derivado sustituido de 1,4-piperidin-4-il-piperazina combinado con un analgesico opioideo y su uso para el tratamiento de dolor y efectos secundarios asociados con tratamientos de base opioidea.
ATE395062T1 (de) * 2003-06-10 2008-05-15 Janssen Pharmaceutica Nv Kombination von opioiden und einem piperazin- derivat für die behandlung von schmerzen
UY28538A1 (es) * 2003-09-26 2005-04-29 Vertex Pharma Derivados de fenil-piperazina como moduladores de receptores muscarínicos
JO2676B1 (en) * 2004-04-06 2012-06-17 جانسين فارماسوتيكا ان. في Derivatives of second-aza-spiro- (5,4) -dikan and their use as antihistamines
JO2527B1 (en) * 2004-04-06 2010-03-17 شركة جانسين فارماسوتيكا ان. في Derivatives of second-aza-Spiro- (5,5) -andecan and their use as antihistamines
JO2525B1 (en) * 2004-04-08 2010-03-17 شركة جانسين فارماسوتيكا ان. في Derived 4-alkyl-and-4-canoelperidine derivatives and their use as anti-neroquin
EA015517B1 (ru) 2004-04-13 2011-08-30 Инсайт Корпорейшн Производные пиперазинилпиперидина в качестве антагонистов хемокинового рецептора
WO2005123081A2 (en) * 2004-06-22 2005-12-29 Janssen Pharmaceutica N.V. (2-benzyl-4-{4-[1-(tetrahydrofuran-3-carbonyl)-pyrrolidin-3-yl]-piperazin-1-yl}-piperidin-1-yl)-(3,5-trifluoromethyl-phenyl))-methanone for the treatment of schizophrenia
US20060024481A1 (en) * 2004-07-29 2006-02-02 Eastman Kodak Company Jet printing of patterned metal
WO2006023431A2 (en) 2004-08-19 2006-03-02 Monsanto Technology Llc Glyphosate salt herbicidal composition
US7635698B2 (en) * 2004-12-29 2009-12-22 Millennium Pharmaceuticals, Inc. Compounds useful as chemokine receptor antagonists
ES2350647T3 (es) 2005-03-08 2011-01-25 Janssen Pharmaceutica Nv Derivados de diaza-espiro-[4.4]-nonano como antagonistas de neuroquininas (nk1).
CN101190330A (zh) 2006-11-30 2008-06-04 深圳市鼎兴生物医药技术开发有限公司 胆碱酯酶在拮抗速激肽药物中的应用
KR20090112722A (ko) 2007-01-24 2009-10-28 글락소 그룹 리미티드 3,5-디아미노-6-(2,3-디클로로페닐)-1,2,4-트리아진 또는 ｒ(-)-2,4-디아미노-5-(2,3-디클로로페닐)-6-플루오로메틸 피리미딘 및 ｎｋ1을 포함하는 제약 조성물
WO2010081851A1 (en) 2009-01-14 2010-07-22 Genoscience Pharma Piperidin-4-ylpiperazine compounds for the treatment of hcv infection
GB201106817D0 (en) 2011-04-21 2011-06-01 Astex Therapeutics Ltd New compound
GB201218850D0 (en) 2012-10-19 2012-12-05 Astex Therapeutics Ltd Bicyclic heterocycle compounds and their uses in therapy
GB201218862D0 (en) 2012-10-19 2012-12-05 Astex Therapeutics Ltd Bicyclic heterocycle compounds and their uses in therapy
US9980973B2 (en) 2012-10-19 2018-05-29 Astex Therapeutics Limited Bicyclic heterocycle compounds and their uses in therapy
GB201218864D0 (en) 2012-10-19 2012-12-05 Astex Therapeutics Ltd Bicyclic heterocycle compounds and their uses in therapy
ES2704880T3 (es) 2013-02-08 2019-03-20 Gen Mills Inc Productos alimentarios reducidos en sodio
MY193649A (en) 2013-12-20 2022-10-21 Astex Therapeutics Ltd Bicyclic heterocycle compounds and their uses in therapy
US9750739B2 (en) * 2016-01-08 2017-09-05 Nerre Therapeutics Limited Orvepitant for chronic cough therapy

