[go: up one dir, main page]

AP2009004791A0 - Sulfonamide derivatives as adrenergic agonists andmuscarinic antagonists - Google Patents

Sulfonamide derivatives as adrenergic agonists andmuscarinic antagonists

Info

Publication number
AP2009004791A0
AP2009004791A0 AP2009004791A AP2009004791A AP2009004791A0 AP 2009004791 A0 AP2009004791 A0 AP 2009004791A0 AP 2009004791 A AP2009004791 A AP 2009004791A AP 2009004791 A AP2009004791 A AP 2009004791A AP 2009004791 A0 AP2009004791 A0 AP 2009004791A0
Authority
AP
ARIPO
Prior art keywords
andmuscarinic
antagonists
adrenergic agonists
sulfonamide derivatives
sulfonamide
Prior art date
Application number
AP2009004791A
Other languages
English (en)
Inventor
Lyn Howard Jones
Original Assignee
Pfizer Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Ltd filed Critical Pfizer Ltd
Publication of AP2009004791A0 publication Critical patent/AP2009004791A0/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C07D211/44—Oxygen atoms attached in position 4
    • C07D211/46—Oxygen atoms attached in position 4 having a hydrogen atom as the second substituent in position 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pulmonology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Hydrogenated Pyridines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
AP2009004791A 2006-10-04 2007-09-21 Sulfonamide derivatives as adrenergic agonists andmuscarinic antagonists AP2009004791A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US82809906P 2006-10-04 2006-10-04
PCT/IB2007/002896 WO2008041095A1 (fr) 2006-10-04 2007-09-21 Dérivés de sulfonamide en tant qu'agonistes adrénergiques et qu'antagonistes muscariniques

Publications (1)

Publication Number Publication Date
AP2009004791A0 true AP2009004791A0 (en) 2009-04-30

Family

ID=38947725

Family Applications (1)

Application Number Title Priority Date Filing Date
AP2009004791A AP2009004791A0 (en) 2006-10-04 2007-09-21 Sulfonamide derivatives as adrenergic agonists andmuscarinic antagonists

Country Status (25)

