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AP2016008989A0 - New isoindoline or isoquinoline compounds, a process for their preparation and pharmaceutical compositions containing them - Google Patents

New isoindoline or isoquinoline compounds, a process for their preparation and pharmaceutical compositions containing them

Info

Publication number
AP2016008989A0
AP2016008989A0 AP2016008989A AP2016008989A AP2016008989A0 AP 2016008989 A0 AP2016008989 A0 AP 2016008989A0 AP 2016008989 A AP2016008989 A AP 2016008989A AP 2016008989 A AP2016008989 A AP 2016008989A AP 2016008989 A0 AP2016008989 A0 AP 2016008989A0
Authority
AP
ARIPO
Prior art keywords
preparation
pharmaceutical compositions
compositions containing
isoquinoline compounds
new isoindoline
Prior art date
Application number
AP2016008989A
Other languages
English (en)
Inventor
Nanteuil Guillaume De
Anne-Francoise Guillouzic
Jérôme-Benoît Starck
Original Assignee
Vernalis R&D Ltd
Servier Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vernalis R&D Ltd, Servier Lab filed Critical Vernalis R&D Ltd
Publication of AP2016008989A0 publication Critical patent/AP2016008989A0/xx

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47Quinolines; Isoquinolines
    • A61K31/472Non-condensed isoquinolines, e.g. papaverine
    • A61K31/4725Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965Non-condensed pyrazines
    • A61K31/497Non-condensed pyrazines containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/53751,4-Oxazines, e.g. morpholine
    • A61K31/53771,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/66Phosphorus compounds
    • A61K31/675Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00Radiation therapy
    • A61N5/10X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D409/00Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/547Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • C07F9/65616Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system having three or more than three double bonds between ring members or between ring members and non-ring members, e.g. purine or analogs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Pathology (AREA)
  • Molecular Biology (AREA)
  • Radiology & Medical Imaging (AREA)
  • Biochemistry (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Transplantation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Indole Compounds (AREA)
AP2016008989A 2013-07-23 2014-07-22 New isoindoline or isoquinoline compounds, a process for their preparation and pharmaceutical compositions containing them AP2016008989A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR1357276A FR3008977A1 (fr) 2013-07-23 2013-07-23 Nouveaux derives d'isoindoline ou d'isoquinoline, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
PCT/EP2014/065764 WO2015011164A1 (en) 2013-07-23 2014-07-22 New isoindoline or isoquinoline compounds, a process for their preparation and pharmaceutical compositions containing them

Publications (1)

Publication Number Publication Date
AP2016008989A0 true AP2016008989A0 (en) 2016-01-31

Family

ID=49911606

Family Applications (1)

Application Number Title Priority Date Filing Date
AP2016008989A AP2016008989A0 (en) 2013-07-23 2014-07-22 New isoindoline or isoquinoline compounds, a process for their preparation and pharmaceutical compositions containing them

Country Status (49)

Country Link
US (3) US9809574B2 (es)
EP (1) EP3024826B1 (es)
JP (1) JP6395829B2 (es)
KR (1) KR102008431B1 (es)
CN (2) CN109456324B (es)
AP (1) AP2016008989A0 (es)
AR (1) AR097009A1 (es)
AU (1) AU2014295101B2 (es)
BR (1) BR112016001080B1 (es)
CA (1) CA2919572C (es)
CL (1) CL2016000148A1 (es)
CR (1) CR20160030A (es)
CU (1) CU24352B1 (es)
CY (1) CY1121247T1 (es)
DK (1) DK3024826T3 (es)
DO (1) DOP2016000009A (es)
EA (1) EA032301B1 (es)
ES (1) ES2711371T3 (es)
FR (1) FR3008977A1 (es)
GE (2) GEP20207070B (es)
HK (1) HK1218754A1 (es)
HR (1) HRP20190277T1 (es)
HU (1) HUE041443T2 (es)
IL (1) IL243449A0 (es)
JO (1) JO3457B1 (es)
LT (1) LT3024826T (es)
MA (1) MA38801B1 (es)
MD (1) MD4793C1 (es)
ME (1) ME03346B (es)
MX (1) MX365373B (es)
MY (1) MY193619A (es)
NI (1) NI201600016A (es)
NZ (1) NZ716155A (es)
PE (1) PE20160241A1 (es)
PH (1) PH12016500034A1 (es)
PL (1) PL3024826T3 (es)
PT (1) PT3024826T (es)
RS (1) RS58344B1 (es)
RU (1) RU2689305C2 (es)
SA (1) SA516370439B1 (es)
SG (1) SG11201600205XA (es)
SI (1) SI3024826T1 (es)
TN (1) TN2016000003A1 (es)
TR (1) TR201819155T4 (es)
TW (1) TWI560184B (es)
UA (1) UA117490C2 (es)
UY (1) UY35664A (es)
WO (1) WO2015011164A1 (es)
ZA (1) ZA201600198B (es)

