NZ515567A - Method for treating chronic pain using MEK inhibitors - Google Patents

Method for treating chronic pain using MEK inhibitors

Info

Publication number: NZ515567A
Authority: NZ; New Zealand
Prior art keywords: chronic pain; treating chronic; mek inhibitors; formula; pain
Prior art date: 1999-07-16

Application number

NZ515567A

Other languages

English (en)

Inventor

Alistair Dixon

Kevin Lee

Robert Denham Pinnock

Original Assignee

Warner Lambert Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-07-16

Filing date

2000-07-05

Publication date

2004-03-26

2000-07-05 Application filed by Warner Lambert Co filed Critical Warner Lambert Co

2004-03-26 Publication of NZ515567A publication Critical patent/NZ515567A/xx

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/196—Carboxylic acids, e.g. valproic acid having an amino group the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A61K31/166—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Chemical & Material Sciences (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Virology (AREA)
Epidemiology (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Addiction (AREA)
Molecular Biology (AREA)
Diabetes (AREA)
Physical Education & Sports Medicine (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Dermatology (AREA)
Biotechnology (AREA)
Obesity (AREA)
Tropical Medicine & Parasitology (AREA)
AIDS & HIV (AREA)
Psychiatry (AREA)
Nutrition Science (AREA)
Urology & Nephrology (AREA)
Immunology (AREA)
Orthopedic Medicine & Surgery (AREA)
Endocrinology (AREA)
Hematology (AREA)

NZ515567A 1999-07-16 2000-07-05 Method for treating chronic pain using MEK inhibitors NZ515567A (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US14429299P	1999-07-16	1999-07-16
PCT/US2000/018347 WO2001005392A2 (en)	1999-07-16	2000-07-05	Method for treating chronic pain using mek inhibitors

Publications (1)

Publication Number	Publication Date
NZ515567A true NZ515567A (en)	2004-03-26

Family

ID=22507940

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NZ515567A NZ515567A (en)	1999-07-16	2000-07-05	Method for treating chronic pain using MEK inhibitors

Country Status (16)

Country	Link
EP (1)	EP1202726A2 (xx)
JP (1)	JP2003504400A (xx)
KR (1)	KR20020012315A (xx)
CN (1)	CN1373660A (xx)
AR (1)	AR024732A1 (xx)
AU (1)	AU5786000A (xx)
CA (1)	CA2374052A1 (xx)
CO (1)	CO5300398A1 (xx)
HU (1)	HUP0202623A3 (xx)
IL (1)	IL147619A0 (xx)
NZ (1)	NZ515567A (xx)
PE (1)	PE20010545A1 (xx)
PL (1)	PL352684A1 (xx)
TR (1)	TR200200082T2 (xx)
WO (1)	WO2001005392A2 (xx)
ZA (1)	ZA200109907B (xx)