Country Link
US (1) US20080090873A1 (fr)
EP (1) EP2074094A1 (fr)
JP (1) JP2010505810A (fr)
KR (1) KR20090050104A (fr)
CN (1) CN101522622A (fr)
AP (1) AP2009004791A0 (fr)
AR (1) AR063118A1 (fr)
AU (1) AU2007303909A1 (fr)
BR (1) BRPI0719270A2 (fr)
CA (1) CA2665385A1 (fr)
CL (1) CL2007002791A1 (fr)
CO (1) CO6180437A2 (fr)
CR (1) CR10700A (fr)
EA (1) EA200900337A1 (fr)
IL (1) IL197244A0 (fr)
MA (1) MA30778B1 (fr)
MX (1) MX2009002209A (fr)
NO (1) NO20090910L (fr)
PE (1) PE20080831A1 (fr)
RS (1) RS20090137A (fr)
TN (1) TN2009000112A1 (fr)
TW (1) TW200823185A (fr)
UY (1) UY30617A1 (fr)
WO (1) WO2008041095A1 (fr)
ZA (1) ZA200901320B (fr)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW201036957A (en) 2009-02-20 2010-10-16 Astrazeneca Ab Novel salt 628
JP5801997B2 (ja) 2009-07-07 2015-10-28 ファイザー・リミテッドＰｆｉｚｅｒ Ｌｉｍｉｔｅｄ 薬品の組合せを吸入するための投薬ユニット、投薬ユニットのパック、および吸入器
WO2011061527A1 (fr) 2009-11-17 2011-05-26 Astrazeneca Ab Combinaisons qui comprennent un modulateur du récepteur glucocorticoïde, destinées au traitement de maladies respiratoires
WO2011081937A1 (fr) 2009-12-15 2011-07-07 Gilead Sciences, Inc. Composés de type corticostéroïde-bêta-agoniste-antagoniste muscarinique pour applications thérapeutiques
ITRM20110083U1 (it) 2010-05-13 2011-11-14 De La Cruz Jose Antonio Freire Piastra per la costruzione di carrelli per aeroplani
EP2386555A1 (fr) 2010-05-13 2011-11-16 Almirall, S.A. Nouveaux dérivés de cyclohéxylamine dotés d'activités agoniste bêta 2 adrénergique et antagoniste muscarinique m3
GB201016912D0 (en) 2010-10-07 2010-11-24 Astrazeneca Ab Novel combination
EP2592078A1 (fr) 2011-11-11 2013-05-15 Almirall, S.A. Nouveaux dérivés de cyclohéxylamine dotés d'activités agonistes bêta 2 adrénergique et antagoniste muscarinique M3
MA38260B1 (fr) 2012-12-18 2018-04-30 Almirall Sa Nouveaux dérivés de cyclohexyl et quinuclidinyl carbamate ayant une activité d'agoniste adrénergique beta2 et une activité d'antagoniste muscarinique m3
TWI643853B (zh) 2013-02-27 2018-12-11 阿爾米雷爾有限公司 同時具有β2腎上腺素受體促效劑和M3毒蕈鹼受體拮抗劑活性之2-氨基-1-羥乙基-8-羥基喹啉-2(1H)-酮衍生物之鹽類
TWI641373B (zh) 2013-07-25 2018-11-21 阿爾米雷爾有限公司 具有蕈毒鹼受體拮抗劑和β２腎上腺素受體促效劑二者之活性的２－胺基－１－羥乙基－８－羥基喹啉－２（１Ｈ）－酮衍生物之鹽
TW201517906A (zh) 2013-07-25 2015-05-16 Almirall Sa 含有ｍａｂａ化合物和皮質類固醇之組合
TW201617343A (zh) 2014-09-26 2016-05-16 阿爾米雷爾有限公司 具有β２腎上腺素促效劑及Ｍ３蕈毒拮抗劑活性之新穎雙環衍生物
CN106336406B (zh) * 2015-07-10 2020-01-03 四川海思科制药有限公司 具有β2受体激动及M受体拮抗活性的八氢并环戊二烯衍生物及其在医药上的用途
EP3556435B1 (fr) 2016-12-14 2020-10-28 Beijing Showby Pharmaceutical Co., Ltd. Classe de composés bifonctionnels de structure de sel d'ammonium quaternaire
US10342786B2 (en) 2017-10-05 2019-07-09 Fulcrum Therapeutics, Inc. P38 kinase inhibitors reduce DUX4 and downstream gene expression for the treatment of FSHD
RS63581B1 (sr) 2017-10-05 2022-10-31 Fulcrum Therapeutics Inc Inhibitori p38 kinaze smanjuju ekspresiju dux4 i nizvodnih gena u cilju lečenja fshd
WO2019110521A1 (fr) * 2017-12-04 2019-06-13 Friedrich-Alexander-Universität Erlangen-Nürnberg Ligands des récepteurs muscariniques à substitution fluorophényle ayant une sélectivité pour m3 sur m2
WO2021260441A1 (fr) 2020-06-26 2021-12-30 Mylan Pharma Uk Limited Formulations comprenant du (5-[3-(3-hydroxyphénoxy)azétidin-1-yl]-5-méthyl-2,2-diphénylhexanamide

