[go: up one dir, main page]

AR002240A1 - Derivado de 2,4-oxazolidinadiona, composicion farmaceutica que lo comprende y metodo de preparacion del mismo. - Google Patents

Derivado de 2,4-oxazolidinadiona, composicion farmaceutica que lo comprende y metodo de preparacion del mismo.

Info

Publication number
AR002240A1
AR002240A1 ARP950100021A AR10002195A AR002240A1 AR 002240 A1 AR002240 A1 AR 002240A1 AR P950100021 A ARP950100021 A AR P950100021A AR 10002195 A AR10002195 A AR 10002195A AR 002240 A1 AR002240 A1 AR 002240A1
Authority
AR
Argentina
Prior art keywords
alkyl group
formula
oxazolidinadiona
understands
derivative
Prior art date
Application number
ARP950100021A
Other languages
English (en)
Inventor
T Sohda
H Odaka
Y Momose
M Kawada
Original Assignee
Takeda Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Chemical Industries Ltd filed Critical Takeda Chemical Industries Ltd
Publication of AR002240A1 publication Critical patent/AR002240A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D263/32—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D263/34—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/44—Two oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D277/24—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Un derivado de 2,4-oxazolidinadiona representado por la fórmula (I) en la cual R representa un residuo de hidrocarburo opcionalmente sustituido o ungrupo heterocíclico; Y constituye un grupo representado por -CO-, -CH(OH) o NR3 (en donde R3 esun grupo alquilo opcionalmente sustituido); m es 0 ó 1; nes 0, 1 ó 2; A representa un residuo de hidrocarburo alifático divalente; R1 es hidrógeno o un grupo alquilo; el anillo E es un anillo de benceno que posee1 ó 2 sustituyentes; L y M respectivamente son hidrógeno, o pueden opcionalmente combinarse entre sí formando un enlace; en tanto la fórmulaparcial:(II) no incluya la fórmula (III), en la cual R es un grupo alquilo; o una sal del mismo; el cual posee excelentes propiedadespara bajar el nivelde azúcar y lípido en sangre.
ARP950100021A 1994-11-02 1995-11-02 Derivado de 2,4-oxazolidinadiona, composicion farmaceutica que lo comprende y metodo de preparacion del mismo. AR002240A1 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP26982694 1994-11-02
JP17176895 1995-07-07
JP22094295 1995-08-29

Publications (1)

Publication Number Publication Date
AR002240A1 true AR002240A1 (es) 1998-03-11

Family

ID=27323527

Family Applications (2)

Application Number Title Priority Date Filing Date
ARP950100021A AR002240A1 (es) 1994-11-02 1995-11-02 Derivado de 2,4-oxazolidinadiona, composicion farmaceutica que lo comprende y metodo de preparacion del mismo.
ARP950100022A AR002241A1 (es) 1994-11-02 1995-11-02 Derivado de 2,4-oxazolidinadiona, composicion farmaceutica que lo comprende y metodo de preparacion del mismo.

Family Applications After (1)

Application Number Title Priority Date Filing Date
ARP950100022A AR002241A1 (es) 1994-11-02 1995-11-02 Derivado de 2,4-oxazolidinadiona, composicion farmaceutica que lo comprende y metodo de preparacion del mismo.

Country Status (14)

Country Link
US (1) US5932601A (es)
EP (1) EP0710659B1 (es)
KR (1) KR960017648A (es)
AR (2) AR002240A1 (es)
AT (1) ATE258549T1 (es)
AU (1) AU701847B2 (es)
BR (1) BR9505051A (es)
CA (1) CA2161944A1 (es)
DE (1) DE69532495T2 (es)
FI (1) FI955235L (es)
HU (1) HUT75101A (es)
NO (1) NO306401B1 (es)
RU (1) RU2144030C1 (es)
TW (1) TW403748B (es)

