[go: up one dir, main page]

AP468A - Lysine salt of 6-chloro-5-fluoro-3(2-thenoyl)-2-oxindole-1- carboxamide. - Google Patents

Lysine salt of 6-chloro-5-fluoro-3(2-thenoyl)-2-oxindole-1- carboxamide. Download PDF

Info

Publication number
AP468A
AP468A APAP/P/1994/000609A AP9400609A AP468A AP 468 A AP468 A AP 468A AP 9400609 A AP9400609 A AP 9400609A AP 468 A AP468 A AP 468A
Authority
AP
ARIPO
Prior art keywords
carboxamide
chloro
oxindole
thenoyl
lysine salt
Prior art date
Application number
APAP/P/1994/000609A
Other languages
English (en)
Other versions
AP9400609A0 (en
Inventor
Kevin Cooper
Thomas C Crawford
Bruce H Littman
Christopher J Pazoles
Sally G Ruggeri
Keith D Wilner
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/007,217 external-priority patent/US5298522A/en
Application filed by Pfizer filed Critical Pfizer
Publication of AP9400609A0 publication Critical patent/AP9400609A0/xx
Application granted granted Critical
Publication of AP468A publication Critical patent/AP468A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pain & Pain Management (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Rheumatology (AREA)
  • Indole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
APAP/P/1994/000609A 1993-01-22 1994-01-13 Lysine salt of 6-chloro-5-fluoro-3(2-thenoyl)-2-oxindole-1- carboxamide. AP468A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/007,217 US5298522A (en) 1993-01-22 1993-01-22 6-chloro-5-fluoro-3-(2-thenoyl)-2-oxindole-1-carboxamide as an analgesic and anti-inflammatory agent while maintaining a normal urine protein/creatinine ratio
US13827793A 1993-10-18 1993-10-18

Publications (2)

Publication Number Publication Date
AP9400609A0 AP9400609A0 (en) 1994-01-31
AP468A true AP468A (en) 1996-03-05

Family

ID=26676677

Family Applications (1)

Application Number Title Priority Date Filing Date
APAP/P/1994/000609A AP468A (en) 1993-01-22 1994-01-13 Lysine salt of 6-chloro-5-fluoro-3(2-thenoyl)-2-oxindole-1- carboxamide.

Country Status (27)

Country Link
EP (1) EP0680321B1 (fr)
JP (1) JP2711939B2 (fr)
CN (1) CN1116822A (fr)
AP (1) AP468A (fr)
AT (1) ATE171373T1 (fr)
AU (1) AU671533B2 (fr)
BG (1) BG61966B1 (fr)
BR (1) BR9405661A (fr)
CA (1) CA2153050C (fr)
CZ (1) CZ182895A3 (fr)
DE (1) DE69413518T2 (fr)
DK (1) DK0680321T3 (fr)
DZ (1) DZ1748A1 (fr)
ES (1) ES2122236T3 (fr)
FI (1) FI940309A7 (fr)
HU (1) HUT69687A (fr)
IL (1) IL108326A0 (fr)
LV (1) LV10920B (fr)
MA (1) MA23095A1 (fr)
NO (1) NO952904D0 (fr)
NZ (1) NZ261449A (fr)
OA (1) OA10173A (fr)
PL (1) PL309957A1 (fr)
SK (1) SK91395A3 (fr)
UY (1) UY23723A1 (fr)
WO (1) WO1994016694A1 (fr)
YU (1) YU48719B (fr)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU7503496A (en) * 1995-12-19 1997-07-14 Pfizer Inc. Stable, long acting salts of indole derivatives for the treatment of joint diseases
EP0826685A1 (fr) * 1996-08-21 1998-03-04 Pfizer Inc. Sels de carboxamides stables à effet prolongé destinés au traitement des maladies articulaires
DE10106852A1 (de) * 2001-02-14 2002-09-05 T Luger Entzündungshemmende Verbindungen

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4556672A (en) * 1984-03-19 1985-12-03 Pfizer Inc. 3-Substituted 2-oxindole-1-carboxamides as analgesic and anti-inflammatory agents
EP0508310A1 (fr) * 1991-04-08 1992-10-14 Heinrich Mack Nachf. Composition pharmaceutique pour l'administration rectale contenant un dérivé du 2-oxindole-1-carboxamide

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4853409A (en) * 1988-04-13 1989-08-01 Pfizer Inc. 3-substituted-2-oxindole-1-carboxamides for suppressing T-cell function
DE4111306C2 (de) * 1991-04-08 1994-06-01 Mack Chem Pharm Pharmazeutische Zubereitungen, die ein 2-Oxindol-l-carboxamid-derivat enthalten und zur Injektion bestimmt sind
US5298522A (en) * 1993-01-22 1994-03-29 Pfizer Inc. 6-chloro-5-fluoro-3-(2-thenoyl)-2-oxindole-1-carboxamide as an analgesic and anti-inflammatory agent while maintaining a normal urine protein/creatinine ratio