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FR3008977A1 (fr) * 2013-07-23 2015-01-30 Servier Lab Nouveaux derives d'isoindoline ou d'isoquinoline, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
SG11201809173TA (en) 2016-04-20 2018-11-29 Bristol Myers Squibb Co Substituted bicyclic heterocyclic compounds
AU2019295765B2 (en) 2018-06-27 2024-08-29 Yumanity, Inc. Proteasome activity enhancing compounds
PH12022551189A1 (en) * 2019-11-15 2023-10-09 Wuhan Ll Science & Technology Development Co Ltd Rock inhibitor, preparation method therefor and use thereof
CN112010796B (zh) * 2020-09-17 2022-04-22 浙江大学 光学活性3-(1,1-二氟-2-氧-2-芳基乙基)异吲哚啉-1-酮衍生物制备方法
TWI843989B (zh) 2021-02-19 2024-06-01 美商美威高能離子醫療系統公司 用於粒子治療系統之支架
US20240208926A1 (en) * 2021-03-24 2024-06-27 Les Laboratoires Servier New process for the synthesis of 5-{5-chloro-2-[(3s)-3-[(morpholin-4-yl)methyl]-3,4-dihydroisoquinoline-2(1h)- carbonyl]phenyl}-1,2-dimethyl-1h-pyrrole-3-carboxylic acid derivatives and its application for the production of pharmaceutical compounds
KR20240152365A (ko) 2022-02-24 2024-10-21 르 라보레또레 쎄르비에르 5-[7-(3,4-디히드로-1h-이소퀴놀린-2-카르보닐)-1,2,3,4-테트라히드로이소퀴놀린-6-일]-1h-피롤-3-카르복스아미드유도체, 그를 함유하는 제약 조성물 및 아폽토시스촉진제로서의 그의 용도
IL317101A (en) 2022-05-20 2025-01-01 Novartis Ag Antibody-drug conjugates of anticancer compounds and methods of using them
KR20250149173A (ko) * 2023-03-31 2025-10-15 미쓰이 가가쿠 가부시키가이샤 카바메이트 화합물
WO2025111450A1 (en) 2023-11-22 2025-05-30 Les Laboratoires Servier Anti-cd74 antibody-drug conjugates and methods of use thereof
WO2025111431A1 (en) 2023-11-22 2025-05-30 Les Laboratoires Servier Anti-cd7 antibody-drug conjugates and methods of use thereof

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WO2004096774A1 (en) * 2003-05-01 2004-11-11 Glaxo Group Limited Acyl isoindoline derivatives and acyl isoquinoline derivatives as anti-viral agents
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BRPI0514504A (pt) * 2004-08-20 2008-06-10 Univ Michigan pequenas moléculas inibidoras de membros da famìlia bcl-2 anti-apoptóticos e os usos das mesmas
KR20070107000A (ko) * 2005-02-15 2007-11-06 노보 노르디스크 에이/에스 3,4-디히드로-1h-이소퀴놀린-2-카르복실산5-아미노피리딘-2-일 에스테르
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KR101682779B1 (ko) 2011-12-27 2016-12-05 인텔 코포레이션 게이팅된 도메인의 부하 조건들에 기초하여 게이팅된 도메인의 활성 상태 동안 전력 게이트들을 제어하기 위한 방법들 및 시스템들
FR2986002B1 (fr) * 2012-01-24 2014-02-21 Servier Lab Nouveaux derives d'indolizine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
FR3008977A1 (fr) * 2013-07-23 2015-01-30 Servier Lab Nouveaux derives d'isoindoline ou d'isoquinoline, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
FR3008979B1 (fr) * 2013-07-23 2015-07-24 Servier Lab Nouveaux derives phosphates, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Also Published As