Families Citing this family (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW438587B (en) 1995-06-20 2001-06-07 Takeda Chemical Industries Ltd A pharmaceutical composition for prophylaxis and treatment of diabetes
JPH09323930A (ja) 1996-04-04 1997-12-16 Takeda Chem Ind Ltd 悪液質の予防・治療剤
JP2002515042A (ja) * 1997-12-02 2002-05-21 ドクター・レディーズ・リサーチ・ファウンデーション 糖尿病、異常脂血症（ｄｙｓｌｉｐｉｄｅｍｉａ）および高血圧の治療に有用なアゾリジンジオン（ａｚｏｌｉｄｉｎｅｄｉｏｎｅ）およびそれらを含有する組成物
US6329372B1 (en) 1998-01-27 2001-12-11 Celltech Therapeutics Limited Phenylalanine derivatives
WO1999043642A1 (en) 1998-02-26 1999-09-02 Celltech Therapeutics Limited Phenylalanine derivatives as inhibitors of alpha4 integrins
GB9805655D0 (en) 1998-03-16 1998-05-13 Celltech Therapeutics Ltd Chemical compounds
US6521626B1 (en) 1998-03-24 2003-02-18 Celltech R&D Limited Thiocarboxamide derivatives
CA2291620C (en) * 1998-03-30 2003-10-07 Japan Tobacco Inc. Production method of isoxazolidinedione compound
GB9811159D0 (en) 1998-05-22 1998-07-22 Celltech Therapeutics Ltd Chemical compounds
GB9811969D0 (en) 1998-06-03 1998-07-29 Celltech Therapeutics Ltd Chemical compounds
GB9812088D0 (en) 1998-06-05 1998-08-05 Celltech Therapeutics Ltd Chemical compounds
ATE274510T1 (de) 1998-06-19 2004-09-15 Chiron Corp Glycogen synthase kinase 3 inhibitoren
US7045519B2 (en) 1998-06-19 2006-05-16 Chiron Corporation Inhibitors of glycogen synthase kinase 3
GB9814414D0 (en) 1998-07-03 1998-09-02 Celltech Therapeutics Ltd Chemical compounds
GB9821061D0 (en) 1998-09-28 1998-11-18 Celltech Therapeutics Ltd Chemical compounds
GB9821222D0 (en) 1998-09-30 1998-11-25 Celltech Therapeutics Ltd Chemical compounds
US6087385A (en) * 1998-10-30 2000-07-11 University Of Mississippi Flavonoid derivatives
GB9825652D0 (en) 1998-11-23 1999-01-13 Celltech Therapeutics Ltd Chemical compounds
GB9826174D0 (en) 1998-11-30 1999-01-20 Celltech Therapeutics Ltd Chemical compounds
TR200103183T2 (tr) * 1999-04-07 2002-05-21 Sankyo Company Limited Amin türevi bileşimler
TWI249401B (en) * 1999-04-14 2006-02-21 Takeda Chemical Industries Ltd Agent for improving ketosis
US6518283B1 (en) 1999-05-28 2003-02-11 Celltech R&D Limited Squaric acid derivatives
WO2000078313A1 (en) 1999-06-18 2000-12-28 Merck & Co., Inc. Arylthiazolidinedione and aryloxazolidinedione derivatives
AU773505B2 (en) 1999-06-18 2004-05-27 Merck & Co., Inc. Arylthiazolidinedione and aryloxazolidinedione derivatives
CZ2002178A3 (cs) * 1999-07-19 2002-05-15 Sankyo Company Limited Terapeutické a profylaktické látky pro nádorová onemocnění
US6534513B1 (en) 1999-09-29 2003-03-18 Celltech R&D Limited Phenylalkanoic acid derivatives
US6455539B2 (en) 1999-12-23 2002-09-24 Celltech R&D Limited Squaric acid derivates
JP2003531141A (ja) 2000-04-17 2003-10-21 セルテック アール アンド ディ リミテッド エナミン誘導体
US6545013B2 (en) 2000-05-30 2003-04-08 Celltech R&D Limited 2,7-naphthyridine derivatives
US6403608B1 (en) 2000-05-30 2002-06-11 Celltech R&D, Ltd. 3-Substituted isoquinolin-1-yl derivatives
WO2002004426A1 (en) 2000-07-07 2002-01-17 Celltech R & D Limited Squaric acid derivatives containing a bicyclic heteroaromatic ring as integrin antagonists
JP2004505110A (ja) 2000-08-02 2004-02-19 セルテック　アール　アンド　ディ　リミテッド ３位置換イソキノリン−１−イル誘導体
AU2001295026B2 (en) * 2000-09-06 2008-04-03 Novartis Vaccines And Diagnostics, Inc. Inhibitors of glycogen synthase kinase 3
US7105551B2 (en) 2000-12-20 2006-09-12 Smithkline Beecham Corporation Thiazole derivatives for treating PPAR related disorders
US7241785B2 (en) * 2001-03-23 2007-07-10 Takeda Pharmaceutical Company Limited Five-membered heterocyclic alkanoic acid derivative
AU2003203170A1 (en) * 2002-01-17 2003-07-30 Takeda Chemical Industries, Ltd. Nitrogenous heterocyclic compounds, process for preparation of the same and use thereof
TWI327462B (en) * 2002-01-18 2010-07-21 Sumitomo Chemical Co Condensed heterocyclic sulfonyl urea compound, a herbicide containing the same, and a method for weed control using the same
US7232828B2 (en) * 2002-08-10 2007-06-19 Bethesda Pharmaceuticals, Inc. PPAR Ligands that do not cause fluid retention, edema or congestive heart failure
NZ538781A (en) * 2002-09-17 2007-11-30 Wyeth Corp Oral formulations
ATE450496T1 (de) * 2003-04-22 2009-12-15 Wellstat Therapeutics Corp Verbindungen zur behandlung von stoffwechselstörungen
AU2004291262C1 (en) 2003-11-05 2011-08-11 F. Hoffmann-La Roche Ag Phenyl derivatives as PPAR agonists
US7157584B2 (en) * 2004-02-25 2007-01-02 Takeda Pharmaceutical Company Limited Benzimidazole derivative and use thereof
WO2021231696A1 (en) 2020-05-14 2021-11-18 Johnston Thad Pierce Dental evacuation tip with mount for dental mouth mirror