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HU230251B1 (hu)	2000-07-19	2015-11-30	Warner-Lambert Co.	4-Jód-fenil-amino-benzhidroxámsav-észter-származékok és ezeket tartalmazó gyógyászati készítmények
IL149462A0 (en)	2001-05-09	2002-11-10	Warner Lambert Co	Method of treating or inhibiting neutrophil chemotaxis by administering a mek inhibitor
SI2275102T1 (sl)	2002-03-13	2015-12-31	Array Biopharma, Inc.	N3 alkilirani benzimidazol derivati kot MEK inhibitorji
US7235537B2 (en)	2002-03-13	2007-06-26	Array Biopharma, Inc.	N3 alkylated benzimidazole derivatives as MEK inhibitors
US7632866B2 (en)	2002-10-21	2009-12-15	Ramot At Tel Aviv University	Derivatives of N-phenylanthranilic acid and 2-benzimidazolone as potassium channel and/or neuron activity modulators
JP4896717B2 (ja)	2003-07-24	2012-03-14	ワーナー−ランバートカンパニーリミテッドライアビリティーカンパニー	Ｎ−メチル−置換ベンゾアミダゾール
US7538120B2 (en)	2003-09-03	2009-05-26	Array Biopharma Inc.	Method of treating inflammatory diseases
US7144907B2 (en)	2003-09-03	2006-12-05	Array Biopharma Inc.	Heterocyclic inhibitors of MEK and methods of use thereof
AU2004279721A1 (en) *	2003-10-08	2005-04-21	Teijin Pharma Limited	Process for producing aminopyrrolidine derivative and intermediate compound
NZ546011A (en)	2003-10-21	2009-09-25	Warner Lambert Co	Polymorphic form of N-[(R)-2,3-dihydroxy-propoxy]-3,4-difluoro-2-(2-fluoro-4-iodophenylamino)-benzamide
US7517994B2 (en)	2003-11-19	2009-04-14	Array Biopharma Inc.	Heterocyclic inhibitors of MEK and methods of use thereof
US7732616B2 (en)	2003-11-19	2010-06-08	Array Biopharma Inc.	Dihydropyridine and dihydropyridazine derivatives as inhibitors of MEK and methods of use thereof
EP2251327B1 (en)	2003-11-19	2014-02-12	Array Biopharma, Inc.	Heterocyclic inhibitors of mek
US20050130954A1 (en)	2003-11-21	2005-06-16	Mitchell Ian S.	AKT protein kinase inhibitors
MY144232A (en) *	2004-07-26	2011-08-15	Chugai Pharmaceutical Co Ltd	5-substituted-2-phenylamino benzamides as mek inhibitors
EP2361905B1 (en)	2005-05-18	2013-03-06	Array Biopharma Inc.	Heterocyclic Inhibitors of MEK and methods of use thereof
SI1934174T1 (sl)	2005-10-07	2011-08-31	Exelixis Inc	Inhibitorji MEK in postopki za njihovo uporabo
ES2372955T3 (es)	2006-07-06	2012-01-30	Array Biopharma, Inc.	Ciclopenta[d]pirimidinas como inhibidores de la proteína cinasa akt.
CA2656566C (en)	2006-07-06	2014-06-17	Array Biopharma Inc.	Dihydrofuro pyrimidines as akt protein kinase inhibitors
US8063050B2 (en)	2006-07-06	2011-11-22	Array Biopharma Inc.	Hydroxylated and methoxylated pyrimidyl cyclopentanes as AKT protein kinase inhibitors
WO2008006039A1 (en)	2006-07-06	2008-01-10	Array Biopharma Inc.	Dihydrothieno pyrimidines as akt protein kinase inhibitors
TR201900306T4 (tr)	2006-12-14	2019-02-21	Exelixis Inc	Mek inhibitörlerini kullanma yöntemleri.
US8846683B2 (en)	2007-07-05	2014-09-30	Array Biopharma, Inc.	Pyrimidyl cyclopentanes as Akt protein kinase inhibitors
JP5542282B2 (ja)	2007-07-05	2014-07-09	アレイバイオファーマ、インコーポレイテッド	Ａｋｔプロテインキナーゼ阻害剤としてのピリミジルシクロペンタン
US9409886B2 (en)	2007-07-05	2016-08-09	Array Biopharma Inc.	Pyrimidyl cyclopentanes as AKT protein kinase inhibitors
KR20150089099A (ko)	2007-07-05	2015-08-04	어레이 바이오파마 인크.	Ａｋｔ 단백질 키나제 억제제로서의 피리미딜 시클로펜탄
EP2203411B1 (en) *	2007-09-20	2016-01-06	Ramot at Tel-Aviv University Ltd.	N-phenyl anthranilic acid derivatives and uses thereof
BRPI0821227A2 (pt)	2007-12-19	2015-06-16	Cancer Rec Tech Ltd	Composto, composição farmacêutica, método para preparar a mesma, uso de um composto, método para tratar uma doença ou distúrbio, para inibir função de raf e para inibir proliferação celular, inibir progressão do ciclo celular, promover apoptose, ou uma combinação de um ou mais dos mesmos
JP5539225B2 (ja)	2008-01-09	2014-07-02	アレイバイオファーマ、インコーポレイテッド	Ａｋｔタンパク質キナーゼ阻害剤としての水酸化されたピリミジルシクロペンタン
US8835434B2 (en)	2008-01-09	2014-09-16	Array Biopharma, Inc.	Hydroxylated pyrimidyl cyclopentanes as akt protein kinase inhibitors
JP5746630B2 (ja)	2008-11-10	2015-07-08	バイエル・インテレクチュアル・プロパティ・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツングＢａｙｅｒＩｎｔｅｌｌｅｃｔｕａｌＰｒｏｐｅｒｔｙＧｍｂＨ	置換スルホンアミドフェノキシベンズアミド
US20120269803A1 (en)	2009-10-21	2012-10-25	Bayer Intellectual Property Gmbh	Substituted benzosulphonamides
JP2013508320A (ja)	2009-10-21	2013-03-07	バイエル・ファルマ・アクチェンゲゼルシャフト	置換されたハロフェノキシベンズアミド誘導体
US8962606B2 (en)	2009-10-21	2015-02-24	Bayer Intellectual Property Gmbh	Substituted benzosulphonamides
CN104945401B (zh)	2010-02-01	2017-09-05	癌症研究技术有限公司	Ip化合物及它们在治疗中的应用
CA2816188A1 (en)	2010-10-29	2012-05-03	Marion Hitchcock	Substituted phenoxypyridines
WO2012135753A1 (en)	2011-04-01	2012-10-04	Genentech, Inc.	Combinations of akt inhibitor compounds and erlotinib, and methods of use
RU2013148817A (ru)	2011-04-01	2015-05-10	Дженентек, Инк.	Комбинации соединений-ингибиторов акт и мек и способы их применения
BR112015008113B1 (pt)	2012-10-12	2022-05-24	Exelixis, Inc.	Novo processo para preparar compostos para uso no tratamento de câncer
CA2923835C (en)	2013-09-11	2022-11-29	The Administrators Of The Tulane Educational Fund	Novel anthranilic amides and the use thereof
GB201320729D0 (en)	2013-11-25	2014-01-08	Cancer Rec Tech Ltd	Therapeutic compounds and their use
GB201320732D0 (en)	2013-11-25	2014-01-08	Cancer Rec Tech Ltd	Methods of chemical synthesis
US10040769B2 (en)	2015-10-27	2018-08-07	Regenacy Pharmaceuticals, Llc	HDAC inhibitors for the treatment of diabetic peripheral neuropathy
EP3973960B1 (en)	2017-10-17	2025-09-03	Atriva Therapeutics GmbH	Novel mek-inhibitor for the treatment of viral and bacterial infections
LU101183B1 (en) *	2019-04-16	2020-10-16	Atriva Therapeutics Gmbh	Novel mek-inhibitor for the treatment of viral and bacterial infections
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US6251943B1 (en) *	1997-02-28	2001-06-26	Warner-Lambert Company	Method of treating or preventing septic shock by administering a MEK inhibitor
AU756586C (en) *	1997-07-01	2004-01-29	Warner-Lambert Company	2-(4-bromo or 4-iodo phenylamino) benzoic acid derivatives and their use as MEK inhibitors
IL132840A (en) *	1997-07-01	2004-12-15	Warner Lambert Co	Derivatives 4 - bromo or 4 - benzohydroxamic acid iodine amino iodine and pharmaceutical preparations containing them for use as MEK inhibitors
KR100609800B1 (ko) *	1998-12-16	2006-08-09	워너-램버트 캄파니 엘엘씨	Ｍｅｋ 저해제를 사용한 관절염 치료 방법