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4556672A (en) * 1984-03-19 1985-12-03 Pfizer Inc. 3-Substituted 2-oxindole-1-carboxamides as analgesic and anti-inflammatory agents
EP0508310A1 (fr) * 1991-04-08 1992-10-14 Heinrich Mack Nachf. Composition pharmaceutique pour l'administration rectale contenant un dérivé du 2-oxindole-1-carboxamide

Also Published As

Publication number Publication date
FI940309L (fi) 1994-07-23
EP0680321B1 (fr) 1998-09-23
NO952904L (no) 1995-07-21
CN1116822A (zh) 1996-02-14
FI940309A7 (fi) 1994-07-23
YU2394A (sh) 1996-10-18
PL309957A1 (en) 1995-11-13
AU671533B2 (en) 1996-08-29
BG61966B1 (bg) 1998-11-30
MA23095A1 (fr) 1994-10-01
DE69413518D1 (en) 1998-10-29
CA2153050A1 (fr) 1994-08-04
ATE171373T1 (de) 1998-10-15
WO1994016694A1 (fr) 1994-08-04
NO952904D0 (no) 1995-07-21
EP0680321A1 (fr) 1995-11-08
JPH08501109A (ja) 1996-02-06
DZ1748A1 (fr) 2002-02-17
DE69413518T2 (de) 1999-02-11
NZ261449A (en) 1996-08-27
ES2122236T3 (es) 1998-12-16
UY23723A1 (es) 1994-06-28
IL108326A0 (en) 1994-04-12
CZ182895A3 (en) 1996-01-17
LV10920B (en) 1996-04-20
AU6019894A (en) 1994-08-15
JP2711939B2 (ja) 1998-02-10
AP9400609A0 (en) 1994-01-31
SK91395A3 (en) 1996-12-04
HUT69687A (en) 1995-09-28
DK0680321T3 (da) 1999-06-14
HU9400176D0 (en) 1994-05-30
BG99767A (bg) 1996-02-28
YU48719B (sh) 1999-07-28
OA10173A (en) 1996-12-18
FI940309A0 (fi) 1994-01-21
CA2153050C (fr) 1998-12-29
LV10920A (lv) 1995-12-20
BR9405661A (pt) 1995-11-21

Similar Documents

Publication Publication Date Title
US5298522A (en) 6-chloro-5-fluoro-3-(2-thenoyl)-2-oxindole-1-carboxamide as an analgesic and anti-inflammatory agent while maintaining a normal urine protein/creatinine ratio
US5998467A (en) Medicine for oculopathy
JPS63107970A (ja) チオラクタム−ｎ−酢酸誘導体
HU226976B1 (en) Use of pirrolidine derivatives having kappa-opium-agonist effect for the preparation of a medicament for treating of inflammatory diseases of the intestine
HU193348B (en) Process for producing piroxicam salts of antiflogistic activity
KR100436254B1 (ko) N-메틸-n[(1s)-1-페닐-2-((3s)-3-하이드록시피롤리딘-1-일)에틸]-2,2-디페닐아세트아미드
AP468A (en) Lysine salt of 6-chloro-5-fluoro-3(2-thenoyl)-2-oxindole-1- carboxamide.
WO1989003682A1 (fr) Derives de dioxyde de benzothiazine
JPH08283219A (ja) アラルキルアミノアルキルアミド誘導体
JPH11509520A (ja) 鎮痛特性を有する新規のｎ−アセチル化４−ヒドロキシフェニルアミン誘導体及びそれを含む薬理組成物
KR100556559B1 (ko) 2-(4-(4-(4,5-디클로로-2-메틸이미다졸-1-일)부틸)-1-피페라지닐)-5-플루오로피리미딘, 이것의 제조 방법 및 이것의치료적 용도
JP4011780B2 (ja) ジヒドロキノリン誘導体
US4279910A (en) Quinazoline therapeutic agents
JP2955768B2 (ja) 新規なジアゾシン誘導体
JPH0228113A (ja) 高尿酸血症改善・治療剤
SI9400099A (sl) Lizinova sol 6-kloro-5-fluoro-3-{2-tenoil)-2-oksindol-1-karboksiamida
JP2002539195A (ja) （２ｒ，３ｒ，４ｒ）−３，４−ジヒドロキシ−２−ヒドロキシメチルピロリジンの新規塩
JPWO1998003201A1 (ja) 新規な治療用医薬組成物
JPH01287023A (ja) 利尿剤
JPH09301868A (ja) 抗白内障剤
WO1998003201A1 (fr) Nouvelles compositions medicinales a usage therapeutique