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4342771A (en) * 1981-01-02 1982-08-03 Pfizer Inc. Hypoglycemic 5-substituted oxazolidine-2,4-diones
SG56656G (en) 1980-07-28 1987-03-27 Pfizer Hypoglycemic 5-substituted oxazolidine-2, 4-diones
US4332952A (en) * 1980-07-28 1982-06-01 Pfizer Inc. Hypoglycemic 5-substituted oxazolidine-2,4-diones
SU1194275A3 (ru) * 1980-07-28 1985-11-23 Пфайзер Инк (Фирма) Способ получени 5-замещенных оксазолидин-2,4-дионов или их фармацевтически приемлемых солей с щелочными металлами или кислотно-аддитивных солей в виде рацемата или оптически активного энантиомера
US4430337A (en) 1982-06-23 1984-02-07 Pfizer Inc. Alicyclic substituted oxazolidine-2,4-diones having hypoglycemic activity
CN1003445B (zh) * 1984-10-03 1989-03-01 武田药品工业株式会社 噻唑烷二酮衍生物，其制备方法和用途
WO1991007107A1 (en) 1989-11-13 1991-05-30 Pfizer Inc. Oxazolidinedione hypoglycemic agents
GB9017218D0 (en) * 1990-08-06 1990-09-19 Beecham Group Plc Novel compounds
US5498621A (en) * 1992-05-01 1996-03-12 Pfizer Inc. Oxazolidinedione hypoglycemic agents
TW268952B (es) * 1993-02-26 1996-01-21 Takeda Pharm Industry Co Ltd
US5614544A (en) * 1993-09-14 1997-03-25 Takeda Chemical Industries, Ltd. Oxazolidinedione derivatives and their use
US5478852C1 (en) * 1993-09-15 2001-03-13 Sankyo Co Use of thiazolidinedione derivatives and related antihyperglycemic agents in the treatment of impaired glucose tolerance in order to prevent or delay the onset of noninsulin-dependent diabetes mellitus
DK0684242T3 (da) * 1993-12-27 1999-11-01 Japan Tobacco Inc Isoxazolidindionderivat og anvendelse deraf
NO305987B1 (no) * 1994-04-11 1999-08-30 Sankyo Co Heterosykliske forbindelser med antidiabetisk aktivitet, deres anvendelse og farmasoeytisk preparat inneholdende disse
US5468762A (en) * 1994-05-18 1995-11-21 American Home Products Corporation Azolidinediones as antihyperglycemic agents