2000
- 2000-07-05 NZ NZ515567A patent/NZ515567A/xx unknown
- 2000-07-05 KR KR1020027000609A patent/KR20020012315A/ko not_active Withdrawn
- 2000-07-05 IL IL14761900A patent/IL147619A0/xx unknown
- 2000-07-05 EP EP00943383A patent/EP1202726A2/en not_active Withdrawn
- 2000-07-05 AU AU57860/00A patent/AU5786000A/en not_active Abandoned
- 2000-07-05 WO PCT/US2000/018347 patent/WO2001005392A2/en not_active Ceased
- 2000-07-05 HU HU0202623A patent/HUP0202623A3/hu unknown
- 2000-07-05 PL PL00352684A patent/PL352684A1/xx not_active Application Discontinuation
- 2000-07-05 JP JP2001510449A patent/JP2003504400A/ja active Pending
- 2000-07-05 CA CA002374052A patent/CA2374052A1/en not_active Abandoned
- 2000-07-05 CN CN00809801A patent/CN1373660A/zh active Pending
- 2000-07-05 TR TR2002/00082T patent/TR200200082T2/xx unknown
- 2000-07-13 AR ARP000103604A patent/AR024732A1/es unknown
- 2000-07-14 PE PE2000000705A patent/PE20010545A1/es not_active Application Discontinuation
- 2000-07-14 CO CO00053304A patent/CO5300398A1/es not_active Application Discontinuation
2001
- 2001-11-30 ZA ZA200109907A patent/ZA200109907B/en unknown