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5776983A (en) * 1993-12-21 1998-07-07 Bristol-Myers Squibb Company Catecholamine surrogates useful as β3 agonists
PE20040950A1 (es) * 2003-02-14 2005-01-01 Theravance Inc DERIVADOS DE BIFENILO COMO AGONISTAS DE LOS RECEPTORES ADRENERGICOS ß2 Y COMO ANTAGONISTAS DE LOS RECEPTORES MUSCARINICOS
JP4767842B2 (ja) * 2003-04-01 2011-09-07 セラヴァンス， インコーポレーテッド β２アドレナリン作用性レセプターアゴニスト活性およびムスカリン性レセプターアンタゴニスト活性を有するジアリールメチル化合物および関連化合物
ES2329133T3 (es) * 2003-05-28 2009-11-23 Theravance, Inc. Compuestos azabicicloalcanicos como antagonistas de receptores de muscarinicos.
ES2289691T3 (es) * 2004-01-22 2008-02-01 Pfizer, Inc. Derivados de sulfonamida para el tratamiento de enfermedades.
WO2005080375A1 (fr) * 2004-02-13 2005-09-01 Theravance, Inc. Cristalline d'un compose biphenyle
TWI374883B (en) * 2004-08-16 2012-10-21 Theravance Inc Crystalline form of a biphenyl compound

Also Published As

Publication number Publication date
TN2009000112A1 (fr) 2010-08-19
AU2007303909A1 (en) 2008-04-10
NO20090910L (no) 2009-03-24
IL197244A0 (en) 2009-12-24
CO6180437A2 (es) 2010-07-19
TW200823185A (en) 2008-06-01
CL2007002791A1 (es) 2008-04-11
WO2008041095A1 (fr) 2008-04-10
US20080090873A1 (en) 2008-04-17
BRPI0719270A2 (pt) 2014-03-11
ZA200901320B (en) 2010-04-28
CN101522622A (zh) 2009-09-02
JP2010505810A (ja) 2010-02-25
PE20080831A1 (es) 2008-06-20
RS20090137A (sr) 2010-06-30
CR10700A (es) 2009-04-24
CA2665385A1 (fr) 2008-04-10
UY30617A1 (es) 2008-05-31
MA30778B1 (fr) 2009-10-01
EA200900337A1 (ru) 2009-10-30
EP2074094A1 (fr) 2009-07-01
KR20090050104A (ko) 2009-05-19
AR063118A1 (es) 2008-12-30
MX2009002209A (es) 2009-03-16

Similar Documents

Publication Publication Date Title
AP2009004791A0 (en) Sulfonamide derivatives as adrenergic agonists andmuscarinic antagonists
IL198345A0 (en) New sulfonamide derivatives as bradykinin antagonists
ZA200809289B (en) Heterocyclic gpcr agonists
ZA200806071B (en) Sulfonyl substituted 1H-indoles as ligands for the 5-hydroxytryptamine receptors
DK2206710T3 (da) Indolderivater som s1p1-receptor agonister
IL197814A0 (en) Substituted sulfonamide derivatives
IL239403A0 (en) Kinase antagonists
IL198931A0 (en) Benzamide derivatives as ep4 receptor agonists
HRP20151108T1 (xx) Antagonisti nogo-receptora
DK2094709T3 (da) Thiazol-pyrazolopyrimidiner som CRF1-receptorantagonister
IL195071A0 (en) Cannabinoid receptor antagonists/inverse agonists
IL195298A0 (en) Substituted aryl piperidinylalkynyladenosines as a2ar agonists
SI2069310T1 (sl) Sulfonilpirazolin-1-karboksamidinski derivati kot 5-HT6 antagonisti
IL198542A0 (en) 2-aminoquinolines as 5-ht(5a)receptor antagonists
IL197585A0 (en) New benzamide derivatives as bradykinin antagonists
GB0708226D0 (en) Y-receptor agonists
IL186883A0 (en) Benzimidazole-carboxamide compounds as 5-ht4 receptor agonists
DK2148873T3 (da) 4-alkoxypyridazinderivater som hurtigt dissocierende dopamin 2- receptorantagonister
IL197712A0 (en) Sulfonamide derivatives
HU0600809D0 (en) New phenylsulfamoil benzamide derivatives as bradykinin antagonists
DK1749001T3 (da) 3-piperidinylisochroman-5-ol som dopaminagonister
ZA200903829B (en) Indole derivatives as S1P1 receptor agonists
GB201000798D0 (en) Poly-TLR antagonists
HK1131135A (en) Novel compounds as antagonists or inverse agonists at opioid receptors
GB0614580D0 (en) Agonists 1A