Also Published As

Publication number Publication date
FI955235A0 (fi) 1995-11-01
DE69532495D1 (de) 2004-03-04
BR9505051A (pt) 1997-10-21
TW403748B (en) 2000-09-01
ATE258549T1 (de) 2004-02-15
RU2144030C1 (ru) 2000-01-10
KR960017648A (ko) 1996-06-17
HUT75101A (en) 1997-04-28
AU701847B2 (en) 1999-02-04
NO954369L (no) 1996-05-03
EP0710659A1 (en) 1996-05-08
DE69532495T2 (de) 2004-11-04
FI955235A7 (fi) 1996-05-03
AU3660795A (en) 1996-05-09
HU9503116D0 (en) 1995-12-28
AR002241A1 (es) 1998-03-11
US5932601A (en) 1999-08-03
CA2161944A1 (en) 1996-05-03
NO306401B1 (no) 1999-11-01
FI955235L (fi) 1996-05-03
NO954369D0 (no) 1995-11-01
EP0710659B1 (en) 2004-01-28

Similar Documents

Publication Publication Date Title
AR002240A1 (es) Derivado de 2,4-oxazolidinadiona, composicion farmaceutica que lo comprende y metodo de preparacion del mismo.
FR2377376A1 (fr) Derives d'hexahydroterphenyle et leur application en tant que cristaux liquides
ES2058292T3 (es) Derivados de indol.
ATE240314T1 (de) Kristalle von benzimidazolderivate und verfahren zu ihrer herstellung
ES2059408T3 (es) Un proceso para la preparacion de un compuesto.
DE69100079D1 (de) Naphthalin-derivate, verfahren zu ihrer herstellung und sie enthaltende pharmazeutische zusammensetzungen.
KR870006039A (ko) 신규 티아졸 화합물, 그 제조방법 및 이 화합물을 함유하는 약학적 조성물
ES472742A1 (es) Procedimiento para la obtencion de derivados de alqueno
NL168509C (nl) Werkwijze ter bereiding van een therapeutisch preparaat, alsmede werkwijze ter bereiding van daarvoor geschikte verbindingen.
ES2087097T3 (es) Derivados de acidos fenilcarboxilicos que contienen un heterociclo.
ES2076147T3 (es) Nuevos derivados de amina ciclicos, medicamento que contiene estos compuestos y procedimiento para su preparacion.
ES2011296B3 (es) Derivados de benzo[b]tiofeno y benzo [b]furano carboxamidas, sus procedimientos de preparacion y los medicamentos que los contienen.
FI820061L (fi) Nya karboxylsyraamider deras framstaellning och deras anvaendning saosom laekemedel
ES2070238T3 (es) Emulsion de lipidos que contiene un analogo de prostaglandina.
DK441180A (da) 2-hydroxyalkyl-3,4,5-trihydroxypiperidiner deres fremstilling og anvendelse
BG60338B2 (en) Thienothiazines
BG51155A3 (bg) Метод за получаване на производни на нафталина
AR018632A1 (es) Compuestos derivados de acido 1,2,3,4-tetrahidroquinolin-2-carboxilico, su uso en la fabricacion de medicamentos, composicion farmaceutica que los contiene, proceso para su preparacion.
FI893901A0 (fi) Menetelmä tetrasyklisten masennuslääkkeiden valmistamiseksi
KR890008156A (ko) 깅콜리드의 신규 알콜시 유도체, 그 제조 방법 및 이를 함유한 치료 조성물
ES8606789A1 (es) Procedimiento para coadyuvar vacunas exentas de aceite.
ES488901A1 (es) Procedimiento de preparacion de nuevos derivados de benzoil-2 glicilanilidas substituidas
ES2053755T3 (es) Un procedimiento para preparar compuestos heterociclicos.
ES2146279T3 (es) 1-ciclopropiltetrazolinonas herbicidas.
KR880700813A (ko) 노르-콜란산 유도체,그의 제조방법, 그의 용도 및 이를 함유하는 약제학적 조성물