Also Published As

Publication number	Publication date
EP1202726A2 (en)	2002-05-08
CN1373660A (zh)	2002-10-09
HUP0202623A3 (en)	2003-03-28
WO2001005392A2 (en)	2001-01-25
ZA200109907B (en)	2003-02-28
PE20010545A1 (es)	2001-06-04
JP2003504400A (ja)	2003-02-04
PL352684A1 (pl)	2003-09-08
TR200200082T2 (tr)	2002-04-22
HUP0202623A2 (hu)	2002-11-28
AU5786000A (en)	2001-02-05
CO5300398A1 (es)	2003-07-31
CA2374052A1 (en)	2001-01-25
KR20020012315A (ko)	2002-02-15
WO2001005392A3 (en)	2001-07-19
AR024732A1 (es)	2002-10-23
IL147619A0 (en)	2002-08-14

Publication	Publication Date	Title
NZ515567A (en)	2004-03-26	Method for treating chronic pain using MEK inhibitors
AU2483000A (en)	2000-07-24	Treatment of asthma with mek inhibitors
MY150740A (en)	2014-02-28	Low dose methods for treating disorders in which tnf? activity is detrimental
MXPA05006359A (es)	2006-02-08	Tratamiento de la enfermedad a traves de inhibidores peptidos antimicrobianos.
DK1373215T3 (da)	2006-11-13	Gelanamycinderivater egnet til behandling af cancer
MY151032A (en)	2014-03-31	Treatment of tnf? related disorders
SE0104248D0 (sv)	2001-12-14	Method of treatment
GEP20053631B (en)	2005-10-10	) New Spirotricyclic Derivatives and Their Use as Phosphodiesterase-7 Inhibitors
NZ517616A (en)	2002-12-20	Use of retigabin for treating neuropathic pain
IL165262A (en)	2011-10-31	Kinase inhibitors and pharmaceutical compositions containing them
MY137250A (en)	2009-01-30	Method of treatment of transplant rejection
TR200200204T2 (tr)	2002-11-21	MEK inhibitörleri kullanılarak kronik ağrının tedavi edilmesi.
AU7321598A (en)	1998-09-22	Use of cholinesterase inhibitors to treat disorders of attention
TW200510397A (en)	2005-03-16	Conjugated complement cascade inhibitors
ZA200500323B (en)	2006-02-22	Use of lkb kinase inhibitors for the treatment of pain.
GB2396108B (en)	2005-08-03	Treatment of pain
IN2005KO00312A (xx)	2015-08-14
WO2004007676A3 (en)	2004-04-08	Combination therapy for the treatment of neoplasms
AU2002347984A1 (en)	2003-06-17	Use of norepinephrine reuptake inhibitors for the treatment of tic disorders
IL130500A (en)	2003-02-12	Use of comt inhibitors for the manufacture of a medicament for the prevention of diabetic vascular dysfunctions
MXPA04011018A (es)	2005-01-25	Nueva combinacion de inhibidores reversibles de la bomba de protones y productos terapueticos para tratar trastornos de las vias respiratorias.
AU2444399A (en)	1999-08-09	New use for pain management
MXPA05010800A (es)	2005-12-14	Acidos hidroxamicos utiles en el tratamiento de trastornos hiperproliferativos.
NZ531109A (en)	2006-03-31	New mandelic acid derivatives and their use as thrombin inhibitors
NO20024545D0 (no)	2002-09-23	Fremgangsmåte for behandling av kongestiv hjertefeil

Legal Events

Date	Code	Title	Description
2004-07-30	PSEA	Patent sealed
2004-07-30	RENW	Renewal (renewal fees accepted)