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2676055B1 (fr) * 1991-05-03 1993-09-03 Sanofi Elf Composes polycycliques amines et leurs enantiomeres, procede pour leur preparation et compositions pharmaceutiques les contenant.
MY110227A (en) * 1991-08-12 1998-03-31 Ciba Geigy Ag 1-acylpiperindine compounds.
CN1042335C (zh) * 1993-01-03 1999-03-03 诺瓦提斯公司 1－酰基哌啶化合物、其制备方法、药物组合物及用途
ATE157349T1 (de) * 1993-05-12 1997-09-15 Heumann Pharma Gmbh & Co Stabile und kristalline form von bezafibrat
GB9310066D0 (en) * 1993-05-17 1993-06-30 Zeneca Ltd Alkyl substituted heterocycles
WO1995011895A1 (en) * 1993-10-26 1995-05-04 Ciba-Geigy Ag N-benzoyl-4-oxy/thio-2-substituted piperidines as substance-p receptor antagonists
IL111730A (en) * 1993-11-29 1998-12-06 Fujisawa Pharmaceutical Co Piperazine derivatives processes for the preparation thereof and pharmaceutical compositions containing the same
KR100254666B1 (ko) * 1994-07-15 2000-05-01 이치로 키타사토 혈소판 응집 저해 작용을 갖는 신규 화합물
DK0783490T3 (da) * 1994-09-30 2002-05-13 Novartis Ag 1-Acyl-4-alifatiske aminopiperidinforbindelser
NZ321575A (en) * 1995-10-30 1999-05-28 Janssen Pharmaceutica Nv 1-(1,2-disubstituted piperidinyl)-4- substituted piperazine derivatives

Also Published As

Publication number Publication date
CN100415716C (zh) 2008-09-03
DK0862566T3 (da) 2000-06-13
PL185029B1 (pl) 2003-02-28
EP0862566B1 (en) 2000-01-12
PL327406A1 (en) 1998-12-07
NZ321575A (en) 1999-05-28
TW460473B (en) 2001-10-21
MY116575A (en) 2004-02-28
CZ132298A3 (cs) 1998-09-16
ES2143238T3 (es) 2000-05-01
DE69606196D1 (de) 2000-02-17
CZ291794B6 (cs) 2003-05-14
KR19990064178A (ko) 1999-07-26
CN1438220A (zh) 2003-08-27
HRP960507B1 (en) 2001-08-31
HUP9802985A2 (hu) 1999-10-28
SI0862566T1 (en) 2000-04-30
CN1205699A (zh) 1999-01-20
HRP960507A2 (en) 1998-02-28
JP3073238B2 (ja) 2000-08-07
CA2234096A1 (en) 1997-05-09
KR100407067B1 (ko) 2004-06-04
ATE188691T1 (de) 2000-01-15
NO310232B1 (no) 2001-06-11
CN1117744C (zh) 2003-08-13
GR3033154T3 (en) 2000-08-31
PT862566E (pt) 2000-06-30
HU227341B1 (en) 2011-04-28
TR199800756T2 (xx) 1998-07-21
US6197772B1 (en) 2001-03-06
ZA969090B (en) 1998-04-29
IL123962A (en) 2001-01-11
NO981534D0 (no) 1998-04-03
WO1997016440A1 (en) 1997-05-09
USRE37886E1 (en) 2002-10-15
BR9611184B8 (pt) 2015-02-18
EP0862566A1 (en) 1998-09-09
HUP9802985A3 (en) 2002-10-28
CY2177B1 (en) 2002-08-23
EA199800404A1 (ru) 1998-10-29
AU704155B2 (en) 1999-04-15
BR9611184A (pt) 1999-03-30
NO981534L (no) 1998-06-24
DE69606196T2 (de) 2000-09-21
CA2234096C (en) 2005-06-14
US6521621B1 (en) 2003-02-18
JPH11514634A (ja) 1999-12-14
EA000909B1 (ru) 2000-06-26
AU7493296A (en) 1997-05-22
MX9803407A (es) 1998-09-30