Publication number Publication date
CR20160030A (es) 2016-03-09
PH12016500034B1 (en) 2016-03-28
CY1121247T1 (el) 2020-05-29
HK1222856A1 (en) 2017-07-14
TW201504228A (zh) 2015-02-01
CA2919572A1 (en) 2015-01-29
EA201600122A1 (ru) 2016-07-29
US20160194304A1 (en) 2016-07-07
MA38801A1 (fr) 2018-05-31
DK3024826T3 (en) 2019-03-04
CN109456324B (zh) 2022-04-22
CA2919572C (en) 2017-06-20
JP6395829B2 (ja) 2018-09-26
RU2016106003A (ru) 2017-08-28
US11028070B2 (en) 2021-06-08
GEAP201914063A (en) 2019-10-25
JO3457B1 (ar) 2020-07-05
PL3024826T3 (pl) 2019-05-31
EP3024826B1 (en) 2018-11-14
ME03346B (me) 2019-10-20
CU24352B1 (es) 2018-07-05
SA516370439B1 (ar) 2019-06-27
NZ716155A (en) 2019-05-31
PE20160241A1 (es) 2016-04-30
TR201819155T4 (tr) 2019-01-21
SI3024826T1 (sl) 2019-03-29
CN105431422B (zh) 2019-08-30
LT3024826T (lt) 2019-02-25
HUE041443T2 (hu) 2019-05-28
TWI560184B (en) 2016-12-01
AU2014295101B2 (en) 2018-05-31
HRP20190277T1 (hr) 2019-04-05
ES2711371T3 (es) 2019-05-03
MD4793C1 (ro) 2022-09-30
US20180002313A1 (en) 2018-01-04
UY35664A (es) 2015-01-30
WO2015011164A1 (en) 2015-01-29
UA117490C2 (uk) 2018-08-10
CN105431422A (zh) 2016-03-23
NI201600016A (es) 2016-02-11
DOP2016000009A (es) 2016-03-15
MA38801B1 (fr) 2019-03-29
CN109456324A (zh) 2019-03-12
KR20160033224A (ko) 2016-03-25
RS58344B1 (sr) 2019-03-29
US10689364B2 (en) 2020-06-23
MX365373B (es) 2019-05-31
MD20160018A2 (ro) 2016-07-31
CL2016000148A1 (es) 2016-08-12
US9809574B2 (en) 2017-11-07
PT3024826T (pt) 2019-01-28
EA032301B1 (ru) 2019-05-31
FR3008977A1 (fr) 2015-01-30
AU2014295101A1 (en) 2016-02-04
EP3024826A1 (en) 2016-06-01
HK1218754A1 (zh) 2017-03-10
CU20160010A7 (es) 2016-06-29
IL243449A0 (en) 2016-02-29
JP2016525529A (ja) 2016-08-25
AR097009A1 (es) 2016-02-10
MX2016000904A (es) 2016-04-25
KR102008431B1 (ko) 2019-08-07
RU2689305C2 (ru) 2019-05-27
SG11201600205XA (en) 2016-02-26
BR112016001080B1 (pt) 2022-04-05
MY193619A (en) 2022-10-20
TN2016000003A1 (en) 2017-07-05
ZA201600198B (en) 2019-07-31
PH12016500034A1 (en) 2016-03-28
GEP20207070B (en) 2020-02-25
MD4793B1 (ro) 2022-02-28
BR112016001080A2 (es) 2017-07-25
US20200262816A1 (en) 2020-08-20

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