Similar Documents

Publication Publication Date Title
AR004698A1 (es) Derivados de piperazina 1-(piperidinil -1,2- disustituido) -4- sustituida, composicion que los contiene, proceso para preparar dicha composicion y proceso para preparar dichos derivados
MY117557A (en) 1-(1,2-disubstituted piperidinyl)-4- substituted piperidine derivatives
AR120080A1 (es) Compuestos lipídicos de cola ramificada y composiciones para la administración intracelular de agentes terapéuticos
AR002240A1 (es) Derivado de 2,4-oxazolidinadiona, composicion farmaceutica que lo comprende y metodo de preparacion del mismo.
ES2058292T3 (es) Derivados de indol.
AR030553A1 (es) Uso de derivados de tiazolilo 2,4-disustituidos para la fabricacion de un medicamento para la prevencion o el tratamiento de enfermedades mediadas a traves de citoquinas, derivados de tiazolilo 2,4-disustituidos, composiciones farmaceuticas que los comprenden, procesos para preparar dichos derivados
AR013361A1 (es) BENZAMIDAS BICíCLICAS DE DERIVADOS 3-o4-SUBSTITUíDOS DE 4-(AMINOMETIL)- PIPERIDINAS, PROCEDIMIENTO PARA SU PREPARACIoN, COMPOSICIoN FARMACÉUTICA QUE LOS CONTIENE, PROCEDIMIENTO PARA SU PREPARACIoN, COMPUESTO INTERMEDIARIO Y PROCEDIMIENTO PARA SU PREPARACIoN.
AR005278A1 (es) Derivados de 1- (piperidinil 1,2 - disustituido) -4- (imidazol fusionado) -piperidina, proceso para la preparación de los mismos, composición farmacéutica que los contiene y proceso para la preparación de dicha composición.
SE7714660L (sv) Aminosockerderivat, sett for framstellning derav samt anvendning derav som lekemedel
AR021888A1 (es) Derivados de espiro-benzazepina-piperidina, composiciones farmaceuticas que los comprenden, proceso para preparar dichas composiciones, intermediario util en la preparacion de dichos derivados, procesos para preparar dichos derivados y procesos para preparar dicho intermediario
HUT71811A (en) Triazolobenzazepine derivatives, process for preparing them and antiallergic pharmaceutical compositions containing them
CO5640109A2 (es) Compuestos triciclicos inhibidores de la farnesisl proteino transferasa y composiciones farmaceuticas que los contienen
MY121580A (en) 1-(1,2-disubstituted piperidinyl)-4-(benzimidazolyl-and imidazopyridinyl)- piperidine derivatives
CO4920224A1 (es) Compuestos de pirrolidinil y pirrolinil etilamina como agonistas kappa
GB1291675A (en) 0-(1,3,4-thiadiazol-2-yl)-imidazolidinone(2) derivatives, process for their production and their use as herbicidal agents
DE69301357D1 (de) Indol derivate als "5-ht1-like" agonisten
ES346521A1 (es) Un procedimiento para la preparacion de derivados de sulfo-nilurea.
AR026225A1 (es) Compuestos relacionados con el sistema del periodo circadiano
HUT57183A (en) Process for producing hydrazone derivatives and pharmaceutical preparatives containing said compounds
DK299584D0 (da) Hidtil ukendte prostacyklinderivater, fremgangsmaade til deres fremstilling og deres anvendelse som laegemidler
ES2038654T3 (es) Un procedimiento para preparar derivados de tianafteno.
GB1028234A (en) New pharmaceutical compositions comprising 5-aminodibenzocycloheptene derivatives
ES2149861T3 (es) Derivados antialergicos de triazolo(pirrolo, tieno o furano)azepina.
GB948460A (en) Substituted indoles
ES2180930T3 (es) Esteres de derivados de 3-hidroxi-piperidinametanol.

Legal Events

Date Code Title Description
FG Grant, registration